ID   DHI1_SHEEP              Reviewed;         292 AA.
AC   P51975;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 61.
DE   RecName: Full=Corticosteroid 11-beta-dehydrogenase isozyme 1;
DE            EC=1.1.1.146;
DE   AltName: Full=11-beta-hydroxysteroid dehydrogenase 1;
DE            Short=11-beta-HSD1;
DE            Short=11-DH;
GN   Name=HSD11B1;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   MEDLINE=93048946; PubMed=1425412; DOI=10.1210/en.131.5.2120;
RA   Yang K., Smith C.L., Dales D., Hammond G.L., Challis J.R.;
RT   "Cloning of an ovine 11 beta-hydroxysteroid dehydrogenase
RT   complementary deoxyribonucleic acid: tissue and temporal distribution
RT   of its messenger ribonucleic acid during fetal and neonatal
RT   development.";
RL   Endocrinology 131:2120-2126(1992).
CC   -!- FUNCTION: Catalyzes reversibly the conversion of corticosterone to
CC       11-dehydrocorticosterone.
CC   -!- CATALYTIC ACTIVITY: An 11-beta-hydroxysteroid + NADP(+) = an 11-
CC       oxosteroid + NADPH.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC       type II membrane protein.
CC   -!- TISSUE SPECIFICITY: Liver, kidney, lung, hypothalamus, anterior
CC       pituitary and placenta.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; X69561; CAA49290.1; -; mRNA.
DR   PIR; S33117; S33117.
DR   RefSeq; NP_001009395.1; -.
DR   UniGene; Oar.418; -.
DR   SMR; P51975; 23-288, 24-289.
DR   GeneID; 443409; -.
DR   HOVERGEN; P51975; -.
DR   BRENDA; 1.1.1.146; 271.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070524; F:11-beta-hydroxysteroid dehydrogenase (NADP+...; IEA:EC.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Lipid metabolism; Membrane; NADP;
KW   Oxidoreductase; Signal-anchor; Steroid metabolism; Transmembrane.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    292       Corticosteroid 11-beta-dehydrogenase
FT                                isozyme 1.
FT                                /FTId=PRO_0000054625.
FT   TOPO_DOM      2      7       Cytoplasmic (Potential).
FT   TRANSMEM      8     24       Signal-anchor for type II membrane
FT                                protein (Potential).
FT   TOPO_DOM     25    292       Lumenal (Potential).
FT   NP_BIND      34     63       NADP (By similarity).
FT   ACT_SITE    183    183       Proton acceptor (By similarity).
FT   BINDING     170    170       Substrate (By similarity).
FT   CARBOHYD     95     95       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    207    207       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   292 AA;  32154 MW;  ADBD024E73EB95E3 CRC64;
     MAFMKKYLLP ILGIFLAYYY YSANEEFRPE MLRGKRVIVT GASKGIGREM AYHLARMGAH
     VVVTARSEES LKKVVSRCLE LGAASAHYVA GTMENMTFAE QFVAKAGELV GGLDMLILNH
     INYTPLRVFS NDIHLLRRSL EVNLLSYVVL STAALPMLKQ TSGSIVVVSS VAGKIACPLA
     AAYSASKFAL DGFFSSLRTE YEATKVNVSI TLCILGLIDT DTAMKAVAGI YNAEASPKEE
     CALEIIKGGA LRQDEVYYDN SILTSLLLKN PGRKIMEFLS LKKYNMERFI NN
//