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P52030

- G6PI_DROSI

UniProt

P52030 - G6PI_DROSI

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Protein

Glucose-6-phosphate isomerase

Gene
Pgi
Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei362 – 3621Proton donor By similarity
Active sitei393 – 3931 By similarity
Active sitei523 – 5231 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:Pgi
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012850. Dsim\Pgi.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Glucose-6-phosphate isomeraseUniRule annotationPRO_0000180544Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP52030.
SMRiP52030. Positions 8-554.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52030-1 [UniParc]FASTAAdd to Basket

« Hide

MAGPLPPLNQ EPAFQKLQEY YDSKAKDLNI KDLFVKDSKR FSKYSLRLHT    50
QNDGEILLDY SKNRINDEVW DLLLALAKVR RVNAARDAMF SGQHINITEN 100
RAVLHTALRN RGTDPVLVDD KDVMPDVRAE LAHMKEFTNM VISGVWRGCT 150
GKQITDVVNI GIGGSDLGPL MVTEALKPYG KGLHSHFVSN IDGTHLAEVL 200
KKVNYETTLF IVASKTFTTQ ETITNATSAK TWLLEHSKEP ESVAKHFVAL 250
STNKEKVTEF GIDSTNMFGF WDWVGGRYSL WSAIGLSICL SIGFENFEQL 300
LDGAHFMDNH FKTTPFEKNA PVILALLGVW YSNFFKAETH ALLPYDQYLH 350
RFAAYFQQGD MESNGKFVSK SGKPVKYSTG PIVWGEPGTN GQHAFYQLIH 400
QGTRLIPCDF IAPAQTHNPI AGGKHHKILL SNFLAQTEAL MAGKTVDEAR 450
TELSKAGLCG NELDNLLPHK VFVGNRPTNS IVVKKVSPFT LGALIALYEH 500
KIFVQGIIWD INSFDQWGVE LGKQLAKAIE PELDHCNEVS THDSSTNGLI 550
NFIKANWK 558
Length:558
Mass (Da):62,349
Last modified:October 1, 1996 - v1
Checksum:iD3E25A3F02327890
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121P → A in strain: various strains.
Natural varianti25 – 251A → G in strain: various strains.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27547 Genomic DNA. Translation: AAA28797.1.
L27548 Genomic DNA. Translation: AAA28798.1.
L27549 Genomic DNA. Translation: AAA28799.1.
L27550 Genomic DNA. Translation: AAA28800.1.
L27551 Genomic DNA. Translation: AAA28801.1.
L27552 Genomic DNA. Translation: AAA28802.1.
U20556 Genomic DNA. Translation: AAA63663.1.
U20557 Genomic DNA. Translation: AAA63664.1.
U20558 Genomic DNA. Translation: AAA63665.1.
U20559 Genomic DNA. Translation: AAA63666.1.
U20560 Genomic DNA. Translation: AAA63667.1.
U20561 Genomic DNA. Translation: AAA63668.1.
U20564 Genomic DNA. Translation: AAA63669.1.
U20565 Genomic DNA. Translation: AAA63670.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27547 Genomic DNA. Translation: AAA28797.1 .
L27548 Genomic DNA. Translation: AAA28798.1 .
L27549 Genomic DNA. Translation: AAA28799.1 .
L27550 Genomic DNA. Translation: AAA28800.1 .
L27551 Genomic DNA. Translation: AAA28801.1 .
L27552 Genomic DNA. Translation: AAA28802.1 .
U20556 Genomic DNA. Translation: AAA63663.1 .
U20557 Genomic DNA. Translation: AAA63664.1 .
U20558 Genomic DNA. Translation: AAA63665.1 .
U20559 Genomic DNA. Translation: AAA63666.1 .
U20560 Genomic DNA. Translation: AAA63667.1 .
U20561 Genomic DNA. Translation: AAA63668.1 .
U20564 Genomic DNA. Translation: AAA63669.1 .
U20565 Genomic DNA. Translation: AAA63670.1 .

3D structure databases

ProteinModelPortali P52030.
SMRi P52030. Positions 8-554.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0012850. Dsim\Pgi.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. McDonald J.H., Kreitman M.E.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Various strains.

Entry informationi

Entry nameiG6PI_DROSI
AccessioniPrimary (citable) accession number: P52030
Secondary accession number(s): Q27867
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi