Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P51976

- DHI2_RABIT

UniProt

P51976 - DHI2_RABIT

Protein

Corticosteroid 11-beta-dehydrogenase isozyme 2

Gene

HSD11B2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

    Catalytic activityi

    An 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei219 – 2191SubstrateBy similarity
    Active sitei232 – 2321Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi82 – 11130NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC:1.1.1.-)
    Alternative name(s):
    11-beta-hydroxysteroid dehydrogenase type 2
    Short name:
    11-DH2
    Short name:
    11-beta-HSD2
    NAD-dependent 11-beta-hydroxysteroid dehydrogenase
    Gene namesi
    Name:HSD11B2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Corticosteroid 11-beta-dehydrogenase isozyme 2PRO_0000054629Add
    BLAST

    Expressioni

    Tissue specificityi

    Highly expressed in the kidney.

    Interactioni

    Subunit structurei

    Interacts with ligand-free cytoplasmic NR3C2.By similarity

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000010179.

    Structurei

    3D structure databases

    ProteinModelPortaliP51976.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG005482.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51976-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERWPWPSGG AWLLVAARAL IQLLRADLRL GRPLLAALAL LAALDWLCQS    50
    LLPPSAALAV LAAAGWIALS RLARPQRLPV ATRAVLITGC DSGFGKETAK 100
    KLDAMGFTVL ATVLEMNGPG ALELRACCSP RLKLLQMDLT KPADISRALE 150
    FTKAHTTSTG LWGLVNNAGH NDVVADVELS PVATFRNCME VNFFGALELT 200
    KGLLPLLHHS RGRIVTLGSP AGEMPYPCLA AYGTSKAAMA LLMDAFSCEL 250
    LPWGVKVSVI QPGCFKTESV SNVSHWEQRK QLLLANLPGE LRQAYGEDYI 300
    EHLHREFLHS LRLALPDLSP VVDAITDALL AARPRPRYYP GRGLGLMYFI 350
    HYYLPEGLRR RFLQSFFIIP CLPRALRPGQ PGATPAPDTA QDNPNPNPDP 400
    SLVGAR 406
    Length:406
    Mass (Da):44,182
    Last modified:October 1, 1996 - v1
    Checksum:iF14579663918425D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U23835 mRNA. Translation: AAA86387.1.
    PIRiI46535.
    RefSeqiNP_001076221.1. NM_001082752.1.
    UniGeneiOcu.2046.

    Genome annotation databases

    GeneIDi100009531.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U23835 mRNA. Translation: AAA86387.1 .
    PIRi I46535.
    RefSeqi NP_001076221.1. NM_001082752.1.
    UniGenei Ocu.2046.

    3D structure databases

    ProteinModelPortali P51976.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000010179.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100009531.

    Organism-specific databases

    CTDi 3291.

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG005482.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of the aldosterone target cell-specific 11 beta-hydroxysteroid dehydrogenase from rabbit collecting duct cells."
      Naray-Fejes-Toth A., Fejes-Toth G.
      Endocrinology 136:2579-2586(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New Zealand white.
      Tissue: Kidney cortex.

    Entry informationi

    Entry nameiDHI2_RABIT
    AccessioniPrimary (citable) accession number: P51976
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3