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Protein

Histidine transport system permease protein HisQ

Gene

hisQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:HISQ-MONOMER.
ECOL316407:JW2305-MONOMER.

Protein family/group databases

TCDBi3.A.1.3.29. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine transport system permease protein HisQ
Gene namesi
Name:hisQ
Ordered Locus Names:b2308, JW2305
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12125. hisQ.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12PeriplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini34 – 58CytoplasmicSequence analysisAdd BLAST25
Transmembranei59 – 79HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini80 – 87PeriplasmicSequence analysis8
Transmembranei88 – 108HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini109 – 152CytoplasmicSequence analysisAdd BLAST44
Transmembranei153 – 173HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini174 – 194PeriplasmicSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini216 – 228CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600501 – 228Histidine transport system permease protein HisQAdd BLAST228

Proteomic databases

PaxDbiP52094.
PRIDEiP52094.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).By similarity

Protein-protein interaction databases

BioGridi4260523. 8 interactors.
DIPiDIP-9912N.
STRINGi511145.b2308.

Structurei

3D structure databases

ProteinModelPortaliP52094.
SMRiP52094.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 212ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST200

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DSP. Bacteria.
COG4215. LUCA.
HOGENOMiHOG000267551.
InParanoidiP52094.
KOiK10016.
OMAiMWLERRY.
PhylomeDBiP52094.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR030199. HisQ.
IPR000515. MetI-like.
[Graphical view]
PANTHERiPTHR30133:SF1. PTHR30133:SF1. 1 hit.
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYGFSGVIL QGALVTLELA ISSVVLAVII GLIGAGGKLS QNRLSGLIFE
60 70 80 90 100
GYTTLIRGVP DLVLMLLIFY GLQIALNTVT EAMGVGQIDI DPMVAGIITL
110 120 130 140 150
GFIYGAYFTE TFRGAFMAVP KGHIEAATAF GFTRGQVFRR IMFPSMMRYA
160 170 180 190 200
LPGIGNNWQV ILKSTALVSL LGLEDVVKAT QLAGKSTWEP FYFAIVCGVI
210 220
YLVFTTVSNG VLLFLERRYS VGVKRADL
Length:228
Mass (Da):24,649
Last modified:November 1, 1997 - v2
Checksum:iE30595A18C1B8E2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15V → C in AAA85770 (Ref. 1) Curated1
Sequence conflicti61D → Y in AAA85770 (Ref. 1) Curated1
Sequence conflicti88I → M in AAA85770 (Ref. 1) Curated1
Sequence conflicti114G → C in AAA85770 (Ref. 1) Curated1
Sequence conflicti120P → A in AAA85770 (Ref. 1) Curated1
Sequence conflicti137 – 138VF → MC in AAA85770 (Ref. 1) Curated2
Sequence conflicti199V → L in AAA85770 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47027 Genomic DNA. Translation: AAA85770.1.
U00096 Genomic DNA. Translation: AAC75368.1.
AP009048 Genomic DNA. Translation: BAA16154.1.
PIRiB65003.
RefSeqiNP_416811.1. NC_000913.3.
WP_000965522.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75368; AAC75368; b2308.
BAA16154; BAA16154; BAA16154.
GeneIDi947235.
KEGGiecj:JW2305.
eco:b2308.
PATRICi32119987. VBIEscCol129921_2403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47027 Genomic DNA. Translation: AAA85770.1.
U00096 Genomic DNA. Translation: AAC75368.1.
AP009048 Genomic DNA. Translation: BAA16154.1.
PIRiB65003.
RefSeqiNP_416811.1. NC_000913.3.
WP_000965522.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP52094.
SMRiP52094.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260523. 8 interactors.
DIPiDIP-9912N.
STRINGi511145.b2308.

Protein family/group databases

TCDBi3.A.1.3.29. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP52094.
PRIDEiP52094.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75368; AAC75368; b2308.
BAA16154; BAA16154; BAA16154.
GeneIDi947235.
KEGGiecj:JW2305.
eco:b2308.
PATRICi32119987. VBIEscCol129921_2403.

Organism-specific databases

EchoBASEiEB2046.
EcoGeneiEG12125. hisQ.

Phylogenomic databases

eggNOGiENOG4105DSP. Bacteria.
COG4215. LUCA.
HOGENOMiHOG000267551.
InParanoidiP52094.
KOiK10016.
OMAiMWLERRY.
PhylomeDBiP52094.

Enzyme and pathway databases

BioCyciEcoCyc:HISQ-MONOMER.
ECOL316407:JW2305-MONOMER.

Miscellaneous databases

PROiP52094.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR030199. HisQ.
IPR000515. MetI-like.
[Graphical view]
PANTHERiPTHR30133:SF1. PTHR30133:SF1. 1 hit.
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHISQ_ECOLI
AccessioniPrimary (citable) accession number: P52094
Secondary accession number(s): P77635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.