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P52042 (ACDS_CLOAB) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acyl-CoA dehydrogenase, short-chain specific

EC=1.3.8.1
Alternative name(s):
Butyryl-CoA dehydrogenase
SCAD
Gene names
Name:bcd
Ordered Locus Names:CA_C2711
OrganismClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) [Reference proteome] [HAMAP]
Taxonomic identifier272562 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.

Cofactor

FAD.

Pathway

Lipid metabolism; butanoate metabolism.

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Acyl-CoA dehydrogenase, short-chain specific
PRO_0000201189

Sequences

Sequence LengthMass (Da)Tools
P52042 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4BC50A1991BD9FB2

FASTA37941,387
        10         20         30         40         50         60 
MDFNLTREQE LVRQMVREFA ENEVKPIAAE IDETERFPME NVKKMGQYGM MGIPFSKEYG 

        70         80         90        100        110        120 
GAGGDVLSYI IAVEELSKVC GTTGVILSAH TSLCASLINE HGTEEQKQKY LVPLAKGEKI 

       130        140        150        160        170        180 
GAYGLTEPNA GTDSGAQQTV AVLEGDHYVI NGSKIFITNG GVADTFVIFA MTDRTKGTKG 

       190        200        210        220        230        240 
ISAFIIEKGF KGFSIGKVEQ KLGIRASSTT ELVFEDMIVP VENMIGKEGK GFPIAMKTLD 

       250        260        270        280        290        300 
GGRIGIAAQA LGIAEGAFNE ARAYMKERKQ FGRSLDKFQG LAWMMADMDV AIESARYLVY 

       310        320        330        340        350        360 
KAAYLKQAGL PYTVDAARAK LHAANVAMDV TTKAVQLFGG YGYTKDYPVE RMMRDAKITE 

       370 
IYEGTSEVQK LVISGKIFR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, sequencing, and expression of clustered genes encoding beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824."
Boynton Z.L., Bennett G.N., Rudolph F.B.
J. Bacteriol. 178:3015-3024(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
[2]"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum."
Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.
J. Bacteriol. 183:4823-4838(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U17110 Genomic DNA. Translation: AAA95968.1.
AE001437 Genomic DNA. Translation: AAK80657.1.
PIRF97233.
T47262.
RefSeqNP_349317.1. NC_003030.1.

3D structure databases

ProteinModelPortalP52042.
SMRP52042. Positions 1-379.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272562.CA_C2711.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK80657; AAK80657; CA_C2711.
GeneID1118894.
KEGGcac:CA_C2711.
PATRIC32039835. VBICloAce74127_2901.

Phylogenomic databases

eggNOGCOG1960.
HOGENOMHOG000131659.
KOK00248.
OMAFLIFANV.
OrthoDBEOG600DMX.
ProtClustDBCLSK2751956.

Enzyme and pathway databases

BioCycCACE272562:GJIH-2789-MONOMER.
MetaCyc:BCDCLOS-MONOMER.
UniPathwayUPA00863.

Family and domain databases

Gene3D1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACDS_CLOAB
AccessionPrimary (citable) accession number: P52042
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 13, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways