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Protein

Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW

Gene

yggW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of porphyrin-containing compound.By similarity

Cofactori

[4Fe-4S] clusterBy similarityCuratedNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarityCurated

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in the pathway protoporphyrin-IX biosynthesis, which is part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10S-adenosyl-L-methionine 1By similarity1
Metal bindingi16Iron-sulfur (4Fe-4S-S-AdoMet)Sequence analysis1
Metal bindingi20Iron-sulfur (4Fe-4S-S-AdoMet)Sequence analysis1
Binding sitei22S-adenosyl-L-methionine 2; via carbonyl oxygenBy similarity1
Metal bindingi23Iron-sulfur (4Fe-4S-S-AdoMet)Sequence analysis1
Binding sitei66S-adenosyl-L-methionine 1; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei99S-adenosyl-L-methionine 1By similarity1
Binding sitei126S-adenosyl-L-methionine 2By similarity1
Binding sitei138S-adenosyl-L-methionine 2By similarity1
Binding sitei163S-adenosyl-L-methionine 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPorphyrin biosynthesis
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciEcoCyc:G7531-MONOMER
UniPathwayiUPA00251

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW (EC:1.3.99.-)
Gene namesi
Name:yggW
Ordered Locus Names:b2955, JW2922
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12983 yggW

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001099561 – 378Oxygen-independent coproporphyrinogen-III oxidase-like protein YggWAdd BLAST378

Proteomic databases

PaxDbiP52062
PRIDEiP52062

Interactioni

Protein-protein interaction databases

BioGridi4262352, 41 interactors
IntActiP52062, 15 interactors
STRINGi316385.ECDH10B_3130

Structurei

3D structure databases

ProteinModelPortaliP52062
SMRiP52062
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 68S-adenosyl-L-methionine 2 bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CSA Bacteria
COG0635 LUCA
HOGENOMiHOG000015379
InParanoidiP52062
OMAiSNFARPG
PhylomeDBiP52062

Family and domain databases

Gene3Di3.80.30.20, 1 hit
InterProiView protein in InterPro
IPR034505 Coproporphyrinogen-III_oxidase
IPR006638 Elp3/MiaB/NifB
IPR004559 HemN-like
IPR010723 HemN_C
IPR007197 rSAM
IPR023404 rSAM_horseshoe
PANTHERiPTHR13932 PTHR13932, 1 hit
PfamiView protein in Pfam
PF06969 HemN_C, 1 hit
PF04055 Radical_SAM, 1 hit
SFLDiSFLDG01065 anaerobic_coproporphyrinogen-I, 1 hit
SFLDS00029 Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
TIGRFAMsiTIGR00539 hemN_rel, 1 hit

Sequencei

Sequence statusi: Complete.

P52062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLPPLSLY IHIPWCVQKC PYCDFNSHAL KGEVPHDDYV QHLLNDLDND
60 70 80 90 100
VAYAQGREVK TIFIGGGTPS LLSGPAMQTL LDGVRARLPL AADAEITMEA
110 120 130 140 150
NPGTVEADRF VDYQRAGVNR ISIGVQSFSE EKLKRLGRIH GPQEAKRAAK
160 170 180 190 200
LASGLGLRSF NLDLMHGLPD QSLEEALGDL RQAIELNPPH LSWYQLTIEP
210 220 230 240 250
NTLFGSRPPV LPDDDALWDI FEQGHQLLTA AGYQQYETSA YAKPGYQCQH
260 270 280 290 300
NLNYWRFGDY IGIGCGAHGK VTFPDGRILR TTKTRHPRGF MQGRYLESQR
310 320 330 340 350
DVEATDKPFE FFMNRFRLLE AAPRVEFIAY TGLCEDVIRP QLDEAIAQGY
360 370
LTECADYWQI TEHGKLFLNS LLELFLAE
Length:378
Mass (Da):42,584
Last modified:October 1, 1996 - v1
Checksum:i00A115BFDE4386AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69122.1
U00096 Genomic DNA Translation: AAC75992.1
AP009048 Genomic DNA Translation: BAE77018.1
PIRiB65081
RefSeqiNP_417430.1, NC_000913.3
WP_000239943.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75992; AAC75992; b2955
BAE77018; BAE77018; BAE77018
GeneIDi947446
KEGGiecj:JW2922
eco:b2955
PATRICifig|1411691.4.peg.3777

Similar proteinsi

Entry informationi

Entry nameiYGGW_ECOLI
AccessioniPrimary (citable) accession number: P52062
Secondary accession number(s): Q2M9N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health