Reviewed, UniProtKB/Swiss-Prot P52033 (GPXC_DIRIM)

Names and origin

Protein names	Recommended name:     Glutathione peroxidase     EC=1.11.1.9 Alternative name(s):     Di29
Organism	Dirofilaria immitis (Canine heartworm)
Taxonomic identifier	6287 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Nematoda › Chromadorea › Spirurida › Filarioidea › Onchocercidae › Dirofilaria

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subunit structure	Homotetramer By similarity.
Subcellular location	Secreted › extracellular space By similarity.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Oxidoreductase Peroxidase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 221	202	Glutathione peroxidase		PRO_0000013094
Sites
	Active site	72	1	By similarity
Amino acid modifications
	Glycosylation	28	1	N-linked (GlcNAc...) Potential
	Glycosylation	87	1	N-linked (GlcNAc...) Potential
	Glycosylation	90	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P52033-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 88FFF848D567CF28	FASTA	221	25,453
	10 20 30 40 50 60 MFIQLLILSY AILLQLIATQ VADKQLPNLT KQCEPTSQTI YDFHVPTLDG SEKSLAEYRG 70 80 90 100 110 120 KVLLLVNVAT YCAYTFQYND FNPMLENNSN GTLKILAFPC NQFLLQEPAE NHELLNGLKY 130 140 150 160 170 180 VRPGNGWEPH GNMHIFGKVE VNGDDHHPLY KFLKEHCPQT VPIIGDRHQL MYNPIGTNDI 190 200 210 220 IWNFEKFLID KKGHPRYRFH PSAWVQGSVI APFIDELERE I

References

[1]	Venkatakrishnaiah L., James E. Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Dirofilaria immitis: molecular cloning and expression of a cDNA encoding a selenium-independent secreted glutathione peroxidase." Tripp C.A., Frank R.S., Selkirk M.E., Tang L., Mika-Grieve M., Frank G.R., Grieve R.B. Exp. Parasitol. 88:43-50(1998) [PubMed: 9501847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U04693 mRNA. Translation: AAA16224.1. U87457 mRNA. Translation: AAB58573.1. U87458 Genomic DNA. Translation: AAB58574.1.
3D structure databases
SMR	P52033. Positions 39-217.
ModBase	Search...
Protein family/group databases
PeroxiBase	3752. DiGPx01.
Enzyme and pathway databases
BRENDA	1.11.1.9. 260127.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPXC_DIRIM

Accession

Primary (citable) accession number: P52033

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 19, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)