Reviewed, UniProtKB/Swiss-Prot P51995 (PNTAB_RICPR)

Names and origin

Protein names

Recommended name:
    NAD(P) transhydrogenase subunit alpha part 2
    EC=1.6.1.2
Alternative name(s):
    Nicotinamide nucleotide transhydrogenase subunit alpha 2
    Pyridine nucleotide transhydrogenase subunit alpha 2

Gene names

Name:	pntAB
Ordered Locus Names:	RP862

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

782 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane By similarity.
Catalytic activity	NADPH + NAD+ = NADP+ + NADH.
Subunit structure	Complex of an alpha and a beta chain; in Rickettsia, the alpha chain seems to be made of two subunits.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Ligand	NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD(P)+ transhydrogenase (AB-specific) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 132	132	NAD(P) transhydrogenase subunit alpha part 2		PRO_0000199022
Regions
	Transmembrane	43 – 63	21	Potential
	Transmembrane	72 – 92	21	Potential
	Transmembrane	103 – 123	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P51995-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 8A56163C9F394F0D	FASTA	132	14,325
	10 20 30 40 50 60 MNQLPIMAKQ AAEIASNAQE LSNKLKDLVI DASWQTNTNT IDPLVFAITI FVLASFVGYY 70 80 90 100 110 120 VVWKVTPALH TPLMSITNAI SGIIVISSMI AITSSSAFEF SSLLGSFATL LASINIFGGF 130 IVTTRMLEMF KK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Wood D.O., Marks G.L., Winkler H.H. Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Madrid E.
[2]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.
[3]	"Codon usage and base composition in Rickettsia prowazekii." Andersson S.G.E., Sharp P.M. J. Mol. Evol. 42:525-536(1996) [PubMed: 8662004] [Abstract] Cited for: IDENTIFICATION, GENE NAME.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U02878 Unassigned DNA. No translation available. AJ235273 Genomic DNA. Translation: CAA15286.1.
PIR	F71648.
RefSeq	NP_221210.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	883350.
GenomeReviews	Gene locus RP862 in contig AJ235269_GR.
KEGG	rpr:RP862.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P51995.
OMA	MELVNHT.
Enzyme and pathway databases
BioCyc	RPRO272947:RP862-MON.
BRENDA	1.6.1.2. 141977.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PNTAB_RICPR

Accession

Primary (citable) accession number: P51995

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	May 30, 2000
Last modified:	November 3, 2009
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)