Reviewed,
UniProtKB/Swiss-Prot P52032 (GPX1_ARATH)
Last modified
November 25, 2008.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic Short name=PHGPx EC=1.11.1.12 | ||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 236 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione By similarity. |
| Catalytic activity | 2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O. |
| Subcellular location | |
| Tissue specificity | Expressed in leaves, stems, flowers, green siliques and seeds. |
| Induction | By salt stress, osmotic stress, metals and heat treatment. Up-regulated by abscisic acid (ABA) and auxin. |
| Sequence similarities | Belongs to the glutathione peroxidase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Stress response |
| Cellular component | Chloroplast Plastid |
| Domain | Transit peptide |
| Molecular function | Oxidoreductase Peroxidase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stressInferred from electronic annotation. Source: InterPro |
| Cellular component | chloroplast Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | glutathione peroxidase activity Inferred from electronic annotation. Source: InterPro phospholipid-hydroperoxide glutathione peroxidase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 64 | 64 | Chloroplast Potential | ||||||
| Chain | 65 – 236 | 172 | Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic | PRO_0000013086 | |||||
Sites | |||||||||
| Active site | 111 | 1 | By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 18 | 1 | V → F in CAA61965. Ref.1 | ||||||
| Sequence conflict | 236 | 1 | A → ELKNF Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and sequencing of a glutathione peroxidase homologue from Arabidopsis thaliana." Gachotte D., Benveniste P. (er) Plant Gene Register PGR95-133 Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia. |
| [2] | "Identification of cDNAS encoding plastid-targeted glutathione peroxidase." Mullineaux P.M., Karpinski S., Jimenez A., Cleary S.P., Robinson C., Creissen G.P. Plant J. 13:375-379(1998) [PubMed: 9680987] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia. |
| [3] | "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. Venter J.C.Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [4] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [5] | "Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana." Ferro M., Salvi D., Brugiere S., Miras S., Kowalski S., Louwagie M., Garin J., Joyard J., Rolland N. Mol. Cell. Proteomics 2:325-345(2003) [PubMed: 12766230] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [6] | "Glutathione peroxidase genes in Arabidopsis are ubiquitous and regulated by abiotic stresses through diverse signaling pathways." Rodriguez Milla M.A., Maurer A., Rodriguez Huete A., Gustafson J.P. Plant J. 36:602-615(2003) [PubMed: 14617062] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION. |
Cross-references
Sequence databases | |
|---|---|
| X89866 mRNA. Translation: CAA61965.1. AJ000469 mRNA. Translation: CAA04112.1. AY035153 mRNA. Translation: AAK59657.1. AY063024 mRNA. Translation: AAL34198.1. | |
| PIR | A84644. S71250. |
| RefSeq | NP_180080.1. |
| UniGene | At.24670 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GP1 based on UniProtKB P00435. |
| ModBase | Search... |
Protein family/group databases | |
| PeroxiBase | 2499. AtGPx01. |
Genome annotation databases | |
| GeneID | 817046. |
| GenomeReviews | Gene locus AT2G25080 in contig CT485783_GR. |
| KEGG | ath:AT2G25080. |
| NMPDR | fig|3702.1.peg.9525. |
Organism-specific databases | |
| GeneFarm | 2047. 163. |
| TAIR | At2g25080. |
Gene expression databases | |
| ArrayExpress | P52032. |
| GermOnline | AT2G25080. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR000889. Glut_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| PANTHER | PTHR11592. Glut_peroxidase. 1 hit. |
| Pfam | PF00255. GSHPx. 1 hit. [Graphical view] |
| PIRSF | PIRSF000303. Glutathion_perox. 1 hit. |
| PRINTS | PR01011. GLUTPROXDASE. |
| PROSITE | PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GPX1_ARATH | ||||||||
| Accession | Primary (citable) accession number: P52032 Secondary accession number(s): O19985, O81717 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


