ID   QSEB_ECOLI              Reviewed;         219 AA.
AC   P52076; Q2M9H5;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 155.
DE   RecName: Full=Transcriptional regulatory protein QseB;
GN   Name=qseB; Synonyms=ygiX; OrderedLocusNames=b3025, JW2993;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   FUNCTION.
RC   STRAIN=K12, and O157:H7;
RX   PubMed=11929534; DOI=10.1046/j.1365-2958.2002.02803.x;
RA   Sperandio V., Torres A.G., Kaper J.B.;
RT   "Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-
RT   component regulatory system involved in the regulation of flagella and
RT   motility by quorum sensing in E. coli.";
RL   Mol. Microbiol. 43:809-821(2002).
RN   [4]
RP   INDUCTION BY AI-2 AND MQSR.
RC   STRAIN=K12 / ATCC 25404 / DSM 5698 / NCIMB 11290, K12 / DH5-alpha, and
RC   K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16352847; DOI=10.1128/jb.188.1.305-316.2006;
RA   Gonzalez Barrios A.F., Zuo R., Hashimoto Y., Yang L., Bentley W.E.,
RA   Wood T.K.;
RT   "Autoinducer 2 controls biofilm formation in Escherichia coli through a
RT   novel motility quorum-sensing regulator (MqsR, B3022).";
RL   J. Bacteriol. 188:305-316(2006).
CC   -!- FUNCTION: Member of a two-component regulatory system QseB/QseC.
CC       Activates the flagella regulon by activating transcription of FlhDC.
CC       Currently it is not known whether this effect is direct or not.
CC       {ECO:0000269|PubMed:11929534}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: By the signal autoinducer AI-2, through MqsR.
CC       {ECO:0000269|PubMed:16352847}.
CC   -!- PTM: Phosphorylated by QseC. {ECO:0000305}.
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DR   EMBL; U28377; AAA69193.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76061.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77081.1; -; Genomic_DNA.
DR   PIR; G65089; G65089.
DR   RefSeq; NP_417497.1; NC_000913.3.
DR   RefSeq; WP_001221495.1; NZ_LN832404.1.
DR   AlphaFoldDB; P52076; -.
DR   SMR; P52076; -.
DR   BioGRID; 4262391; 127.
DR   IntAct; P52076; 5.
DR   STRING; 511145.b3025; -.
DR   jPOST; P52076; -.
DR   PaxDb; 511145-b3025; -.
DR   EnsemblBacteria; AAC76061; AAC76061; b3025.
DR   GeneID; 945369; -.
DR   KEGG; ecj:JW2993; -.
DR   KEGG; eco:b3025; -.
DR   PATRIC; fig|1411691.4.peg.3705; -.
DR   EchoBASE; EB2844; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_1_6; -.
DR   InParanoid; P52076; -.
DR   OMA; VWGWDFG; -.
DR   OrthoDB; 9802426at2; -.
DR   PhylomeDB; P52076; -.
DR   BioCyc; EcoCyc:G7575-MONOMER; -.
DR   PRO; PR:P52076; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006351; P:DNA-templated transcription; EXP:EcoCyc.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   GO; GO:0010038; P:response to metal ion; IMP:EcoCyc.
DR   CDD; cd17624; REC_OmpR_PmrA-like; 1.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 6.10.250.690; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; REGULATOR OF RPOS; 1.
DR   PANTHER; PTHR48111:SF35; TRANSCRIPTIONAL REGULATORY PROTEIN QSEB; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..219
FT                   /note="Transcriptional regulatory protein QseB"
FT                   /id="PRO_0000081025"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        124..218
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   219 AA;  24678 MW;  9408B2B7261E042E CRC64;
     MRILLIEDDM LIGDGIKTGL SKMGFSVDWF TQGRQGKEAL YSAPYDAVIL DLTLPGMDGR
     DILREWREKG QREPVLILTA RDALAERVEG LRLGADDYLC KPFALIEVAA RLEALMRRTN
     GQASNELRHG NVMLDPGKRI ATLAGEPLTL KPKEFALLEL LMRNAGRVLS RKLIEEKLYT
     WDEEVTSNAV EVHVHHLRRK LGSDFIRTVH GIGYTLGEK
//