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P52019

- ERG1_MOUSE

UniProt

P52019 - ERG1_MOUSE

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Protein

Squalene monooxygenase

Gene

Sqle

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.

Catalytic activityi

Squalene + NADPH + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP+ + H2O.

Cofactori

FAD.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi124 – 15128FADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. squalene monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular aromatic compound metabolic process Source: Ensembl
  2. cholesterol metabolic process Source: Ensembl
  3. response to organic substance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

ReactomeiREACT_198969. Activation of gene expression by SREBF (SREBP).
REACT_208531. Cholesterol biosynthesis.
UniPathwayiUPA00767; UER00752.

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene monooxygenase (EC:1.14.13.132)
Alternative name(s):
Squalene epoxidase
Short name:
SE
Gene namesi
Name:Sqle
Synonyms:Erg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:109296. Sqle.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Squalene monooxygenasePRO_0000209839Add
BLAST

Proteomic databases

MaxQBiP52019.
PaxDbiP52019.
PRIDEiP52019.

PTM databases

PhosphoSiteiP52019.

Expressioni

Gene expression databases

BgeeiP52019.
CleanExiMM_SQLE.
ExpressionAtlasiP52019. baseline and differential.
GenevestigatoriP52019.

Interactioni

Subunit structurei

May form a complex with squalene synthase.

Structurei

3D structure databases

ProteinModelPortaliP52019.
SMRiP52019. Positions 122-154.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Transmembranei544 – 56421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the squalene monooxygenase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0654.
HOGENOMiHOG000174713.
HOVERGENiHBG005603.
InParanoidiP52019.
KOiK00511.
OMAiFITLANR.
OrthoDBiEOG7J446G.
PhylomeDBiP52019.
TreeFamiTF331056.

Family and domain databases

InterProiIPR003042. Rng_hydrolase-like.
IPR013698. Squalene_epoxidase.
[Graphical view]
PfamiPF08491. SE. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.

Sequencei

Sequence statusi: Complete.

P52019-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWTFLGIATF TYFYKKCGDV TLANKELLLC VLVFLSLGLV LSYRCRHRHG
60 70 80 90 100
GLLGRHQSGA QFAAFSDILS ALPLIGFFWA KSPESEKKEQ LESKKCRKEI
110 120 130 140 150
GLSETTLTGA ATSVSTSFVT DPEVIIVGSG VLGSALAAVL SRDGRKVTVI
160 170 180 190 200
ERDLKEPDRI VGELLQPGGY RVLQELGLGD TVEGLNAHHI HGYIVHDYES
210 220 230 240 250
RSEVQIPYPL SETNQVQSGI AFHHGRFIMS LRKAAMAEPN VKFIEGVVLQ
260 270 280 290 300
LLEEDDAVIG VQYKDKETGD TKELHAPLTV VADGLFSKFR KSLISSKVSV
310 320 330 340 350
SSHFVGFLMK DAPQFKPNFA ELVLVNPSPV LIYQISSSET RVLVDIRGEL
360 370 380 390 400
PRNLREYMAE QIYPQLPEHL KESFLEASQN GRLRTMPASF LPPSSVNKRG
410 420 430 440 450
VLILGDAYNL RHPLTGGGMT VALKDIKLWR QLLKDIPDLY DDAAIFQAKK
460 470 480 490 500
SFFWSRKRTH SFVVNVLAQA LYELFSATDD SLHQLRKACF LYFKLGGECV
510 520 530 540 550
TGPVGLLSIL SPHPLVLIRH FFSVAIYATY FCFKSEPWAT KPRALFSSGA
560 570
VLYKACSILF PLIYSEMKYL VH
Length:572
Mass (Da):63,770
Last modified:October 1, 1996 - v1
Checksum:i5C30D80A204664D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D42048 mRNA. Translation: BAA07649.1.
BC042781 mRNA. Translation: AAH42781.1.
BC056361 mRNA. Translation: AAH56361.1.
CCDSiCCDS27497.1.
PIRiS52113.
RefSeqiNP_033296.1. NM_009270.3.
UniGeneiMm.296169.

Genome annotation databases

EnsembliENSMUST00000022977; ENSMUSP00000022977; ENSMUSG00000022351.
GeneIDi20775.
KEGGimmu:20775.
UCSCiuc007vxq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D42048 mRNA. Translation: BAA07649.1 .
BC042781 mRNA. Translation: AAH42781.1 .
BC056361 mRNA. Translation: AAH56361.1 .
CCDSi CCDS27497.1.
PIRi S52113.
RefSeqi NP_033296.1. NM_009270.3.
UniGenei Mm.296169.

3D structure databases

ProteinModelPortali P52019.
SMRi P52019. Positions 122-154.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P52019.

Proteomic databases

MaxQBi P52019.
PaxDbi P52019.
PRIDEi P52019.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022977 ; ENSMUSP00000022977 ; ENSMUSG00000022351 .
GeneIDi 20775.
KEGGi mmu:20775.
UCSCi uc007vxq.1. mouse.

Organism-specific databases

CTDi 6713.
MGIi MGI:109296. Sqle.

Phylogenomic databases

eggNOGi COG0654.
HOGENOMi HOG000174713.
HOVERGENi HBG005603.
InParanoidi P52019.
KOi K00511.
OMAi FITLANR.
OrthoDBi EOG7J446G.
PhylomeDBi P52019.
TreeFami TF331056.

Enzyme and pathway databases

UniPathwayi UPA00767 ; UER00752 .
Reactomei REACT_198969. Activation of gene expression by SREBF (SREBP).
REACT_208531. Cholesterol biosynthesis.

Miscellaneous databases

ChiTaRSi SQLE. mouse.
NextBioi 299491.
PROi P52019.
SOURCEi Search...

Gene expression databases

Bgeei P52019.
CleanExi MM_SQLE.
ExpressionAtlasi P52019. baseline and differential.
Genevestigatori P52019.

Family and domain databases

InterProi IPR003042. Rng_hydrolase-like.
IPR013698. Squalene_epoxidase.
[Graphical view ]
Pfami PF08491. SE. 1 hit.
[Graphical view ]
PRINTSi PR00420. RNGMNOXGNASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a cDNA for mouse squalene epoxidase."
    Kosuga K., Hata S., Osumi T., Sakakibara J., Ono T.
    Biochim. Biophys. Acta 1260:345-348(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and NMRI.
    Tissue: Brain and Mammary gland.

Entry informationi

Entry nameiERG1_MOUSE
AccessioniPrimary (citable) accession number: P52019
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3