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Protein

Bacterial non-heme ferritin

Gene

ftnA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Iron-storage protein.

Catalytic activityi

4 Fe2+ + O2 + 6 H2O = 4 (FeO(OH)) + 8 H+.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17Iron 1PROSITE-ProRule annotation1
Metal bindingi50Iron 1PROSITE-ProRule annotation1
Metal bindingi50Iron 2PROSITE-ProRule annotation1
Metal bindingi53Iron 1PROSITE-ProRule annotation1
Metal bindingi94Iron 2PROSITE-ProRule annotation1
Metal bindingi127Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0653-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterial non-heme ferritin (EC:1.16.3.2)
Gene namesi
Name:ftnA
Synonyms:pfr
Ordered Locus Names:HP_0653
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002010961 – 167Bacterial non-heme ferritinAdd BLAST167

Proteomic databases

PaxDbiP52093.

Interactioni

Subunit structurei

Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms.By similarity

Protein-protein interaction databases

DIPiDIP-3470N.
IntActiP52093. 6 interactors.
MINTiMINT-167098.
STRINGi85962.HP0653.

Structurei

3D structure databases

ProteinModelPortaliP52093.
SMRiP52093.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 145Ferritin-like diironPROSITE-ProRule annotationAdd BLAST145

Sequence similaritiesi

Belongs to the ferritin family. Prokaryotic subfamily.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41090A1. Bacteria.
COG1528. LUCA.
KOiK02217.
OMAiCEDKGFE.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKDIIKLL NEQVNKEMNS SNLYMSMSSW CYTHSLDGAG LFLFDHAAEE
60 70 80 90 100
YEHAKKLIVF LNENNVPVQL TSISAPEHKF EGLTQIFQKA YEHEQHISES
110 120 130 140 150
INNIVDHAIK GKDHATFNFL QWYVSEQHEE EVLFKDILDK IELIGNENHG
160
LYLADQYVKG IAKSRKS
Length:167
Mass (Da):19,286
Last modified:November 1, 1997 - v2
Checksum:i2829A4EC2AE616D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39A → S in AAB25329 (PubMed:8432720).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54729 Genomic DNA. Translation: AAB25329.1.
AE000511 Genomic DNA. Translation: AAD07712.1.
PIRiA49694.
RefSeqiNP_207447.1. NC_000915.1.
WP_000949202.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07712; AAD07712; HP_0653.
GeneIDi899994.
KEGGiheo:C694_03375.
hpy:HP0653.
PATRICi20592591. VBIHelPyl33062_0684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54729 Genomic DNA. Translation: AAB25329.1.
AE000511 Genomic DNA. Translation: AAD07712.1.
PIRiA49694.
RefSeqiNP_207447.1. NC_000915.1.
WP_000949202.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP52093.
SMRiP52093.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3470N.
IntActiP52093. 6 interactors.
MINTiMINT-167098.
STRINGi85962.HP0653.

Proteomic databases

PaxDbiP52093.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07712; AAD07712; HP_0653.
GeneIDi899994.
KEGGiheo:C694_03375.
hpy:HP0653.
PATRICi20592591. VBIHelPyl33062_0684.

Phylogenomic databases

eggNOGiENOG41090A1. Bacteria.
COG1528. LUCA.
KOiK02217.
OMAiCEDKGFE.

Enzyme and pathway databases

BioCyciHPY:HP0653-MONOMER.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTN_HELPY
AccessioniPrimary (citable) accession number: P52093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Was originally thought to be an adhesin.1 Publication
In PubMed:1556073 only the sequence of residues 1-12 of strain 5294 was determined.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.