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P52031

- G6PI_DROYA

UniProt

P52031 - G6PI_DROYA

Protein

Glucose-6-phosphate isomerase

Gene

Pgi

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei362 – 3621Proton donorBy similarity
    Active sitei393 – 3931By similarity
    Active sitei523 – 5231By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-KW
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:Pgi
    ORF Names:GE22729
    OrganismiDrosophila yakuba (Fruit fly)
    Taxonomic identifieri7245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000002282: Chromosome 2L, UP000002282: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0013171. Dyak\Pgi.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Glucose-6-phosphate isomerasePRO_0000180545Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7245.FBpp0267739.

    Structurei

    3D structure databases

    ProteinModelPortaliP52031.
    SMRiP52031. Positions 8-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    KOiK01810.
    OrthoDBiEOG7FXZXV.
    PhylomeDBiP52031.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52031-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPLPPLNQ EAAFQKLQEY YDSSGKDLNI KDLFVKDAKR FSKYSLRLHT    50
    QNDGEILLDY SKNRINDEVW DLLLALAKVR RVDAARDAMF SGQHINITEN 100
    RAVLHTALRN RGTDPVLVDD KDVMPDVRAE LAHMKEFTNM VISGVWRGCT 150
    GKQITDVVNI GIGGSDLGPL MVTEALKPYG KGLHSHFVSN IDGTHLAEVL 200
    KKVNYETTLF IVASKTFTTQ ETITNATSAK TWLLEHSKEP ESVAKHFVAL 250
    STNKEKVTEF GIDSTNMFGF WDWVGGRYSL WSAIGLSICL SIGFENFEQL 300
    LDGAHYMDNH FRTTPLEKNA PVILALLGVW YSNFFKAETH ALLPYDQYLH 350
    RFAAYFQQGD MESNGKFVSK AGKAVKYSTG PIVWGEPGTN GQHAFYQLIH 400
    QGTRLIPCDF IAPAQTHNPI AGGKHHKILL SNFLAQTEAL MAGKTVDEAR 450
    AELSKAGLCG NELDNLLPHK VFVGNRPTNS IVVKKVSPFT LGALIALYEH 500
    KIFVQGIIWD INSFDQWGVE LGKQLAKAIE PELDHCNEVS THDSSTNGLI 550
    NFIKANWK 558
    Length:558
    Mass (Da):62,191
    Last modified:October 1, 1996 - v1
    Checksum:iBB73495CE60D3356
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27673 Genomic DNA. Translation: AAA28787.1.
    L27674 Genomic DNA. Translation: AAA28788.1.
    L27675 Genomic DNA. Translation: AAB59188.1.
    L27676 Genomic DNA. Translation: AAA28806.1.
    L27677 Genomic DNA. Translation: AAA28807.1.
    L27678 Genomic DNA. Translation: AAA28808.1.
    L27679 Genomic DNA. Translation: AAA28809.1.
    L27680 Genomic DNA. Translation: AAA28810.1.
    L27681 Genomic DNA. Translation: AAA28811.1.
    L27682 Genomic DNA. Translation: AAA28812.1.
    L27683 Genomic DNA. Translation: AAA28813.1.
    L27684 Genomic DNA. Translation: AAA28814.1.
    L27685 Genomic DNA. Translation: AAA28815.1.
    CM000157 Genomic DNA. Translation: EDW89413.1.
    RefSeqiXP_002089701.1. XM_002089665.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0269247; FBpp0267739; FBgn0013171.
    GeneIDi6528659.
    KEGGidya:Dyak_GE22729.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27673 Genomic DNA. Translation: AAA28787.1 .
    L27674 Genomic DNA. Translation: AAA28788.1 .
    L27675 Genomic DNA. Translation: AAB59188.1 .
    L27676 Genomic DNA. Translation: AAA28806.1 .
    L27677 Genomic DNA. Translation: AAA28807.1 .
    L27678 Genomic DNA. Translation: AAA28808.1 .
    L27679 Genomic DNA. Translation: AAA28809.1 .
    L27680 Genomic DNA. Translation: AAA28810.1 .
    L27681 Genomic DNA. Translation: AAA28811.1 .
    L27682 Genomic DNA. Translation: AAA28812.1 .
    L27683 Genomic DNA. Translation: AAA28813.1 .
    L27684 Genomic DNA. Translation: AAA28814.1 .
    L27685 Genomic DNA. Translation: AAA28815.1 .
    CM000157 Genomic DNA. Translation: EDW89413.1 .
    RefSeqi XP_002089701.1. XM_002089665.1.

    3D structure databases

    ProteinModelPortali P52031.
    SMRi P52031. Positions 8-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7245.FBpp0267739.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0269247 ; FBpp0267739 ; FBgn0013171 .
    GeneIDi 6528659.
    KEGGi dya:Dyak_GE22729.

    Organism-specific databases

    FlyBasei FBgn0013171. Dyak\Pgi.

    Phylogenomic databases

    eggNOGi COG0166.
    KOi K01810.
    OrthoDBi EOG7FXZXV.
    PhylomeDBi P52031.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. McDonald J.H., Kreitman M.E.
      Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Brazzaville.
    2. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tai18E2 / Tucson 14021-0261.01.

    Entry informationi

    Entry nameiG6PI_DROYA
    AccessioniPrimary (citable) accession number: P52031
    Secondary accession number(s): B4P3E0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3