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Protein

Glucose-6-phosphate isomerase

Gene

Pgi

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei362 – 3621Proton donorBy similarity
Active sitei393 – 3931By similarity
Active sitei523 – 5231By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:Pgi
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012850. Dsim\Pgi.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Glucose-6-phosphate isomerasePRO_0000180544Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP52030.
SMRiP52030. Positions 8-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52030-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGPLPPLNQ EPAFQKLQEY YDSKAKDLNI KDLFVKDSKR FSKYSLRLHT
60 70 80 90 100
QNDGEILLDY SKNRINDEVW DLLLALAKVR RVNAARDAMF SGQHINITEN
110 120 130 140 150
RAVLHTALRN RGTDPVLVDD KDVMPDVRAE LAHMKEFTNM VISGVWRGCT
160 170 180 190 200
GKQITDVVNI GIGGSDLGPL MVTEALKPYG KGLHSHFVSN IDGTHLAEVL
210 220 230 240 250
KKVNYETTLF IVASKTFTTQ ETITNATSAK TWLLEHSKEP ESVAKHFVAL
260 270 280 290 300
STNKEKVTEF GIDSTNMFGF WDWVGGRYSL WSAIGLSICL SIGFENFEQL
310 320 330 340 350
LDGAHFMDNH FKTTPFEKNA PVILALLGVW YSNFFKAETH ALLPYDQYLH
360 370 380 390 400
RFAAYFQQGD MESNGKFVSK SGKPVKYSTG PIVWGEPGTN GQHAFYQLIH
410 420 430 440 450
QGTRLIPCDF IAPAQTHNPI AGGKHHKILL SNFLAQTEAL MAGKTVDEAR
460 470 480 490 500
TELSKAGLCG NELDNLLPHK VFVGNRPTNS IVVKKVSPFT LGALIALYEH
510 520 530 540 550
KIFVQGIIWD INSFDQWGVE LGKQLAKAIE PELDHCNEVS THDSSTNGLI

NFIKANWK
Length:558
Mass (Da):62,349
Last modified:October 1, 1996 - v1
Checksum:iD3E25A3F02327890
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121P → A in strain: various strains.
Natural varianti25 – 251A → G in strain: various strains.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27547 Genomic DNA. Translation: AAA28797.1.
L27548 Genomic DNA. Translation: AAA28798.1.
L27549 Genomic DNA. Translation: AAA28799.1.
L27550 Genomic DNA. Translation: AAA28800.1.
L27551 Genomic DNA. Translation: AAA28801.1.
L27552 Genomic DNA. Translation: AAA28802.1.
U20556 Genomic DNA. Translation: AAA63663.1.
U20557 Genomic DNA. Translation: AAA63664.1.
U20558 Genomic DNA. Translation: AAA63665.1.
U20559 Genomic DNA. Translation: AAA63666.1.
U20560 Genomic DNA. Translation: AAA63667.1.
U20561 Genomic DNA. Translation: AAA63668.1.
U20564 Genomic DNA. Translation: AAA63669.1.
U20565 Genomic DNA. Translation: AAA63670.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27547 Genomic DNA. Translation: AAA28797.1.
L27548 Genomic DNA. Translation: AAA28798.1.
L27549 Genomic DNA. Translation: AAA28799.1.
L27550 Genomic DNA. Translation: AAA28800.1.
L27551 Genomic DNA. Translation: AAA28801.1.
L27552 Genomic DNA. Translation: AAA28802.1.
U20556 Genomic DNA. Translation: AAA63663.1.
U20557 Genomic DNA. Translation: AAA63664.1.
U20558 Genomic DNA. Translation: AAA63665.1.
U20559 Genomic DNA. Translation: AAA63666.1.
U20560 Genomic DNA. Translation: AAA63667.1.
U20561 Genomic DNA. Translation: AAA63668.1.
U20564 Genomic DNA. Translation: AAA63669.1.
U20565 Genomic DNA. Translation: AAA63670.1.

3D structure databases

ProteinModelPortaliP52030.
SMRiP52030. Positions 8-554.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0012850. Dsim\Pgi.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. McDonald J.H., Kreitman M.E.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Various strains.

Entry informationi

Entry nameiG6PI_DROSI
AccessioniPrimary (citable) accession number: P52030
Secondary accession number(s): Q27867
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.