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Protein

Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic

Gene

GPX1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.By similarity

Catalytic activityi

2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei111By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processStress response

Enzyme and pathway databases

BioCyciARA:AT2G25080-MONOMER
ReactomeiR-ATH-3299685 Detoxification of Reactive Oxygen Species

Protein family/group databases

PeroxiBasei2499 AtGPx01

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic (EC:1.11.1.12)
Short name:
PHGPx
Gene namesi
Name:GPX1
Ordered Locus Names:At2g25080
ORF Names:F13D4.40
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G25080
TAIRilocus:2040179 AT2G25080

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 64ChloroplastSequence analysisAdd BLAST64
ChainiPRO_000001308665 – 236Phospholipid hydroperoxide glutathione peroxidase 1, chloroplasticAdd BLAST172

Proteomic databases

PaxDbiP52032
PRIDEiP52032

PTM databases

iPTMnetiP52032

Expressioni

Tissue specificityi

Expressed in leaves, stems, flowers, green siliques and seeds.1 Publication

Inductioni

By salt stress, osmotic stress, metals and heat treatment. Up-regulated by abscisic acid (ABA) and auxin.1 Publication

Gene expression databases

ExpressionAtlasiP52032 baseline and differential
GenevisibleiP52032 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G25080.1

Structurei

3D structure databases

ProteinModelPortaliP52032
SMRiP52032
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
HOGENOMiHOG000277054
InParanoidiP52032
KOiK00432
OMAiERYPPTI
OrthoDBiEOG09360NO2
PhylomeDBiP52032

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSMTTSSSS YGTFSTVVNS SRPNSSATFL VPSLKFSTGI SNFANLSNGF
60 70 80 90 100
SLKSPINPGF LFKSRPFTVQ ARAAAEKTVH DFTVKDIDGK DVALNKFKGK
110 120 130 140 150
VMLIVNVASR CGLTSSNYSE LSHLYEKYKT QGFEILAFPC NQFGFQEPGS
160 170 180 190 200
NSEIKQFACT RFKAEFPIFD KVDVNGPSTA PIYEFLKSNA GGFLGGLIKW
210 220 230
NFEKFLIDKK GKVVERYPPT TSPFQIEKDI QKLLAA
Length:236
Mass (Da):26,016
Last modified:March 27, 2002 - v2
Checksum:iD676C0381526C37A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18V → F in CAA61965 (Ref. 1) Curated1
Sequence conflicti236A → ELKNF (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89866 mRNA Translation: CAA61965.1
AJ000469 mRNA Translation: CAA04112.1
CP002685 Genomic DNA Translation: AEC07655.1
AY035153 mRNA Translation: AAK59657.1
AY063024 mRNA Translation: AAL34198.1
PIRiA84644
S71250
RefSeqiNP_180080.1, NM_128065.5
UniGeneiAt.24670

Genome annotation databases

EnsemblPlantsiAT2G25080.1; AT2G25080.1; AT2G25080
GeneIDi817046
GrameneiAT2G25080.1; AT2G25080.1; AT2G25080
KEGGiath:AT2G25080

Similar proteinsi

Entry informationi

Entry nameiGPX1_ARATH
AccessioniPrimary (citable) accession number: P52032
Secondary accession number(s): O19985, O81717
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 27, 2002
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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