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Protein

Bacterial non-heme ferritin

Gene

ftnA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Iron-storage protein.

Catalytic activityi

4 Fe2+ + O2 + 6 H2O = 4 (FeO(OH)) + 8 H+.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Iron 1PROSITE-ProRule annotation
Metal bindingi50 – 501Iron 1PROSITE-ProRule annotation
Metal bindingi50 – 501Iron 2PROSITE-ProRule annotation
Metal bindingi53 – 531Iron 1PROSITE-ProRule annotation
Metal bindingi94 – 941Iron 2PROSITE-ProRule annotation
Metal bindingi127 – 1271Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0653-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterial non-heme ferritin (EC:1.16.3.2)
Gene namesi
Name:ftnA
Synonyms:pfr
Ordered Locus Names:HP_0653
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Bacterial non-heme ferritinPRO_0000201096Add
BLAST

Proteomic databases

PRIDEiP52093.

Interactioni

Subunit structurei

Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms.By similarity

Protein-protein interaction databases

DIPiDIP-3470N.
IntActiP52093. 6 interactions.
MINTiMINT-167098.
STRINGi85962.HP0653.

Structurei

3D structure databases

ProteinModelPortaliP52093.
SMRiP52093. Positions 1-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 145145Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family. Prokaryotic subfamily.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1528.
KOiK02217.
OMAiCEDKGFE.
OrthoDBiEOG6G4W12.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKDIIKLL NEQVNKEMNS SNLYMSMSSW CYTHSLDGAG LFLFDHAAEE
60 70 80 90 100
YEHAKKLIVF LNENNVPVQL TSISAPEHKF EGLTQIFQKA YEHEQHISES
110 120 130 140 150
INNIVDHAIK GKDHATFNFL QWYVSEQHEE EVLFKDILDK IELIGNENHG
160
LYLADQYVKG IAKSRKS
Length:167
Mass (Da):19,286
Last modified:November 1, 1997 - v2
Checksum:i2829A4EC2AE616D4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391A → S in AAB25329 (PubMed:8432720).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54729 Genomic DNA. Translation: AAB25329.1.
AE000511 Genomic DNA. Translation: AAD07712.1.
PIRiA49694.
RefSeqiNP_207447.1. NC_000915.1.
WP_000949202.1. NC_018939.1.
YP_006934577.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07712; AAD07712; HP_0653.
GeneIDi899994.
KEGGiheo:C694_03375.
hpy:HP0653.
PATRICi20592591. VBIHelPyl33062_0684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54729 Genomic DNA. Translation: AAB25329.1.
AE000511 Genomic DNA. Translation: AAD07712.1.
PIRiA49694.
RefSeqiNP_207447.1. NC_000915.1.
WP_000949202.1. NC_018939.1.
YP_006934577.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP52093.
SMRiP52093. Positions 1-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3470N.
IntActiP52093. 6 interactions.
MINTiMINT-167098.
STRINGi85962.HP0653.

Proteomic databases

PRIDEiP52093.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07712; AAD07712; HP_0653.
GeneIDi899994.
KEGGiheo:C694_03375.
hpy:HP0653.
PATRICi20592591. VBIHelPyl33062_0684.

Phylogenomic databases

eggNOGiCOG1528.
KOiK02217.
OMAiCEDKGFE.
OrthoDBiEOG6G4W12.

Enzyme and pathway databases

BioCyciHPY:HP0653-MONOMER.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Paracrystalline inclusions of a novel ferritin containing nonheme iron, produced by the human gastric pathogen Helicobacter pylori: evidence for a third class of ferritins."
    Frazier B.A., Pfeifer J.D., Russell D.G., Falk P., Olsen A.N., Hammar M., Westblom T.U., Normark S.J.
    J. Bacteriol. 175:966-972(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25.
    Strain: DSM 4867 / CCUG 17874 / NCTC 11638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  3. "Production of a conserved adhesin by the human gastroduodenal pathogen Helicobacter pylori."
    Doig P., Austin J.W., Kostrzynska M., Trust T.J.
    J. Bacteriol. 174:2539-2547(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-28.
    Strain: 5294, ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487 and CCUG 915.
  4. "The Helicobacter pylori 19.6-kilodalton protein is an iron-containing protein resembling ferritin."
    Doig P., Austin J.W., Trust T.J.
    J. Bacteriol. 175:557-560(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION AS A FERRITIN, SUBCELLULAR LOCATION.
    Strain: ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487.

Entry informationi

Entry nameiFTN_HELPY
AccessioniPrimary (citable) accession number: P52093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: May 27, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Was originally thought to be an adhesin.1 Publication
In PubMed:1556073 only the sequence of residues 1-12 of strain 5294 was determined.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.