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P52093 (FTN_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin

EC=1.16.3.1
Gene names
Name:ftnA
Synonyms:pfr
Ordered Locus Names:HP_0653
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Iron-storage protein.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms By similarity.

Subcellular location

Cytoplasm Ref.4.

Miscellaneous

Was originally (Ref.3) thought to be an adhesin.

In Ref.3 only the sequence of residues 1-12 of strain 5294 was determined.

Sequence similarities

Belongs to the ferritin family. Prokaryotic subfamily.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 167167Ferritin
PRO_0000201096

Regions

Domain1 – 145145Ferritin-like diiron

Sites

Metal binding171Iron 1 By similarity
Metal binding501Iron 1 By similarity
Metal binding501Iron 2 By similarity
Metal binding531Iron 1 By similarity
Metal binding941Iron 2 By similarity
Metal binding1271Iron 2 By similarity

Experimental info

Sequence conflict391A → S in AAB25329. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P52093 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 2829A4EC2AE616D4

FASTA16719,286
        10         20         30         40         50         60 
MLSKDIIKLL NEQVNKEMNS SNLYMSMSSW CYTHSLDGAG LFLFDHAAEE YEHAKKLIVF 

        70         80         90        100        110        120 
LNENNVPVQL TSISAPEHKF EGLTQIFQKA YEHEQHISES INNIVDHAIK GKDHATFNFL 

       130        140        150        160 
QWYVSEQHEE EVLFKDILDK IELIGNENHG LYLADQYVKG IAKSRKS 

« Hide

References

« Hide 'large scale' references
[1]"Paracrystalline inclusions of a novel ferritin containing nonheme iron, produced by the human gastric pathogen Helicobacter pylori: evidence for a third class of ferritins."
Frazier B.A., Pfeifer J.D., Russell D.G., Falk P., Olsen A.N., Hammar M., Westblom T.U., Normark S.J.
J. Bacteriol. 175:966-972(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25.
Strain: DSM 4867 / CCUG 17874 / NCTC 11638.
[2]"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. expand/collapse author list , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.
Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.
[3]"Production of a conserved adhesin by the human gastroduodenal pathogen Helicobacter pylori."
Doig P., Austin J.W., Kostrzynska M., Trust T.J.
J. Bacteriol. 174:2539-2547(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-28.
Strain: 5294, ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487 and CCUG 915.
[4]"The Helicobacter pylori 19.6-kilodalton protein is an iron-containing protein resembling ferritin."
Doig P., Austin J.W., Trust T.J.
J. Bacteriol. 175:557-560(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION AS A FERRITIN, SUBCELLULAR LOCATION.
Strain: ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S54729 Genomic DNA. Translation: AAB25329.1.
AE000511 Genomic DNA. Translation: AAD07712.1.
PIRA49694.
RefSeqNP_207447.1. NC_000915.1.
YP_006934577.1. NC_018939.1.

3D structure databases

ProteinModelPortalP52093.
SMRP52093. Positions 1-164.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3470N.
IntActP52093. 6 interactions.
MINTMINT-167098.
STRING85962.HP0653.

Proteomic databases

PRIDEP52093.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07712; AAD07712; HP_0653.
GeneID899994.
KEGGheo:C694_03375.
hpy:HP0653.
PATRIC20592591. VBIHelPyl33062_0684.

Phylogenomic databases

eggNOGCOG1528.
KOK02217.
OMAFITRHIH.
OrthoDBEOG6G4W12.

Enzyme and pathway databases

BioCycHPY:HP0653-MONOMER.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTN_HELPY
AccessionPrimary (citable) accession number: P52093
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names