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P52019

- ERG1_MOUSE

UniProt

P52019 - ERG1_MOUSE

Protein

Squalene monooxygenase

Gene

Sqle

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.

    Catalytic activityi

    Squalene + NADPH + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP+ + H2O.

    Cofactori

    FAD.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi124 – 15128FADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. squalene monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular aromatic compound metabolic process Source: Ensembl
    2. cholesterol metabolic process Source: Ensembl
    3. response to organic substance Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    ReactomeiREACT_198969. Activation of gene expression by SREBF (SREBP).
    REACT_208531. Cholesterol biosynthesis.
    UniPathwayiUPA00767; UER00752.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Squalene monooxygenase (EC:1.14.13.132)
    Alternative name(s):
    Squalene epoxidase
    Short name:
    SE
    Gene namesi
    Name:Sqle
    Synonyms:Erg1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:109296. Sqle.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 572572Squalene monooxygenasePRO_0000209839Add
    BLAST

    Proteomic databases

    MaxQBiP52019.
    PaxDbiP52019.
    PRIDEiP52019.

    PTM databases

    PhosphoSiteiP52019.

    Expressioni

    Gene expression databases

    ArrayExpressiP52019.
    BgeeiP52019.
    CleanExiMM_SQLE.
    GenevestigatoriP52019.

    Interactioni

    Subunit structurei

    May form a complex with squalene synthase.

    Structurei

    3D structure databases

    ProteinModelPortaliP52019.
    SMRiP52019. Positions 114-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei544 – 56421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the squalene monooxygenase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0654.
    HOGENOMiHOG000174713.
    HOVERGENiHBG005603.
    InParanoidiP52019.
    KOiK00511.
    OMAiFITLANR.
    OrthoDBiEOG7J446G.
    PhylomeDBiP52019.
    TreeFamiTF331056.

    Family and domain databases

    InterProiIPR003042. Rng_hydrolase-like.
    IPR013698. Squalene_epoxidase.
    [Graphical view]
    PfamiPF08491. SE. 1 hit.
    [Graphical view]
    PRINTSiPR00420. RNGMNOXGNASE.

    Sequencei

    Sequence statusi: Complete.

    P52019-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWTFLGIATF TYFYKKCGDV TLANKELLLC VLVFLSLGLV LSYRCRHRHG    50
    GLLGRHQSGA QFAAFSDILS ALPLIGFFWA KSPESEKKEQ LESKKCRKEI 100
    GLSETTLTGA ATSVSTSFVT DPEVIIVGSG VLGSALAAVL SRDGRKVTVI 150
    ERDLKEPDRI VGELLQPGGY RVLQELGLGD TVEGLNAHHI HGYIVHDYES 200
    RSEVQIPYPL SETNQVQSGI AFHHGRFIMS LRKAAMAEPN VKFIEGVVLQ 250
    LLEEDDAVIG VQYKDKETGD TKELHAPLTV VADGLFSKFR KSLISSKVSV 300
    SSHFVGFLMK DAPQFKPNFA ELVLVNPSPV LIYQISSSET RVLVDIRGEL 350
    PRNLREYMAE QIYPQLPEHL KESFLEASQN GRLRTMPASF LPPSSVNKRG 400
    VLILGDAYNL RHPLTGGGMT VALKDIKLWR QLLKDIPDLY DDAAIFQAKK 450
    SFFWSRKRTH SFVVNVLAQA LYELFSATDD SLHQLRKACF LYFKLGGECV 500
    TGPVGLLSIL SPHPLVLIRH FFSVAIYATY FCFKSEPWAT KPRALFSSGA 550
    VLYKACSILF PLIYSEMKYL VH 572
    Length:572
    Mass (Da):63,770
    Last modified:October 1, 1996 - v1
    Checksum:i5C30D80A204664D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D42048 mRNA. Translation: BAA07649.1.
    BC042781 mRNA. Translation: AAH42781.1.
    BC056361 mRNA. Translation: AAH56361.1.
    CCDSiCCDS27497.1.
    PIRiS52113.
    RefSeqiNP_033296.1. NM_009270.3.
    UniGeneiMm.296169.

    Genome annotation databases

    EnsembliENSMUST00000022977; ENSMUSP00000022977; ENSMUSG00000022351.
    GeneIDi20775.
    KEGGimmu:20775.
    UCSCiuc007vxq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D42048 mRNA. Translation: BAA07649.1 .
    BC042781 mRNA. Translation: AAH42781.1 .
    BC056361 mRNA. Translation: AAH56361.1 .
    CCDSi CCDS27497.1.
    PIRi S52113.
    RefSeqi NP_033296.1. NM_009270.3.
    UniGenei Mm.296169.

    3D structure databases

    ProteinModelPortali P52019.
    SMRi P52019. Positions 114-180.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P52019.

    Proteomic databases

    MaxQBi P52019.
    PaxDbi P52019.
    PRIDEi P52019.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022977 ; ENSMUSP00000022977 ; ENSMUSG00000022351 .
    GeneIDi 20775.
    KEGGi mmu:20775.
    UCSCi uc007vxq.1. mouse.

    Organism-specific databases

    CTDi 6713.
    MGIi MGI:109296. Sqle.

    Phylogenomic databases

    eggNOGi COG0654.
    HOGENOMi HOG000174713.
    HOVERGENi HBG005603.
    InParanoidi P52019.
    KOi K00511.
    OMAi FITLANR.
    OrthoDBi EOG7J446G.
    PhylomeDBi P52019.
    TreeFami TF331056.

    Enzyme and pathway databases

    UniPathwayi UPA00767 ; UER00752 .
    Reactomei REACT_198969. Activation of gene expression by SREBF (SREBP).
    REACT_208531. Cholesterol biosynthesis.

    Miscellaneous databases

    ChiTaRSi SQLE. mouse.
    NextBioi 299491.
    PROi P52019.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P52019.
    Bgeei P52019.
    CleanExi MM_SQLE.
    Genevestigatori P52019.

    Family and domain databases

    InterProi IPR003042. Rng_hydrolase-like.
    IPR013698. Squalene_epoxidase.
    [Graphical view ]
    Pfami PF08491. SE. 1 hit.
    [Graphical view ]
    PRINTSi PR00420. RNGMNOXGNASE.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a cDNA for mouse squalene epoxidase."
      Kosuga K., Hata S., Osumi T., Sakakibara J., Ono T.
      Biochim. Biophys. Acta 1260:345-348(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and NMRI.
      Tissue: Brain and Mammary gland.

    Entry informationi

    Entry nameiERG1_MOUSE
    AccessioniPrimary (citable) accession number: P52019
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3