Reviewed, UniProtKB/Swiss-Prot P52010 (CYP2_CAEEL)

Names and origin

Protein names

Recommended name:
    Peptidyl-prolyl cis-trans isomerase 2
      Short name=PPIase
      Short name=Rotamase
    EC=5.2.1.8
Alternative name(s):
    Cyclophilin-2

Gene names

Name:	cyn-2
Synonyms:	cyp-2
ORF Names:	ZK520.5

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Sequence similarities	Belongs to the cyclophilin-type PPIase family. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Molecular function	Isomerase Rotamase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Peptidyl-prolyl cis-trans isomerase 2		PRO_0000064191
Regions
	Domain	7 – 170	164	PPIase cyclophilin-type
Experimental info
	Sequence conflict	8	1	F → I in AAC47127. Ref.1
	Sequence conflict	29	1	V → A in AAC47127. Ref.1
	Sequence conflict	82	1	Missing in AAC47127. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P52010-1 [UniParc]. Last modified March 28, 2003. Version 2. Checksum: 87CB148261CAC2B5	FASTA	172	18,535
	10 20 30 40 50 60 MPRVKVFFDI TIGGKKGGRI VMELYNDIVP KTAENFRALC TGEKGKGKSG KKLHFKGSKF 70 80 90 100 110 120 HRIIPEFMIQ GGDFTEGNGT GGESIHGEKF DDENFKEKHT GPGVLSMANC GANTNGSQFF 130 140 150 160 170 LCTVKTTWLD GKHVVFGKVI EGMDVVKAIE SKGSEDGAPS APCVIADCGE MK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans." Page A.P., Macniven K., Hengartner M.O. Biochem. J. 317:179-185(1996) [PubMed: 8694762] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U34354 mRNA. Translation: AAC47127.1. Z92822 Genomic DNA. Translation: CAB07303.1.
PIR	T27882.
RefSeq	NP_499828.1.
UniGene	Cel.6107
3D structure databases
HSSP	HSSP built from PDB template 1E3B based on UniProtKB P52011.
SMR	P52010. Positions 1-172.
ModBase	Search...
Protein-protein interaction databases
IntAct	P52010. 1 interaction.
Genome annotation databases
Ensembl	ZK520.5.1; ZK520.5.1; ZK520.5; Caenorhabditis elegans. [Genome view] ZK520.5.2; ZK520.5.2; ZK520.5; Caenorhabditis elegans. [Genome view]
GeneID	176807.
KEGG	cel:ZK520.5.
UCSC	ZK520.5.1. c. elegans.
Organism-specific databases
CTD	176807.
WormBase	WBGene00000878. cyn-2.
WormPep	ZK520.5. CE16730. [WorfDB]
Phylogenomic databases
OMA	FDTSING.
Enzyme and pathway databases
BRENDA	5.2.1.8. 672.
Gene expression databases
ArrayExpress	P52010.
Family and domain databases
InterPro	IPR002130. PPIase_cyclophilin. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	894084.

Entry information

Entry name

CYP2_CAEEL

Accession

Primary (citable) accession number: P52010
Secondary accession number(s): O46022

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	March 28, 2003
Last modified:	November 3, 2009
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project