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Protein

Peptidyl-prolyl cis-trans isomerase 7

Gene

cyn-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase 7 (EC:5.2.1.8)
Short name:
PPIase 7
Alternative name(s):
Cyclophilin-7
Rotamase 7
Gene namesi
Name:cyn-7
Synonyms:cyp-7
ORF Names:Y75B12B.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiY75B12B.2 ; CE20371 ; WBGene00000883 ; cyn-7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641941 – 171Peptidyl-prolyl cis-trans isomerase 7Add BLAST171

Proteomic databases

EPDiP52015
PaxDbiP52015
PeptideAtlasiP52015
PRIDEiP52015

Expressioni

Gene expression databases

BgeeiWBGene00000883

Interactioni

Protein-protein interaction databases

BioGridi45022, 1 interactor
DIPiDIP-24704N
STRINGi6239.Y75B12B.2.2

Structurei

3D structure databases

ProteinModelPortaliP52015
SMRiP52015
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 170PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST164

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119119
HOGENOMiHOG000065981
InParanoidiP52015
KOiK01802
OMAiFELYNDT
OrthoDBiEOG091G0BGL
PhylomeDBiP52015

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPRVFFDI TIAGKPTGRI VMELYNDIVP KTAENFRALC TGEKGVGKSG
60 70 80 90 100
KPLHFKGSKF HRIIPEFMIQ GGDFTRGNGT GGESIYGEKF PDENFKEKHT
110 120 130 140 150
GPGVLSMANA GPNTNGSQFF LCTVKTAWLD GKHVVFGRVV EGLDIVSKVE
160 170
GNGSSSGTPK SECLIADCGQ L
Length:171
Mass (Da):18,401
Last modified:December 1, 2000 - v2
Checksum:iD5BD5E32A32942A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12I → T in AAC47125 (PubMed:8694762).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27559 mRNA Translation: AAC47125.1
AL032663 Genomic DNA Translation: CAA21760.1
PIRiT27371
RefSeqiNP_506749.1, NM_074348.7
UniGeneiCel.6641

Genome annotation databases

EnsemblMetazoaiY75B12B.2.1; Y75B12B.2.1; WBGene00000883
Y75B12B.2.2; Y75B12B.2.2; WBGene00000883
GeneIDi180027
KEGGicel:CELE_Y75B12B.2
UCSCiY75B12B.2.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiCYP7_CAEEL
AccessioniPrimary (citable) accession number: P52015
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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