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Protein

Alpha-(1,3)-fucosyltransferase 6

Gene

FUT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Source: UniProtKB-EC
  • alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
  • fucosyltransferase activity Source: ProtInc

GO - Biological processi

  • L-fucose catabolic process Source: UniProtKB
  • protein glycosylation Source: UniProtKB
  • protein N-linked glycosylation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:HS08124-MONOMER.
BRENDAi2.4.1.152. 2681.
2.4.1.65. 2681.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Chemistry databases

SwissLipidsiSLP:000001436. [P51993-1]

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 6 (EC:2.4.1.65)
Alternative name(s):
Fucosyltransferase 6
Fucosyltransferase VI
Short name:
Fuc-TVI
Short name:
FucT-VI
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:FUT6
Synonyms:FCT3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4017. FUT6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini35 – 359LumenalSequence analysisAdd BLAST325

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • Golgi membrane Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2528.
MalaCardsiFUT6.
MIMi613852. phenotype.
OpenTargetsiENSG00000156413.
PharmGKBiPA28433.

Chemistry databases

ChEMBLiCHEMBL4443.

Polymorphism and mutation databases

BioMutaiFUT6.
DMDMi1730136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211101 – 359Alpha-(1,3)-fucosyltransferase 6Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1
Glycosylationi153N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP51993.
PaxDbiP51993.
PeptideAtlasiP51993.
PRIDEiP51993.

PTM databases

iPTMnetiP51993.
PhosphoSitePlusiP51993.

Expressioni

Tissue specificityi

Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.

Gene expression databases

BgeeiENSG00000156413.
CleanExiHS_FUT6.
ExpressionAtlasiP51993. baseline and differential.
GenevisibleiP51993. HS.

Organism-specific databases

HPAiHPA043707.
HPA046966.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000286955.

Chemistry databases

BindingDBiP51993.

Structurei

3D structure databases

ProteinModelPortaliP51993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619. Eukaryota.
ENOG410ZIMX. LUCA.
GeneTreeiENSGT00680000099679.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiP51993.
KOiK07634.
OMAiNSARVRY.
OrthoDBiEOG091G0846.
PhylomeDBiP51993.
TreeFamiTF316348.

Family and domain databases

InterProiIPR031481. Glyco_tran_10_N.
IPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiPF17039. Glyco_tran_10_N. 1 hit.
PF00852. Glyco_transf_10. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51993-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPLGPAKPQ WSWRCCLTTL LFQLLMAVCF FSYLRVSQDD PTVYPNGSRF
60 70 80 90 100
PDSTGTPAHS IPLILLWTWP FNKPIALPRC SEMVPGTADC NITADRKVYP
110 120 130 140 150
QADAVIVHHR EVMYNPSAQL PRSPRRQGQR WIWFSMESPS HCWQLKAMDG
160 170 180 190 200
YFNLTMSYRS DSDIFTPYGW LEPWSGQPAH PPLNLSAKTE LVAWAVSNWG
210 220 230 240 250
PNSARVRYYQ SLQAHLKVDV YGRSHKPLPQ GTMMETLSRY KFYLAFENSL
260 270 280 290 300
HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD
310 320 330 340 350
LARYLQELDK DHARYLSYFR WRETLRPRSF SWALAFCKAC WKLQEESRYQ

TRGIAAWFT
Length:359
Mass (Da):41,860
Last modified:October 1, 1996 - v1
Checksum:i67ABDF058F0999DA
GO
Isoform 2 (identifier: P51993-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-359: RYQTRGIAAWFT → SGGLIYLRTRLPEASPA

Show »
Length:364
Mass (Da):42,191
Checksum:iBD0B020AB1580EEF
GO

Sequence cautioni

The sequence AAC50191 differs from that shown. Probable cloning artifact.Curated

Polymorphismi

Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma alpha(1,3)-fucosyltransferase deficiency [MIMi:613852].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024463124P → S Found in alpha(1,3)-fucosyltransferase-deficient individuals; results in partial enzyme inactivation; complete enzyme inactivation when associated with V-244 and G-303. 2 PublicationsCorresponds to variant rs778805dbSNPEnsembl.1
Natural variantiVAR_024464230Q → K.Corresponds to variant rs364637dbSNPEnsembl.1
Natural variantiVAR_065915244L → V Found in alpha(1,3)-fucosyltransferase-deficient individuals; complete enzyme inactivation when associated with S-124 and G-303. 1 Publication1
Natural variantiVAR_065916247E → K Found in alpha(1,3)-fucosyltransferase-deficient individuals; complete enzyme inactivation. 2 PublicationsCorresponds to variant rs17855739dbSNPEnsembl.1
Natural variantiVAR_065917303R → G Found in alpha(1,3)-fucosyltransferase-deficient individuals; complete enzyme inactivation when associated with S-124 and V-244. 1 PublicationCorresponds to variant rs61147939dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001780348 – 359RYQTR…AAWFT → SGGLIYLRTRLPEASPA in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98825 mRNA. Translation: AAA99222.1.
L01698 Genomic DNA. Translation: AAB03078.1.
U27331 mRNA. Translation: AAC50190.1.
U27332 mRNA. Translation: AAC50191.1. Sequence problems.
U27333 mRNA. Translation: AAC50192.1.
U27334 mRNA. Translation: AAC50193.1.
U27335 mRNA. Translation: AAC50194.1.
U27336 mRNA. Translation: AAC50195.1.
U27337 mRNA. Translation: AAC50196.1.
AF131211 mRNA. Translation: AAD33509.1.
AL031258 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69136.1.
CH471139 Genomic DNA. Translation: EAW69137.1.
CH471139 Genomic DNA. Translation: EAW69138.1.
CH471139 Genomic DNA. Translation: EAW69139.1.
CCDSiCCDS12152.1. [P51993-1]
PIRiA45156.
I39048.
I39049.
RefSeqiNP_000141.1. NM_000150.2. [P51993-1]
NP_001035791.1. NM_001040701.1. [P51993-1]
XP_005259583.1. XM_005259526.4. [P51993-1]
XP_011526170.1. XM_011527868.2. [P51993-1]
XP_011526171.1. XM_011527869.2. [P51993-1]
XP_011526172.1. XM_011527870.2. [P51993-1]
XP_011526174.1. XM_011527872.2. [P51993-1]
XP_011526175.1. XM_011527873.2. [P51993-1]
XP_011526176.1. XM_011527874.2. [P51993-1]
XP_011526177.1. XM_011527875.2. [P51993-1]
XP_011526178.1. XM_011527876.2. [P51993-1]
XP_011526180.1. XM_011527878.2. [P51993-1]
XP_011526181.1. XM_011527879.2. [P51993-1]
UniGeneiHs.631846.
Hs.705615.

Genome annotation databases

EnsembliENST00000286955; ENSP00000286955; ENSG00000156413. [P51993-1]
ENST00000318336; ENSP00000313398; ENSG00000156413. [P51993-1]
ENST00000524754; ENSP00000431708; ENSG00000156413. [P51993-1]
ENST00000527106; ENSP00000432954; ENSG00000156413. [P51993-1]
ENST00000592563; ENSP00000466016; ENSG00000156413. [P51993-2]
GeneIDi2528.
KEGGihsa:2528.
UCSCiuc002mdf.2. human. [P51993-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Fucosyltransferase 6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98825 mRNA. Translation: AAA99222.1.
L01698 Genomic DNA. Translation: AAB03078.1.
U27331 mRNA. Translation: AAC50190.1.
U27332 mRNA. Translation: AAC50191.1. Sequence problems.
U27333 mRNA. Translation: AAC50192.1.
U27334 mRNA. Translation: AAC50193.1.
U27335 mRNA. Translation: AAC50194.1.
U27336 mRNA. Translation: AAC50195.1.
U27337 mRNA. Translation: AAC50196.1.
AF131211 mRNA. Translation: AAD33509.1.
AL031258 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69136.1.
CH471139 Genomic DNA. Translation: EAW69137.1.
CH471139 Genomic DNA. Translation: EAW69138.1.
CH471139 Genomic DNA. Translation: EAW69139.1.
CCDSiCCDS12152.1. [P51993-1]
PIRiA45156.
I39048.
I39049.
RefSeqiNP_000141.1. NM_000150.2. [P51993-1]
NP_001035791.1. NM_001040701.1. [P51993-1]
XP_005259583.1. XM_005259526.4. [P51993-1]
XP_011526170.1. XM_011527868.2. [P51993-1]
XP_011526171.1. XM_011527869.2. [P51993-1]
XP_011526172.1. XM_011527870.2. [P51993-1]
XP_011526174.1. XM_011527872.2. [P51993-1]
XP_011526175.1. XM_011527873.2. [P51993-1]
XP_011526176.1. XM_011527874.2. [P51993-1]
XP_011526177.1. XM_011527875.2. [P51993-1]
XP_011526178.1. XM_011527876.2. [P51993-1]
XP_011526180.1. XM_011527878.2. [P51993-1]
XP_011526181.1. XM_011527879.2. [P51993-1]
UniGeneiHs.631846.
Hs.705615.

3D structure databases

ProteinModelPortaliP51993.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000286955.

Chemistry databases

BindingDBiP51993.
ChEMBLiCHEMBL4443.
SwissLipidsiSLP:000001436. [P51993-1]

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

PTM databases

iPTMnetiP51993.
PhosphoSitePlusiP51993.

Polymorphism and mutation databases

BioMutaiFUT6.
DMDMi1730136.

Proteomic databases

MaxQBiP51993.
PaxDbiP51993.
PeptideAtlasiP51993.
PRIDEiP51993.

Protocols and materials databases

DNASUi2528.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286955; ENSP00000286955; ENSG00000156413. [P51993-1]
ENST00000318336; ENSP00000313398; ENSG00000156413. [P51993-1]
ENST00000524754; ENSP00000431708; ENSG00000156413. [P51993-1]
ENST00000527106; ENSP00000432954; ENSG00000156413. [P51993-1]
ENST00000592563; ENSP00000466016; ENSG00000156413. [P51993-2]
GeneIDi2528.
KEGGihsa:2528.
UCSCiuc002mdf.2. human. [P51993-1]

Organism-specific databases

CTDi2528.
DisGeNETi2528.
GeneCardsiFUT6.
HGNCiHGNC:4017. FUT6.
HPAiHPA043707.
HPA046966.
MalaCardsiFUT6.
MIMi136836. gene.
613852. phenotype.
neXtProtiNX_P51993.
OpenTargetsiENSG00000156413.
PharmGKBiPA28433.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2619. Eukaryota.
ENOG410ZIMX. LUCA.
GeneTreeiENSGT00680000099679.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiP51993.
KOiK07634.
OMAiNSARVRY.
OrthoDBiEOG091G0846.
PhylomeDBiP51993.
TreeFamiTF316348.

Enzyme and pathway databases

UniPathwayiUPA00378.
BioCyciZFISH:HS08124-MONOMER.
BRENDAi2.4.1.152. 2681.
2.4.1.65. 2681.

Miscellaneous databases

GeneWikiiFUT6.
GenomeRNAii2528.
PROiP51993.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156413.
CleanExiHS_FUT6.
ExpressionAtlasiP51993. baseline and differential.
GenevisibleiP51993. HS.

Family and domain databases

InterProiIPR031481. Glyco_tran_10_N.
IPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiPF17039. Glyco_tran_10_N. 1 hit.
PF00852. Glyco_transf_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUT6_HUMAN
AccessioniPrimary (citable) accession number: P51993
Secondary accession number(s): A6NEX0, D6W637, Q9UND8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.