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P51976 (DHI2_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Corticosteroid 11-beta-dehydrogenase isozyme 2

EC=1.1.1.-
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase type 2
Short name=11-DH2
Short name=11-beta-HSD2
NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Gene names
Name:HSD11B2
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

Catalytic activity

An 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH.

Subunit structure

Interacts with ligand-free cytoplasmic NR3C2 By similarity.

Subcellular location

Microsome. Endoplasmic reticulum Potential.

Tissue specificity

Highly expressed in the kidney.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Microsome
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionoxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406Corticosteroid 11-beta-dehydrogenase isozyme 2
PRO_0000054629

Regions

Nucleotide binding82 – 11130NAD By similarity

Sites

Active site2321Proton acceptor By similarity
Binding site2191Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P51976 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: F14579663918425D

FASTA40644,182
        10         20         30         40         50         60 
MERWPWPSGG AWLLVAARAL IQLLRADLRL GRPLLAALAL LAALDWLCQS LLPPSAALAV 

        70         80         90        100        110        120 
LAAAGWIALS RLARPQRLPV ATRAVLITGC DSGFGKETAK KLDAMGFTVL ATVLEMNGPG 

       130        140        150        160        170        180 
ALELRACCSP RLKLLQMDLT KPADISRALE FTKAHTTSTG LWGLVNNAGH NDVVADVELS 

       190        200        210        220        230        240 
PVATFRNCME VNFFGALELT KGLLPLLHHS RGRIVTLGSP AGEMPYPCLA AYGTSKAAMA 

       250        260        270        280        290        300 
LLMDAFSCEL LPWGVKVSVI QPGCFKTESV SNVSHWEQRK QLLLANLPGE LRQAYGEDYI 

       310        320        330        340        350        360 
EHLHREFLHS LRLALPDLSP VVDAITDALL AARPRPRYYP GRGLGLMYFI HYYLPEGLRR 

       370        380        390        400 
RFLQSFFIIP CLPRALRPGQ PGATPAPDTA QDNPNPNPDP SLVGAR 

« Hide

References

[1]"Expression cloning of the aldosterone target cell-specific 11 beta-hydroxysteroid dehydrogenase from rabbit collecting duct cells."
Naray-Fejes-Toth A., Fejes-Toth G.
Endocrinology 136:2579-2586(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New Zealand white.
Tissue: Kidney cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U23835 mRNA. Translation: AAA86387.1.
PIRI46535.
RefSeqNP_001076221.1. NM_001082752.1.
UniGeneOcu.2046.

3D structure databases

ProteinModelPortalP51976.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000010179.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009531.

Organism-specific databases

CTD3291.

Phylogenomic databases

eggNOGCOG1028.
HOVERGENHBG005482.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHI2_RABIT
AccessionPrimary (citable) accession number: P51976
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families