Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fosmidomycin resistance protein

Gene

fsr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Confers the resistance against fosmidomycin.

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • response to antibiotic Source: EcoCyc
  • transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciEcoCyc:FSR-MONOMER.
ECOL316407:JW0468-MONOMER.
MetaCyc:FSR-MONOMER.

Protein family/group databases

TCDBi2.A.1.35.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Fosmidomycin resistance protein
Gene namesi
Name:fsr
Ordered Locus Names:b0479, JW0468
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13268. fsr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42PeriplasmicSequence analysisAdd BLAST42
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 102PeriplasmicSequence analysisAdd BLAST18
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 151CytoplasmicSequence analysisAdd BLAST28
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 177PeriplasmicSequence analysis5
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 225CytoplasmicSequence analysisAdd BLAST27
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 266PeriplasmicSequence analysisAdd BLAST20
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 294CytoplasmicSequence analysis7
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 319PeriplasmicSequence analysis4
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 353CytoplasmicSequence analysisAdd BLAST13
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Topological domaini375 – 378PeriplasmicSequence analysis4
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 406CytoplasmicSequence analysis7

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848381 – 406Fosmidomycin resistance proteinAdd BLAST406

Proteomic databases

PaxDbiP52067.
PRIDEiP52067.

Interactioni

Protein-protein interaction databases

BioGridi4260849. 5 interactors.
STRINGi511145.b0479.

Structurei

3D structure databases

ProteinModelPortaliP52067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EU0. Bacteria.
ENOG410XPTC. LUCA.
HOGENOMiHOG000259361.
InParanoidiP52067.
KOiK08223.
OMAiRHPKPYS.
PhylomeDBiP52067.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSEQPQPV AGAAASTTKA RTSFGILGAI SLSHLLNDMI QSLILAIYPL
60 70 80 90 100
LQSEFSLTFM QIGMITLTFQ LASSLLQPVV GYWTDKYPMP WSLPIGMCFT
110 120 130 140 150
LSGLVLLALA GSFGAVLLAA ALVGTGSSVF HPESSRVARM ASGGRHGLAQ
160 170 180 190 200
SIFQVGGNFG SSLGPLLAAV IIAPYGKGNV AWFVLAALLA IVVLAQISRW
210 220 230 240 250
YSAQHRMNKG KPKATIINPL PRNKVVLAVS ILLILIFSKY FYMASISSYY
260 270 280 290 300
TFYLMQKFGL SIQNAQLHLF AFLFAVAAGT VIGGPVGDKI GRKYVIWGSI
310 320 330 340 350
LGVAPFTLIL PYASLHWTGV LTVIIGFILA SAFSAILVYA QELLPGRIGM
360 370 380 390 400
VSGLFFGFAF GMGGLGAAVL GLIADHTSIE LVYKICAFLP LLGMLTIFLP

DNRHKD
Length:406
Mass (Da):43,306
Last modified:October 1, 1996 - v1
Checksum:iE1FC88D0E3F471F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D73370 Genomic DNA. Translation: BAA11120.1.
U82664 Genomic DNA. Translation: AAB40233.1.
U00096 Genomic DNA. Translation: AAC73581.1.
AP009048 Genomic DNA. Translation: BAE76258.1.
PIRiJC5041.
RefSeqiNP_415012.1. NC_000913.3.
WP_001251608.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73581; AAC73581; b0479.
BAE76258; BAE76258; BAE76258.
GeneIDi945119.
KEGGiecj:JW0468.
eco:b0479.
PATRICi32116115. VBIEscCol129921_0499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D73370 Genomic DNA. Translation: BAA11120.1.
U82664 Genomic DNA. Translation: AAB40233.1.
U00096 Genomic DNA. Translation: AAC73581.1.
AP009048 Genomic DNA. Translation: BAE76258.1.
PIRiJC5041.
RefSeqiNP_415012.1. NC_000913.3.
WP_001251608.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP52067.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260849. 5 interactors.
STRINGi511145.b0479.

Protein family/group databases

TCDBi2.A.1.35.1. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP52067.
PRIDEiP52067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73581; AAC73581; b0479.
BAE76258; BAE76258; BAE76258.
GeneIDi945119.
KEGGiecj:JW0468.
eco:b0479.
PATRICi32116115. VBIEscCol129921_0499.

Organism-specific databases

EchoBASEiEB3054.
EcoGeneiEG13268. fsr.

Phylogenomic databases

eggNOGiENOG4105EU0. Bacteria.
ENOG410XPTC. LUCA.
HOGENOMiHOG000259361.
InParanoidiP52067.
KOiK08223.
OMAiRHPKPYS.
PhylomeDBiP52067.

Enzyme and pathway databases

BioCyciEcoCyc:FSR-MONOMER.
ECOL316407:JW0468-MONOMER.
MetaCyc:FSR-MONOMER.

Miscellaneous databases

PROiP52067.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFSR_ECOLI
AccessioniPrimary (citable) accession number: P52067
Secondary accession number(s): Q2MBU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.