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P52030

- G6PI_DROSI

UniProt

P52030 - G6PI_DROSI

Protein

Glucose-6-phosphate isomerase

Gene

Pgi

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei362 – 3621Proton donorBy similarity
    Active sitei393 – 3931By similarity
    Active sitei523 – 5231By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-KW
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:Pgi
    OrganismiDrosophila simulans (Fruit fly)
    Taxonomic identifieri7240 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

    Organism-specific databases

    FlyBaseiFBgn0012850. Dsim\Pgi.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Glucose-6-phosphate isomerasePRO_0000180544Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP52030.
    SMRiP52030. Positions 8-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52030-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPLPPLNQ EPAFQKLQEY YDSKAKDLNI KDLFVKDSKR FSKYSLRLHT    50
    QNDGEILLDY SKNRINDEVW DLLLALAKVR RVNAARDAMF SGQHINITEN 100
    RAVLHTALRN RGTDPVLVDD KDVMPDVRAE LAHMKEFTNM VISGVWRGCT 150
    GKQITDVVNI GIGGSDLGPL MVTEALKPYG KGLHSHFVSN IDGTHLAEVL 200
    KKVNYETTLF IVASKTFTTQ ETITNATSAK TWLLEHSKEP ESVAKHFVAL 250
    STNKEKVTEF GIDSTNMFGF WDWVGGRYSL WSAIGLSICL SIGFENFEQL 300
    LDGAHFMDNH FKTTPFEKNA PVILALLGVW YSNFFKAETH ALLPYDQYLH 350
    RFAAYFQQGD MESNGKFVSK SGKPVKYSTG PIVWGEPGTN GQHAFYQLIH 400
    QGTRLIPCDF IAPAQTHNPI AGGKHHKILL SNFLAQTEAL MAGKTVDEAR 450
    TELSKAGLCG NELDNLLPHK VFVGNRPTNS IVVKKVSPFT LGALIALYEH 500
    KIFVQGIIWD INSFDQWGVE LGKQLAKAIE PELDHCNEVS THDSSTNGLI 550
    NFIKANWK 558
    Length:558
    Mass (Da):62,349
    Last modified:October 1, 1996 - v1
    Checksum:iD3E25A3F02327890
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121P → A in strain: various strains.
    Natural varianti25 – 251A → G in strain: various strains.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27547 Genomic DNA. Translation: AAA28797.1.
    L27548 Genomic DNA. Translation: AAA28798.1.
    L27549 Genomic DNA. Translation: AAA28799.1.
    L27550 Genomic DNA. Translation: AAA28800.1.
    L27551 Genomic DNA. Translation: AAA28801.1.
    L27552 Genomic DNA. Translation: AAA28802.1.
    U20556 Genomic DNA. Translation: AAA63663.1.
    U20557 Genomic DNA. Translation: AAA63664.1.
    U20558 Genomic DNA. Translation: AAA63665.1.
    U20559 Genomic DNA. Translation: AAA63666.1.
    U20560 Genomic DNA. Translation: AAA63667.1.
    U20561 Genomic DNA. Translation: AAA63668.1.
    U20564 Genomic DNA. Translation: AAA63669.1.
    U20565 Genomic DNA. Translation: AAA63670.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27547 Genomic DNA. Translation: AAA28797.1 .
    L27548 Genomic DNA. Translation: AAA28798.1 .
    L27549 Genomic DNA. Translation: AAA28799.1 .
    L27550 Genomic DNA. Translation: AAA28800.1 .
    L27551 Genomic DNA. Translation: AAA28801.1 .
    L27552 Genomic DNA. Translation: AAA28802.1 .
    U20556 Genomic DNA. Translation: AAA63663.1 .
    U20557 Genomic DNA. Translation: AAA63664.1 .
    U20558 Genomic DNA. Translation: AAA63665.1 .
    U20559 Genomic DNA. Translation: AAA63666.1 .
    U20560 Genomic DNA. Translation: AAA63667.1 .
    U20561 Genomic DNA. Translation: AAA63668.1 .
    U20564 Genomic DNA. Translation: AAA63669.1 .
    U20565 Genomic DNA. Translation: AAA63670.1 .

    3D structure databases

    ProteinModelPortali P52030.
    SMRi P52030. Positions 8-554.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0012850. Dsim\Pgi.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. McDonald J.H., Kreitman M.E.
      Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Various strains.

    Entry informationi

    Entry nameiG6PI_DROSI
    AccessioniPrimary (citable) accession number: P52030
    Secondary accession number(s): Q27867
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3