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Protein

Heterogeneous nuclear ribonucleoprotein A3

Gene

HNRNPA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.1 Publication

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

  • gene expression Source: Reactome
  • mRNA splicing, via spliceosome Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A3
Short name:
hnRNP A3
Gene namesi
Name:HNRNPA3
Synonyms:HNRPA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24941. HNRNPA3.

Subcellular locationi

  • Nucleus By similarity

  • Note: Component of ribonucleosomes.

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: ProtInc
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi220988.
OpenTargetsiENSG00000170144.
PharmGKBiPA162391169.

Polymorphism and mutation databases

BioMutaiHNRNPA3.
DMDMi51338779.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818381 – 378Heterogeneous nuclear ribonucleoprotein A3Add BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei14PhosphoserineCombined sources1
Modified residuei43PhosphoserineCombined sources1
Modified residuei52Dimethylated arginine; alternate1 Publication1
Modified residuei52Omega-N-methylarginine; alternate1 Publication1
Modified residuei76Omega-N-methylarginineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei124PhosphothreonineCombined sources1
Modified residuei134N6-acetyllysineCombined sources1
Modified residuei214Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei214Omega-N-methylarginine; alternateCombined sources1
Modified residuei216Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei216Omega-N-methylarginine; alternateCombined sources1
Modified residuei226Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei226Omega-N-methylarginine; alternateCombined sources1
Modified residuei239Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei239Omega-N-methylarginine; alternateBy similarity1
Modified residuei246Asymmetric dimethylarginine; alternateCombined sources1 Publication1
Modified residuei246Omega-N-methylarginine; alternateCombined sources1
Modified residuei257Omega-N-methylarginineBy similarity1
Modified residuei286Asymmetric dimethylarginineBy similarity1
Modified residuei350PhosphoserineCombined sources1
Modified residuei354Omega-N-methylarginineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei360PhosphotyrosineCombined sources1
Modified residuei364PhosphotyrosineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei373PhosphotyrosineCombined sources1
Modified residuei375PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP51991.
MaxQBiP51991.
PaxDbiP51991.
PeptideAtlasiP51991.
PRIDEiP51991.
TopDownProteomicsiP51991-1. [P51991-1]
P51991-2. [P51991-2]

PTM databases

iPTMnetiP51991.
PhosphoSitePlusiP51991.
SwissPalmiP51991.

Miscellaneous databases

PMAP-CutDBP51991.

Expressioni

Gene expression databases

BgeeiENSG00000170144.
CleanExiHS_HNRNPA3.
ExpressionAtlasiP51991. baseline and differential.
GenevisibleiP51991. HS.

Organism-specific databases

HPAiHPA001666.
HPA005812.

Interactioni

Subunit structurei

Identified in the spliceosome C complex.1 Publication

Protein-protein interaction databases

BioGridi128670. 119 interactors.
IntActiP51991. 40 interactors.
MINTiMINT-4999802.
STRINGi9606.ENSP00000376309.

Structurei

3D structure databases

ProteinModelPortaliP51991.
SMRiP51991.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 118RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini126 – 205RRM 2PROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 378Gly-richAdd BLAST168

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234442.
HOVERGENiHBG002295.
InParanoidiP51991.
KOiK12741.
OMAiQGHDPKE.
OrthoDBiEOG091G1CPI.
PhylomeDBiP51991.
TreeFamiTF314808.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51991-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVKPPPGRP QPDSGRRRRR RGEEGHDPKE PEQLRKLFIG GLSFETTDDS
60 70 80 90 100
LREHFEKWGT LTDCVVMRDP QTKRSRGFGF VTYSCVEEVD AAMCARPHKV
110 120 130 140 150
DGRVVEPKRA VSREDSVKPG AHLTVKKIFV GGIKEDTEEY NLRDYFEKYG
160 170 180 190 200
KIETIEVMED RQSGKKRGFA FVTFDDHDTV DKIVVQKYHT INGHNCEVKK
210 220 230 240 250
ALSKQEMQSA GSQRGRGGGS GNFMGRGGNF GGGGGNFGRG GNFGGRGGYG
260 270 280 290 300
GGGGGSRGSY GGGDGGYNGF GGDGGNYGGG PGYSSRGGYG GGGPGYGNQG
310 320 330 340 350
GGYGGGGGYD GYNEGGNFGG GNYGGGGNYN DFGNYSGQQQ SNYGPMKGGS
360 370
FGGRSSGSPY GGGYGSGGGS GGYGSRRF
Length:378
Mass (Da):39,595
Last modified:August 16, 2004 - v2
Checksum:i832372C4C29547B1
GO
Isoform 2 (identifier: P51991-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MEVKPPPGRPQPDSGRRRRRRGE → M

Show »
Length:356
Mass (Da):37,029
Checksum:iC2D8451FC6D6A60A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0114181 – 23MEVKP…RRRGE → M in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363225 mRNA. Translation: AAQ63629.1.
AC079305 Genomic DNA. Translation: AAY14709.1.
CH471058 Genomic DNA. Translation: EAX11066.1.
BC112027 mRNA. Translation: AAI12028.1.
BC113470 mRNA. Translation: AAI13471.1.
CCDSiCCDS2273.1. [P51991-1]
CCDS82536.1. [P51991-2]
PIRiI52962.
RefSeqiNP_001317178.1. NM_001330249.1.
NP_919223.1. NM_194247.3. [P51991-1]
UniGeneiHs.516539.

Genome annotation databases

EnsembliENST00000392524; ENSP00000376309; ENSG00000170144. [P51991-1]
ENST00000411529; ENSP00000408487; ENSG00000170144. [P51991-2]
ENST00000435711; ENSP00000416340; ENSG00000170144. [P51991-1]
GeneIDi220988.
KEGGihsa:220988.
UCSCiuc002ulb.2. human. [P51991-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363225 mRNA. Translation: AAQ63629.1.
AC079305 Genomic DNA. Translation: AAY14709.1.
CH471058 Genomic DNA. Translation: EAX11066.1.
BC112027 mRNA. Translation: AAI12028.1.
BC113470 mRNA. Translation: AAI13471.1.
CCDSiCCDS2273.1. [P51991-1]
CCDS82536.1. [P51991-2]
PIRiI52962.
RefSeqiNP_001317178.1. NM_001330249.1.
NP_919223.1. NM_194247.3. [P51991-1]
UniGeneiHs.516539.

3D structure databases

ProteinModelPortaliP51991.
SMRiP51991.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128670. 119 interactors.
IntActiP51991. 40 interactors.
MINTiMINT-4999802.
STRINGi9606.ENSP00000376309.

PTM databases

iPTMnetiP51991.
PhosphoSitePlusiP51991.
SwissPalmiP51991.

Polymorphism and mutation databases

BioMutaiHNRNPA3.
DMDMi51338779.

Proteomic databases

EPDiP51991.
MaxQBiP51991.
PaxDbiP51991.
PeptideAtlasiP51991.
PRIDEiP51991.
TopDownProteomicsiP51991-1. [P51991-1]
P51991-2. [P51991-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392524; ENSP00000376309; ENSG00000170144. [P51991-1]
ENST00000411529; ENSP00000408487; ENSG00000170144. [P51991-2]
ENST00000435711; ENSP00000416340; ENSG00000170144. [P51991-1]
GeneIDi220988.
KEGGihsa:220988.
UCSCiuc002ulb.2. human. [P51991-1]

Organism-specific databases

CTDi220988.
DisGeNETi220988.
GeneCardsiHNRNPA3.
HGNCiHGNC:24941. HNRNPA3.
HPAiHPA001666.
HPA005812.
MIMi605372. gene.
neXtProtiNX_P51991.
OpenTargetsiENSG00000170144.
PharmGKBiPA162391169.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234442.
HOVERGENiHBG002295.
InParanoidiP51991.
KOiK12741.
OMAiQGHDPKE.
OrthoDBiEOG091G1CPI.
PhylomeDBiP51991.
TreeFamiTF314808.

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Miscellaneous databases

ChiTaRSiHNRNPA3. human.
GeneWikiiHNRPA3.
GenomeRNAii220988.
PMAP-CutDBP51991.
PROiP51991.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170144.
CleanExiHS_HNRNPA3.
ExpressionAtlasiP51991. baseline and differential.
GenevisibleiP51991. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROA3_HUMAN
AccessioniPrimary (citable) accession number: P51991
Secondary accession number(s): D3DPF4, Q53RW7, Q6URK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

An older version of this entry represented the conceptual translation of what was thought to be HNRNPA3 but which was in fact a pseudogene (HNRPA3P1/FBRNP) located on chromosome 10.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.