P52107 (CSGC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Curli assembly protein CsgC

Gene names

Name:	csgC
Ordered Locus Names:	b1043, JW1026

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway By similarity.
Subcellular location	Periplasm By similarity.
Induction	Under control of the CsgD transcription factor, part of the csgBAC/ymdA operon. Ref.5
Sequence similarities	Belongs to the CsgC/AgfC family.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 8	8	Potential
	Chain	9 – 110	102	Curli assembly protein CsgC		PRO_0000021013

Sequences

	Sequence		Length	Mass (Da)
	P52107 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: FD84CFB9C082CEE8	FASTA	110	11,967
	10 20 30 40 50 60 MNTLLLLAAL SSQITFNTTQ QGDVYTIIPE VTLTQSCLCR VQILSLREGS SGQSQTKQEK 70 80 90 100 110 TLSLPANQPI ALTKLSLNIS PDDRVKIVVT VSDGQSLHLS QQWPPSSEKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of two csg operons is required for production of fibronectin- and congo red-binding curli polymers in Escherichia coli K-12." Hammar M., Arnqvist A., Bian Z., Olsen A., Normark S. Mol. Microbiol. 18:661-670(1995) [PubMed: 8817489] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
[2]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed: 8905232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Cyclic-di-GMP-mediated signalling within the sigma network of Escherichia coli." Weber H., Pesavento C., Possling A., Tischendorf G., Hengge R. Mol. Microbiol. 62:1014-1034(2006) [PubMed: 17010156] [Abstract] Cited for: INDUCTION. Strain: K12 / MC4100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X90754 Genomic DNA. Translation: CAA62283.1. U00096 Genomic DNA. Translation: AAC74127.1. AP009048 Genomic DNA. Translation: BAA35833.1.
PIR	S70789.
RefSeq	NP_415561.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P52107.
SMR	P52107. Positions 11-105.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000001881; EBESCP00000001881; EBESCG00000001547. EBESCT00000016792; EBESCP00000016083; EBESCG00000015851.
GeneID	945623.
GenomeReviews	Gene locus JW1026 in contig AP009048_GR. Gene locus b1043 in contig U00096_GR.
KEGG	ecj:JW1026. eco:b1043.
PATRIC	32117323. VBIEscCol129921_1084.
Organism-specific databases
EchoBASE	EB3190.
EcoGene	EG13414. csgC.
Phylogenomic databases
eggNOG	NOG12351.
GeneTree	EBGT00050000009280.
HOGENOM	HBG416348.
OMA	LSQQWPS.
ProtClustDB	PRK10102.
Enzyme and pathway databases
BioCyc	EcoCyc:G6548-MONOMER.
Gene expression databases
Genevestigator	P52107.
Family and domain databases
InterPro	IPR014491. Curli_production_prot_CsgC. [Graphical view]
KO	K04336.
Pfam	PF10610. Tafi-CsgC. 1 hit. [Graphical view]
PIRSF	PIRSF018100. CsgC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CSGC_ECOLI

Accession

Primary (citable) accession number: P52107

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program