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P51976

- DHI2_RABIT

UniProt

P51976 - DHI2_RABIT

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Protein

Corticosteroid 11-beta-dehydrogenase isozyme 2

Gene

HSD11B2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

Catalytic activityi

An 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei219 – 2191SubstrateBy similarity
Active sitei232 – 2321Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi82 – 11130NADBy similarityAdd
BLAST

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC:1.1.1.-)
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase type 2
Short name:
11-DH2
Short name:
11-beta-HSD2
NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Gene namesi
Name:HSD11B2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Corticosteroid 11-beta-dehydrogenase isozyme 2PRO_0000054629Add
BLAST

Expressioni

Tissue specificityi

Highly expressed in the kidney.

Interactioni

Subunit structurei

Interacts with ligand-free cytoplasmic NR3C2.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000010179.

Structurei

3D structure databases

ProteinModelPortaliP51976.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG005482.
InParanoidiP51976.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51976-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERWPWPSGG AWLLVAARAL IQLLRADLRL GRPLLAALAL LAALDWLCQS
60 70 80 90 100
LLPPSAALAV LAAAGWIALS RLARPQRLPV ATRAVLITGC DSGFGKETAK
110 120 130 140 150
KLDAMGFTVL ATVLEMNGPG ALELRACCSP RLKLLQMDLT KPADISRALE
160 170 180 190 200
FTKAHTTSTG LWGLVNNAGH NDVVADVELS PVATFRNCME VNFFGALELT
210 220 230 240 250
KGLLPLLHHS RGRIVTLGSP AGEMPYPCLA AYGTSKAAMA LLMDAFSCEL
260 270 280 290 300
LPWGVKVSVI QPGCFKTESV SNVSHWEQRK QLLLANLPGE LRQAYGEDYI
310 320 330 340 350
EHLHREFLHS LRLALPDLSP VVDAITDALL AARPRPRYYP GRGLGLMYFI
360 370 380 390 400
HYYLPEGLRR RFLQSFFIIP CLPRALRPGQ PGATPAPDTA QDNPNPNPDP

SLVGAR
Length:406
Mass (Da):44,182
Last modified:October 1, 1996 - v1
Checksum:iF14579663918425D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23835 mRNA. Translation: AAA86387.1.
PIRiI46535.
RefSeqiNP_001076221.1. NM_001082752.1.
UniGeneiOcu.2046.

Genome annotation databases

GeneIDi100009531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23835 mRNA. Translation: AAA86387.1 .
PIRi I46535.
RefSeqi NP_001076221.1. NM_001082752.1.
UniGenei Ocu.2046.

3D structure databases

ProteinModelPortali P51976.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000010179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100009531.

Organism-specific databases

CTDi 3291.

Phylogenomic databases

eggNOGi COG1028.
HOVERGENi HBG005482.
InParanoidi P51976.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression cloning of the aldosterone target cell-specific 11 beta-hydroxysteroid dehydrogenase from rabbit collecting duct cells."
    Naray-Fejes-Toth A., Fejes-Toth G.
    Endocrinology 136:2579-2586(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Kidney cortex.

Entry informationi

Entry nameiDHI2_RABIT
AccessioniPrimary (citable) accession number: P51976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3