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Protein

Methylmalonyl-CoA decarboxylase

Gene

scpB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the decarboxylation of methylmalonyl-CoA to propionyl-CoA. Could be part of a pathway that converts succinate to propionate.1 Publication

Catalytic activityi

(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110Substrate; via amide nitrogen1 Publication1
Binding sitei132Substrate1 Publication1
Binding sitei253Substrate1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciEcoCyc:G7516-MONOMER.
ECOL316407:JW2886-MONOMER.
MetaCyc:G7516-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Alternative name(s):
Transcarboxylase
Gene namesi
Name:scpB
Synonyms:mmcD, ygfG
Ordered Locus Names:b2919, JW2886
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12972. scpB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001093551 – 261Methylmalonyl-CoA decarboxylaseAdd BLAST261

Proteomic databases

PaxDbiP52045.
PRIDEiP52045.

Interactioni

Subunit structurei

Dimer of homotrimers.1 Publication

Protein-protein interaction databases

BioGridi4259438. 2 interactors.
STRINGi511145.b2919.

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Beta strandi14 – 19Combined sources6
Helixi22 – 24Combined sources3
Helixi30 – 42Combined sources13
Beta strandi50 – 54Combined sources5
Beta strandi60 – 63Combined sources4
Helixi68 – 70Combined sources3
Beta strandi74 – 76Combined sources3
Beta strandi81 – 83Combined sources3
Helixi84 – 94Combined sources11
Beta strandi99 – 103Combined sources5
Beta strandi105 – 108Combined sources4
Helixi110 – 117Combined sources8
Beta strandi118 – 124Combined sources7
Beta strandi128 – 130Combined sources3
Helixi133 – 136Combined sources4
Helixi142 – 146Combined sources5
Beta strandi149 – 152Combined sources4
Helixi154 – 163Combined sources10
Helixi169 – 174Combined sources6
Beta strandi179 – 182Combined sources4
Helixi184 – 186Combined sources3
Helixi187 – 198Combined sources12
Helixi203 – 218Combined sources16
Helixi224 – 238Combined sources15
Helixi241 – 251Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EF8X-ray1.85A/B/C1-261[»]
1EF9X-ray2.70A1-261[»]
ProteinModelPortaliP52045.
SMRiP52045.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52045.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 68Substrate binding5

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108M7F. Bacteria.
COG1024. LUCA.
HOGENOMiHOG000027939.
InParanoidiP52045.
KOiK11264.
OMAiVNVVIIQ.
PhylomeDBiP52045.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQYVNVVT INKVAVIEFN YGRKLNALSK VFIDDLMQAL SDLNRPEIRC
60 70 80 90 100
IILRAPSGSK VFSAGHDIHE LPSGGRDPLS YDDPLRQITR MIQKFPKPII
110 120 130 140 150
SMVEGSVWGG AFEMIMSSDL IIAASTSTFS MTPVNLGVPY NLVGIHNLTR
160 170 180 190 200
DAGFHIVKEL IFTASPITAQ RALAVGILNH VVEVEELEDF TLQMAHHISE
210 220 230 240 250
KAPLAIAVIK EELRVLGEAH TMNSDEFERI QGMRRAVYDS EDYQEGMNAF
260
LEKRKPNFVG H
Length:261
Mass (Da):29,173
Last modified:October 1, 1996 - v1
Checksum:iB6A8A13EC2C2EBE0
GO

Sequence cautioni

The sequence AAA69086 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69086.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75956.2.
AP009048 Genomic DNA. Translation: BAE76983.1.
RefSeqiNP_417394.4. NC_000913.3.
WP_000122080.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75956; AAC75956; b2919.
BAE76983; BAE76983; BAE76983.
GeneIDi947408.
KEGGiecj:JW2886.
eco:b2919.
PATRICi32121252. VBIEscCol129921_3014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69086.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75956.2.
AP009048 Genomic DNA. Translation: BAE76983.1.
RefSeqiNP_417394.4. NC_000913.3.
WP_000122080.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EF8X-ray1.85A/B/C1-261[»]
1EF9X-ray2.70A1-261[»]
ProteinModelPortaliP52045.
SMRiP52045.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259438. 2 interactors.
STRINGi511145.b2919.

Proteomic databases

PaxDbiP52045.
PRIDEiP52045.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75956; AAC75956; b2919.
BAE76983; BAE76983; BAE76983.
GeneIDi947408.
KEGGiecj:JW2886.
eco:b2919.
PATRICi32121252. VBIEscCol129921_3014.

Organism-specific databases

EchoBASEiEB2799.
EcoGeneiEG12972. scpB.

Phylogenomic databases

eggNOGiENOG4108M7F. Bacteria.
COG1024. LUCA.
HOGENOMiHOG000027939.
InParanoidiP52045.
KOiK11264.
OMAiVNVVIIQ.
PhylomeDBiP52045.

Enzyme and pathway databases

BioCyciEcoCyc:G7516-MONOMER.
ECOL316407:JW2886-MONOMER.
MetaCyc:G7516-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP52045.
PROiP52045.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCPB_ECOLI
AccessioniPrimary (citable) accession number: P52045
Secondary accession number(s): P76643, Q2M9S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.