P52017 (CYP10_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase 10
Short name=PPIase 10
EC=5.2.1.8

Alternative name(s):
Cyclophilin-10
Rotamase 10

Gene names

Name:	cyn-10
Synonyms:	cyp-10
ORF Names:	B0252.4

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Sequence similarities	Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform b (identifier: P52017-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform a (identifier: P52017-2)

The sequence of this isoform differs from the canonical sequence as follows:
     148-161: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 161	161	Peptidyl-prolyl cis-trans isomerase 10		PRO_0000064197
Regions
	Domain	1 – 153	153	PPIase cyclophilin-type
Natural variations
	Alternative sequence	148 – 161	14	Missing in isoform a.		VSP_005183

Sequences

	Sequence		Length	Mass (Da)
	Isoform b [UniParc]. Last modified August 2, 2002. Version 2. Checksum: D7D18CA11572DF72	FASTA	161	17,960
	10 20 30 40 50 60 MSVTLHTTSG DIKIELYVDD APKACENFLA LCASDYYNGC IFHRNIKDFM VQTGDPTHSG 70 80 90 100 110 120 KGGESIWGGP FEDEFVSALK HDSRGCVSMA NNGPDSNRSQ FFITYAKQAH LDMKYTLFGK 130 140 150 160 VIDGFDTLEE IETIKVDNKY RPLVQQKIQN VTIHANPMAA D
	Isoform a [UniParc]. Checksum: C11E0BC4FF79CD82	FASTA	147	16,484
	10 20 30 40 50 60 MSVTLHTTSG DIKIELYVDD APKACENFLA LCASDYYNGC IFHRNIKDFM VQTGDPTHSG 70 80 90 100 110 120 KGGESIWGGP FEDEFVSALK HDSRGCVSMA NNGPDSNRSQ FFITYAKQAH LDMKYTLFGK 130 140 VIDGFDTLEE IETIKVDNKY RPLVQQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans." Page A.P., Macniven K., Hengartner M.O. Biochem. J. 317:179-185(1996) [PubMed: 8694762] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U34954 mRNA. Translation: AAC47114.1. FO080139 Genomic DNA. Translation: CCD61541.1. FO080139 Genomic DNA. Translation: CCD61542.1.
PIR	T18577.
RefSeq	NP_001021890.1. NM_001026719.3. NP_495416.2. NM_063015.3.
UniGene	Cel.16071.
3D structure databases
ProteinModelPortal	P52017.
SMR	P52017. Positions 1-159.
ModBase	Search...
Protein-protein interaction databases
STRING	P52017.
Proteomic databases
PRIDE	P52017.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	B0252.4b; B0252.4b; B0252.4.
GeneID	174132.
KEGG	cel:B0252.4.
NMPDR	fig|6239.3.peg.6072.
UCSC	B0252.4b. c. elegans.
Organism-specific databases
CTD	174132.
WormBase	B0252.4a; CE02420; WBGene00000886; cyn-10. B0252.4b; CE27567; WBGene00000886; cyn-10.
Phylogenomic databases
eggNOG	meNOG09012.
GeneTree	EMGT00050000002627.
HOGENOM	HBG610621.
InParanoid	P52017.
OMA	CVFHRNI.
PhylomeDB	P52017.
Gene expression databases
ArrayExpress	P52017.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR024936. Cyclophilin-type_PPIase. IPR020892. Cyclophilin-type_PPIase_CS. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
KO	K12734.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PIRSF	PIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	882659.

Entry information

Entry name

CYP10_CAEEL

Accession

Primary (citable) accession number: P52017
Secondary accession number(s): Q95ZZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	August 2, 2002
Last modified:	January 25, 2012
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project