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P52111 (GLPD_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase

EC=1.1.5.3
Gene names
Name:glpD
Ordered Locus Names:PA3584
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactor

FAD.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycerol metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentglycerol-3-phosphate dehydrogenase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionsn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Glycerol-3-phosphate dehydrogenase
PRO_0000126104

Regions

Nucleotide binding16 – 4429FAD Potential

Experimental info

Sequence conflict77 – 782EA → DT in AAA81584. Ref.1
Sequence conflict133 – 1408GLRFTGSS → ACVHRQQ in AAA81584. Ref.1
Sequence conflict180 – 20829RTRCV…LYSIR → APAASAPVAARDSGTCTWSA ATAACIRS in AAA81584. Ref.1
Sequence conflict425 – 4306LRWART → PALGAH in AAA81584. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P52111 [UniParc].

Last modified December 8, 2000. Version 2.
Checksum: DFF734821ABD730C

FASTA51257,135
        10         20         30         40         50         60 
MSQAHTPSAP LAEVYDVAVV GGGINGVGIA ADAAGRGLSV FLCEQHDLAQ HTSSASSKLI 

        70         80         90        100        110        120 
HGGLRYLEHY EFRLVREALA EREVLLAKAP HIVKPLRFVL PHRPHLRPAW MIRAGLFLYD 

       130        140        150        160        170        180 
HLGKREKLPA SRGLRFTGSS PLKAEIRRGF EYSDCAVDDA RLVVLNAISA REHGAHVHTR 

       190        200        210        220        230        240 
TRCVSARRSK GLWHLHLERS DGSLYSIRAR ALVNAAGPWV ARFIQDDLKQ KSPYGIRLIQ 

       250        260        270        280        290        300 
GSHIIVPKLY EGEHAYILQN EDRRIVFAIP YLDRFTMIGT TDREYQGDPA KVAISEEETA 

       310        320        330        340        350        360 
YLLQVVNAHF KQQLAAADIL HSFAGVRPLC DDESDEPSAI TRDYTLSLSA GNGEPPLLSV 

       370        380        390        400        410        420 
FGGKLTTYRK LAESALTQLQ PFFANLGPAW TAKAPLPGGE QMQSVEALTE QLANRYAWLD 

       430        440        450        460        470        480 
RELALRWART YGTRVWRLLD GVNGEADLGE HLGGGLYARE VDYLCKHEWA QDAEDILWRR 

       490        500        510 
SKLGLFLSPS QQVRLGQYLQ SEHPHRPRVH AA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and nucleotide sequence of the glpD gene encoding sn-glycerol-3-phosphate dehydrogenase of Pseudomonas aeruginosa."
Schweizer H.P., Po C.
J. Bacteriol. 176:2184-2193(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CD10.
[2]"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen."
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. expand/collapse author list , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.
Nature 406:959-964(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L06231 Genomic DNA. Translation: AAA81584.1.
AE004091 Genomic DNA. Translation: AAG06972.1.
PIRA55207.
B83197.
RefSeqNP_252274.1. NC_002516.2.

3D structure databases

ProteinModelPortalP52111.
SMRP52111. Positions 38-499.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA3584.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG06972; AAG06972; PA3584.
GeneID880179.
KEGGpae:PA3584.
PATRIC19841787. VBIPseAer58763_3751.

Organism-specific databases

PseudoCAPPA3584.

Phylogenomic databases

eggNOGCOG0578.
HOGENOMHOG000004811.
KOK00111.
OMAVINNIWH.
OrthoDBEOG651SR7.
PhylomeDBP52111.

Family and domain databases

InterProIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamPF01266. DAO. 1 hit.
[Graphical view]
PRINTSPR01001. FADG3PDH.
PROSITEPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPD_PSEAE
AccessionPrimary (citable) accession number: P52111
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 8, 2000
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families