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Protein

Paired box protein Pax-8

Gene

Pax8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-8
Gene namesi
Name:Pax8
Synonyms:Pax-8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620434. Pax8.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: UniProtKB
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Paired box protein Pax-8PRO_0000050199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei304 – 3041PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP51974.

PTM databases

iPTMnetiP51974.
PhosphoSiteiP51974.

Expressioni

Gene expression databases

ExpressionAtlasiP51974. baseline and differential.
GenevisibleiP51974. RN.

Interactioni

Subunit structurei

Interacts with WWTR1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Nkx2-1P234415EBI-1223113,EBI-1223127
Wbp2Q8R4784EBI-1223113,EBI-1223229

Protein-protein interaction databases

IntActiP51974. 2 interactions.
MINTiMINT-275462.
STRINGi10116.ENSRNOP00000033966.

Structurei

3D structure databases

ProteinModelPortaliP51974.
SMRiP51974. Positions 12-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 135127PairedPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi316 – 32813Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 paired domain.PROSITE-ProRule annotation

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiKOG3862. Eukaryota.
ENOG410ZT0S. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230938.
HOVERGENiHBG009115.
InParanoidiP51974.
KOiK09293.
PhylomeDBiP51974.
TreeFamiTF315397.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
PF12403. Pax2_C. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51974-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ
60 70 80 90 100
LRVSHGCVSK ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP
110 120 130 140 150
TMFAWEIRDR LLAEGVCDND TVPSVSSINR IIRTKVQQPF NLPMDSCVAT
160 170 180 190 200
KSLSPGHTLI PSSAVTPPES PQSDSLGSTY SINGLLGIAQ PGSDNKRKMD
210 220 230 240 250
DSDQDSCRLS IDSQSSSSGP RKHLRTDTFG QHHLEPLECP FERQHYPEAY
260 270 280 290 300
ASPSHTKGEQ GLYPLPLLNS TLDDGKATLT PSNTPLGRNL STHQTYPVVA
310 320 330 340 350
DPHSPYAIKQ ETPELSSSSS TPSSLSSSAF LDLQQVGSGG PAGASVPPFN
360 370 380 390 400
AFSHAASVYG QFTGQALLSG REMVGPTLPG YPPHIPTSGQ GSYASSAIAG
410 420 430 440 450
MVAGSEYSGN AYSHTPYASY SEAWRFPNSS LLSSPYYYSS TTRPSAPPTS

ATAFDHL
Length:457
Mass (Da):48,806
Last modified:September 5, 2006 - v2
Checksum:i50946E0829936D62
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1831N → H in CAA63930 (Ref. 1) Curated
Sequence conflicti191 – 1911P → A in CAA63930 (Ref. 1) Curated
Sequence conflicti195 – 1995NKRKM → THRGRC in CAA63930 (Ref. 1) Curated
Sequence conflicti205 – 2062DS → GQ in CAA63930 (Ref. 1) Curated
Sequence conflicti377 – 3771T → S in CAA63930 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94246 mRNA. Translation: CAA63930.1.
BC081779 mRNA. Translation: AAH81779.1.
RefSeqiNP_112403.2. NM_031141.2.
UniGeneiRn.10392.

Genome annotation databases

EnsembliENSRNOT00000031058; ENSRNOP00000033966; ENSRNOG00000026203.
GeneIDi81819.
KEGGirno:81819.
UCSCiRGD:620434. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94246 mRNA. Translation: CAA63930.1.
BC081779 mRNA. Translation: AAH81779.1.
RefSeqiNP_112403.2. NM_031141.2.
UniGeneiRn.10392.

3D structure databases

ProteinModelPortaliP51974.
SMRiP51974. Positions 12-135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP51974. 2 interactions.
MINTiMINT-275462.
STRINGi10116.ENSRNOP00000033966.

PTM databases

iPTMnetiP51974.
PhosphoSiteiP51974.

Proteomic databases

PaxDbiP51974.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000031058; ENSRNOP00000033966; ENSRNOG00000026203.
GeneIDi81819.
KEGGirno:81819.
UCSCiRGD:620434. rat.

Organism-specific databases

CTDi7849.
RGDi620434. Pax8.

Phylogenomic databases

eggNOGiKOG3862. Eukaryota.
ENOG410ZT0S. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230938.
HOVERGENiHBG009115.
InParanoidiP51974.
KOiK09293.
PhylomeDBiP51974.
TreeFamiTF315397.

Miscellaneous databases

PROiP51974.

Gene expression databases

ExpressionAtlasiP51974. baseline and differential.
GenevisibleiP51974. RN.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
PF12403. Pax2_C. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Zannini M.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thyroid.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiPAX8_RAT
AccessioniPrimary (citable) accession number: P51974
Secondary accession number(s): Q66HM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 5, 2006
Last modified: June 8, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.