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P52029 (G6PI_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:Pgi
ORF Names:CG8251
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180543

Sites

Active site3621Proton donor By similarity
Active site3931 By similarity
Active site5231 By similarity

Natural variations

Natural variant1841H → Y in strain: LW15. Ref.1
Natural variant3291V → I in strain: AF-F, F1-F, F1-1S, JA-F, LW8, MW18 and ZW20. Ref.1
Natural variant4711V → A in strain: JA-S. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P52029 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 8DD54FCFCCBD1488

FASTA55862,339
        10         20         30         40         50         60 
MAGPLPPLNQ EAAFQKLQEY YDSKGKDLNI KDLFVKDSKR FSKYSLRLHT QNDGEILLDY 

        70         80         90        100        110        120 
SKNRINDEVW DLLLTLAKVR RVNAARDAMF SGQHINITEN RAVLHTALRN RGTDPVLVDD 

       130        140        150        160        170        180 
KDVMPDVRAE LAHMKEFTNM VISGVWRGCT GKQITDVVNI GIGGSDLGPL MVTEALKPYG 

       190        200        210        220        230        240 
KGLHSHFVSN IDGTHLAEVL KKVNYETTLF IVASKTFTTQ ETITNATSAK TWLLEHSKEP 

       250        260        270        280        290        300 
ESVAKHFVAL STNKEKVTEF GIDSTNMFGF WDWVGGRYSL WSAIGLSICL SIGFENFEQL 

       310        320        330        340        350        360 
LDGAHFMDNH FKTTPFEKNA PVILALLGVW YSNFFKAETH ALLPYDQYLH RFAAYFQQGD 

       370        380        390        400        410        420 
MESNGKFVSK SGKPVKYSTG PIVWGEPGTN GQHAFYQLIH QGTRLIPCDF IAPAQTHNPI 

       430        440        450        460        470        480 
AGGKHHKILL SNFLAQTEAL MAGKTVDEAR TELSKAGLCG NELDNLLPHK VFVGNRPTNS 

       490        500        510        520        530        540 
IVVKKVSPFT LGALIALYEH KIFVQGIIWD INSFDQWGVE LGKQLAKAIE PELDHCNEVS 

       550 
THDSSTNGLI NFIKANWK 

« Hide

References

« Hide 'large scale' references
[1]McDonald J.H., Kreitman M.E.
Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-184; ILE-329 AND ALA-471.
Strain: AF-F, AF-S, F1-1S, F1-F, FL-2S, FR-F, FR-S, JA-F, JA-S, LW15, LW8, MW13, MW17, MW18, WA-F, WA-S, ZW20, ZW29, ZW34, ZW53 and ZW56.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L27539 Genomic DNA. Translation: AAA28789.1.
L27540 Genomic DNA. Translation: AAA28790.1.
L27541 Genomic DNA. Translation: AAA28791.1.
L27542 Genomic DNA. Translation: AAA28792.1.
L27543 Genomic DNA. Translation: AAA28793.1.
L27544 Genomic DNA. Translation: AAA28794.1.
L27545 Genomic DNA. Translation: AAA28795.1.
L27546 Genomic DNA. Translation: AAA28796.1.
L27553 Genomic DNA. Translation: AAA28803.1.
L27554 Genomic DNA. Translation: AAA28804.1.
L27555 Genomic DNA. Translation: AAA28805.1.
U20566 Genomic DNA. Translation: AAA63671.1.
U20567 Genomic DNA. Translation: AAA63672.1.
U20568 Genomic DNA. Translation: AAA63673.1.
U20569 Genomic DNA. Translation: AAA63674.1.
U20570 Genomic DNA. Translation: AAA63675.1.
U20571 Genomic DNA. Translation: AAA63676.1.
U20572 Genomic DNA. Translation: AAA63677.1.
U20573 Genomic DNA. Translation: AAA63678.1.
U20574 Genomic DNA. Translation: AAA63679.1.
U20575 Genomic DNA. Translation: AAA63680.1.
AE013599 Genomic DNA. Translation: AAF59025.1.
AE013599 Genomic DNA. Translation: AAM71091.1.
AY051468 mRNA. Translation: AAK92892.1.
RefSeqNP_523663.1. NM_078939.2.
NP_724723.1. NM_165635.1.
NP_724724.1. NM_165636.1.
UniGeneDm.2587.

3D structure databases

ProteinModelPortalP52029.
SMRP52029. Positions 8-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid61725. 4 interactions.
DIPDIP-17637N.
MINTMINT-314135.

Proteomic databases

PaxDbP52029.
PRIDEP52029.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0088679; FBpp0087760; FBgn0003074.
FBtr0088680; FBpp0087761; FBgn0003074.
FBtr0088681; FBpp0087762; FBgn0003074.
GeneID35886.
KEGGdme:Dmel_CG8251.

Organism-specific databases

CTD35886.
FlyBaseFBgn0003074. Pgi.

Phylogenomic databases

eggNOGCOG0166.
GeneTreeENSGT00390000000707.
InParanoidP52029.
KOK01810.
OMACGNELDN.
OrthoDBEOG7FXZXV.
PhylomeDBP52029.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Gene expression databases

BgeeP52029.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi35886.
NextBio795651.
PROP52029.

Entry information

Entry nameG6PI_DROME
AccessionPrimary (citable) accession number: P52029
Secondary accession number(s): A4UZ93 expand/collapse secondary AC list , Q0E9F0, Q27868, Q27870, Q9V4Z8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase