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Protein

Heterogeneous nuclear ribonucleoprotein A3

Gene

HNRNPA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.1 Publication

Caution

An older version of this entry represented the conceptual translation of what was thought to be HNRNPA3 but which was in fact a pseudogene (HNRPA3P1/FBRNP) located on chromosome 10.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A3
Short name:
hnRNP A3
Gene namesi
Name:HNRNPA3
Synonyms:HNRPA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000170144.18
HGNCiHGNC:24941 HNRNPA3
MIMi605372 gene
neXtProtiNX_P51991

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi220988
OpenTargetsiENSG00000170144
PharmGKBiPA162391169

Polymorphism and mutation databases

BioMutaiHNRNPA3
DMDMi51338779

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818381 – 378Heterogeneous nuclear ribonucleoprotein A3Add BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei14PhosphoserineCombined sources1
Cross-linki36Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei43PhosphoserineCombined sources1
Modified residuei52Dimethylated arginine; alternate1 Publication1
Modified residuei52Omega-N-methylarginine; alternate1 Publication1
Modified residuei76Omega-N-methylarginineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei124PhosphothreonineCombined sources1
Modified residuei134N6-acetyllysine; alternateCombined sources1
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei214Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei214Omega-N-methylarginine; alternateCombined sources1
Modified residuei216Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei216Omega-N-methylarginine; alternateCombined sources1
Modified residuei226Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei226Omega-N-methylarginine; alternateCombined sources1
Modified residuei239Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei239Omega-N-methylarginine; alternateBy similarity1
Modified residuei246Asymmetric dimethylarginine; alternateCombined sources1 Publication1
Modified residuei246Omega-N-methylarginine; alternateCombined sources1
Modified residuei257Omega-N-methylarginineBy similarity1
Modified residuei286Asymmetric dimethylarginineBy similarity1
Modified residuei350PhosphoserineCombined sources1
Modified residuei354Omega-N-methylarginineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei360PhosphotyrosineCombined sources1
Modified residuei364PhosphotyrosineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei373PhosphotyrosineCombined sources1
Modified residuei375PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP51991
MaxQBiP51991
PaxDbiP51991
PeptideAtlasiP51991
PRIDEiP51991
ProteomicsDBi56465
56466 [P51991-2]
TopDownProteomicsiP51991-1 [P51991-1]
P51991-2 [P51991-2]

PTM databases

iPTMnetiP51991
PhosphoSitePlusiP51991
SwissPalmiP51991

Miscellaneous databases

PMAP-CutDBiP51991

Expressioni

Gene expression databases

BgeeiENSG00000170144
CleanExiHS_HNRNPA3
ExpressionAtlasiP51991 baseline and differential
GenevisibleiP51991 HS

Organism-specific databases

HPAiHPA001666
HPA005812
HPA066381

Interactioni

Subunit structurei

Identified in the spliceosome C complex.1 Publication

Protein-protein interaction databases

BioGridi128670, 125 interactors
CORUMiP51991
IntActiP51991, 45 interactors
MINTiP51991
STRINGi9606.ENSP00000376309

Structurei

3D structure databases

ProteinModelPortaliP51991
SMRiP51991
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 118RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini126 – 205RRM 2PROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 378Gly-richAdd BLAST168

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00900000140828
HOGENOMiHOG000234442
HOVERGENiHBG002295
InParanoidiP51991
KOiK12741
OMAiYYDSTGY
OrthoDBiEOG091G1CPI
PhylomeDBiP51991
TreeFamiTF314808

Family and domain databases

CDDicd12763 RRM1_hnRNPA3, 1 hit
cd12582 RRM2_hnRNPA3, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034513 hnRNPA3_RRM1
IPR034516 hnRNPA3_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51991-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVKPPPGRP QPDSGRRRRR RGEEGHDPKE PEQLRKLFIG GLSFETTDDS
60 70 80 90 100
LREHFEKWGT LTDCVVMRDP QTKRSRGFGF VTYSCVEEVD AAMCARPHKV
110 120 130 140 150
DGRVVEPKRA VSREDSVKPG AHLTVKKIFV GGIKEDTEEY NLRDYFEKYG
160 170 180 190 200
KIETIEVMED RQSGKKRGFA FVTFDDHDTV DKIVVQKYHT INGHNCEVKK
210 220 230 240 250
ALSKQEMQSA GSQRGRGGGS GNFMGRGGNF GGGGGNFGRG GNFGGRGGYG
260 270 280 290 300
GGGGGSRGSY GGGDGGYNGF GGDGGNYGGG PGYSSRGGYG GGGPGYGNQG
310 320 330 340 350
GGYGGGGGYD GYNEGGNFGG GNYGGGGNYN DFGNYSGQQQ SNYGPMKGGS
360 370
FGGRSSGSPY GGGYGSGGGS GGYGSRRF
Length:378
Mass (Da):39,595
Last modified:August 16, 2004 - v2
Checksum:i832372C4C29547B1
GO
Isoform 2 (identifier: P51991-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MEVKPPPGRPQPDSGRRRRRRGE → M

Show »
Length:356
Mass (Da):37,029
Checksum:iC2D8451FC6D6A60A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0114181 – 23MEVKP…RRRGE → M in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363225 mRNA Translation: AAQ63629.1
AC079305 Genomic DNA Translation: AAY14709.1
CH471058 Genomic DNA Translation: EAX11066.1
BC112027 mRNA Translation: AAI12028.1
BC113470 mRNA Translation: AAI13471.1
CCDSiCCDS2273.1 [P51991-1]
CCDS82536.1 [P51991-2]
PIRiI52962
RefSeqiNP_001317178.1, NM_001330249.1 [P51991-1]
NP_919223.1, NM_194247.3 [P51991-1]
UniGeneiHs.516539

Genome annotation databases

EnsembliENST00000392524; ENSP00000376309; ENSG00000170144 [P51991-1]
ENST00000411529; ENSP00000408487; ENSG00000170144 [P51991-2]
ENST00000435711; ENSP00000416340; ENSG00000170144 [P51991-1]
GeneIDi220988
KEGGihsa:220988
UCSCiuc002ulb.2 human [P51991-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiROA3_HUMAN
AccessioniPrimary (citable) accession number: P51991
Secondary accession number(s): D3DPF4, Q53RW7, Q6URK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 16, 2004
Last modified: June 20, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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