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Protein

Glucose-6-phosphate isomerase

Gene

Pgi

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (Pgi), Glucose-6-phosphate isomerase (Pgi)
  3. ATP-dependent 6-phosphofructokinase (Pfk), ATP-dependent 6-phosphofructokinase (Pfk), ATP-dependent 6-phosphofructokinase (Pfk), ATP-dependent 6-phosphofructokinase (Pfk)
  4. Fructose-bisphosphate aldolase (Dyak\GE10635), Fructose-bisphosphate aldolase (Ald)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei362Proton donorBy similarity1
Active sitei393By similarity1
Active sitei523By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:Pgi
ORF Names:GE22729
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000002282 Componentsi: Chromosome 2L, Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0013171 Dyak\Pgi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001805451 – 558Glucose-6-phosphate isomeraseAdd BLAST558

Expressioni

Gene expression databases

BgeeiFBgn0013171

Interactioni

Protein-protein interaction databases

STRINGi7245.FBpp0267739

Structurei

3D structure databases

ProteinModelPortaliP52031
SMRiP52031
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiKOG2446 Eukaryota
COG0166 LUCA
KOiK01810
OMAiTNSQHAF
OrthoDBiEOG091G03ZI
PhylomeDBiP52031

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P52031-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPLPPLNQ EAAFQKLQEY YDSSGKDLNI KDLFVKDAKR FSKYSLRLHT
60 70 80 90 100
QNDGEILLDY SKNRINDEVW DLLLALAKVR RVDAARDAMF SGQHINITEN
110 120 130 140 150
RAVLHTALRN RGTDPVLVDD KDVMPDVRAE LAHMKEFTNM VISGVWRGCT
160 170 180 190 200
GKQITDVVNI GIGGSDLGPL MVTEALKPYG KGLHSHFVSN IDGTHLAEVL
210 220 230 240 250
KKVNYETTLF IVASKTFTTQ ETITNATSAK TWLLEHSKEP ESVAKHFVAL
260 270 280 290 300
STNKEKVTEF GIDSTNMFGF WDWVGGRYSL WSAIGLSICL SIGFENFEQL
310 320 330 340 350
LDGAHYMDNH FRTTPLEKNA PVILALLGVW YSNFFKAETH ALLPYDQYLH
360 370 380 390 400
RFAAYFQQGD MESNGKFVSK AGKAVKYSTG PIVWGEPGTN GQHAFYQLIH
410 420 430 440 450
QGTRLIPCDF IAPAQTHNPI AGGKHHKILL SNFLAQTEAL MAGKTVDEAR
460 470 480 490 500
AELSKAGLCG NELDNLLPHK VFVGNRPTNS IVVKKVSPFT LGALIALYEH
510 520 530 540 550
KIFVQGIIWD INSFDQWGVE LGKQLAKAIE PELDHCNEVS THDSSTNGLI

NFIKANWK
Length:558
Mass (Da):62,191
Last modified:October 1, 1996 - v1
Checksum:iBB73495CE60D3356
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27673 Genomic DNA Translation: AAA28787.1
L27674 Genomic DNA Translation: AAA28788.1
L27675 Genomic DNA Translation: AAB59188.1
L27676 Genomic DNA Translation: AAA28806.1
L27677 Genomic DNA Translation: AAA28807.1
L27678 Genomic DNA Translation: AAA28808.1
L27679 Genomic DNA Translation: AAA28809.1
L27680 Genomic DNA Translation: AAA28810.1
L27681 Genomic DNA Translation: AAA28811.1
L27682 Genomic DNA Translation: AAA28812.1
L27683 Genomic DNA Translation: AAA28813.1
L27684 Genomic DNA Translation: AAA28814.1
L27685 Genomic DNA Translation: AAA28815.1
CM000157 Genomic DNA Translation: EDW89413.1
RefSeqiXP_002089701.1, XM_002089665.2
XP_015054313.1, XM_015198827.1

Genome annotation databases

EnsemblMetazoaiFBtr0269247; FBpp0267739; FBgn0013171
FBtr0399001; FBpp0358056; FBgn0013171
GeneIDi6528659
KEGGidya:Dyak_GE22729

Similar proteinsi

Entry informationi

Entry nameiG6PI_DROYA
AccessioniPrimary (citable) accession number: P52031
Secondary accession number(s): B4P3E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health