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P52108

- RSTA_ECOLI

UniProt

P52108 - RSTA_ECOLI

Protein

Transcriptional regulatory protein RstA

Gene

rstA

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Member of the two-component regulatory system RstB/RstA.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. phosphorelay response regulator activity Source: InterPro
    3. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation, Two-component regulatory system

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:RSTA-MONOMER.
    ECOL316407:JW1600-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulatory protein RstA
    Gene namesi
    Name:rstA
    Synonyms:urpT
    Ordered Locus Names:b1608, JW1600
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13190. rstA.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239Transcriptional regulatory protein RstAPRO_0000081223Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei52 – 5214-aspartylphosphatePROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated by RstB.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP52108.

    Expressioni

    Inductioni

    Induced by low extracellular levels of magnesium via the PhoQ/PhoP two-component regulatory system.1 Publication

    Gene expression databases

    GenevestigatoriP52108.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    kdpEP218662EBI-558990,EBI-6403634

    Protein-protein interaction databases

    DIPiDIP-10807N.
    IntActiP52108. 12 interactions.
    MINTiMINT-1274913.
    STRINGi511145.b1608.

    Structurei

    3D structure databases

    ProteinModelPortaliP52108.
    SMRiP52108. Positions 4-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 116114Response regulatoryPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0745.
    HOGENOMiHOG000034819.
    KOiK07661.
    OMAiYDGPILM.
    OrthoDBiEOG6G4VQG.
    PhylomeDBiP52108.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR016032. Sig_transdc_resp-reg_C-effctor.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46894. SSF46894. 1 hit.
    SSF52172. SSF52172. 1 hit.
    PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52108-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTIVFVEDD AEVGSLIAAY LAKHDMQVTV EPRGDQAEET ILRENPDLVL    50
    LDIMLPGKDG MTICRDLRAK WSGPIVLLTS LDSDMNHILA LEMGACDYIL 100
    KTTPPAVLLA RLRLHLRQNE QATLTKGLQE TSLTPYKALH FGTLTIDPIN 150
    RVVTLANTEI SLSTADFELL WELATHAGQI MDRDALLKNL RGVSYDGLDR 200
    SVDVAISRLR KKLLDNAAEP YRIKTVRNKG YLFAPHAWE 239
    Length:239
    Mass (Da):26,704
    Last modified:June 26, 2007 - v2
    Checksum:i409A1B3A2588A77D
    GO

    Sequence cautioni

    The sequence AAA82081.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA15346.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41101 Genomic DNA. Translation: AAA82081.1. Different initiation.
    U00096 Genomic DNA. Translation: AAC74680.2.
    AP009048 Genomic DNA. Translation: BAA15346.1. Different initiation.
    PIRiB64917.
    RefSeqiNP_416125.2. NC_000913.3.
    YP_489871.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC74680; AAC74680; b1608.
    BAA15346; BAA15346; BAA15346.
    GeneIDi12932769.
    946199.
    KEGGiecj:Y75_p1584.
    eco:b1608.
    PATRICi32118518. VBIEscCol129921_1679.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41101 Genomic DNA. Translation: AAA82081.1 . Different initiation.
    U00096 Genomic DNA. Translation: AAC74680.2 .
    AP009048 Genomic DNA. Translation: BAA15346.1 . Different initiation.
    PIRi B64917.
    RefSeqi NP_416125.2. NC_000913.3.
    YP_489871.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P52108.
    SMRi P52108. Positions 4-235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-10807N.
    IntActi P52108. 12 interactions.
    MINTi MINT-1274913.
    STRINGi 511145.b1608.

    Proteomic databases

    PaxDbi P52108.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC74680 ; AAC74680 ; b1608 .
    BAA15346 ; BAA15346 ; BAA15346 .
    GeneIDi 12932769.
    946199.
    KEGGi ecj:Y75_p1584.
    eco:b1608.
    PATRICi 32118518. VBIEscCol129921_1679.

    Organism-specific databases

    EchoBASEi EB2982.
    EcoGenei EG13190. rstA.

    Phylogenomic databases

    eggNOGi COG0745.
    HOGENOMi HOG000034819.
    KOi K07661.
    OMAi YDGPILM.
    OrthoDBi EOG6G4VQG.
    PhylomeDBi P52108.

    Enzyme and pathway databases

    BioCyci EcoCyc:RSTA-MONOMER.
    ECOL316407:JW1600-MONOMER.

    Miscellaneous databases

    PROi P52108.

    Gene expression databases

    Genevestigatori P52108.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR016032. Sig_transdc_resp-reg_C-effctor.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46894. SSF46894. 1 hit.
    SSF52172. SSF52172. 1 hit.
    PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kuempel P.L.
      Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "In vivo characterization of tus gene expression in Escherichia coli."
      Roecklein B.A., Kuempel P.L.
      Mol. Microbiol. 6:1655-1661(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: MAPPING.
    6. "Identification and molecular characterization of the Mg2+ stimulon of Escherichia coli."
      Minagawa S., Ogasawara H., Kato A., Yamamoto K., Eguchi Y., Oshima T., Mori H., Ishihama A., Utsumi R.
      J. Bacteriol. 185:3696-3702(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
      Strain: K12.
    7. "Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli."
      Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.
      J. Biol. Chem. 280:1448-1456(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiRSTA_ECOLI
    AccessioniPrimary (citable) accession number: P52108
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3