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Protein

Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW

Gene

yggW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of porphyrin-containing compound.By similarity

Cofactori

[4Fe-4S] clusterBy similarityCuratedNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarityCurated

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in the pathway protoporphyrin-IX biosynthesis, which is part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101S-adenosyl-L-methionine 1By similarity
Metal bindingi16 – 161Iron-sulfur (4Fe-4S-S-AdoMet)Sequence analysis
Metal bindingi20 – 201Iron-sulfur (4Fe-4S-S-AdoMet)Sequence analysis
Binding sitei22 – 221S-adenosyl-L-methionine 2; via carbonyl oxygenBy similarity
Metal bindingi23 – 231Iron-sulfur (4Fe-4S-S-AdoMet)Sequence analysis
Binding sitei66 – 661S-adenosyl-L-methionine 1; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei99 – 991S-adenosyl-L-methionine 1By similarity
Binding sitei126 – 1261S-adenosyl-L-methionine 2By similarity
Binding sitei138 – 1381S-adenosyl-L-methionine 2By similarity
Binding sitei163 – 1631S-adenosyl-L-methionine 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciEcoCyc:G7531-MONOMER.
ECOL316407:JW2922-MONOMER.
UniPathwayiUPA00251.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW (EC:1.3.99.-)
Gene namesi
Name:yggW
Ordered Locus Names:b2955, JW2922
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12983. yggW.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Oxygen-independent coproporphyrinogen-III oxidase-like protein YggWPRO_0000109956Add
BLAST

Proteomic databases

PaxDbiP52062.
PRIDEiP52062.

Interactioni

Protein-protein interaction databases

BioGridi4262352. 14 interactions.
IntActiP52062. 15 interactions.
MINTiMINT-1261070.
STRINGi511145.b2955.

Structurei

3D structure databases

ProteinModelPortaliP52062.
SMRiP52062. Positions 6-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 682S-adenosyl-L-methionine 2 bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CSA. Bacteria.
COG0635. LUCA.
HOGENOMiHOG000015379.
InParanoidiP52062.
KOiK02495.
OMAiRTAKTRH.
OrthoDBiEOG683S9D.
PhylomeDBiP52062.

Family and domain databases

Gene3Di3.80.30.20. 1 hit.
InterProiIPR004559. Coprogen_oxidase_HemN-rel.
IPR006638. Elp3/MiaB/NifB.
IPR010723. HemN_C.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamiPF06969. HemN_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00539. hemN_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

P52062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLPPLSLY IHIPWCVQKC PYCDFNSHAL KGEVPHDDYV QHLLNDLDND
60 70 80 90 100
VAYAQGREVK TIFIGGGTPS LLSGPAMQTL LDGVRARLPL AADAEITMEA
110 120 130 140 150
NPGTVEADRF VDYQRAGVNR ISIGVQSFSE EKLKRLGRIH GPQEAKRAAK
160 170 180 190 200
LASGLGLRSF NLDLMHGLPD QSLEEALGDL RQAIELNPPH LSWYQLTIEP
210 220 230 240 250
NTLFGSRPPV LPDDDALWDI FEQGHQLLTA AGYQQYETSA YAKPGYQCQH
260 270 280 290 300
NLNYWRFGDY IGIGCGAHGK VTFPDGRILR TTKTRHPRGF MQGRYLESQR
310 320 330 340 350
DVEATDKPFE FFMNRFRLLE AAPRVEFIAY TGLCEDVIRP QLDEAIAQGY
360 370
LTECADYWQI TEHGKLFLNS LLELFLAE
Length:378
Mass (Da):42,584
Last modified:October 1, 1996 - v1
Checksum:i00A115BFDE4386AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69122.1.
U00096 Genomic DNA. Translation: AAC75992.1.
AP009048 Genomic DNA. Translation: BAE77018.1.
PIRiB65081.
RefSeqiNP_417430.1. NC_000913.3.
WP_000239943.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75992; AAC75992; b2955.
BAE77018; BAE77018; BAE77018.
GeneIDi947446.
KEGGiecj:JW2922.
eco:b2955.
PATRICi32121322. VBIEscCol129921_3049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69122.1.
U00096 Genomic DNA. Translation: AAC75992.1.
AP009048 Genomic DNA. Translation: BAE77018.1.
PIRiB65081.
RefSeqiNP_417430.1. NC_000913.3.
WP_000239943.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP52062.
SMRiP52062. Positions 6-244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262352. 14 interactions.
IntActiP52062. 15 interactions.
MINTiMINT-1261070.
STRINGi511145.b2955.

Proteomic databases

PaxDbiP52062.
PRIDEiP52062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75992; AAC75992; b2955.
BAE77018; BAE77018; BAE77018.
GeneIDi947446.
KEGGiecj:JW2922.
eco:b2955.
PATRICi32121322. VBIEscCol129921_3049.

Organism-specific databases

EchoBASEiEB2808.
EcoGeneiEG12983. yggW.

Phylogenomic databases

eggNOGiENOG4105CSA. Bacteria.
COG0635. LUCA.
HOGENOMiHOG000015379.
InParanoidiP52062.
KOiK02495.
OMAiRTAKTRH.
OrthoDBiEOG683S9D.
PhylomeDBiP52062.

Enzyme and pathway databases

UniPathwayiUPA00251.
BioCyciEcoCyc:G7531-MONOMER.
ECOL316407:JW2922-MONOMER.

Miscellaneous databases

PROiP52062.

Family and domain databases

Gene3Di3.80.30.20. 1 hit.
InterProiIPR004559. Coprogen_oxidase_HemN-rel.
IPR006638. Elp3/MiaB/NifB.
IPR010723. HemN_C.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamiPF06969. HemN_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00539. hemN_rel. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Hauert J.
    Thesis (1977), University of Geneva, Switzerland
    Cited for: COFACTOR.
    Strain: K12.

Entry informationi

Entry nameiYGGW_ECOLI
AccessioniPrimary (citable) accession number: P52062
Secondary accession number(s): Q2M9N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 20, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.