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P51993

- FUT6_HUMAN

UniProt

P51993 - FUT6_HUMAN

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Protein
Alpha-(1,3)-fucosyltransferase 6
Gene
FUT6, FCT3A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.

Pathwayi

GO - Molecular functioni

  1. 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Source: UniProtKB-EC
  2. alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
  3. fucosyltransferase activity Source: ProtInc

GO - Biological processi

  1. L-fucose catabolic process Source: UniProtKB
  2. fucosylation Source: GOC
  3. protein glycosylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.65. 2681.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 6 (EC:2.4.1.65)
Alternative name(s):
Fucosyltransferase 6
Fucosyltransferase VI
Short name:
Fuc-TVI
Short name:
FucT-VI
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:FUT6
Synonyms:FCT3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:4017. FUT6.

Subcellular locationi

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein
Note: Membrane-bound form in trans cisternae of Golgi.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei15 – 3420Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini35 – 359325Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi cisterna membrane Source: UniProtKB-SubCell
  3. extracellular vesicular exosome Source: UniProt
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi613852. phenotype.
PharmGKBiPA28433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Alpha-(1,3)-fucosyltransferase 6
PRO_0000221110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi91 – 911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP51993.
PaxDbiP51993.
PRIDEiP51993.

PTM databases

PhosphoSiteiP51993.

Expressioni

Tissue specificityi

Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.

Gene expression databases

ArrayExpressiP51993.
BgeeiP51993.
CleanExiHS_FUT6.
GenevestigatoriP51993.

Organism-specific databases

HPAiHPA046966.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000286955.

Structurei

3D structure databases

ProteinModelPortaliP51993.
SMRiP51993. Positions 187-324.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283180.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
KOiK07634.
OMAiNSARVRY.
OrthoDBiEOG78H3T8.
PhylomeDBiP51993.
TreeFamiTF316348.

Family and domain databases

InterProiIPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiPF00852. Glyco_transf_10. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P51993-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDPLGPAKPQ WSWRCCLTTL LFQLLMAVCF FSYLRVSQDD PTVYPNGSRF    50
PDSTGTPAHS IPLILLWTWP FNKPIALPRC SEMVPGTADC NITADRKVYP 100
QADAVIVHHR EVMYNPSAQL PRSPRRQGQR WIWFSMESPS HCWQLKAMDG 150
YFNLTMSYRS DSDIFTPYGW LEPWSGQPAH PPLNLSAKTE LVAWAVSNWG 200
PNSARVRYYQ SLQAHLKVDV YGRSHKPLPQ GTMMETLSRY KFYLAFENSL 250
HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD 300
LARYLQELDK DHARYLSYFR WRETLRPRSF SWALAFCKAC WKLQEESRYQ 350
TRGIAAWFT 359
Length:359
Mass (Da):41,860
Last modified:October 1, 1996 - v1
Checksum:i67ABDF058F0999DA
GO
Isoform 2 (identifier: P51993-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-359: RYQTRGIAAWFT → SGGLIYLRTRLPEASPA

Show »
Length:364
Mass (Da):42,191
Checksum:iBD0B020AB1580EEF
GO

Sequence cautioni

The sequence AAC50191.1 differs from that shown. Reason: Probable cloning artifact.

Polymorphismi

Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma alpha(1,3)-fucosyltransferase deficiency [MIMi:613852].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241P → S Found in alpha(1,3)-fucosyltransferase-deficient individuals; results in partial enzyme inactivation; complete enzyme inactivation when associated with V-244 and G-303. 2 Publications
Corresponds to variant rs778805 [ dbSNP | Ensembl ].
VAR_024463
Natural varianti230 – 2301Q → K.
Corresponds to variant rs364637 [ dbSNP | Ensembl ].
VAR_024464
Natural varianti244 – 2441L → V Found in alpha(1,3)-fucosyltransferase-deficient individuals; complete enzyme inactivation when associated with S-124 and G-303. 1 Publication
VAR_065915
Natural varianti247 – 2471E → K Found in alpha(1,3)-fucosyltransferase-deficient individuals; complete enzyme inactivation. 2 Publications
Corresponds to variant rs17855739 [ dbSNP | Ensembl ].
VAR_065916
Natural varianti303 – 3031R → G Found in alpha(1,3)-fucosyltransferase-deficient individuals; complete enzyme inactivation when associated with S-124 and V-244. 1 Publication
Corresponds to variant rs61147939 [ dbSNP | Ensembl ].
VAR_065917

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei348 – 35912RYQTR…AAWFT → SGGLIYLRTRLPEASPA in isoform 2.
VSP_001780Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M98825 mRNA. Translation: AAA99222.1.
L01698 Genomic DNA. Translation: AAB03078.1.
U27331 mRNA. Translation: AAC50190.1.
U27332 mRNA. Translation: AAC50191.1. Sequence problems.
U27333 mRNA. Translation: AAC50192.1.
U27334 mRNA. Translation: AAC50193.1.
U27335 mRNA. Translation: AAC50194.1.
U27336 mRNA. Translation: AAC50195.1.
U27337 mRNA. Translation: AAC50196.1.
AF131211 mRNA. Translation: AAD33509.1.
AL031258 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69136.1.
CH471139 Genomic DNA. Translation: EAW69137.1.
CH471139 Genomic DNA. Translation: EAW69138.1.
CH471139 Genomic DNA. Translation: EAW69139.1.
CCDSiCCDS12152.1. [P51993-1]
PIRiA45156.
I39048.
I39049.
RefSeqiNP_000141.1. NM_000150.2. [P51993-1]
NP_001035791.1. NM_001040701.1. [P51993-1]
XP_005259583.1. XM_005259526.2. [P51993-1]
UniGeneiHs.631846.
Hs.705615.

Genome annotation databases

EnsembliENST00000286955; ENSP00000286955; ENSG00000156413. [P51993-1]
ENST00000318336; ENSP00000313398; ENSG00000156413. [P51993-1]
ENST00000524754; ENSP00000431708; ENSG00000156413. [P51993-1]
ENST00000527106; ENSP00000432954; ENSG00000156413. [P51993-1]
ENST00000592563; ENSP00000466016; ENSG00000156413. [P51993-2]
GeneIDi2528.
KEGGihsa:2528.
UCSCiuc002mdf.1. human. [P51993-1]

Polymorphism databases

DMDMi1730136.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

Fucosyltransferase 6

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M98825 mRNA. Translation: AAA99222.1 .
L01698 Genomic DNA. Translation: AAB03078.1 .
U27331 mRNA. Translation: AAC50190.1 .
U27332 mRNA. Translation: AAC50191.1 . Sequence problems.
U27333 mRNA. Translation: AAC50192.1 .
U27334 mRNA. Translation: AAC50193.1 .
U27335 mRNA. Translation: AAC50194.1 .
U27336 mRNA. Translation: AAC50195.1 .
U27337 mRNA. Translation: AAC50196.1 .
AF131211 mRNA. Translation: AAD33509.1 .
AL031258 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69136.1 .
CH471139 Genomic DNA. Translation: EAW69137.1 .
CH471139 Genomic DNA. Translation: EAW69138.1 .
CH471139 Genomic DNA. Translation: EAW69139.1 .
CCDSi CCDS12152.1. [P51993-1 ]
PIRi A45156.
I39048.
I39049.
RefSeqi NP_000141.1. NM_000150.2. [P51993-1 ]
NP_001035791.1. NM_001040701.1. [P51993-1 ]
XP_005259583.1. XM_005259526.2. [P51993-1 ]
UniGenei Hs.631846.
Hs.705615.

3D structure databases

ProteinModelPortali P51993.
SMRi P51993. Positions 187-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000286955.

Chemistry

BindingDBi P51993.
ChEMBLi CHEMBL4443.

Protein family/group databases

CAZyi GT10. Glycosyltransferase Family 10.

PTM databases

PhosphoSitei P51993.

Polymorphism databases

DMDMi 1730136.

Proteomic databases

MaxQBi P51993.
PaxDbi P51993.
PRIDEi P51993.

Protocols and materials databases

DNASUi 2528.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286955 ; ENSP00000286955 ; ENSG00000156413 . [P51993-1 ]
ENST00000318336 ; ENSP00000313398 ; ENSG00000156413 . [P51993-1 ]
ENST00000524754 ; ENSP00000431708 ; ENSG00000156413 . [P51993-1 ]
ENST00000527106 ; ENSP00000432954 ; ENSG00000156413 . [P51993-1 ]
ENST00000592563 ; ENSP00000466016 ; ENSG00000156413 . [P51993-2 ]
GeneIDi 2528.
KEGGi hsa:2528.
UCSCi uc002mdf.1. human. [P51993-1 ]

Organism-specific databases

CTDi 2528.
GeneCardsi GC19M005830.
HGNCi HGNC:4017. FUT6.
HPAi HPA046966.
MIMi 136836. gene.
613852. phenotype.
neXtProti NX_P51993.
PharmGKBi PA28433.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283180.
HOGENOMi HOG000045583.
HOVERGENi HBG000274.
KOi K07634.
OMAi NSARVRY.
OrthoDBi EOG78H3T8.
PhylomeDBi P51993.
TreeFami TF316348.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BRENDAi 2.4.1.65. 2681.

Miscellaneous databases

GeneWikii FUT6.
GenomeRNAii 2528.
NextBioi 9961.
PROi P51993.
SOURCEi Search...

Gene expression databases

ArrayExpressi P51993.
Bgeei P51993.
CleanExi HS_FUT6.
Genevestigatori P51993.

Family and domain databases

InterProi IPR001503. Glyco_trans_10.
[Graphical view ]
PANTHERi PTHR11929. PTHR11929. 1 hit.
Pfami