##gff-version 3 P52019 UniProtKB Chain 1 572 . . . ID=PRO_0000209839;Note=Squalene monooxygenase P52019 UniProtKB Topological domain 1 19 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Intramembrane 20 40 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Topological domain 41 572 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Region 1 98 . . . Note=Interaction with MARCHF6;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Region 61 72 . . . Note=Required for degradation in response to high membrane cholesterol levels;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Region 116 572 . . . Note=Sufficient for enzyme activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Region 514 572 . . . Note=Hydrophobic%3B mediates interaction with membranes;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Binding site 131 132 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Binding site 151 152 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Binding site 159 159 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Binding site 232 232 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Binding site 248 248 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Binding site 406 406 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Binding site 419 419 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534 P52019 UniProtKB Site 193 193 . . . Note=Important for enzyme activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14534