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Protein

Fosmidomycin resistance protein

Gene

fsr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Confers the resistance against fosmidomycin.

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • response to antibiotic Source: EcoCyc
  • transmembrane transport Source: InterPro

Keywordsi

Biological processAntibiotic resistance

Enzyme and pathway databases

BioCyciEcoCyc:FSR-MONOMER
MetaCyc:FSR-MONOMER

Protein family/group databases

TCDBi2.A.1.35.1 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Fosmidomycin resistance protein
Gene namesi
Name:fsr
Ordered Locus Names:b0479, JW0468
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13268 fsr

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42PeriplasmicSequence analysisAdd BLAST42
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 102PeriplasmicSequence analysisAdd BLAST18
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 151CytoplasmicSequence analysisAdd BLAST28
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 177PeriplasmicSequence analysis5
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 225CytoplasmicSequence analysisAdd BLAST27
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 266PeriplasmicSequence analysisAdd BLAST20
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 294CytoplasmicSequence analysis7
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 319PeriplasmicSequence analysis4
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 353CytoplasmicSequence analysisAdd BLAST13
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Topological domaini375 – 378PeriplasmicSequence analysis4
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 406CytoplasmicSequence analysis7

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848381 – 406Fosmidomycin resistance proteinAdd BLAST406

Proteomic databases

PaxDbiP52067
PRIDEiP52067

Interactioni

Protein-protein interaction databases

BioGridi4260849, 16 interactors
STRINGi316385.ECDH10B_0435

Structurei

3D structure databases

ProteinModelPortaliP52067
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EU0 Bacteria
ENOG410XPTC LUCA
HOGENOMiHOG000259361
InParanoidiP52067
KOiK08223
OMAiYFYMASF
PhylomeDBiP52067

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P52067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSEQPQPV AGAAASTTKA RTSFGILGAI SLSHLLNDMI QSLILAIYPL
60 70 80 90 100
LQSEFSLTFM QIGMITLTFQ LASSLLQPVV GYWTDKYPMP WSLPIGMCFT
110 120 130 140 150
LSGLVLLALA GSFGAVLLAA ALVGTGSSVF HPESSRVARM ASGGRHGLAQ
160 170 180 190 200
SIFQVGGNFG SSLGPLLAAV IIAPYGKGNV AWFVLAALLA IVVLAQISRW
210 220 230 240 250
YSAQHRMNKG KPKATIINPL PRNKVVLAVS ILLILIFSKY FYMASISSYY
260 270 280 290 300
TFYLMQKFGL SIQNAQLHLF AFLFAVAAGT VIGGPVGDKI GRKYVIWGSI
310 320 330 340 350
LGVAPFTLIL PYASLHWTGV LTVIIGFILA SAFSAILVYA QELLPGRIGM
360 370 380 390 400
VSGLFFGFAF GMGGLGAAVL GLIADHTSIE LVYKICAFLP LLGMLTIFLP

DNRHKD
Length:406
Mass (Da):43,306
Last modified:October 1, 1996 - v1
Checksum:iE1FC88D0E3F471F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D73370 Genomic DNA Translation: BAA11120.1
U82664 Genomic DNA Translation: AAB40233.1
U00096 Genomic DNA Translation: AAC73581.1
AP009048 Genomic DNA Translation: BAE76258.1
PIRiJC5041
RefSeqiNP_415012.1, NC_000913.3
WP_001251608.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73581; AAC73581; b0479
BAE76258; BAE76258; BAE76258
GeneIDi945119
KEGGiecj:JW0468
eco:b0479
PATRICifig|1411691.4.peg.1797

Entry informationi

Entry nameiFSR_ECOLI
AccessioniPrimary (citable) accession number: P52067
Secondary accession number(s): Q2MBU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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