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Protein

Multidrug resistance operon repressor

Gene

mexR

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon.

GO - Molecular functioni

GO - Biological processi

  • negative regulation of protein secretion Source: PseudoCAP
  • negative regulation of transcription, DNA-templated Source: PseudoCAP
  • negative regulation of transmembrane transport Source: PseudoCAP
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance operon repressor
Gene namesi
Name:mexR
Ordered Locus Names:PA0424
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0424.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000543651 – 147Multidrug resistance operon repressorAdd BLAST147

Proteomic databases

PaxDbiP52003.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-6400193,EBI-6400193
armRQ9HXS22EBI-6400193,EBI-6400203

Protein-protein interaction databases

DIPiDIP-46302N.
IntActiP52003. 1 interactor.
MINTiMINT-8011533.
STRINGi208964.PA0424.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 30Combined sources22
Helixi37 – 48Combined sources12
Turni49 – 51Combined sources3
Helixi54 – 61Combined sources8
Helixi67 – 77Combined sources11
Beta strandi80 – 82Combined sources3
Beta strandi87 – 97Combined sources11
Helixi99 – 120Combined sources22
Helixi125 – 140Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LNWX-ray2.10A/B/C/D/E/F/G/H1-147[»]
3ECHX-ray1.80A/B1-142[»]
3MEXX-ray2.10A/B1-142[»]
4ZZLX-ray2.19A/B5-139[»]
ProteinModelPortaliP52003.
SMRiP52003.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52003.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 140HTH marR-typePROSITE-ProRule annotationAdd BLAST135

Sequence similaritiesi

Contains 1 HTH marR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107MHI. Bacteria.
COG1846. LUCA.
InParanoidiP52003.
KOiK18131.
OMAiSIMDGER.
PhylomeDBiP52003.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000835. HTH_MarR-typ.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01047. MarR. 1 hit.
[Graphical view]
PRINTSiPR00598. HTHMARR.
SMARTiSM00347. HTH_MARR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50995. HTH_MARR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYPVNPDLM PALMAVFQHV RTRIQSELDC QRLDLTPPDV HVLKLIDEQR
60 70 80 90 100
GLNLQDLGRQ MCRDKALITR KIRELEGRNL VRRERNPSDQ RSFQLFLTDE
110 120 130 140
GLAIHQHAEA IMSRVHDELF APLTPVEQAT LVHLLDQCLA AQPLEDI
Length:147
Mass (Da):16,965
Last modified:October 1, 1996 - v1
Checksum:i59F5146394BE89DD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti69T → A in strain: PA48. 1
Natural varianti70R → W in strain: OCR1; leads to increased expression of mexAB-oprM. 1
Natural varianti95L → F in strain: PA41. 1
Natural varianti126V → E in strain: 58823, 65629, 55699 and GRR. 1
Natural varianti130T → S in strain: PA36. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23763 Genomic DNA. Translation: AAA69479.1.
AY190292 Genomic DNA. Translation: AAO40255.1.
AY190294 Genomic DNA. Translation: AAO40257.1.
AY190293 Genomic DNA. Translation: AAO40256.1.
AY190295 Genomic DNA. Translation: AAO40258.1.
AY899299 Genomic DNA. Translation: AAW82614.1.
AY899300 Genomic DNA. Translation: AAW82615.1.
AY899301 Genomic DNA. Translation: AAW82616.1.
AE004091 Genomic DNA. Translation: AAG03813.1.
PIRiC83593.
RefSeqiNP_249115.1. NC_002516.2.
WP_003114897.1. NZ_ASJY01000084.1.

Genome annotation databases

EnsemblBacteriaiAAG03813; AAG03813; PA0424.
GeneIDi877857.
KEGGipae:PA0424.
PATRICi19835090. VBIPseAer58763_0446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23763 Genomic DNA. Translation: AAA69479.1.
AY190292 Genomic DNA. Translation: AAO40255.1.
AY190294 Genomic DNA. Translation: AAO40257.1.
AY190293 Genomic DNA. Translation: AAO40256.1.
AY190295 Genomic DNA. Translation: AAO40258.1.
AY899299 Genomic DNA. Translation: AAW82614.1.
AY899300 Genomic DNA. Translation: AAW82615.1.
AY899301 Genomic DNA. Translation: AAW82616.1.
AE004091 Genomic DNA. Translation: AAG03813.1.
PIRiC83593.
RefSeqiNP_249115.1. NC_002516.2.
WP_003114897.1. NZ_ASJY01000084.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LNWX-ray2.10A/B/C/D/E/F/G/H1-147[»]
3ECHX-ray1.80A/B1-142[»]
3MEXX-ray2.10A/B1-142[»]
4ZZLX-ray2.19A/B5-139[»]
ProteinModelPortaliP52003.
SMRiP52003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46302N.
IntActiP52003. 1 interactor.
MINTiMINT-8011533.
STRINGi208964.PA0424.

Proteomic databases

PaxDbiP52003.

Protocols and materials databases

DNASUi877857.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG03813; AAG03813; PA0424.
GeneIDi877857.
KEGGipae:PA0424.
PATRICi19835090. VBIPseAer58763_0446.

Organism-specific databases

PseudoCAPiPA0424.

Phylogenomic databases

eggNOGiENOG4107MHI. Bacteria.
COG1846. LUCA.
InParanoidiP52003.
KOiK18131.
OMAiSIMDGER.
PhylomeDBiP52003.

Miscellaneous databases

EvolutionaryTraceiP52003.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000835. HTH_MarR-typ.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01047. MarR. 1 hit.
[Graphical view]
PRINTSiPR00598. HTHMARR.
SMARTiSM00347. HTH_MARR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50995. HTH_MARR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEXR_PSEAE
AccessioniPrimary (citable) accession number: P52003
Secondary accession number(s): Q5EEX3
, Q5EEX4, Q5EEX5, Q83UE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.