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Protein

Propionyl-CoA:succinate CoA transferase

Gene

scpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of coenzyme A from propionyl-CoA to succinate. Could be part of a pathway that converts succinate to propionate.1 Publication

Catalytic activityi

Propanoyl-CoA + succinate = propionate + succinyl-CoA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2865-glutamyl coenzyme A thioester intermediateBy similarity1
Binding sitei376Coenzyme ABy similarity1
Binding sitei380Coenzyme A; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciEcoCyc:G7517-MONOMER
MetaCyc:G7517-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Propionyl-CoA:succinate CoA transferase (EC:2.8.3.-)
Gene namesi
Name:scpC
Synonyms:ygfH
Ordered Locus Names:b2920, JW2887
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12973 scpC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155271 – 492Propionyl-CoA:succinate CoA transferaseAdd BLAST492

Proteomic databases

PaxDbiP52043
PRIDEiP52043

Interactioni

Protein-protein interaction databases

BioGridi4262329, 6 interactors
DIPiDIP-12167N
IntActiP52043, 9 interactors
STRINGi316407.85675731

Structurei

3D structure databases

ProteinModelPortaliP52043
SMRiP52043
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni260 – 264Coenzyme A bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CYC Bacteria
COG0427 LUCA
HOGENOMiHOG000172597
InParanoidiP52043
KOiK22214
OMAiDEALSWH
PhylomeDBiP52043

Family and domain databases

Gene3Di3.40.1080.20, 1 hit
InterProiView protein in InterPro
IPR026888 AcetylCoA_hyd_C
IPR038460 AcetylCoA_hyd_C_sf
IPR003702 ActCoA_hydro
IPR037171 NagB/RpiA_transferase-like
IPR017821 Succinate_CoA_transferase
PfamiView protein in Pfam
PF13336 AcetylCoA_hyd_C, 1 hit
PF02550 AcetylCoA_hydro, 1 hit
SUPFAMiSSF100950 SSF100950, 2 hits
TIGRFAMsiTIGR03458 YgfH_subfam, 1 hit

Sequencei

Sequence statusi: Complete.

P52043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQWTRMTA NEAAEIIQHN DMVAFSGFTP AGSPKALPTA IARRANEQHE
60 70 80 90 100
AKKPYQIRLL TGASISAAAD DVLSDADAVS WRAPYQTSSG LRKKINQGAV
110 120 130 140 150
SFVDLHLSEV AQMVNYGFFG DIDVAVIEAS ALAPDGRVWL TSGIGNAPTW
160 170 180 190 200
LLRAKKVIIE LNHYHDPRVA ELADIVIPGA PPRRNSVSIF HAMDRVGTRY
210 220 230 240 250
VQIDPKKIVA VVETNLPDAG NMLDKQNPMC QQIADNVVTF LLQEMAHGRI
260 270 280 290 300
PPEFLPLQSG VGNINNAVMA RLGENPVIPP FMMYSEVLQE SVVHLLETGK
310 320 330 340 350
ISGASASSLT ISADSLRKIY DNMDYFASRI VLRPQEISNN PEIIRRLGVI
360 370 380 390 400
ALNVGLEFDI YGHANSTHVA GVDLMNGIGG SGDFERNAYL SIFMAPSIAK
410 420 430 440 450
EGKISTVVPM CSHVDHSEHS VKVIITEQGI ADLRGLSPLQ RARTIIDNCA
460 470 480 490
HPMYRDYLHR YLENAPGGHI HHDLSHVFDL HRNLIATGSM LG
Length:492
Mass (Da):53,824
Last modified:October 1, 1996 - v1
Checksum:i4C84C10B91D2CA65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69087.1
U00096 Genomic DNA Translation: AAC75957.1
AP009048 Genomic DNA Translation: BAE76984.1
PIRiG65076
RefSeqiNP_417395.1, NC_000913.3
WP_000449965.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75957; AAC75957; b2920
BAE76984; BAE76984; BAE76984
GeneIDi947402
KEGGiecj:JW2887
eco:b2920
PATRICifig|1411691.4.peg.3812

Similar proteinsi

Entry informationi

Entry nameiSCPC_ECOLI
AccessioniPrimary (citable) accession number: P52043
Secondary accession number(s): Q2M9S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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