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P52093

- FTN_HELPY

UniProt

P52093 - FTN_HELPY

Protein

Bacterial non-heme ferritin

Gene

ftnA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Iron-storage protein.

    Catalytic activityi

    4 Fe2+ + O2 + 6 H2O = 4 (FeO(OH)) + 8 H+.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi17 – 171Iron 1PROSITE-ProRule annotation
    Metal bindingi50 – 501Iron 1PROSITE-ProRule annotation
    Metal bindingi50 – 501Iron 2PROSITE-ProRule annotation
    Metal bindingi53 – 531Iron 1PROSITE-ProRule annotation
    Metal bindingi94 – 941Iron 2PROSITE-ProRule annotation
    Metal bindingi127 – 1271Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0653-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bacterial non-heme ferritin (EC:1.16.3.2)
    Gene namesi
    Name:ftnA
    Synonyms:pfr
    Ordered Locus Names:HP_0653
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 167167Bacterial non-heme ferritinPRO_0000201096Add
    BLAST

    Proteomic databases

    PRIDEiP52093.

    Interactioni

    Subunit structurei

    Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms.By similarity

    Protein-protein interaction databases

    DIPiDIP-3470N.
    IntActiP52093. 6 interactions.
    MINTiMINT-167098.
    STRINGi85962.HP0653.

    Structurei

    3D structure databases

    ProteinModelPortaliP52093.
    SMRiP52093. Positions 1-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 145145Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family. Prokaryotic subfamily.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1528.
    KOiK02217.
    OMAiFITRHIH.
    OrthoDBiEOG6G4W12.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52093-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSKDIIKLL NEQVNKEMNS SNLYMSMSSW CYTHSLDGAG LFLFDHAAEE    50
    YEHAKKLIVF LNENNVPVQL TSISAPEHKF EGLTQIFQKA YEHEQHISES 100
    INNIVDHAIK GKDHATFNFL QWYVSEQHEE EVLFKDILDK IELIGNENHG 150
    LYLADQYVKG IAKSRKS 167
    Length:167
    Mass (Da):19,286
    Last modified:November 1, 1997 - v2
    Checksum:i2829A4EC2AE616D4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391A → S in AAB25329. (PubMed:8432720)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S54729 Genomic DNA. Translation: AAB25329.1.
    AE000511 Genomic DNA. Translation: AAD07712.1.
    PIRiA49694.
    RefSeqiNP_207447.1. NC_000915.1.
    YP_006934577.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07712; AAD07712; HP_0653.
    GeneIDi13869845.
    899994.
    KEGGiheo:C694_03375.
    hpy:HP0653.
    PATRICi20592591. VBIHelPyl33062_0684.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S54729 Genomic DNA. Translation: AAB25329.1 .
    AE000511 Genomic DNA. Translation: AAD07712.1 .
    PIRi A49694.
    RefSeqi NP_207447.1. NC_000915.1.
    YP_006934577.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P52093.
    SMRi P52093. Positions 1-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3470N.
    IntActi P52093. 6 interactions.
    MINTi MINT-167098.
    STRINGi 85962.HP0653.

    Proteomic databases

    PRIDEi P52093.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07712 ; AAD07712 ; HP_0653 .
    GeneIDi 13869845.
    899994.
    KEGGi heo:C694_03375.
    hpy:HP0653.
    PATRICi 20592591. VBIHelPyl33062_0684.

    Phylogenomic databases

    eggNOGi COG1528.
    KOi K02217.
    OMAi FITRHIH.
    OrthoDBi EOG6G4W12.

    Enzyme and pathway databases

    BioCyci HPY:HP0653-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Paracrystalline inclusions of a novel ferritin containing nonheme iron, produced by the human gastric pathogen Helicobacter pylori: evidence for a third class of ferritins."
      Frazier B.A., Pfeifer J.D., Russell D.G., Falk P., Olsen A.N., Hammar M., Westblom T.U., Normark S.J.
      J. Bacteriol. 175:966-972(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25.
      Strain: DSM 4867 / CCUG 17874 / NCTC 11638.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.
    3. "Production of a conserved adhesin by the human gastroduodenal pathogen Helicobacter pylori."
      Doig P., Austin J.W., Kostrzynska M., Trust T.J.
      J. Bacteriol. 174:2539-2547(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-28.
      Strain: 5294, ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487 and CCUG 915.
    4. "The Helicobacter pylori 19.6-kilodalton protein is an iron-containing protein resembling ferritin."
      Doig P., Austin J.W., Trust T.J.
      J. Bacteriol. 175:557-560(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION AS A FERRITIN, SUBCELLULAR LOCATION.
      Strain: ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487.

    Entry informationi

    Entry nameiFTN_HELPY
    AccessioniPrimary (citable) accession number: P52093
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Was originally thought to be an adhesin.1 Publication
    In PubMed:1556073 only the sequence of residues 1-12 of strain 5294 was determined.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3