P52014 (CYP6_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase 6
Short name=PPIase 6
EC=5.2.1.8

Alternative name(s):
Cyclophilin-6
Rotamase 6

Gene names

Name:	cyn-6
Synonyms:	cyp-6
ORF Names:	F42G9.2

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Sequence similarities	Belongs to the cyclophilin-type PPIase family. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Domain	Signal
Molecular function	Isomerase Rotamase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 201	185	Peptidyl-prolyl cis-trans isomerase 6		PRO_0000025496
Regions
	Domain	29 – 186	158	PPIase cyclophilin-type
Amino acid modifications
	Glycosylation	130	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P52014 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 084C5762917F958B	FASTA	201	21,864
	10 20 30 40 50 60 MSRALLFFVL AILALSAEAR GPRVTDKVFF DMEIGGRPVG KIVIGLFGEV VPKTVKNFVE 70 80 90 100 110 120 LAQRAEGEGY VGSKFHRVIE NFMIQGGDFT RGDGTGGRSI YGERFEDENF KLQHYGPGWL 130 140 150 160 170 180 SMANAGEDTN GSQFFITTAK TSWLDGKHVV FGKILEGMDV VREIEATPKG AGDRPIEDVV 190 200 IANAGHIPVE NPFTVARAGV N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans." Page A.P., Macniven K., Hengartner M.O. Biochem. J. 317:179-185(1996) [PubMed: 8694762] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U27354 mRNA. Translation: AAC47124.1. FO080196 Genomic DNA. Translation: CCD61884.1.
PIR	T18573.
RefSeq	NP_497257.1. NM_064856.5.
UniGene	Cel.23333.
3D structure databases
ProteinModelPortal	P52014.
SMR	P52014. Positions 20-200.
ModBase	Search...
Protein-protein interaction databases
IntAct	P52014. 1 interaction.
STRING	P52014.
Proteomic databases
PRIDE	P52014.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F42G9.2; F42G9.2; F42G9.2.
GeneID	175231.
KEGG	cel:F42G9.2.
UCSC	F42G9.2. c. elegans.
Organism-specific databases
CTD	175231.
WormBase	F42G9.2; CE01301; WBGene00000882; cyn-6.
Phylogenomic databases
eggNOG	meNOG10184.
GeneTree	EMGT00050000000009.
HOGENOM	HBG610621.
InParanoid	P52014.
OMA	VGSKFHR.
PhylomeDB	P52014.
Gene expression databases
ArrayExpress	P52014.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR024936. Cyclophilin-type_PPIase. IPR020892. Cyclophilin-type_PPIase_CS. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
KO	K03768.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PIRSF	PIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	887330.

Entry information

Entry name

CYP6_CAEEL

Accession

Primary (citable) accession number: P52014

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project