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Protein

Propionyl-CoA:succinate CoA transferase

Gene

scpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of coenzyme A from propionyl-CoA to succinate. Could be part of a pathway that converts succinate to propionate.1 Publication

Catalytic activityi

Propanoyl-CoA + succinate = propionate + succinyl-CoA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2865-glutamyl coenzyme A thioester intermediateBy similarity1
Binding sitei376Coenzyme ABy similarity1
Binding sitei380Coenzyme A; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciEcoCyc:G7517-MONOMER.
ECOL316407:JW2887-MONOMER.
MetaCyc:G7517-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Propionyl-CoA:succinate CoA transferase (EC:2.8.3.-)
Gene namesi
Name:scpC
Synonyms:ygfH
Ordered Locus Names:b2920, JW2887
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12973. scpC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155271 – 492Propionyl-CoA:succinate CoA transferaseAdd BLAST492

Proteomic databases

PaxDbiP52043.
PRIDEiP52043.

Interactioni

Protein-protein interaction databases

BioGridi4262329. 6 interactors.
DIPiDIP-12167N.
IntActiP52043. 9 interactors.
MINTiMINT-1232787.
STRINGi511145.b2920.

Structurei

3D structure databases

ProteinModelPortaliP52043.
SMRiP52043.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni260 – 264Coenzyme A bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CYC. Bacteria.
COG0427. LUCA.
HOGENOMiHOG000172597.
InParanoidiP52043.
OMAiQAGIGNI.
PhylomeDBiP52043.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
IPR017821. Succinate_CoA_transferase.
[Graphical view]
PANTHERiPTHR21432. PTHR21432. 1 hit.
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03458. YgfH_subfam. 1 hit.

Sequencei

Sequence statusi: Complete.

P52043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQWTRMTA NEAAEIIQHN DMVAFSGFTP AGSPKALPTA IARRANEQHE
60 70 80 90 100
AKKPYQIRLL TGASISAAAD DVLSDADAVS WRAPYQTSSG LRKKINQGAV
110 120 130 140 150
SFVDLHLSEV AQMVNYGFFG DIDVAVIEAS ALAPDGRVWL TSGIGNAPTW
160 170 180 190 200
LLRAKKVIIE LNHYHDPRVA ELADIVIPGA PPRRNSVSIF HAMDRVGTRY
210 220 230 240 250
VQIDPKKIVA VVETNLPDAG NMLDKQNPMC QQIADNVVTF LLQEMAHGRI
260 270 280 290 300
PPEFLPLQSG VGNINNAVMA RLGENPVIPP FMMYSEVLQE SVVHLLETGK
310 320 330 340 350
ISGASASSLT ISADSLRKIY DNMDYFASRI VLRPQEISNN PEIIRRLGVI
360 370 380 390 400
ALNVGLEFDI YGHANSTHVA GVDLMNGIGG SGDFERNAYL SIFMAPSIAK
410 420 430 440 450
EGKISTVVPM CSHVDHSEHS VKVIITEQGI ADLRGLSPLQ RARTIIDNCA
460 470 480 490
HPMYRDYLHR YLENAPGGHI HHDLSHVFDL HRNLIATGSM LG
Length:492
Mass (Da):53,824
Last modified:October 1, 1996 - v1
Checksum:i4C84C10B91D2CA65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69087.1.
U00096 Genomic DNA. Translation: AAC75957.1.
AP009048 Genomic DNA. Translation: BAE76984.1.
PIRiG65076.
RefSeqiNP_417395.1. NC_000913.3.
WP_000449965.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75957; AAC75957; b2920.
BAE76984; BAE76984; BAE76984.
GeneIDi947402.
KEGGiecj:JW2887.
eco:b2920.
PATRICi32121254. VBIEscCol129921_3015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69087.1.
U00096 Genomic DNA. Translation: AAC75957.1.
AP009048 Genomic DNA. Translation: BAE76984.1.
PIRiG65076.
RefSeqiNP_417395.1. NC_000913.3.
WP_000449965.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP52043.
SMRiP52043.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262329. 6 interactors.
DIPiDIP-12167N.
IntActiP52043. 9 interactors.
MINTiMINT-1232787.
STRINGi511145.b2920.

Proteomic databases

PaxDbiP52043.
PRIDEiP52043.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75957; AAC75957; b2920.
BAE76984; BAE76984; BAE76984.
GeneIDi947402.
KEGGiecj:JW2887.
eco:b2920.
PATRICi32121254. VBIEscCol129921_3015.

Organism-specific databases

EchoBASEiEB2800.
EcoGeneiEG12973. scpC.

Phylogenomic databases

eggNOGiENOG4105CYC. Bacteria.
COG0427. LUCA.
HOGENOMiHOG000172597.
InParanoidiP52043.
OMAiQAGIGNI.
PhylomeDBiP52043.

Enzyme and pathway databases

BioCyciEcoCyc:G7517-MONOMER.
ECOL316407:JW2887-MONOMER.
MetaCyc:G7517-MONOMER.

Miscellaneous databases

PROiP52043.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
IPR017821. Succinate_CoA_transferase.
[Graphical view]
PANTHERiPTHR21432. PTHR21432. 1 hit.
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03458. YgfH_subfam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSCPC_ECOLI
AccessioniPrimary (citable) accession number: P52043
Secondary accession number(s): Q2M9S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.