P52053 (P5CR_VIBAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase
Short name=P5C reductase
Short name=P5CR
EC=1.5.1.2

Gene names

Name:

proC

Organism

Vibrio alginolyticus

Taxonomic identifier

663 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Pyrroline-5-carboxylate reductase		PRO_0000187311

Sequences

	Sequence		Length	Mass (Da)
	P52053 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 50359E5EF97CD68B	FASTA	278	29,815
	10 20 30 40 50 60 MMEIRQMEHK KIAFIGAGNM VRAIVSGLVA NGYPAQNITA TAPSEARRLP LEQDFGIRTT 70 80 90 100 110 120 SDNIQAATEA DVVVLSVKPQ MMADVCKPLQ AIDFTNKLVI SIAAGINCSR LDDMLATKLN 130 140 150 160 170 180 LVRVMPNTPS QLGLGMSGLF APIHVTEHDK AFAAELMEAV GKVCWVEQES GINNVIAAAG 190 200 210 220 230 240 SAPAYFFLFM EAMQAEAIAQ GFDKESARLL VQQAALGAAS MVVSNPETEL STLRENVTSK 250 260 270 GGTTAEALRT FNEHQLSDIV AKAMQAAVAR AEEMEKLF

References

[1]

"Cloning and sequencing of novel genes from Vibrio alginolyticus that support the growth of K+ uptake-deficient mutant of Escherichia coli." Nakamura T., Katoh Y., Shimizu Y., Matsuba Y., Unemoto T. Biochim. Biophys. Acta 1277:201-208(1996) [PubMed: 8982386] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 138-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50472 Genomic DNA. Translation: BAA09063.1.
3D structure databases
ProteinModelPortal	P52053.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_VIBAL

Accession

Primary (citable) accession number: P52053

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program