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P51993

- FUT6_HUMAN

UniProt

P51993 - FUT6_HUMAN

Protein

Alpha-(1,3)-fucosyltransferase 6

Gene

FUT6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.

    Catalytic activityi

    GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.

    Pathwayi

    GO - Molecular functioni

    1. 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Source: UniProtKB-EC
    2. alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
    3. fucosyltransferase activity Source: ProtInc

    GO - Biological processi

    1. fucosylation Source: GOC
    2. L-fucose catabolic process Source: UniProtKB
    3. protein glycosylation Source: UniProtKB

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.65. 2681.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT10. Glycosyltransferase Family 10.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 6 (EC:2.4.1.65)
    Alternative name(s):
    Fucosyltransferase 6
    Fucosyltransferase VI
    Short name:
    Fuc-TVI
    Short name:
    FucT-VI
    Galactoside 3-L-fucosyltransferase
    Gene namesi
    Name:FUT6
    Synonyms:FCT3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:4017. FUT6.

    Subcellular locationi

    Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein
    Note: Membrane-bound form in trans cisternae of Golgi.

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi apparatus Source: UniProtKB
    3. Golgi cisterna membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi613852. phenotype.
    PharmGKBiPA28433.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Alpha-(1,3)-fucosyltransferase 6PRO_0000221110Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP51993.
    PaxDbiP51993.
    PRIDEiP51993.

    PTM databases

    PhosphoSiteiP51993.

    Expressioni

    Tissue specificityi

    Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.

    Gene expression databases

    ArrayExpressiP51993.
    BgeeiP51993.
    CleanExiHS_FUT6.
    GenevestigatoriP51993.

    Organism-specific databases

    HPAiHPA046966.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000286955.

    Structurei

    3D structure databases

    ProteinModelPortaliP51993.
    SMRiP51993. Positions 187-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini35 – 359325LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3420Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 10 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283180.
    HOGENOMiHOG000045583.
    HOVERGENiHBG000274.
    KOiK07634.
    OMAiNSARVRY.
    OrthoDBiEOG78H3T8.
    PhylomeDBiP51993.
    TreeFamiTF316348.

    Family and domain databases

    InterProiIPR001503. Glyco_trans_10.
    [Graphical view]
    PANTHERiPTHR11929. PTHR11929. 1 hit.
    PfamiPF00852. Glyco_transf_10. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P51993-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPLGPAKPQ WSWRCCLTTL LFQLLMAVCF FSYLRVSQDD PTVYPNGSRF    50
    PDSTGTPAHS IPLILLWTWP FNKPIALPRC SEMVPGTADC NITADRKVYP 100
    QADAVIVHHR EVMYNPSAQL PRSPRRQGQR WIWFSMESPS HCWQLKAMDG 150
    YFNLTMSYRS DSDIFTPYGW LEPWSGQPAH PPLNLSAKTE LVAWAVSNWG 200
    PNSARVRYYQ SLQAHLKVDV YGRSHKPLPQ GTMMETLSRY KFYLAFENSL 250
    HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD 300
    LARYLQELDK DHARYLSYFR WRETLRPRSF SWALAFCKAC WKLQEESRYQ 350
    TRGIAAWFT 359
    Length:359
    Mass (Da):41,860
    Last modified:October 1, 1996 - v1
    Checksum:i67ABDF058F0999DA
    GO
    Isoform 2 (identifier: P51993-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         348-359: RYQTRGIAAWFT → SGGLIYLRTRLPEASPA

    Show »
    Length:364
    Mass (Da):42,191
    Checksum:iBD0B020AB1580EEF
    GO

    Sequence cautioni

    The sequence AAC50191.1 differs from that shown. Reason: Probable cloning artifact.

    Polymorphismi

    Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma alpha(1,3)-fucosyltransferase deficiency [MIMi:613852].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti124 – 1241P → S Found in alpha(1,3)-fucosyltransferase-deficient individuals; results in partial enzyme inactivation; complete enzyme inactivation when associated with V-244 and G-303. 2 Publications
    Corresponds to variant rs778805 [ dbSNP | Ensembl ].
    VAR_024463
    Natural varianti230 – 2301Q → K.
    Corresponds to variant rs364637 [ dbSNP | Ensembl ].
    VAR_024464
    Natural varianti244 – 2441L → V Found in alpha(1,3)-fucosyltransferase-deficient individuals; complete enzyme inactivation when associated with S-124 and G-303. 1 Publication
    VAR_065915
    Natural varianti247 – 2471E → K Found in alpha(1,3)-fucosyltransferase-deficient individuals; complete enzyme inactivation. 2 Publications
    Corresponds to variant rs17855739 [ dbSNP | Ensembl ].
    VAR_065916
    Natural varianti303 – 3031R → G Found in alpha(1,3)-fucosyltransferase-deficient individuals; complete enzyme inactivation when associated with S-124 and V-244. 1 Publication
    Corresponds to variant rs61147939 [ dbSNP | Ensembl ].
    VAR_065917

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei348 – 35912RYQTR…AAWFT → SGGLIYLRTRLPEASPA in isoform 2. 1 PublicationVSP_001780Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M98825 mRNA. Translation: AAA99222.1.
    L01698 Genomic DNA. Translation: AAB03078.1.
    U27331 mRNA. Translation: AAC50190.1.
    U27332 mRNA. Translation: AAC50191.1. Sequence problems.
    U27333 mRNA. Translation: AAC50192.1.
    U27334 mRNA. Translation: AAC50193.1.
    U27335 mRNA. Translation: AAC50194.1.
    U27336 mRNA. Translation: AAC50195.1.
    U27337 mRNA. Translation: AAC50196.1.
    AF131211 mRNA. Translation: AAD33509.1.
    AL031258 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69136.1.
    CH471139 Genomic DNA. Translation: EAW69137.1.
    CH471139 Genomic DNA. Translation: EAW69138.1.
    CH471139 Genomic DNA. Translation: EAW69139.1.
    CCDSiCCDS12152.1. [P51993-1]
    PIRiA45156.
    I39048.
    I39049.
    RefSeqiNP_000141.1. NM_000150.2. [P51993-1]
    NP_001035791.1. NM_001040701.1. [P51993-1]
    XP_005259583.1. XM_005259526.2. [P51993-1]
    UniGeneiHs.631846.
    Hs.705615.

    Genome annotation databases

    EnsembliENST00000286955; ENSP00000286955; ENSG00000156413. [P51993-1]
    ENST00000318336; ENSP00000313398; ENSG00000156413. [P51993-1]
    ENST00000524754; ENSP00000431708; ENSG00000156413. [P51993-1]
    ENST00000527106; ENSP00000432954; ENSG00000156413. [P51993-1]
    ENST00000592563; ENSP00000466016; ENSG00000156413. [P51993-2]
    GeneIDi2528.
    KEGGihsa:2528.
    UCSCiuc002mdf.1. human. [P51993-1]

    Polymorphism databases

    DMDMi1730136.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Functional Glycomics Gateway - GTase

    Fucosyltransferase 6

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M98825 mRNA. Translation: AAA99222.1 .
    L01698 Genomic DNA. Translation: AAB03078.1 .
    U27331 mRNA. Translation: AAC50190.1 .
    U27332 mRNA. Translation: AAC50191.1 . Sequence problems.
    U27333 mRNA. Translation: AAC50192.1 .
    U27334 mRNA. Translation: AAC50193.1 .
    U27335 mRNA. Translation: AAC50194.1 .
    U27336 mRNA. Translation: AAC50195.1 .
    U27337 mRNA. Translation: AAC50196.1 .
    AF131211 mRNA. Translation: AAD33509.1 .
    AL031258 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69136.1 .
    CH471139 Genomic DNA. Translation: EAW69137.1 .
    CH471139 Genomic DNA. Translation: EAW69138.1 .
    CH471139 Genomic DNA. Translation: EAW69139.1 .
    CCDSi CCDS12152.1. [P51993-1 ]
    PIRi A45156.
    I39048.
    I39049.
    RefSeqi NP_000141.1. NM_000150.2. [P51993-1 ]
    NP_001035791.1. NM_001040701.1. [P51993-1 ]
    XP_005259583.1. XM_005259526.2. [P51993-1 ]
    UniGenei Hs.631846.
    Hs.705615.

    3D structure databases

    ProteinModelPortali P51993.
    SMRi P51993. Positions 187-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000286955.

    Chemistry

    BindingDBi P51993.
    ChEMBLi CHEMBL4443.

    Protein family/group databases

    CAZyi GT10. Glycosyltransferase Family 10.

    PTM databases

    PhosphoSitei P51993.

    Polymorphism databases

    DMDMi 1730136.

    Proteomic databases

    MaxQBi P51993.
    PaxDbi P51993.
    PRIDEi P51993.

    Protocols and materials databases

    DNASUi 2528.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000286955 ; ENSP00000286955 ; ENSG00000156413 . [P51993-1 ]
    ENST00000318336 ; ENSP00000313398 ; ENSG00000156413 . [P51993-1 ]
    ENST00000524754 ; ENSP00000431708 ; ENSG00000156413 . [P51993-1 ]
    ENST00000527106 ; ENSP00000432954 ; ENSG00000156413 . [P51993-1 ]
    ENST00000592563 ; ENSP00000466016 ; ENSG00000156413 . [P51993-2 ]
    GeneIDi 2528.
    KEGGi hsa:2528.
    UCSCi uc002mdf.1. human. [P51993-1 ]

    Organism-specific databases

    CTDi 2528.
    GeneCardsi GC19M005830.
    HGNCi HGNC:4017. FUT6.
    HPAi HPA046966.
    MIMi 136836. gene.
    613852. phenotype.
    neXtProti NX_P51993.
    PharmGKBi PA28433.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283180.
    HOGENOMi HOG000045583.
    HOVERGENi HBG000274.
    KOi K07634.
    OMAi NSARVRY.
    OrthoDBi EOG78H3T8.
    PhylomeDBi P51993.
    TreeFami TF316348.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BRENDAi 2.4.1.65. 2681.

    Miscellaneous databases

    GeneWikii FUT6.
    GenomeRNAii 2528.
    NextBioi 9961.
    PROi P51993.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51993.
    Bgeei P51993.
    CleanExi HS_FUT6.
    Genevestigatori P51993.

    Family and domain databases

    InterProi IPR001503. Glyco_trans_10.
    [Graphical view ]
    PANTHERi PTHR11929. PTHR11929. 1 hit.
    Pfami PF00852. Glyco_transf_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand."
      Koszdin K.L., Bowen B.R.
      Biochem. Biophys. Res. Commun. 187:152-157(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes."
      Weston B.W., Smith P.L., Kelly R.J., Lowe J.B.
      J. Biol. Chem. 267:24575-24584(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    3. "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms."
      Cameron H.S., Szczepaniak D., Weston B.W.
      J. Biol. Chem. 270:20112-20122(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Kidney.
    4. "Isolation and expression of human alpha-(1,3)-fucosyltransferase."
      Rahim I., Schmidt L.R., Wahl D., Drayson E., Maslanik W., Stranahan P.L., Pettijohn D.E.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-124.
      Tissue: Squamous cell carcinoma.
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6)."
      Mollicone R., Reguigne I., Fletcher A., Aziz A., Rustam M., Weston B.W., Kelly R.J., Lowe J.B., Oriol R.
      J. Biol. Chem. 269:12662-12671(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYMORPHISM, VARIANT LYS-247, CHARACTERIZATION OF VARIANT LYS-247.
    8. "Identification of two functionally deficient plasma alpha 3-fucosyltransferase (FUT6) alleles."
      Elmgren A., Borjeson C., Mollicone R., Oriol R., Fletcher A., Larson G.
      Hum. Mutat. 16:473-481(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SER-124; VAL-244; LYS-247 AND GLY-303, CHARACTERIZATION OF VARIANTS SER-124; VAL-244; LYS-247 AND GLY-303.

    Entry informationi

    Entry nameiFUT6_HUMAN
    AccessioniPrimary (citable) accession number: P51993
    Secondary accession number(s): A6NEX0, D6W637, Q9UND8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3