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P52042

- ACDS_CLOAB

UniProt

P52042 - ACDS_CLOAB

Protein

Acyl-CoA dehydrogenase, short-chain specific

Gene

bcd

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.1 Publication

    Cofactori

    FAD.

    Pathwayi

    GO - Molecular functioni

    1. acyl-CoA dehydrogenase activity Source: InterPro
    2. butyryl-CoA dehydrogenase activity Source: UniProtKB-EC
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. butyrate metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciCACE272562:GJIH-2789-MONOMER.
    MetaCyc:BCDCLOS-MONOMER.
    UniPathwayiUPA00863.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-CoA dehydrogenase, short-chain specific (EC:1.3.8.1)
    Alternative name(s):
    Butyryl-CoA dehydrogenase
    SCAD
    Gene namesi
    Name:bcd
    Ordered Locus Names:CA_C2711
    OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
    Taxonomic identifieri272562 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000814: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Acyl-CoA dehydrogenase, short-chain specificPRO_0000201189Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272562.CA_C2711.

    Structurei

    3D structure databases

    ProteinModelPortaliP52042.
    SMRiP52042. Positions 1-379.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acyl-CoA dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1960.
    HOGENOMiHOG000131659.
    KOiK00248.
    OMAiCYAIAME.
    OrthoDBiEOG600DMX.

    Family and domain databases

    Gene3Di1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProiIPR006089. Acyl-CoA_DH_CS.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view]
    PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF02771. Acyl-CoA_dh_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47203. SSF47203. 1 hit.
    SSF56645. SSF56645. 1 hit.
    PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
    PS00073. ACYL_COA_DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52042-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFNLTREQE LVRQMVREFA ENEVKPIAAE IDETERFPME NVKKMGQYGM    50
    MGIPFSKEYG GAGGDVLSYI IAVEELSKVC GTTGVILSAH TSLCASLINE 100
    HGTEEQKQKY LVPLAKGEKI GAYGLTEPNA GTDSGAQQTV AVLEGDHYVI 150
    NGSKIFITNG GVADTFVIFA MTDRTKGTKG ISAFIIEKGF KGFSIGKVEQ 200
    KLGIRASSTT ELVFEDMIVP VENMIGKEGK GFPIAMKTLD GGRIGIAAQA 250
    LGIAEGAFNE ARAYMKERKQ FGRSLDKFQG LAWMMADMDV AIESARYLVY 300
    KAAYLKQAGL PYTVDAARAK LHAANVAMDV TTKAVQLFGG YGYTKDYPVE 350
    RMMRDAKITE IYEGTSEVQK LVISGKIFR 379
    Length:379
    Mass (Da):41,387
    Last modified:October 1, 1996 - v1
    Checksum:i4BC50A1991BD9FB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17110 Genomic DNA. Translation: AAA95968.1.
    AE001437 Genomic DNA. Translation: AAK80657.1.
    PIRiF97233.
    T47262.
    RefSeqiNP_349317.1. NC_003030.1.

    Genome annotation databases

    EnsemblBacteriaiAAK80657; AAK80657; CA_C2711.
    GeneIDi1118894.
    KEGGicac:CA_C2711.
    PATRICi32039835. VBICloAce74127_2901.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17110 Genomic DNA. Translation: AAA95968.1 .
    AE001437 Genomic DNA. Translation: AAK80657.1 .
    PIRi F97233.
    T47262.
    RefSeqi NP_349317.1. NC_003030.1.

    3D structure databases

    ProteinModelPortali P52042.
    SMRi P52042. Positions 1-379.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272562.CA_C2711.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK80657 ; AAK80657 ; CA_C2711 .
    GeneIDi 1118894.
    KEGGi cac:CA_C2711.
    PATRICi 32039835. VBICloAce74127_2901.

    Phylogenomic databases

    eggNOGi COG1960.
    HOGENOMi HOG000131659.
    KOi K00248.
    OMAi CYAIAME.
    OrthoDBi EOG600DMX.

    Enzyme and pathway databases

    UniPathwayi UPA00863 .
    BioCyci CACE272562:GJIH-2789-MONOMER.
    MetaCyc:BCDCLOS-MONOMER.

    Family and domain databases

    Gene3Di 1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProi IPR006089. Acyl-CoA_DH_CS.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view ]
    Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF02771. Acyl-CoA_dh_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47203. SSF47203. 1 hit.
    SSF56645. SSF56645. 1 hit.
    PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
    PS00073. ACYL_COA_DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing, and expression of clustered genes encoding beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824."
      Boynton Z.L., Bennett G.N., Rudolph F.B.
      J. Bacteriol. 178:3015-3024(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY.
      Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

    Entry informationi

    Entry nameiACDS_CLOAB
    AccessioniPrimary (citable) accession number: P52042
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3