P52016 (CYP8_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase 8
Short name=PPIase 8
EC=5.2.1.8

Alternative name(s):
Cyclophilin-8
Rotamase 8

Gene names

Name:	cyn-8
Synonyms:	cyp-8
ORF Names:	D1009.2

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Sequence similarities	Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: WormBase
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from direct assay Ref.1. Source: WormBase
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform a (identifier: P52016-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform b (identifier: P52016-2)

The sequence of this isoform differs from the canonical sequence as follows:
     294-312: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Peptidyl-prolyl cis-trans isomerase 8		PRO_0000064195
Regions
	Domain	12 – 175	164	PPIase cyclophilin-type
	Compositional bias	234 – 239	6	Poly-Arg
	Compositional bias	419 – 423	5	Poly-Arg
	Compositional bias	450 – 459	10	Poly-Ser
Natural variations
	Alternative sequence	294 – 312	19	Missing in isoform b.		VSP_019292

Sequences

	Sequence		Length	Mass (Da)
	Isoform a [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 6E014ABA0E54BAF3	FASTA	466	53,565
	10 20 30 40 50 60 MPPEVRGNKR AFFDISINGE PAGRIVFSLW NHCCPRTVEN FRAFCTGELG KMNGHYASYQ 70 80 90 100 110 120 GSVFHRVIKG FMIQGGDITH GNGTGGYSIY GRTFDDENLA LKHKKPYLLS MANRGPDTNG 130 140 150 160 170 180 SQFFITSEEV PHLDGKHCVF GEVIKGVEVV KAIENLETGN EDKPVCKVEI THCGEMVRKG 190 200 210 220 230 240 DVVGNAGAAA SEPEPTGVKM EDEPKTRNWL MRYSKSPESR EEKKKDKHGR EEKRDRRRRS 250 260 270 280 290 300 NDRHGRDRRS RSRSQSRDRN RRRDDRSGRD GRVGRNERDD RSGRDERRDD RRSSAPVNVK 310 320 330 340 350 360 KKTQMKSPNF VHAPTKDGIK VRGRGKLTFL GGRTRSTTPP HWKREESKKL TLEAHQKRQE 370 380 390 400 410 420 ELEERQKRAA QREKEEAERN ARLEKERVER QNQRELERQK QEAERELKRQ QENEESGNRR 430 440 450 460 RRRSSRSGSE NDESELEEPK NRSASPRKRS SSSSSSSSSG HSSDSD
	Isoform b [UniParc]. Checksum: A246463F9A40AB42	FASTA	447	51,443
	10 20 30 40 50 60 MPPEVRGNKR AFFDISINGE PAGRIVFSLW NHCCPRTVEN FRAFCTGELG KMNGHYASYQ 70 80 90 100 110 120 GSVFHRVIKG FMIQGGDITH GNGTGGYSIY GRTFDDENLA LKHKKPYLLS MANRGPDTNG 130 140 150 160 170 180 SQFFITSEEV PHLDGKHCVF GEVIKGVEVV KAIENLETGN EDKPVCKVEI THCGEMVRKG 190 200 210 220 230 240 DVVGNAGAAA SEPEPTGVKM EDEPKTRNWL MRYSKSPESR EEKKKDKHGR EEKRDRRRRS 250 260 270 280 290 300 NDRHGRDRRS RSRSQSRDRN RRRDDRSGRD GRVGRNERDD RSGRDERRDD RRSAPTKDGI 310 320 330 340 350 360 KVRGRGKLTF LGGRTRSTTP PHWKREESKK LTLEAHQKRQ EELEERQKRA AQREKEEAER 370 380 390 400 410 420 NARLEKERVE RQNQRELERQ KQEAERELKR QQENEESGNR RRRRSSRSGS ENDESELEEP 430 440 KNRSASPRKR SSSSSSSSSS GHSSDSD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans." Page A.P., Macniven K., Hengartner M.O. Biochem. J. 317:179-185(1996) [PubMed: 8694762] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U31078 mRNA. Translation: AAC47130.1. FO080528 Genomic DNA. Translation: CCD64413.1. FO080528 Genomic DNA. Translation: CCD64414.1.
PIR	T18575.
RefSeq	NP_509506.1. NM_077105.3. NP_509507.1. NM_077106.1.
UniGene	Cel.17426.
3D structure databases
ProteinModelPortal	P52016.
SMR	P52016. Positions 8-177.
ModBase	Search...
Protein-protein interaction databases
STRING	P52016.
Proteomic databases
PRIDE	P52016.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	D1009.2a; D1009.2a; D1009.2.
GeneID	181136.
KEGG	cel:D1009.2.
NMPDR	fig|6239.3.peg.24122.
UCSC	D1009.2a. c. elegans.
Organism-specific databases
CTD	181136.
WormBase	D1009.2a; CE04286; WBGene00000884; cyn-8. D1009.2b; CE27892; WBGene00000884; cyn-8.
Phylogenomic databases
eggNOG	meNOG09927.
GeneTree	EMGT00050000000009.
HOGENOM	HBG610621.
InParanoid	P52016.
OMA	RTFDDEN.
PhylomeDB	P52016.
Gene expression databases
ArrayExpress	P52016.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR020892. Cyclophilin-type_PPIase_CS. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
KO	K09566.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	912560.

Entry information

Entry name

CYP8_CAEEL

Accession

Primary (citable) accession number: P52016
Secondary accession number(s): Q95QQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project