Reviewed,
UniProtKB/Swiss-Prot P51993 (FUT6_HUMAN)
Last modified
November 25, 2008.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
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Names and origin
| Protein names | Recommended name: Alpha-(1,3)-fucosyltransferase EC=2.4.1.65 Alternative name(s): Galactoside 3-L-fucosyltransferase Fucosyltransferase 6 FucT-VI | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 359 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates. |
| Catalytic activity | GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R. |
| Pathway | |
| Subcellular location | Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein. Note= Membrane-bound form in trans cisternae of Golgi. |
| Tissue specificity | Kidney, liver, colon, small intestine, bladder, uterus and salivary gland. |
| Sequence similarities | Belongs to the glycosyltransferase 10 family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Signal-anchor Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Glycoprotein |
Gene Ontology (GO) | |
| Biological process | L-fucose catabolic process Non-traceable author statement. Source: UniProtKB protein amino acid glycosylationTraceable author statement. Source: UniProtKB |
| Cellular component | Golgi apparatus Traceable author statement. Source: UniProtKB integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC alpha(1,3)-fucosyltransferase activityTraceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: P51993-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: P51993-2) The sequence of this isoform differs from the canonical sequence as follows: 348-359: RYQTRGIAAWFT → SSGGLIYLRTRLPEASPA |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 359 | 359 | Alpha-(1,3)-fucosyltransferase | PRO_0000221110 | |||||
Regions | |||||||||
| Topological domain | 1 – 14 | 14 | Cytoplasmic Potential | ||||||
| Transmembrane | 15 – 34 | 20 | Signal-anchor for type II membrane protein Potential | ||||||
| Topological domain | 35 – 359 | 325 | Lumenal Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 46 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 91 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 153 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 184 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 348 – 359 | 12 | RYQTR…AAWFT → SSGGLIYLRTRLPEASPA in isoform 2. | VSP_001780 | |||||
| Natural variant | 124 | 1 | P → S: dbSNP rs778805. | VAR_024463 | |||||
| Natural variant | 230 | 1 | Q → K: dbSNP rs364637. | VAR_024464 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand." Koszdin K.L., Bowen B.R. Biochem. Biophys. Res. Commun. 187:152-157(1992) [PubMed: 1520296] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes." Weston B.W., Smith P.L., Kelly R.J., Lowe J.B. J. Biol. Chem. 267:24575-24584(1992) [PubMed: 1339443] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms." Cameron H.S., Szczepaniak D., Weston B.W. J. Biol. Chem. 270:20112-20122(1995) [PubMed: 7650030] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney. |
| [4] | "The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M.Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Web resources
| GGDB GlycoGene database |
| Functional Glycomics Gateway - GTase Fucosyltransferase 6 |
Cross-references
Sequence databases | |
|---|---|
| M98825 mRNA. Translation: AAA99222.1. L01698 Genomic DNA. Translation: AAB03078.1. U27333 mRNA. Translation: AAC50192.1. U27334 mRNA. Translation: AAC50193.1. U27335 mRNA. Translation: AAC50194.1. U27336 mRNA. Translation: AAC50195.1. U27331 mRNA. Translation: AAC50190.1. U27332 mRNA. Translation: AAC50191.1. Sequence problems. U27337 mRNA. Translation: AAC50196.1. AL031258 Genomic DNA. No translation available. CH471139 Genomic DNA. Translation: EAW69136.1. | |
| PIR | A45156. I39048. I39049. |
| RefSeq | NP_000141.1. NP_001035791.1. |
| UniGene | Hs.631846 Hs.705615 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000156413. Homo sapiens. [Contig view] |
| GeneID | 2528. |
| KEGG | hsa:2528. |
Organism-specific databases | |
| H-InvDB | HIX0014674. |
| HGNC | HGNC:4017. FUT6. |
| MIM | 136836. gene+phenotype. |
| PharmGKB | PA28433. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | P51993. |
Gene expression databases | |
| ArrayExpress | P51993. |
| CleanEx | HS_FUT6. |
| GermOnline | ENSG00000156413. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001503. Glyco_trans_10. [Graphical view] |
| PANTHER | PTHR11929. Glyco_trans_10. 1 hit. |
| Pfam | PF00852. Glyco_transf_10. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 9961. |
| SOURCE | Search... |
Entry information
| Entry name | FUT6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P51993 Secondary accession number(s): A6NEX0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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