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P52019 (ERG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Squalene monooxygenase
EC=1.14.13.132
Alternative name(s):
Squalene epoxidase
Short name=SE
Gene names
Name:Sqle
Synonyms:Erg1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.

Catalytic activity

Squalene + NADPH + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP+ + H2O.

Cofactor

FAD.

Pathway

Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.

Subunit structure

May form a complex with squalene synthase.

Subcellular location

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the squalene monooxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Squalene monooxygenase
PRO_0000209839

Regions

Transmembrane20 – 4021Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane544 – 56421Helical; Potential
Nucleotide binding124 – 15128FAD Potential

Sequences

Sequence LengthMass (Da)Tools
P52019 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 5C30D80A204664D4

FASTA57263,770
        10         20         30         40         50         60 
MWTFLGIATF TYFYKKCGDV TLANKELLLC VLVFLSLGLV LSYRCRHRHG GLLGRHQSGA 

        70         80         90        100        110        120 
QFAAFSDILS ALPLIGFFWA KSPESEKKEQ LESKKCRKEI GLSETTLTGA ATSVSTSFVT 

       130        140        150        160        170        180 
DPEVIIVGSG VLGSALAAVL SRDGRKVTVI ERDLKEPDRI VGELLQPGGY RVLQELGLGD 

       190        200        210        220        230        240 
TVEGLNAHHI HGYIVHDYES RSEVQIPYPL SETNQVQSGI AFHHGRFIMS LRKAAMAEPN 

       250        260        270        280        290        300 
VKFIEGVVLQ LLEEDDAVIG VQYKDKETGD TKELHAPLTV VADGLFSKFR KSLISSKVSV 

       310        320        330        340        350        360 
SSHFVGFLMK DAPQFKPNFA ELVLVNPSPV LIYQISSSET RVLVDIRGEL PRNLREYMAE 

       370        380        390        400        410        420 
QIYPQLPEHL KESFLEASQN GRLRTMPASF LPPSSVNKRG VLILGDAYNL RHPLTGGGMT 

       430        440        450        460        470        480 
VALKDIKLWR QLLKDIPDLY DDAAIFQAKK SFFWSRKRTH SFVVNVLAQA LYELFSATDD 

       490        500        510        520        530        540 
SLHQLRKACF LYFKLGGECV TGPVGLLSIL SPHPLVLIRH FFSVAIYATY FCFKSEPWAT 

       550        560        570 
KPRALFSSGA VLYKACSILF PLIYSEMKYL VH

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of a cDNA for mouse squalene epoxidase."
Kosuga K., Hata S., Osumi T., Sakakibara J., Ono T.
Biochim. Biophys. Acta 1260:345-348(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and NMRI.
Tissue: Brain and Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D42048 mRNA. Translation: BAA07649.1.
BC042781 mRNA. Translation: AAH42781.1.
BC056361 mRNA. Translation: AAH56361.1.
IPIIPI00122217.
PIRS52113.
RefSeqNP_033296.1. NM_009270.3.
UniGeneMm.296169.

3D structure databases

ProteinModelPortalP52019.
SMRP52019. Positions 123-434.
ModBaseSearch...

PTM databases

PhosphoSiteP52019.

Proteomic databases

PaxDbP52019.
PRIDEP52019.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022977; ENSMUSP00000022977; ENSMUSG00000022351.
GeneID20775.
KEGGmmu:20775.

Organism-specific databases

CTD6713.
MGIMGI:109296. Sqle.

Phylogenomic databases

eggNOGCOG0654.
HOGENOMHOG000174713.
HOVERGENHBG005603.
InParanoidP52019.
KOK00511.
OMAYSEMKYM.
OrthoDBEOG4NZTT2.

Enzyme and pathway databases

UniPathwayUPA00767; UER00752.

Gene expression databases

ArrayExpressP52019.
BgeeP52019.
CleanExMM_SQLE.
GenevestigatorP52019.
GermOnlineENSMUSG00000022351. Mus musculus.

Family and domain databases

InterProIPR003042. Rng_hydrolase-like.
IPR013698. Squalene_epoxidase.
[Graphical view]
PfamPF08491. SE. 1 hit.
[Graphical view]
PRINTSPR00420. RNGMNOXGNASE.
ProtoNetSearch...

Other

ChiTaRSSQLE. mouse.
NextBio299491.
SOURCESearch...

Entry information

Entry nameERG1_MOUSE
AccessionPrimary (citable) accession number: P52019
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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