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Protein

Methylmalonyl-CoA decarboxylase

Gene

scpB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the decarboxylation of methylmalonyl-CoA to propionyl-CoA. Could be part of a pathway that converts succinate to propionate.1 Publication

Catalytic activityi

(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110Substrate; via amide nitrogen1 Publication1
Binding sitei132Substrate1 Publication1
Binding sitei253Substrate1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciEcoCyc:G7516-MONOMER
MetaCyc:G7516-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Alternative name(s):
Transcarboxylase
Gene namesi
Name:scpB
Synonyms:mmcD, ygfG
Ordered Locus Names:b2919, JW2886
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12972 scpB

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Chemistry databases

DrugBankiDB03117 2-Carboxypropyl-Coenzyme A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001093551 – 261Methylmalonyl-CoA decarboxylaseAdd BLAST261

Proteomic databases

PaxDbiP52045
PRIDEiP52045

Interactioni

Subunit structurei

Dimer of homotrimers.1 Publication

Protein-protein interaction databases

BioGridi4259438, 2 interactors
STRINGi316385.ECDH10B_3094

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Beta strandi14 – 19Combined sources6
Helixi22 – 24Combined sources3
Helixi30 – 42Combined sources13
Beta strandi50 – 54Combined sources5
Beta strandi60 – 63Combined sources4
Helixi68 – 70Combined sources3
Beta strandi74 – 76Combined sources3
Beta strandi81 – 83Combined sources3
Helixi84 – 94Combined sources11
Beta strandi99 – 103Combined sources5
Beta strandi105 – 108Combined sources4
Helixi110 – 117Combined sources8
Beta strandi118 – 124Combined sources7
Beta strandi128 – 130Combined sources3
Helixi133 – 136Combined sources4
Helixi142 – 146Combined sources5
Beta strandi149 – 152Combined sources4
Helixi154 – 163Combined sources10
Helixi169 – 174Combined sources6
Beta strandi179 – 182Combined sources4
Helixi184 – 186Combined sources3
Helixi187 – 198Combined sources12
Helixi203 – 218Combined sources16
Helixi224 – 238Combined sources15
Helixi241 – 251Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EF8X-ray1.85A/B/C1-261[»]
1EF9X-ray2.70A1-261[»]
ProteinModelPortaliP52045
SMRiP52045
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52045

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 68Substrate binding5

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108M7F Bacteria
COG1024 LUCA
HOGENOMiHOG000027939
InParanoidiP52045
KOiK11264
OMAiVGGGCQL
PhylomeDBiP52045

Family and domain databases

Gene3Di1.10.12.10, 1 hit
InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
IPR014748 enoyl-CoA_hydra_C
PfamiView protein in Pfam
PF00378 ECH_1, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit
PROSITEiView protein in PROSITE
PS00166 ENOYL_COA_HYDRATASE, 1 hit

Sequencei

Sequence statusi: Complete.

P52045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQYVNVVT INKVAVIEFN YGRKLNALSK VFIDDLMQAL SDLNRPEIRC
60 70 80 90 100
IILRAPSGSK VFSAGHDIHE LPSGGRDPLS YDDPLRQITR MIQKFPKPII
110 120 130 140 150
SMVEGSVWGG AFEMIMSSDL IIAASTSTFS MTPVNLGVPY NLVGIHNLTR
160 170 180 190 200
DAGFHIVKEL IFTASPITAQ RALAVGILNH VVEVEELEDF TLQMAHHISE
210 220 230 240 250
KAPLAIAVIK EELRVLGEAH TMNSDEFERI QGMRRAVYDS EDYQEGMNAF
260
LEKRKPNFVG H
Length:261
Mass (Da):29,173
Last modified:October 1, 1996 - v1
Checksum:iB6A8A13EC2C2EBE0
GO

Sequence cautioni

The sequence AAA69086 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69086.1 Different initiation.
U00096 Genomic DNA Translation: AAC75956.2
AP009048 Genomic DNA Translation: BAE76983.1
RefSeqiNP_417394.4, NC_000913.3
WP_000122080.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75956; AAC75956; b2919
BAE76983; BAE76983; BAE76983
GeneIDi947408
KEGGiecj:JW2886
eco:b2919
PATRICifig|1411691.4.peg.3813

Similar proteinsi

Entry informationi

Entry nameiSCPB_ECOLI
AccessioniPrimary (citable) accession number: P52045
Secondary accession number(s): P76643, Q2M9S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health