P52073 (GLCE_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycolate oxidase subunit GlcE

Gene names

Name:	glcE
Synonyms:	gox, yghL
Ordered Locus Names:	b4468, JW5487

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities	Contains 1 FAD-binding PCMH-type domain.
Sequence caution	The sequence AAA69145.1 differs from that shown. Reason: Frameshift at position 319. Fuses together glcE and glcF.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolate catabolic process Inferred from mutant phenotype Ref.1. Source: EcoCyc
Molecular_function	UDP-N-acetylmuramate dehydrogenase activity Inferred from electronic annotation. Source: InterPro flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro glycolate dehydrogenase activity Inferred from mutant phenotype Ref.1. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Glycolate oxidase subunit GlcE		PRO_0000087503
Regions
	Domain	1 – 173	173	FAD-binding PCMH-type

Sequences

	Sequence		Length	Mass (Da)
	P52073 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: D6471A76FD354D5A	FASTA	350	38,361
	10 20 30 40 50 60 MLRECDYSQA LLEQVNQAIS DKTPLVIQGS NSKAFLGRPV TGQTLDVRCH RGIVNYDPTE 70 80 90 100 110 120 LVITARVGTP LVTIEAALES AGQMLPCEPP HYGEEATWGG MVACGLAGPR RPWSGSVRDF 130 140 150 160 170 180 VLGTRIITGA GKHLRFGGEV MKNVAGYDLS RLMVGSYGCL GVLTEISMKV LPRPRASLSL 190 200 210 220 230 240 RREISLQEAM SEIAEWQLQP LPISGLCYFD NALWIRLEGG EGSVKAAREL LGGEEVAGQF 250 260 270 280 290 300 WQQLREQQLP FFSLPGTLWR ISLPSDAPMM DLPGEQLIDW GGALRWLKST AEDNQIHRIA 310 320 330 340 350 RNAGGHATRF SAGDGGFAPL SAPLFRYHQQ LKQQLDPCGV FNPGRMYAEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"glc locus of Escherichia coli: characterization of genes encoding the subunits of glycolate oxidase and the glc regulator protein." Pellicer M.T., Badia J., Aguilar J.T., Baldoma L. J. Bacteriol. 178:2051-2059(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005." Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R., Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T., Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H., Thomson N.R., Wishart D., Wanner B.L. Nucleic Acids Res. 34:1-9(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43490 Genomic DNA. Translation: AAB02531.1. U28377 Genomic DNA. Translation: AAA69145.1. Frameshift. U00096 Genomic DNA. Translation: AAT48158.1. AP009048 Genomic DNA. Translation: BAE77039.1.
RefSeq	YP_026191.1. NC_000913.2. YP_491175.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P52073.
SMR	P52073. Positions 10-185.
ModBase	Search...
Protein-protein interaction databases
STRING	511145.b4468.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAT48158; AAT48158; b4468. BAE77039; BAE77039; BAE77039.
GeneID	12933373. 2847718.
KEGG	ecj:Y75_p2907. eco:b4468.
PATRIC	32121372. VBIEscCol129921_3073.
Organism-specific databases
EchoBASE	EB2819.
EcoGene	EG12996. glcE.
Phylogenomic databases
eggNOG	COG0277.
HOGENOM	HOG000230994.
KO	K11472.
OMA	WAGAVRD.
ProtClustDB	PRK11282.
Enzyme and pathway databases
BioCyc	EcoCyc:G7544-MONOMER. ECOL316407:JW5487-MONOMER. MetaCyc:G7544-MONOMER.
Gene expression databases
Genevestigator	P52073.
Family and domain databases
Gene3D	1.10.45.10. 1 hit. 3.30.465.10. 1 hit.
InterPro	IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR016164. FAD-linked_Oxase-like_C. IPR006094. Oxid_FAD_bind_N. IPR016171. Vanillyl_alc_oxidase_C-sub2. [Graphical view]
Pfam	PF01565. FAD_binding_4. 1 hit. [Graphical view]
SUPFAM	SSF55103. FAD-binding_2. 1 hit. SSF56176. FAD-binding_2. 1 hit.
PROSITE	PS51387. FAD_PCMH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLCE_ECOLI

Accession

Primary (citable) accession number: P52073
Secondary accession number(s): P76654, Q2M9L7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program