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Protein

Lysine decarboxylase, constitutive

Gene

ldcC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

LDC is constitutively but weakly expressed under various conditions.

Catalytic activityi

L-lysine = cadaverine + CO2.

Cofactori

pH dependencei

Optimum pH is 6.2-8.0.

GO - Molecular functioni

  • lysine decarboxylase activity Source: EcoCyc

GO - Biological processi

  • lysine catabolic process Source: EcoliWiki
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciEcoCyc:LDC2-MONOMER.
ECOL316407:JW0181-MONOMER.
MetaCyc:LDC2-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine decarboxylase, constitutive (EC:4.1.1.18)
Short name:
LDC
Gene namesi
Name:ldcC
Synonyms:ldc, ldcH
Ordered Locus Names:b0186, JW0181
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13219. ldcC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011421 – 713Lysine decarboxylase, constitutiveAdd BLAST713

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei367N6-(pyridoxal phosphate)lysine1

Proteomic databases

PaxDbiP52095.
PRIDEiP52095.

Interactioni

Subunit structurei

Homodecamer.

Binary interactionsi

WithEntry#Exp.IntActNotes
cadAP0A9H33EBI-545944,EBI-545922

Protein-protein interaction databases

BioGridi4259757. 7 interactors.
DIPiDIP-10086N.
IntActiP52095. 5 interactors.
MINTiMINT-1275881.
STRINGi511145.b0186.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FKZelectron microscopy5.50E1-710[»]
ProteinModelPortaliP52095.
SMRiP52095.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN. Bacteria.
COG1982. LUCA.
HOGENOMiHOG000164394.
InParanoidiP52095.
KOiK01582.
OMAiFSIWQPP.
PhylomeDBiP52095.

Family and domain databases

CDDicd00615. Orn_deC_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009393. Orn_decarb. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIIAIMGPH GVFYKDEPIK ELESALVAQG FQIIWPQNSV DLLKFIEHNP
60 70 80 90 100
RICGVIFDWD EYSLDLCSDI NQLNEYLPLY AFINTHSTMD VSVQDMRMAL
110 120 130 140 150
WFFEYALGQA EDIAIRMRQY TDEYLDNITP PFTKALFTYV KERKYTFCTP
160 170 180 190 200
GHMGGTAYQK SPVGCLFYDF FGGNTLKADV SISVTELGSL LDHTGPHLEA
210 220 230 240 250
EEYIARTFGA EQSYIVTNGT STSNKIVGMY AAPSGSTLLI DRNCHKSLAH
260 270 280 290 300
LLMMNDVVPV WLKPTRNALG ILGGIPRREF TRDSIEEKVA ATTQAQWPVH
310 320 330 340 350
AVITNSTYDG LLYNTDWIKQ TLDVPSIHFD SAWVPYTHFH PIYQGKSGMS
360 370 380 390 400
GERVAGKVIF ETQSTHKMLA ALSQASLIHI KGEYDEEAFN EAFMMHTTTS
410 420 430 440 450
PSYPIVASVE TAAAMLRGNP GKRLINRSVE RALHFRKEVQ RLREESDGWF
460 470 480 490 500
FDIWQPPQVD EAECWPVAPG EQWHGFNDAD ADHMFLDPVK VTILTPGMDE
510 520 530 540 550
QGNMSEEGIP AALVAKFLDE RGIVVEKTGP YNLLFLFSIG IDKTKAMGLL
560 570 580 590 600
RGLTEFKRSY DLNLRIKNML PDLYAEDPDF YRNMRIQDLA QGIHKLIRKH
610 620 630 640 650
DLPGLMLRAF DTLPEMIMTP HQAWQRQIKG EVETIALEQL VGRVSANMIL
660 670 680 690 700
PYPPGVPLLM PGEMLTKESR TVLDFLLMLC SVGQHYPGFE TDIHGAKQDE
710
DGVYRVRVLK MAG
Length:713
Mass (Da):80,590
Last modified:November 1, 1997 - v2
Checksum:i4532C6069744ABDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti284S → T AA sequence (PubMed:9339543).Curated1
Sequence conflicti314N → F AA sequence (PubMed:9339543).Curated1
Sequence conflicti411T → S AA sequence (PubMed:9339543).Curated1
Sequence conflicti413 – 414AA → R AA sequence (PubMed:9339543).Curated2
Sequence conflicti498M → I AA sequence (PubMed:9339543).Curated1
Sequence conflicti673L → I AA sequence (PubMed:9339543).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87518 Genomic DNA. Translation: BAA21656.1.
D49445 Genomic DNA. Translation: BAA08426.1.
U70214 Genomic DNA. Translation: AAB08615.1.
U00096 Genomic DNA. Translation: AAC73297.1.
AP009048 Genomic DNA. Translation: BAA77861.1.
Z50870 Genomic DNA. Translation: CAA90749.1.
PIRiB64743.
RefSeqiNP_414728.1. NC_000913.3.
WP_001020973.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73297; AAC73297; b0186.
BAA77861; BAA77861; BAA77861.
GeneIDi944887.
KEGGiecj:JW0181.
eco:b0186.
PATRICi32115483. VBIEscCol129921_0193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87518 Genomic DNA. Translation: BAA21656.1.
D49445 Genomic DNA. Translation: BAA08426.1.
U70214 Genomic DNA. Translation: AAB08615.1.
U00096 Genomic DNA. Translation: AAC73297.1.
AP009048 Genomic DNA. Translation: BAA77861.1.
Z50870 Genomic DNA. Translation: CAA90749.1.
PIRiB64743.
RefSeqiNP_414728.1. NC_000913.3.
WP_001020973.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FKZelectron microscopy5.50E1-710[»]
ProteinModelPortaliP52095.
SMRiP52095.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259757. 7 interactors.
DIPiDIP-10086N.
IntActiP52095. 5 interactors.
MINTiMINT-1275881.
STRINGi511145.b0186.

Proteomic databases

PaxDbiP52095.
PRIDEiP52095.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73297; AAC73297; b0186.
BAA77861; BAA77861; BAA77861.
GeneIDi944887.
KEGGiecj:JW0181.
eco:b0186.
PATRICi32115483. VBIEscCol129921_0193.

Organism-specific databases

EchoBASEiEB3010.
EcoGeneiEG13219. ldcC.

Phylogenomic databases

eggNOGiENOG4105CXN. Bacteria.
COG1982. LUCA.
HOGENOMiHOG000164394.
InParanoidiP52095.
KOiK01582.
OMAiFSIWQPP.
PhylomeDBiP52095.

Enzyme and pathway databases

BioCyciEcoCyc:LDC2-MONOMER.
ECOL316407:JW0181-MONOMER.
MetaCyc:LDC2-MONOMER.

Miscellaneous databases

PROiP52095.

Family and domain databases

CDDicd00615. Orn_deC_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009393. Orn_decarb. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCLZ_ECOLI
AccessioniPrimary (citable) accession number: P52095
Secondary accession number(s): P78299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.