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P52031 (G6PI_DROYA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:Pgi
ORF Names:GE22729
OrganismDrosophila yakuba (Fruit fly) [Complete proteome]
Taxonomic identifier7245 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180545

Sites

Active site3621Proton donor By similarity
Active site3931 By similarity
Active site5231 By similarity

Sequences

Sequence LengthMass (Da)Tools
P52031 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: BB73495CE60D3356

FASTA55862,191
        10         20         30         40         50         60 
MAGPLPPLNQ EAAFQKLQEY YDSSGKDLNI KDLFVKDAKR FSKYSLRLHT QNDGEILLDY 

        70         80         90        100        110        120 
SKNRINDEVW DLLLALAKVR RVDAARDAMF SGQHINITEN RAVLHTALRN RGTDPVLVDD 

       130        140        150        160        170        180 
KDVMPDVRAE LAHMKEFTNM VISGVWRGCT GKQITDVVNI GIGGSDLGPL MVTEALKPYG 

       190        200        210        220        230        240 
KGLHSHFVSN IDGTHLAEVL KKVNYETTLF IVASKTFTTQ ETITNATSAK TWLLEHSKEP 

       250        260        270        280        290        300 
ESVAKHFVAL STNKEKVTEF GIDSTNMFGF WDWVGGRYSL WSAIGLSICL SIGFENFEQL 

       310        320        330        340        350        360 
LDGAHYMDNH FRTTPLEKNA PVILALLGVW YSNFFKAETH ALLPYDQYLH RFAAYFQQGD 

       370        380        390        400        410        420 
MESNGKFVSK AGKAVKYSTG PIVWGEPGTN GQHAFYQLIH QGTRLIPCDF IAPAQTHNPI 

       430        440        450        460        470        480 
AGGKHHKILL SNFLAQTEAL MAGKTVDEAR AELSKAGLCG NELDNLLPHK VFVGNRPTNS 

       490        500        510        520        530        540 
IVVKKVSPFT LGALIALYEH KIFVQGIIWD INSFDQWGVE LGKQLAKAIE PELDHCNEVS 

       550 
THDSSTNGLI NFIKANWK 

« Hide

References

« Hide 'large scale' references
[1]McDonald J.H., Kreitman M.E.
Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Brazzaville.
[2]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tai18E2 / Tucson 14021-0261.01.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L27673 Genomic DNA. Translation: AAA28787.1.
L27674 Genomic DNA. Translation: AAA28788.1.
L27675 Genomic DNA. Translation: AAB59188.1.
L27676 Genomic DNA. Translation: AAA28806.1.
L27677 Genomic DNA. Translation: AAA28807.1.
L27678 Genomic DNA. Translation: AAA28808.1.
L27679 Genomic DNA. Translation: AAA28809.1.
L27680 Genomic DNA. Translation: AAA28810.1.
L27681 Genomic DNA. Translation: AAA28811.1.
L27682 Genomic DNA. Translation: AAA28812.1.
L27683 Genomic DNA. Translation: AAA28813.1.
L27684 Genomic DNA. Translation: AAA28814.1.
L27685 Genomic DNA. Translation: AAA28815.1.
CM000157 Genomic DNA. Translation: EDW89413.1.
RefSeqXP_002089701.1. XM_002089665.1.

3D structure databases

ProteinModelPortalP52031.
SMRP52031. Positions 8-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7245.FBpp0267739.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0269247; FBpp0267739; FBgn0013171.
GeneID6528659.
KEGGdya:Dyak_GE22729.

Organism-specific databases

FlyBaseFBgn0013171. Dyak\Pgi.

Phylogenomic databases

eggNOGCOG0166.
KOK01810.
OrthoDBEOG7FXZXV.
PhylomeDBP52031.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_DROYA
AccessionPrimary (citable) accession number: P52031
Secondary accession number(s): B4P3E0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase