Transcriptional regulatory protein QseB - Escherichia coli (strain K12)

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P52076 (QSEB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 100. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Transcriptional regulatory protein QseB

Gene names

Name:	qseB
Synonyms:	ygiX
Ordered Locus Names:	b3025, JW2993

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. Currently it is not known whether this effect is direct or not. Ref.3
Subcellular location	Cytoplasm Potential.
Induction	By the signal autoinducer AI-2, through MqsR. Ref.4
Post-translational modification	Phosphorylated by QseC Probable.
Sequence similarities	Contains 1 response regulatory domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Two-component regulatory system
Cellular component	Cytoplasm
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of gene expression Inferred from direct assay Ref.3. Source: EcoCyc quorum sensing Inferred from mutant phenotype Ref.3. Source: EcoCyc regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW response to metal ion Inferred from mutant phenotype PubMed 12897016. Source: EcoCyc transcription, DNA-dependent Inferred from experiment Ref.3. Source: EcoCyc
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell protein-DNA complex Inferred from direct assay PubMed 16194231. Source: EcoCyc
Molecular_function	core promoter sequence-specific DNA binding Inferred from direct assay PubMed 16194231. Source: EcoCyc phosphorelay response regulator activity Inferred from mutant phenotype Ref.3. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 219

219

Transcriptional regulatory protein QseB

PRO_0000081025

Regions

Domain

1 – 116

116

Response regulatory

Amino acid modifications

Modified residue

4-aspartylphosphate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P52076 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 9408B2B7261E042E
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FASTA

219

24,678

        10         20         30         40         50         60 
MRILLIEDDM LIGDGIKTGL SKMGFSVDWF TQGRQGKEAL YSAPYDAVIL DLTLPGMDGR 

        70         80         90        100        110        120 
DILREWREKG QREPVLILTA RDALAERVEG LRLGADDYLC KPFALIEVAA RLEALMRRTN 

       130        140        150        160        170        180 
GQASNELRHG NVMLDPGKRI ATLAGEPLTL KPKEFALLEL LMRNAGRVLS RKLIEEKLYT 

       190        200        210 
WDEEVTSNAV EVHVHHLRRK LGSDFIRTVH GIGYTLGEK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli." Sperandio V., Torres A.G., Kaper J.B. Mol. Microbiol. 43:809-821(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. Strain: K12 and O157:H7.
[4]	"Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)." Gonzalez Barrios A.F., Zuo R., Hashimoto Y., Yang L., Bentley W.E., Wood T.K. J. Bacteriol. 188:305-316(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION BY AI-2 AND MQSR. Strain: K12 / ATCC 25404 / DSM 5698 / NCIMB 11290, K12 / DH5-alpha and K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U28377 Genomic DNA. Translation: AAA69193.1. U00096 Genomic DNA. Translation: AAC76061.1. AP009048 Genomic DNA. Translation: BAE77081.1.
PIR	G65089.
RefSeq	NP_417497.1. NC_000913.2. YP_491217.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P52076.
SMR	P52076. Positions 1-216.
ModBase	Search...
Protein-protein interaction databases
IntAct	P52076. 5 interactions.
STRING	511145.b3025.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC76061; AAC76061; b3025. BAE77081; BAE77081; BAE77081.
GeneID	12933397. 945369.
KEGG	ecj:Y75_p2951. eco:b3025.
PATRIC	32121462. VBIEscCol129921_3118.
Organism-specific databases
EchoBASE	EB2844.
EcoGene	EG13026. qseB.
Phylogenomic databases
eggNOG	COG0745.
HOGENOM	HOG000034815.
KO	K07666.
OMA	LFFCTSP.
ProtClustDB	PRK10336.
Enzyme and pathway databases
BioCyc	EcoCyc:G7575-MONOMER. ECOL316407:JW2993-MONOMER.
Gene expression databases
Genevestigator	P52076.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR011006. CheY-like_superfamily. IPR001867. Sig_transdc_resp-reg_C. IPR001789. Sig_transdc_resp-reg_receiver. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00072. Response_reg. 1 hit. PF00486. Trans_reg_C. 1 hit. [Graphical view]
SMART	SM00448. REC. 1 hit. SM00862. Trans_reg_C. 1 hit. [Graphical view]
SUPFAM	SSF52172. CheY_like. 1 hit.
PROSITE	PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

QSEB_ECOLI

Accession

Primary (citable) accession number: P52076
Secondary accession number(s): Q2M9H5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents