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P52108 (RSTA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional regulatory protein RstA
Gene names
Name:rstA
Synonyms:urpT
Ordered Locus Names:b1608, JW1600
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Member of the two-component regulatory system RstB/RstA.

Subcellular location

Cytoplasm Potential.

Induction

Induced by low extracellular levels of magnesium via the PhoQ/PhoP two-component regulatory system. Ref.6

Post-translational modification

Phosphorylated by RstB. Ref.7

Sequence similarities

Contains 1 response regulatory domain.

Sequence caution

The sequence AAA82081.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA15346.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

kdpEP218662EBI-558990,EBI-6403634

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Transcriptional regulatory protein RstA
PRO_0000081223

Regions

Domain3 – 116114Response regulatory

Amino acid modifications

Modified residue5214-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P52108 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: 409A1B3A2588A77D

FASTA23926,704
        10         20         30         40         50         60 
MNTIVFVEDD AEVGSLIAAY LAKHDMQVTV EPRGDQAEET ILRENPDLVL LDIMLPGKDG 

        70         80         90        100        110        120 
MTICRDLRAK WSGPIVLLTS LDSDMNHILA LEMGACDYIL KTTPPAVLLA RLRLHLRQNE 

       130        140        150        160        170        180 
QATLTKGLQE TSLTPYKALH FGTLTIDPIN RVVTLANTEI SLSTADFELL WELATHAGQI 

       190        200        210        220        230 
MDRDALLKNL RGVSYDGLDR SVDVAISRLR KKLLDNAAEP YRIKTVRNKG YLFAPHAWE 

« Hide

References

« Hide 'large scale' references
[1]Kuempel P.L.
Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map."
Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K. expand/collapse author list , Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T.
DNA Res. 3:363-377(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"In vivo characterization of tus gene expression in Escherichia coli."
Roecklein B.A., Kuempel P.L.
Mol. Microbiol. 6:1655-1661(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: MAPPING.
[6]"Identification and molecular characterization of the Mg2+ stimulon of Escherichia coli."
Minagawa S., Ogasawara H., Kato A., Yamamoto K., Eguchi Y., Oshima T., Mori H., Ishihama A., Utsumi R.
J. Bacteriol. 185:3696-3702(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
Strain: K12.
[7]"Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli."
Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.
J. Biol. Chem. 280:1448-1456(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION.
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U41101 Genomic DNA. Translation: AAA82081.1. Different initiation.
U00096 Genomic DNA. Translation: AAC74680.2.
AP009048 Genomic DNA. Translation: BAA15346.1. Different initiation.
PIRB64917.
RefSeqNP_416125.2. NC_000913.3.
YP_489871.1. NC_007779.1.

3D structure databases

ProteinModelPortalP52108.
SMRP52108. Positions 4-235.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-10807N.
IntActP52108. 12 interactions.
MINTMINT-1274913.
STRING511145.b1608.

Proteomic databases

PaxDbP52108.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC74680; AAC74680; b1608.
BAA15346; BAA15346; BAA15346.
GeneID12932769.
946199.
KEGGecj:Y75_p1584.
eco:b1608.
PATRIC32118518. VBIEscCol129921_1679.

Organism-specific databases

EchoBASEEB2982.
EcoGeneEG13190. rstA.

Phylogenomic databases

eggNOGCOG0745.
HOGENOMHOG000034819.
KOK07661.
OMAYDGPILM.
OrthoDBEOG6G4VQG.
PhylomeDBP52108.

Enzyme and pathway databases

BioCycEcoCyc:RSTA-MONOMER.
ECOL316407:JW1600-MONOMER.

Gene expression databases

GenevestigatorP52108.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP52108.

Entry information

Entry nameRSTA_ECOLI
AccessionPrimary (citable) accession number: P52108
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 26, 2007
Last modified: June 11, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene