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Protein

Retinal dehydrogenase 1

Gene

ALDH1A1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:26373694).By similarity1 Publication

Catalytic activityi

Retinal + NAD+ + H2O = retinoate + NADH.By similarity

Enzyme regulationi

Inhibited by duocarmycin analogs.1 Publication

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei170Transition state stabilizerBy similarity1
Active sitei269Proton acceptorPROSITE-ProRule annotation1
Active sitei303Nucleophile1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 170NADCombined sources4
Nucleotide bindingi193 – 196NADCombined sources4
Nucleotide bindingi226 – 227NADCombined sources2
Nucleotide bindingi246 – 247NADCombined sources2
Nucleotide bindingi269 – 271NADBy similarity3
Nucleotide bindingi349 – 353NADBy similarity5
Nucleotide bindingi400 – 402NADCombined sources3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal dehydrogenase 1Curated (EC:1.2.1.-1 Publication, EC:1.2.1.36By similarity)
Short name:
RALDH 1Curated
Short name:
RalDH1Curated
Alternative name(s):
Aldehyde dehydrogenase family 1 member A11 Publication
Aldehyde dehydrogenase, cytosolic1 Publication
Gene namesi
Name:ALDH1A11 Publication
Synonyms:ALDH11 Publication
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasmcytosol By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000564202 – 501Retinal dehydrogenase 1Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei128N6-acetyllysineBy similarity1
Modified residuei252N6-acetyllysineBy similarity1
Modified residuei337PhosphothreonineBy similarity1
Modified residuei353N6-acetyllysineBy similarity1
Modified residuei367N6-acetyllysineBy similarity1
Modified residuei410N6-acetyllysineBy similarity1
Modified residuei413PhosphoserineBy similarity1
Modified residuei419N6-acetyllysineBy similarity1
Modified residuei495N6-acetyllysineBy similarity1

Post-translational modificationi

The N-terminus is blocked most probably by acetylation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP51977.

Interactioni

Subunit structurei

Homotetramer.2 Publications

Structurei

Secondary structure

1501
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 25Combined sources4
Beta strandi28 – 30Combined sources3
Beta strandi37 – 41Combined sources5
Turni43 – 45Combined sources3
Beta strandi48 – 53Combined sources6
Helixi57 – 70Combined sources14
Helixi76 – 79Combined sources4
Helixi82 – 98Combined sources17
Helixi100 – 111Combined sources12
Helixi115 – 120Combined sources6
Helixi122 – 136Combined sources15
Helixi137 – 139Combined sources3
Beta strandi142 – 145Combined sources4
Beta strandi148 – 159Combined sources12
Beta strandi162 – 166Combined sources5
Beta strandi169 – 171Combined sources3
Helixi172 – 185Combined sources14
Beta strandi189 – 193Combined sources5
Helixi200 – 212Combined sources13
Beta strandi218 – 221Combined sources4
Turni226 – 228Combined sources3
Helixi229 – 234Combined sources6
Beta strandi241 – 246Combined sources6
Helixi248 – 260Combined sources13
Beta strandi265 – 269Combined sources5
Beta strandi275 – 278Combined sources4
Helixi284 – 296Combined sources13
Helixi297 – 300Combined sources4
Beta strandi308 – 312Combined sources5
Helixi313 – 327Combined sources15
Helixi348 – 364Combined sources17
Beta strandi367 – 370Combined sources4
Beta strandi373 – 379Combined sources7
Beta strandi385 – 389Combined sources5
Helixi395 – 398Combined sources4
Beta strandi403 – 411Combined sources9
Helixi414 – 422Combined sources9
Beta strandi428 – 433Combined sources6
Helixi437 – 446Combined sources10
Beta strandi450 – 455Combined sources6
Helixi470 – 472Combined sources3
Beta strandi473 – 475Combined sources3
Helixi479 – 484Combined sources6
Beta strandi487 – 495Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BXSX-ray2.35A/B/C/D1-501[»]
5ABMX-ray1.70A/B/C/D2-501[»]
5AC0X-ray1.90A/B1-501[»]
5AC1X-ray2.08A/B/C/D1-501[»]
ProteinModelPortaliP51977.
SMRiP51977.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51977.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118999.
HOVERGENiHBG000097.
KOiK07249.
OMAiEWHSSVS.
OrthoDBiEOG091G05E8.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSAMPDVP APLTNLQFKY TKIFINNEWH SSVSGKKFPV FNPATEEKLC
60 70 80 90 100
EVEEGDKEDV DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLIERDR
110 120 130 140 150
LLLATMEAMN GGKLFSNAYL MDLGGCIKTL RYCAGWADKI QGRTIPMDGN
160 170 180 190 200
FFTYTRSEPV GVCGQIIPWN FPLLMFLWKI GPALSCGNTV VVKPAEQTPL
210 220 230 240 250
TALHMGSLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDVD KVAFTGSTEV
260 270 280 290 300
GKLIKEAAGK SNLKRVSLEL GGKSPCIVFA DADLDNAVEF AHQGVFYHQG
310 320 330 340 350
QCCIAASRLF VEESIYDEFV RRSVERAKKY VLGNPLTPGV SQGPQIDKEQ
360 370 380 390 400
YEKILDLIES GKKEGAKLEC GGGPWGNKGY FIQPTVFSDV TDDMRIAKEE
410 420 430 440 450
IFGPVQQIMK FKSLDDVIKR ANNTFYGLSA GIFTNDIDKA ITVSSALQSG
460 470 480 490 500
TVWVNCYSVV SAQCPFGGFK MSGNGRELGE YGFHEYTEVK TVTIKISQKN

S
Length:501
Mass (Da):54,825
Last modified:January 23, 2007 - v2
Checksum:i58B897197D621AB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12761 mRNA. Translation: AAA85435.1.
PIRiS78582. S14752.
RefSeqiNP_001009778.1. NM_001009778.1.
UniGeneiOar.873.

Genome annotation databases

EnsembliENSOART00000013815; ENSOARP00000013613; ENSOARG00000012705.
GeneIDi443343.
KEGGioas:443343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12761 mRNA. Translation: AAA85435.1.
PIRiS78582. S14752.
RefSeqiNP_001009778.1. NM_001009778.1.
UniGeneiOar.873.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BXSX-ray2.35A/B/C/D1-501[»]
5ABMX-ray1.70A/B/C/D2-501[»]
5AC0X-ray1.90A/B1-501[»]
5AC1X-ray2.08A/B/C/D1-501[»]
ProteinModelPortaliP51977.
SMRiP51977.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP51977.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000013815; ENSOARP00000013613; ENSOARG00000012705.
GeneIDi443343.
KEGGioas:443343.

Organism-specific databases

CTDi216.

Phylogenomic databases

GeneTreeiENSGT00760000118999.
HOVERGENiHBG000097.
KOiK07249.
OMAiEWHSSVS.
OrthoDBiEOG091G05E8.

Enzyme and pathway databases

UniPathwayiUPA00912.

Miscellaneous databases

EvolutionaryTraceiP51977.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL1A1_SHEEP
AccessioniPrimary (citable) accession number: P51977
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.