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P52042

- ACDS_CLOAB

UniProt

P52042 - ACDS_CLOAB

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Protein

Acyl-CoA dehydrogenase, short-chain specific

Gene

bcd

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.1 Publication

Cofactori

FAD.

Pathwayi

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. butyryl-CoA dehydrogenase activity Source: UniProtKB-EC
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. butyrate metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciCACE272562:GJIH-2789-MONOMER.
MetaCyc:BCDCLOS-MONOMER.
UniPathwayiUPA00863.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA dehydrogenase, short-chain specific (EC:1.3.8.1)
Alternative name(s):
Butyryl-CoA dehydrogenase
SCAD
Gene namesi
Name:bcd
Ordered Locus Names:CA_C2711
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000814: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Acyl-CoA dehydrogenase, short-chain specificPRO_0000201189Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C2711.

Structurei

3D structure databases

ProteinModelPortaliP52042.
SMRiP52042. Positions 1-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000131659.
KOiK00248.
OMAiCYAIAME.
OrthoDBiEOG600DMX.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52042-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFNLTREQE LVRQMVREFA ENEVKPIAAE IDETERFPME NVKKMGQYGM
60 70 80 90 100
MGIPFSKEYG GAGGDVLSYI IAVEELSKVC GTTGVILSAH TSLCASLINE
110 120 130 140 150
HGTEEQKQKY LVPLAKGEKI GAYGLTEPNA GTDSGAQQTV AVLEGDHYVI
160 170 180 190 200
NGSKIFITNG GVADTFVIFA MTDRTKGTKG ISAFIIEKGF KGFSIGKVEQ
210 220 230 240 250
KLGIRASSTT ELVFEDMIVP VENMIGKEGK GFPIAMKTLD GGRIGIAAQA
260 270 280 290 300
LGIAEGAFNE ARAYMKERKQ FGRSLDKFQG LAWMMADMDV AIESARYLVY
310 320 330 340 350
KAAYLKQAGL PYTVDAARAK LHAANVAMDV TTKAVQLFGG YGYTKDYPVE
360 370
RMMRDAKITE IYEGTSEVQK LVISGKIFR
Length:379
Mass (Da):41,387
Last modified:October 1, 1996 - v1
Checksum:i4BC50A1991BD9FB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17110 Genomic DNA. Translation: AAA95968.1.
AE001437 Genomic DNA. Translation: AAK80657.1.
PIRiF97233.
T47262.
RefSeqiNP_349317.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK80657; AAK80657; CA_C2711.
GeneIDi1118894.
KEGGicac:CA_C2711.
PATRICi32039835. VBICloAce74127_2901.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17110 Genomic DNA. Translation: AAA95968.1 .
AE001437 Genomic DNA. Translation: AAK80657.1 .
PIRi F97233.
T47262.
RefSeqi NP_349317.1. NC_003030.1.

3D structure databases

ProteinModelPortali P52042.
SMRi P52042. Positions 1-379.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272562.CA_C2711.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK80657 ; AAK80657 ; CA_C2711 .
GeneIDi 1118894.
KEGGi cac:CA_C2711.
PATRICi 32039835. VBICloAce74127_2901.

Phylogenomic databases

eggNOGi COG1960.
HOGENOMi HOG000131659.
KOi K00248.
OMAi CYAIAME.
OrthoDBi EOG600DMX.

Enzyme and pathway databases

UniPathwayi UPA00863 .
BioCyci CACE272562:GJIH-2789-MONOMER.
MetaCyc:BCDCLOS-MONOMER.

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing, and expression of clustered genes encoding beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824."
    Boynton Z.L., Bennett G.N., Rudolph F.B.
    J. Bacteriol. 178:3015-3024(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY.
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Entry informationi

Entry nameiACDS_CLOAB
AccessioniPrimary (citable) accession number: P52042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3