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Protein

Thioredoxin reductase

Gene

cys-9

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44FAD; via amide nitrogenBy similarity1
Binding sitei53FADBy similarity1
Binding sitei86FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei143FADBy similarity1
Binding sitei287FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 13FADBy similarity4
Nucleotide bindingi39 – 40FADBy similarity2
Nucleotide bindingi294 – 296FADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase (EC:1.8.1.9)
Gene namesi
Name:cys-9
ORF Names:NCU08352
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU08352

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001667641 – 334Thioredoxin reductaseAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi140 ↔ 143Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP51978

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP51978
SMRiP51978
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOGENOMiHOG000072912
InParanoidiP51978
KOiK00384
OMAiDPIQGPW
OrthoDBiEOG092C3AEY

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR008255 Pyr_nucl-diS_OxRdtase_2_AS
IPR000103 Pyridine_nuc-diS_OxRdtase_2
IPR005982 Thioredox_Rdtase
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PRINTSiPR00469 PNDRDTASEII
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01292 TRX_reduct, 1 hit
PROSITEiView protein in PROSITE
PS00573 PYRIDINE_REDOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P51978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSKVVIIGS GPAAHTAAIY LARAELKPVL YEGFMANGIA AGGQLTTTTE
60 70 80 90 100
IENFPGFPDG IMGQELMDKM KAQSERFGTQ IISETVAKVD LSARPFKYAT
110 120 130 140 150
EWSPEEYHTA DSIILATGAS ARRLHLPGEE KYWQNGISAC AVCDGAVPIF
160 170 180 190 200
RNKHLVVIGG GDSAAEEAMY LTKYGSHVTV LVRKDKLRAS SIMAHRLLNH
210 220 230 240 250
EKVTVRFNTV GVEVKGDDKG LMSHLVVKDV TTGKEETLEA NGLFYAIGHD
260 270 280 290 300
PATALVKGQL ETDADGYVVT KPGTTLTSVE GVFAAGDVQD KRYRQAITSA
310 320 330
GTGCMAALDA EKFLSEHEET PAEHRDTSAV QGNL
Length:334
Mass (Da):35,883
Last modified:October 1, 1996 - v1
Checksum:i4D9EE9861E479EB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45049 Genomic DNA Translation: BAA08090.1
CM002236 Genomic DNA Translation: EAA36019.1
PIRiT47256
RefSeqiXP_965255.1, XM_960162.2

Genome annotation databases

EnsemblFungiiEAA36019; EAA36019; NCU08352
GeneIDi3881395
KEGGincr:NCU08352

Similar proteinsi

Entry informationi

Entry nameiTRXB_NEUCR
AccessioniPrimary (citable) accession number: P51978
Secondary accession number(s): Q7RVM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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