P52093 (FTN_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferritin
EC=1.16.3.1

Gene names

Name:	ftnA
Synonyms:	pfr
Ordered Locus Names:	HP_0653

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Iron-storage protein.
Catalytic activity	4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Subunit structure	Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms By similarity.
Subcellular location	Cytoplasm Ref.4.
Miscellaneous	Was originally (Ref.3) thought to be an adhesin. In Ref.3 only the sequence of residues 1-12 of strain 5294 was determined.
Sequence similarities	Belongs to the ferritin family. Prokaryotic subfamily. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW iron ion transport Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ferric iron binding Inferred from electronic annotation. Source: InterPro ferroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Ferritin		PRO_0000201096
Regions
	Domain	1 – 145	145	Ferritin-like diiron
Sites
	Metal binding	17	1	Iron 1 By similarity
	Metal binding	50	1	Iron 1 By similarity
	Metal binding	50	1	Iron 2 By similarity
	Metal binding	53	1	Iron 1 By similarity
	Metal binding	94	1	Iron 2 By similarity
	Metal binding	127	1	Iron 2 By similarity
Experimental info
	Sequence conflict	39	1	A → S in AAB25329. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P52093 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 2829A4EC2AE616D4	FASTA	167	19,286
	10 20 30 40 50 60 MLSKDIIKLL NEQVNKEMNS SNLYMSMSSW CYTHSLDGAG LFLFDHAAEE YEHAKKLIVF 70 80 90 100 110 120 LNENNVPVQL TSISAPEHKF EGLTQIFQKA YEHEQHISES INNIVDHAIK GKDHATFNFL 130 140 150 160 QWYVSEQHEE EVLFKDILDK IELIGNENHG LYLADQYVKG IAKSRKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Paracrystalline inclusions of a novel ferritin containing nonheme iron, produced by the human gastric pathogen Helicobacter pylori: evidence for a third class of ferritins." Frazier B.A., Pfeifer J.D., Russell D.G., Falk P., Olsen A.N., Hammar M., Westblom T.U., Normark S.J. J. Bacteriol. 175:966-972(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25. Strain: DSM 4867 / CCUG 17874 / NCTC 11638.
[2]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
[3]	"Production of a conserved adhesin by the human gastroduodenal pathogen Helicobacter pylori." Doig P., Austin J.W., Kostrzynska M., Trust T.J. J. Bacteriol. 174:2539-2547(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-28. Strain: 5294, ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487 and CCUG 915.
[4]	"The Helicobacter pylori 19.6-kilodalton protein is an iron-containing protein resembling ferritin." Doig P., Austin J.W., Trust T.J. J. Bacteriol. 175:557-560(1993) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION AS A FERRITIN, SUBCELLULAR LOCATION. Strain: ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S54729 Genomic DNA. Translation: AAB25329.1. AE000511 Genomic DNA. Translation: AAD07712.1.
PIR	A49694.
RefSeq	NP_207447.1. NC_000915.1. YP_006934577.1. NC_018939.1.
3D structure databases
ProteinModelPortal	P52093.
SMR	P52093. Positions 1-164.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3470N.
MINT	MINT-167098.
STRING	85962.HP0653.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD07712; AAD07712; HP_0653.
GeneID	13869845. 899994.
KEGG	heo:C694_03375. hpy:HP0653.
PATRIC	20592591. VBIHelPyl33062_0684.
Phylogenomic databases
eggNOG	COG1528.
KO	K02217.
OMA	CEDKGFE.
ProtClustDB	CLSK872406.
Family and domain databases
Gene3D	1.20.1260.10. 1 hit.
InterPro	IPR001519. Ferritin. IPR009040. Ferritin-like_diiron. IPR009078. Ferritin-like_SF. IPR012347. Ferritin-rel. IPR008331. Ferritin_DPS_dom. [Graphical view]
PANTHER	PTHR11431. PTHR11431. 1 hit.
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTN_HELPY

Accession

Primary (citable) accession number: P52093

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program