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Protein

Glycolate oxidase iron-sulfur subunit

Gene

glcF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi25Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi28Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi31Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi35Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi75Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi78Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi81Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi85Iron-sulfur 1 (4Fe-4S)By similarity1

GO - Molecular functioni

  • 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  • glycolate dehydrogenase activity Source: EcoCyc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • glycolate catabolic process Source: EcoCyc

Keywordsi

Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-561
MetaCyc:MONOMER0-561

Names & Taxonomyi

Protein namesi
Recommended name:
Glycolate oxidase iron-sulfur subunit
Gene namesi
Name:glcF
Synonyms:gox, yghL
Ordered Locus Names:b4467, JW5486
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13291 glcF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001592581 – 407Glycolate oxidase iron-sulfur subunitAdd BLAST407

Proteomic databases

PaxDbiP52074
PRIDEiP52074

Interactioni

Protein-protein interaction databases

BioGridi4262366, 14 interactors
STRINGi316385.ECDH10B_3154

Structurei

3D structure databases

ProteinModelPortaliP52074
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 474Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST34
Domaini66 – 954Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105CHG Bacteria
COG0247 LUCA
HOGENOMiHOG000256469
InParanoidiP52074
KOiK11473
OMAiVYQDACH
PhylomeDBiP52074

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR004017 Cys_rich_dom
IPR012257 Glc_ox_4Fe-4S
IPR009051 Helical_ferredxn
PANTHERiPTHR32479:SF17 PTHR32479:SF17, 1 hit
PfamiView protein in Pfam
PF02754 CCG, 2 hits
PF13183 Fer4_8, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 2 hits
PS51379 4FE4S_FER_2, 2 hits

Sequencei

Sequence statusi: Complete.

P52074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTQLTEEMR QNARALEADS ILRACVHCGF CTATCPTYQL LGDELDGPRG
60 70 80 90 100
RIYLIKQVLE GNEVTLKTQE HLDRCLTCRN CETTCPSGVR YHNLLDIGRD
110 120 130 140 150
IVEQKVKRPL PERILREGLR QVVPRPAVFR ALTQVGLVLR PFLPEQVRAK
160 170 180 190 200
LPAETVKAKP RPPLRHKRRV LMLEGCAQPT LSPNTNAATA RVLDRLGISV
210 220 230 240 250
MPANEAGCCG AVDYHLNAQE KGLARARNNI DAWWPAIEAG AEAILQTASG
260 270 280 290 300
CGAFVKEYGQ MLKNDALYAD KARQVSELAV DLVELLREEP LEKLAIRGDK
310 320 330 340 350
KLAFHCPCTL QHAQKLNGEV EKVLLRLGFT LTDVPDSHLC CGSAGTYALT
360 370 380 390 400
HPDLARQLRD NKMNALESGK PEMIVTANIG CQTHLASAGR TSVRHWIEIV

EQALEKE
Length:407
Mass (Da):45,110
Last modified:October 1, 1996 - v1
Checksum:iF983C893063F76DC
GO

Sequence cautioni

The sequence AAA69145 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43490 Genomic DNA Translation: AAB02532.1
U28377 Genomic DNA Translation: AAA69145.1 Different initiation.
U00096 Genomic DNA Translation: AAT48157.1
AP009048 Genomic DNA Translation: BAE77038.1
RefSeqiWP_001194661.1, NZ_LN832404.1
YP_026190.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48157; AAT48157; b4467
BAE77038; BAE77038; BAE77038
GeneIDi2847717
KEGGiecj:JW5486
eco:b4467
PATRICifig|1411691.4.peg.3753

Similar proteinsi

Entry informationi

Entry nameiGLCF_ECOLI
AccessioniPrimary (citable) accession number: P52074
Secondary accession number(s): P76654, Q2M9L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health