Reviewed, UniProtKB/Swiss-Prot P52042 (ACDS_CLOAB)

Names and origin

Protein names

Recommended name:
    Acyl-CoA dehydrogenase, short-chain specific
    EC=1.3.99.2
Alternative name(s):
    SCAD
    Butyryl-CoA dehydrogenase

Gene names

Name:	bcd
Ordered Locus Names:	CA_C2711

Organism

Clostridium acetobutylicum [Complete proteome] [HAMAP]

Taxonomic identifier

1488 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor.
Cofactor	FAD.
Pathway	Lipid metabolism; butyric acid metabolism.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro butyryl-CoA dehydrogenase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	Acyl-CoA dehydrogenase, short-chain specific		PRO_0000201189

Sequences

	Sequence		Length	Mass (Da)
	P52042-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 4BC50A1991BD9FB2	FASTA	379	41,387
	10 20 30 40 50 60 MDFNLTREQE LVRQMVREFA ENEVKPIAAE IDETERFPME NVKKMGQYGM MGIPFSKEYG 70 80 90 100 110 120 GAGGDVLSYI IAVEELSKVC GTTGVILSAH TSLCASLINE HGTEEQKQKY LVPLAKGEKI 130 140 150 160 170 180 GAYGLTEPNA GTDSGAQQTV AVLEGDHYVI NGSKIFITNG GVADTFVIFA MTDRTKGTKG 190 200 210 220 230 240 ISAFIIEKGF KGFSIGKVEQ KLGIRASSTT ELVFEDMIVP VENMIGKEGK GFPIAMKTLD 250 260 270 280 290 300 GGRIGIAAQA LGIAEGAFNE ARAYMKERKQ FGRSLDKFQG LAWMMADMDV AIESARYLVY 310 320 330 340 350 360 KAAYLKQAGL PYTVDAARAK LHAANVAMDV TTKAVQLFGG YGYTKDYPVE RMMRDAKITE 370 IYEGTSEVQK LVISGKIFR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing, and expression of clustered genes encoding beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824." Boynton Z.L., Bennett G.N., Rudolph F.B. J. Bacteriol. 178:3015-3024(1996) [PubMed: 8655474] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
[2]	"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum." Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R. J. Bacteriol. 183:4823-4838(2001) [PubMed: 11466286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U17110 Genomic DNA. Translation: AAA95968.1. AE001437 Genomic DNA. Translation: AAK80657.1.
PIR	F97233. T47262.
RefSeq	NP_349317.1.
3D structure databases
HSSP	HSSP built from PDB template 1BUC based on UniProtKB Q06319.
ModBase	Search...
Genome annotation databases
GeneID	1118894.
GenomeReviews	Gene locus CA_C2711 in contig AE001437_GR.
KEGG	cac:CAC2711.
NMPDR	fig|272562.1.peg.2846.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P52042.
OMA	P52042. RGSATCE.
Enzyme and pathway databases
BioCyc	CACE272562:CAC2711-MON.
BRENDA	1.3.99.2. 2866.
Family and domain databases
InterPro	IPR006089. Acyl-CoA_DH_CS. IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACDS_CLOAB

Accession

Primary (citable) accession number: P52042

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)