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Protein

Transcriptional regulatory protein QseB

Gene

qseB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. Currently it is not known whether this effect is direct or not.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi124 – 21895OmpR/PhoB-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • core promoter sequence-specific DNA binding Source: EcoCyc
  • phosphorelay response regulator activity Source: EcoCyc

GO - Biological processi

  • positive regulation of gene expression Source: EcoCyc
  • quorum sensing Source: EcoCyc
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • response to metal ion Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7575-MONOMER.
ECOL316407:JW2993-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein QseB
Gene namesi
Name:qseB
Synonyms:ygiX
Ordered Locus Names:b3025, JW2993
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13026. qseB.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • protein-DNA complex Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Transcriptional regulatory protein QseBPRO_0000081025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 5114-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by QseC.Curated

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By the signal autoinducer AI-2, through MqsR.1 Publication

Interactioni

Protein-protein interaction databases

IntActiP52076. 5 interactions.
STRINGi511145.b3025.

Structurei

3D structure databases

ProteinModelPortaliP52076.
SMRiP52076. Positions 1-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 116115Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 OmpR/PhoB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034815.
InParanoidiP52076.
KOiK07666.
OMAiIDWFTEG.
OrthoDBiEOG6G4VQG.
PhylomeDBiP52076.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52076-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILLIEDDM LIGDGIKTGL SKMGFSVDWF TQGRQGKEAL YSAPYDAVIL
60 70 80 90 100
DLTLPGMDGR DILREWREKG QREPVLILTA RDALAERVEG LRLGADDYLC
110 120 130 140 150
KPFALIEVAA RLEALMRRTN GQASNELRHG NVMLDPGKRI ATLAGEPLTL
160 170 180 190 200
KPKEFALLEL LMRNAGRVLS RKLIEEKLYT WDEEVTSNAV EVHVHHLRRK
210
LGSDFIRTVH GIGYTLGEK
Length:219
Mass (Da):24,678
Last modified:October 1, 1996 - v1
Checksum:i9408B2B7261E042E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69193.1.
U00096 Genomic DNA. Translation: AAC76061.1.
AP009048 Genomic DNA. Translation: BAE77081.1.
PIRiG65089.
RefSeqiNP_417497.1. NC_000913.3.
WP_001221495.1. NZ_CP010445.1.

Genome annotation databases

EnsemblBacteriaiAAC76061; AAC76061; b3025.
BAE77081; BAE77081; BAE77081.
GeneIDi945369.
KEGGieco:b3025.
PATRICi32121462. VBIEscCol129921_3118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69193.1.
U00096 Genomic DNA. Translation: AAC76061.1.
AP009048 Genomic DNA. Translation: BAE77081.1.
PIRiG65089.
RefSeqiNP_417497.1. NC_000913.3.
WP_001221495.1. NZ_CP010445.1.

3D structure databases

ProteinModelPortaliP52076.
SMRiP52076. Positions 1-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP52076. 5 interactions.
STRINGi511145.b3025.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76061; AAC76061; b3025.
BAE77081; BAE77081; BAE77081.
GeneIDi945369.
KEGGieco:b3025.
PATRICi32121462. VBIEscCol129921_3118.

Organism-specific databases

EchoBASEiEB2844.
EcoGeneiEG13026. qseB.

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034815.
InParanoidiP52076.
KOiK07666.
OMAiIDWFTEG.
OrthoDBiEOG6G4VQG.
PhylomeDBiP52076.

Enzyme and pathway databases

BioCyciEcoCyc:G7575-MONOMER.
ECOL316407:JW2993-MONOMER.

Miscellaneous databases

PROiP52076.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli."
    Sperandio V., Torres A.G., Kaper J.B.
    Mol. Microbiol. 43:809-821(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12 and O157:H7.
  4. "Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)."
    Gonzalez Barrios A.F., Zuo R., Hashimoto Y., Yang L., Bentley W.E., Wood T.K.
    J. Bacteriol. 188:305-316(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY AI-2 AND MQSR.
    Strain: K12 / ATCC 25404 / DSM 5698 / NCIMB 11290, K12 / DH5-alpha and K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiQSEB_ECOLI
AccessioniPrimary (citable) accession number: P52076
Secondary accession number(s): Q2M9H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 22, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.