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P52029

- G6PI_DROME

UniProt

P52029 - G6PI_DROME

Protein

Glucose-6-phosphate isomerase

Gene

Pgi

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei362 – 3621Proton donorBy similarity
    Active sitei393 – 3931By similarity
    Active sitei523 – 5231By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: FlyBase
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: FlyBase

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-KW
    2. glycolytic process Source: UniProtKB-UniPathway
    3. oxidation-reduction process Source: GOC

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    ReactomeiREACT_206319. Glycolysis.
    REACT_220315. Gluconeogenesis.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:Pgi
    ORF Names:CG8251
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0003074. Pgi.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. lipid particle Source: FlyBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Glucose-6-phosphate isomerasePRO_0000180543Add
    BLAST

    Proteomic databases

    PaxDbiP52029.
    PRIDEiP52029.

    Expressioni

    Gene expression databases

    BgeeiP52029.

    Interactioni

    Protein-protein interaction databases

    BioGridi61725. 4 interactions.
    DIPiDIP-17637N.
    MINTiMINT-314135.

    Structurei

    3D structure databases

    ProteinModelPortaliP52029.
    SMRiP52029. Positions 8-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    GeneTreeiENSGT00390000000707.
    InParanoidiP52029.
    KOiK01810.
    OMAiCGNELDN.
    OrthoDBiEOG7FXZXV.
    PhylomeDBiP52029.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52029-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPLPPLNQ EAAFQKLQEY YDSKGKDLNI KDLFVKDSKR FSKYSLRLHT    50
    QNDGEILLDY SKNRINDEVW DLLLTLAKVR RVNAARDAMF SGQHINITEN 100
    RAVLHTALRN RGTDPVLVDD KDVMPDVRAE LAHMKEFTNM VISGVWRGCT 150
    GKQITDVVNI GIGGSDLGPL MVTEALKPYG KGLHSHFVSN IDGTHLAEVL 200
    KKVNYETTLF IVASKTFTTQ ETITNATSAK TWLLEHSKEP ESVAKHFVAL 250
    STNKEKVTEF GIDSTNMFGF WDWVGGRYSL WSAIGLSICL SIGFENFEQL 300
    LDGAHFMDNH FKTTPFEKNA PVILALLGVW YSNFFKAETH ALLPYDQYLH 350
    RFAAYFQQGD MESNGKFVSK SGKPVKYSTG PIVWGEPGTN GQHAFYQLIH 400
    QGTRLIPCDF IAPAQTHNPI AGGKHHKILL SNFLAQTEAL MAGKTVDEAR 450
    TELSKAGLCG NELDNLLPHK VFVGNRPTNS IVVKKVSPFT LGALIALYEH 500
    KIFVQGIIWD INSFDQWGVE LGKQLAKAIE PELDHCNEVS THDSSTNGLI 550
    NFIKANWK 558
    Length:558
    Mass (Da):62,339
    Last modified:June 1, 2001 - v2
    Checksum:i8DD54FCFCCBD1488
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti184 – 1841H → Y in strain: LW15. 1 Publication
    Natural varianti329 – 3291V → I in strain: AF-F, F1-F, F1-1S, JA-F, LW8, MW18 and ZW20. 1 Publication
    Natural varianti471 – 4711V → A in strain: JA-S. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27539 Genomic DNA. Translation: AAA28789.1.
    L27540 Genomic DNA. Translation: AAA28790.1.
    L27541 Genomic DNA. Translation: AAA28791.1.
    L27542 Genomic DNA. Translation: AAA28792.1.
    L27543 Genomic DNA. Translation: AAA28793.1.
    L27544 Genomic DNA. Translation: AAA28794.1.
    L27545 Genomic DNA. Translation: AAA28795.1.
    L27546 Genomic DNA. Translation: AAA28796.1.
    L27553 Genomic DNA. Translation: AAA28803.1.
    L27554 Genomic DNA. Translation: AAA28804.1.
    L27555 Genomic DNA. Translation: AAA28805.1.
    U20566 Genomic DNA. Translation: AAA63671.1.
    U20567 Genomic DNA. Translation: AAA63672.1.
    U20568 Genomic DNA. Translation: AAA63673.1.
    U20569 Genomic DNA. Translation: AAA63674.1.
    U20570 Genomic DNA. Translation: AAA63675.1.
    U20571 Genomic DNA. Translation: AAA63676.1.
    U20572 Genomic DNA. Translation: AAA63677.1.
    U20573 Genomic DNA. Translation: AAA63678.1.
    U20574 Genomic DNA. Translation: AAA63679.1.
    U20575 Genomic DNA. Translation: AAA63680.1.
    AE013599 Genomic DNA. Translation: AAF59025.1.
    AE013599 Genomic DNA. Translation: AAM71091.1.
    AY051468 mRNA. Translation: AAK92892.1.
    RefSeqiNP_523663.1. NM_078939.2.
    NP_724723.1. NM_165635.1.
    NP_724724.1. NM_165636.1.
    UniGeneiDm.2587.

    Genome annotation databases

    EnsemblMetazoaiFBtr0088679; FBpp0087760; FBgn0003074.
    FBtr0088680; FBpp0087761; FBgn0003074.
    FBtr0088681; FBpp0087762; FBgn0003074.
    GeneIDi35886.
    KEGGidme:Dmel_CG8251.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27539 Genomic DNA. Translation: AAA28789.1 .
    L27540 Genomic DNA. Translation: AAA28790.1 .
    L27541 Genomic DNA. Translation: AAA28791.1 .
    L27542 Genomic DNA. Translation: AAA28792.1 .
    L27543 Genomic DNA. Translation: AAA28793.1 .
    L27544 Genomic DNA. Translation: AAA28794.1 .
    L27545 Genomic DNA. Translation: AAA28795.1 .
    L27546 Genomic DNA. Translation: AAA28796.1 .
    L27553 Genomic DNA. Translation: AAA28803.1 .
    L27554 Genomic DNA. Translation: AAA28804.1 .
    L27555 Genomic DNA. Translation: AAA28805.1 .
    U20566 Genomic DNA. Translation: AAA63671.1 .
    U20567 Genomic DNA. Translation: AAA63672.1 .
    U20568 Genomic DNA. Translation: AAA63673.1 .
    U20569 Genomic DNA. Translation: AAA63674.1 .
    U20570 Genomic DNA. Translation: AAA63675.1 .
    U20571 Genomic DNA. Translation: AAA63676.1 .
    U20572 Genomic DNA. Translation: AAA63677.1 .
    U20573 Genomic DNA. Translation: AAA63678.1 .
    U20574 Genomic DNA. Translation: AAA63679.1 .
    U20575 Genomic DNA. Translation: AAA63680.1 .
    AE013599 Genomic DNA. Translation: AAF59025.1 .
    AE013599 Genomic DNA. Translation: AAM71091.1 .
    AY051468 mRNA. Translation: AAK92892.1 .
    RefSeqi NP_523663.1. NM_078939.2.
    NP_724723.1. NM_165635.1.
    NP_724724.1. NM_165636.1.
    UniGenei Dm.2587.

    3D structure databases

    ProteinModelPortali P52029.
    SMRi P52029. Positions 8-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 61725. 4 interactions.
    DIPi DIP-17637N.
    MINTi MINT-314135.

    Proteomic databases

    PaxDbi P52029.
    PRIDEi P52029.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0088679 ; FBpp0087760 ; FBgn0003074 .
    FBtr0088680 ; FBpp0087761 ; FBgn0003074 .
    FBtr0088681 ; FBpp0087762 ; FBgn0003074 .
    GeneIDi 35886.
    KEGGi dme:Dmel_CG8251.

    Organism-specific databases

    CTDi 35886.
    FlyBasei FBgn0003074. Pgi.

    Phylogenomic databases

    eggNOGi COG0166.
    GeneTreei ENSGT00390000000707.
    InParanoidi P52029.
    KOi K01810.
    OMAi CGNELDN.
    OrthoDBi EOG7FXZXV.
    PhylomeDBi P52029.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    Reactomei REACT_206319. Glycolysis.
    REACT_220315. Gluconeogenesis.

    Miscellaneous databases

    GenomeRNAii 35886.
    NextBioi 795651.
    PROi P52029.

    Gene expression databases

    Bgeei P52029.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. McDonald J.H., Kreitman M.E.
      Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-184; ILE-329 AND ALA-471.
      Strain: AF-F, AF-S, F1-1S, F1-F, FL-2S, FR-F, FR-S, JA-F, JA-S, LW15, LW8, MW13, MW17, MW18, WA-F, WA-S, ZW20, ZW29, ZW34, ZW53 and ZW56.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Head.

    Entry informationi

    Entry nameiG6PI_DROME
    AccessioniPrimary (citable) accession number: P52029
    Secondary accession number(s): A4UZ93
    , Q0E9F0, Q27868, Q27870, Q9V4Z8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3