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P52076

- QSEB_ECOLI

UniProt

P52076 - QSEB_ECOLI

Protein

Transcriptional regulatory protein QseB

Gene

qseB

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. Currently it is not known whether this effect is direct or not.1 Publication

    GO - Molecular functioni

    1. core promoter sequence-specific DNA binding Source: EcoCyc
    2. phosphorelay response regulator activity Source: EcoCyc

    GO - Biological processi

    1. intracellular signal transduction Source: GOC
    2. positive regulation of gene expression Source: EcoCyc
    3. quorum sensing Source: EcoCyc
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. response to metal ion Source: EcoCyc
    6. transcription, DNA-templated Source: EcoCyc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation, Two-component regulatory system

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:G7575-MONOMER.
    ECOL316407:JW2993-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulatory protein QseB
    Gene namesi
    Name:qseB
    Synonyms:ygiX
    Ordered Locus Names:b3025, JW2993
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13026. qseB.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. protein-DNA complex Source: EcoCyc

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219Transcriptional regulatory protein QseBPRO_0000081025Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 5114-aspartylphosphatePROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated by QseC.Curated

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Inductioni

    By the signal autoinducer AI-2, through MqsR.1 Publication

    Gene expression databases

    GenevestigatoriP52076.

    Interactioni

    Protein-protein interaction databases

    IntActiP52076. 5 interactions.
    STRINGi511145.b3025.

    Structurei

    3D structure databases

    ProteinModelPortaliP52076.
    SMRiP52076. Positions 1-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 116116Response regulatoryPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0745.
    HOGENOMiHOG000034815.
    KOiK07666.
    OMAiGTEVCRE.
    OrthoDBiEOG6G4VQG.
    PhylomeDBiP52076.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52172. SSF52172. 1 hit.
    PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52076-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRILLIEDDM LIGDGIKTGL SKMGFSVDWF TQGRQGKEAL YSAPYDAVIL    50
    DLTLPGMDGR DILREWREKG QREPVLILTA RDALAERVEG LRLGADDYLC 100
    KPFALIEVAA RLEALMRRTN GQASNELRHG NVMLDPGKRI ATLAGEPLTL 150
    KPKEFALLEL LMRNAGRVLS RKLIEEKLYT WDEEVTSNAV EVHVHHLRRK 200
    LGSDFIRTVH GIGYTLGEK 219
    Length:219
    Mass (Da):24,678
    Last modified:October 1, 1996 - v1
    Checksum:i9408B2B7261E042E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28377 Genomic DNA. Translation: AAA69193.1.
    U00096 Genomic DNA. Translation: AAC76061.1.
    AP009048 Genomic DNA. Translation: BAE77081.1.
    PIRiG65089.
    RefSeqiNP_417497.1. NC_000913.3.
    YP_491217.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC76061; AAC76061; b3025.
    BAE77081; BAE77081; BAE77081.
    GeneIDi12933397.
    945369.
    KEGGiecj:Y75_p2951.
    eco:b3025.
    PATRICi32121462. VBIEscCol129921_3118.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28377 Genomic DNA. Translation: AAA69193.1 .
    U00096 Genomic DNA. Translation: AAC76061.1 .
    AP009048 Genomic DNA. Translation: BAE77081.1 .
    PIRi G65089.
    RefSeqi NP_417497.1. NC_000913.3.
    YP_491217.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P52076.
    SMRi P52076. Positions 1-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P52076. 5 interactions.
    STRINGi 511145.b3025.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC76061 ; AAC76061 ; b3025 .
    BAE77081 ; BAE77081 ; BAE77081 .
    GeneIDi 12933397.
    945369.
    KEGGi ecj:Y75_p2951.
    eco:b3025.
    PATRICi 32121462. VBIEscCol129921_3118.

    Organism-specific databases

    EchoBASEi EB2844.
    EcoGenei EG13026. qseB.

    Phylogenomic databases

    eggNOGi COG0745.
    HOGENOMi HOG000034815.
    KOi K07666.
    OMAi GTEVCRE.
    OrthoDBi EOG6G4VQG.
    PhylomeDBi P52076.

    Enzyme and pathway databases

    BioCyci EcoCyc:G7575-MONOMER.
    ECOL316407:JW2993-MONOMER.

    Miscellaneous databases

    PROi P52076.

    Gene expression databases

    Genevestigatori P52076.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52172. SSF52172. 1 hit.
    PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. "Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli."
      Sperandio V., Torres A.G., Kaper J.B.
      Mol. Microbiol. 43:809-821(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: K12 and O157:H7.
    4. "Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)."
      Gonzalez Barrios A.F., Zuo R., Hashimoto Y., Yang L., Bentley W.E., Wood T.K.
      J. Bacteriol. 188:305-316(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY AI-2 AND MQSR.
      Strain: K12 / ATCC 25404 / DSM 5698 / NCIMB 11290, K12 / DH5-alpha and K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiQSEB_ECOLI
    AccessioniPrimary (citable) accession number: P52076
    Secondary accession number(s): Q2M9H5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3