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P51975 (DHI1_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Corticosteroid 11-beta-dehydrogenase isozyme 1
EC=1.1.1.146
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase 1
Short name=11-DH
Short name=11-beta-HSD1
Gene names
Name:HSD11B1
OrganismOvis aries (Sheep)
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes reversibly the conversion of corticosterone to 11-dehydrocorticosterone.

Catalytic activity

An 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH.

Subunit structure

Homodimer By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Tissue specificity

Liver, kidney, lung, hypothalamus, anterior pituitary and placenta.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 292291Corticosteroid 11-beta-dehydrogenase isozyme 1
PRO_0000054625

Regions

Topological domain2 – 76Cytoplasmic Potential
Transmembrane8 – 2417Helical; Signal-anchor for type II membrane protein; Potential
Topological domain25 – 292268Lumenal Potential
Nucleotide binding41 – 6727NADP By similarity
Nucleotide binding92 – 932NADP By similarity
Nucleotide binding119 – 1213NADP By similarity
Nucleotide binding183 – 1875NADP By similarity
Nucleotide binding216 – 2227NADP By similarity

Sites

Active site1831Proton acceptor By similarity
Binding site1701Substrate By similarity

Amino acid modifications

Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation2071N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P51975 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: ADBD024E73EB95E3

FASTA29232,154
        10         20         30         40         50         60 
MAFMKKYLLP ILGIFLAYYY YSANEEFRPE MLRGKRVIVT GASKGIGREM AYHLARMGAH 

        70         80         90        100        110        120 
VVVTARSEES LKKVVSRCLE LGAASAHYVA GTMENMTFAE QFVAKAGELV GGLDMLILNH 

       130        140        150        160        170        180 
INYTPLRVFS NDIHLLRRSL EVNLLSYVVL STAALPMLKQ TSGSIVVVSS VAGKIACPLA 

       190        200        210        220        230        240 
AAYSASKFAL DGFFSSLRTE YEATKVNVSI TLCILGLIDT DTAMKAVAGI YNAEASPKEE 

       250        260        270        280        290 
CALEIIKGGA LRQDEVYYDN SILTSLLLKN PGRKIMEFLS LKKYNMERFI NN

« Hide

References

[1]"Cloning of an ovine 11 beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development."
Yang K., Smith C.L., Dales D., Hammond G.L., Challis J.R.
Endocrinology 131:2120-2126(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X69561 mRNA. Translation: CAA49290.1.
PIRS33117.
RefSeqNP_001009395.1. NM_001009395.2.
UniGeneOar.418.

3D structure databases

ProteinModelPortalP51975.
SMRP51975. Positions 24-289.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID443409.

Organism-specific databases

CTD3290.

Phylogenomic databases

HOVERGENHBG005481.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHI1_SHEEP
AccessionPrimary (citable) accession number: P51975
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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