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Protein

Paired box protein Pax-8

Gene

Pax8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-8
Gene namesi
Name:Pax8
Synonyms:Pax-8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620434 Pax8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501991 – 457Paired box protein Pax-8Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei304PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP51974

PTM databases

iPTMnetiP51974
PhosphoSitePlusiP51974

Expressioni

Gene expression databases

BgeeiENSRNOG00000026203
ExpressionAtlasiP51974 baseline and differential
GenevisibleiP51974 RN

Interactioni

Subunit structurei

Interacts with WWTR1.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiP51974, 2 interactors
STRINGi10116.ENSRNOP00000033966

Structurei

3D structure databases

ProteinModelPortaliP51974
SMRiP51974
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 135PairedPROSITE-ProRule annotationAdd BLAST127

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi316 – 328Ser-richAdd BLAST13

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiKOG3862 Eukaryota
ENOG410ZT0S LUCA
GeneTreeiENSGT00680000099553
HOGENOMiHOG000230938
HOVERGENiHBG009115
InParanoidiP51974
KOiK09293
OMAiDTFSQHH
OrthoDBiEOG091G0S4E
PhylomeDBiP51974
TreeFamiTF315397

Family and domain databases

CDDicd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR022130 Pax2_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PF12403 Pax2_C, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

P51974-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ
60 70 80 90 100
LRVSHGCVSK ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP
110 120 130 140 150
TMFAWEIRDR LLAEGVCDND TVPSVSSINR IIRTKVQQPF NLPMDSCVAT
160 170 180 190 200
KSLSPGHTLI PSSAVTPPES PQSDSLGSTY SINGLLGIAQ PGSDNKRKMD
210 220 230 240 250
DSDQDSCRLS IDSQSSSSGP RKHLRTDTFG QHHLEPLECP FERQHYPEAY
260 270 280 290 300
ASPSHTKGEQ GLYPLPLLNS TLDDGKATLT PSNTPLGRNL STHQTYPVVA
310 320 330 340 350
DPHSPYAIKQ ETPELSSSSS TPSSLSSSAF LDLQQVGSGG PAGASVPPFN
360 370 380 390 400
AFSHAASVYG QFTGQALLSG REMVGPTLPG YPPHIPTSGQ GSYASSAIAG
410 420 430 440 450
MVAGSEYSGN AYSHTPYASY SEAWRFPNSS LLSSPYYYSS TTRPSAPPTS

ATAFDHL
Length:457
Mass (Da):48,806
Last modified:September 5, 2006 - v2
Checksum:i50946E0829936D62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183N → H in CAA63930 (Ref. 1) Curated1
Sequence conflicti191P → A in CAA63930 (Ref. 1) Curated1
Sequence conflicti195 – 199NKRKM → THRGRC in CAA63930 (Ref. 1) Curated5
Sequence conflicti205 – 206DS → GQ in CAA63930 (Ref. 1) Curated2
Sequence conflicti377T → S in CAA63930 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94246 mRNA Translation: CAA63930.1
BC081779 mRNA Translation: AAH81779.1
RefSeqiNP_112403.2, NM_031141.2
UniGeneiRn.10392

Genome annotation databases

EnsembliENSRNOT00000031058; ENSRNOP00000033966; ENSRNOG00000026203
GeneIDi81819
KEGGirno:81819
UCSCiRGD:620434 rat

Similar proteinsi

Entry informationi

Entry nameiPAX8_RAT
AccessioniPrimary (citable) accession number: P51974
Secondary accession number(s): Q66HM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health