Reviewed, UniProtKB/Swiss-Prot P52018 (CYP11_CAEEL)

Names and origin

Protein names

Recommended name:
    Peptidyl-prolyl cis-trans isomerase 11
      Short name=PPIase
      Short name=Rotamase
    EC=5.2.1.8
Alternative name(s):
    Cyclophilin-11

Gene names

Name:	cyn-11
Synonyms:	cyp-11
ORF Names:	T01B7.4

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Sequence similarities	Belongs to the cyclophilin-type PPIase family. PPIase H subfamily. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Molecular function	Isomerase Rotamase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 183	183	Peptidyl-prolyl cis-trans isomerase 11		PRO_0000064198
Regions
	Domain	20 – 182	163	PPIase cyclophilin-type

Sequences

	Sequence		Length	Mass (Da)
	P52018-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 23549C922828C533	FASTA	183	20,193
	10 20 30 40 50 60 MTEYDKFAEQ LRHPDNPIVF LEVTAGGAPI GTIVIELFAD VTPRTAENFR QFCTGEYKKD 70 80 90 100 110 120 GVPNGYKNCT FHRVIKDFMI QGGDFCNGDG TGLMSIYGSK FRDENFELKH IGPGMLSMAN 130 140 150 160 170 180 AGSDTNGCQF FITCAKTDFL DNKHVVFGRV LDGMLTVRKI ENVPTGANNK PKLPIVVVQC GQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans." Page A.P., Macniven K., Hengartner M.O. Biochem. J. 317:179-185(1996) [PubMed: 8694762] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U34955 mRNA. Translation: AAC47115.1. Z66499 Genomic DNA. Translation: CAA91297.1.
PIR	T18578.
RefSeq	NP_495855.1.
UniGene	Cel.19632
3D structure databases
HSSP	HSSP built from PDB template 1QOI based on UniProtKB O43447.
SMR	P52018. Positions 14-183.
ModBase	Search...
Genome annotation databases
Ensembl	T01B7.4; T01B7.4; T01B7.4; Caenorhabditis elegans. [Genome view]
GeneID	174394.
KEGG	cel:T01B7.4.
NMPDR	fig|6239.3.peg.6699.
UCSC	T01B7.4. c. elegans.
Organism-specific databases
CTD	174394.
WormBase	WBGene00000887. cyn-11.
WormPep	T01B7.4. CE03588. [WorfDB]
Phylogenomic databases
OMA	DGLLIMR.
Enzyme and pathway databases
BRENDA	5.2.1.8. 672.
Gene expression databases
ArrayExpress	P52018.
Family and domain databases
InterPro	IPR002130. PPIase_cyclophilin. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	883844.

Entry information

Entry name

CYP11_CAEEL

Accession

Primary (citable) accession number: P52018

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 3, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project