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P52093

- FTN_HELPY

UniProt

P52093 - FTN_HELPY

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Protein

Bacterial non-heme ferritin

Gene

ftnA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Iron-storage protein.

Catalytic activityi

4 Fe2+ + O2 + 6 H2O = 4 (FeO(OH)) + 8 H+.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Iron 1PROSITE-ProRule annotation
Metal bindingi50 – 501Iron 1PROSITE-ProRule annotation
Metal bindingi50 – 501Iron 2PROSITE-ProRule annotation
Metal bindingi53 – 531Iron 1PROSITE-ProRule annotation
Metal bindingi94 – 941Iron 2PROSITE-ProRule annotation
Metal bindingi127 – 1271Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0653-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterial non-heme ferritin (EC:1.16.3.2)
Gene namesi
Name:ftnA
Synonyms:pfr
Ordered Locus Names:HP_0653
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Bacterial non-heme ferritinPRO_0000201096Add
BLAST

Proteomic databases

PRIDEiP52093.

Interactioni

Subunit structurei

Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms.By similarity

Protein-protein interaction databases

DIPiDIP-3470N.
IntActiP52093. 6 interactions.
MINTiMINT-167098.
STRINGi85962.HP0653.

Structurei

3D structure databases

ProteinModelPortaliP52093.
SMRiP52093. Positions 1-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 145145Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family. Prokaryotic subfamily.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1528.
KOiK02217.
OMAiFITRHIH.
OrthoDBiEOG6G4W12.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52093-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSKDIIKLL NEQVNKEMNS SNLYMSMSSW CYTHSLDGAG LFLFDHAAEE
60 70 80 90 100
YEHAKKLIVF LNENNVPVQL TSISAPEHKF EGLTQIFQKA YEHEQHISES
110 120 130 140 150
INNIVDHAIK GKDHATFNFL QWYVSEQHEE EVLFKDILDK IELIGNENHG
160
LYLADQYVKG IAKSRKS
Length:167
Mass (Da):19,286
Last modified:November 1, 1997 - v2
Checksum:i2829A4EC2AE616D4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391A → S in AAB25329. (PubMed:8432720)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S54729 Genomic DNA. Translation: AAB25329.1.
AE000511 Genomic DNA. Translation: AAD07712.1.
PIRiA49694.
RefSeqiNP_207447.1. NC_000915.1.
YP_006934577.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07712; AAD07712; HP_0653.
GeneIDi13869845.
899994.
KEGGiheo:C694_03375.
hpy:HP0653.
PATRICi20592591. VBIHelPyl33062_0684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S54729 Genomic DNA. Translation: AAB25329.1 .
AE000511 Genomic DNA. Translation: AAD07712.1 .
PIRi A49694.
RefSeqi NP_207447.1. NC_000915.1.
YP_006934577.1. NC_018939.1.

3D structure databases

ProteinModelPortali P52093.
SMRi P52093. Positions 1-164.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3470N.
IntActi P52093. 6 interactions.
MINTi MINT-167098.
STRINGi 85962.HP0653.

Proteomic databases

PRIDEi P52093.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07712 ; AAD07712 ; HP_0653 .
GeneIDi 13869845.
899994.
KEGGi heo:C694_03375.
hpy:HP0653.
PATRICi 20592591. VBIHelPyl33062_0684.

Phylogenomic databases

eggNOGi COG1528.
KOi K02217.
OMAi FITRHIH.
OrthoDBi EOG6G4W12.

Enzyme and pathway databases

BioCyci HPY:HP0653-MONOMER.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Paracrystalline inclusions of a novel ferritin containing nonheme iron, produced by the human gastric pathogen Helicobacter pylori: evidence for a third class of ferritins."
    Frazier B.A., Pfeifer J.D., Russell D.G., Falk P., Olsen A.N., Hammar M., Westblom T.U., Normark S.J.
    J. Bacteriol. 175:966-972(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25.
    Strain: DSM 4867 / CCUG 17874 / NCTC 11638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  3. "Production of a conserved adhesin by the human gastroduodenal pathogen Helicobacter pylori."
    Doig P., Austin J.W., Kostrzynska M., Trust T.J.
    J. Bacteriol. 174:2539-2547(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-28.
    Strain: 5294, ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487 and CCUG 915.
  4. "The Helicobacter pylori 19.6-kilodalton protein is an iron-containing protein resembling ferritin."
    Doig P., Austin J.W., Trust T.J.
    J. Bacteriol. 175:557-560(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION AS A FERRITIN, SUBCELLULAR LOCATION.
    Strain: ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487.

Entry informationi

Entry nameiFTN_HELPY
AccessioniPrimary (citable) accession number: P52093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Was originally thought to be an adhesin.1 Publication
In PubMed:1556073 only the sequence of residues 1-12 of strain 5294 was determined.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3