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Protein

Glycolate oxidase subunit GlcE

Gene

glcE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: InterPro
  • glycolate dehydrogenase activity Source: EcoCyc

GO - Biological processi

  • glycolate catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:G7544-MONOMER.
ECOL316407:JW5487-MONOMER.
MetaCyc:G7544-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycolate oxidase subunit GlcE
Gene namesi
Name:glcE
Synonyms:gox, yghL
Ordered Locus Names:b4468, JW5487
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12996. glcE.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Glycolate oxidase subunit GlcEPRO_0000087503Add
BLAST

Proteomic databases

PaxDbiP52073.

Interactioni

Protein-protein interaction databases

BioGridi4262367. 16 interactions.
STRINGi511145.b4468.

Structurei

3D structure databases

ProteinModelPortaliP52073.
SMRiP52073. Positions 10-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 173173FAD-binding PCMH-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105EU8. Bacteria.
COG0277. LUCA.
HOGENOMiHOG000230994.
InParanoidiP52073.
KOiK11472.
OMAiFLRIEGF.
OrthoDBiEOG62RS9V.
PhylomeDBiP52073.

Family and domain databases

Gene3Di1.10.45.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016164. FAD-linked_Oxase-like_C.
IPR006094. Oxid_FAD_bind_N.
IPR016171. Vanillyl_alc_oxidase_C-sub2.
[Graphical view]
PfamiPF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMiSSF55103. SSF55103. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRECDYSQA LLEQVNQAIS DKTPLVIQGS NSKAFLGRPV TGQTLDVRCH
60 70 80 90 100
RGIVNYDPTE LVITARVGTP LVTIEAALES AGQMLPCEPP HYGEEATWGG
110 120 130 140 150
MVACGLAGPR RPWSGSVRDF VLGTRIITGA GKHLRFGGEV MKNVAGYDLS
160 170 180 190 200
RLMVGSYGCL GVLTEISMKV LPRPRASLSL RREISLQEAM SEIAEWQLQP
210 220 230 240 250
LPISGLCYFD NALWIRLEGG EGSVKAAREL LGGEEVAGQF WQQLREQQLP
260 270 280 290 300
FFSLPGTLWR ISLPSDAPMM DLPGEQLIDW GGALRWLKST AEDNQIHRIA
310 320 330 340 350
RNAGGHATRF SAGDGGFAPL SAPLFRYHQQ LKQQLDPCGV FNPGRMYAEL
Length:350
Mass (Da):38,361
Last modified:October 1, 1996 - v1
Checksum:iD6471A76FD354D5A
GO

Sequence cautioni

The sequence AAA69145.1 differs from that shown. Reason: Frameshift at position 319. Fuses together glcE and glcF.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43490 Genomic DNA. Translation: AAB02531.1.
U28377 Genomic DNA. Translation: AAA69145.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48158.1.
AP009048 Genomic DNA. Translation: BAE77039.1.
RefSeqiWP_000943100.1. NZ_LN832404.1.
YP_026191.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48158; AAT48158; b4468.
BAE77039; BAE77039; BAE77039.
GeneIDi2847718.
KEGGiecj:JW5487.
eco:b4468.
PATRICi32121372. VBIEscCol129921_3073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43490 Genomic DNA. Translation: AAB02531.1.
U28377 Genomic DNA. Translation: AAA69145.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48158.1.
AP009048 Genomic DNA. Translation: BAE77039.1.
RefSeqiWP_000943100.1. NZ_LN832404.1.
YP_026191.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP52073.
SMRiP52073. Positions 10-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262367. 16 interactions.
STRINGi511145.b4468.

Proteomic databases

PaxDbiP52073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48158; AAT48158; b4468.
BAE77039; BAE77039; BAE77039.
GeneIDi2847718.
KEGGiecj:JW5487.
eco:b4468.
PATRICi32121372. VBIEscCol129921_3073.

Organism-specific databases

EchoBASEiEB2819.
EcoGeneiEG12996. glcE.

Phylogenomic databases

eggNOGiENOG4105EU8. Bacteria.
COG0277. LUCA.
HOGENOMiHOG000230994.
InParanoidiP52073.
KOiK11472.
OMAiFLRIEGF.
OrthoDBiEOG62RS9V.
PhylomeDBiP52073.

Enzyme and pathway databases

BioCyciEcoCyc:G7544-MONOMER.
ECOL316407:JW5487-MONOMER.
MetaCyc:G7544-MONOMER.

Miscellaneous databases

PROiP52073.

Family and domain databases

Gene3Di1.10.45.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016164. FAD-linked_Oxase-like_C.
IPR006094. Oxid_FAD_bind_N.
IPR016171. Vanillyl_alc_oxidase_C-sub2.
[Graphical view]
PfamiPF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMiSSF55103. SSF55103. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "glc locus of Escherichia coli: characterization of genes encoding the subunits of glycolate oxidase and the glc regulator protein."
    Pellicer M.T., Badia J., Aguilar J.T., Baldoma L.
    J. Bacteriol. 178:2051-2059(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: SEQUENCE REVISION.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiGLCE_ECOLI
AccessioniPrimary (citable) accession number: P52073
Secondary accession number(s): P76654, Q2M9L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 20, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.