P51961 (RISA_PHOPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
October 19, 2011.
Version 57.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Riboflavin synthase alpha chain EC=2.5.1.9 | ||
| Gene names |
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| Organism | Photobacterium phosphoreum | ||
| Taxonomic identifier | 659 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium |
Protein attributes
| Sequence length | 218 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 6,7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione. |
| Catalytic activity | 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. |
| Pathway | |
| Subunit structure | Oligomer that consist of 3 alpha subunits and 60 beta subunits By similarity. |
| Sequence similarities | Contains 2 lumazine-binding repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Riboflavin biosynthesis |
| Domain | Repeat |
| Molecular function | Transferase |
| Gene Ontology (GO) | |
| Biological process | riboflavin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | oxidoreductase activity Inferred from electronic annotation. Source: InterPro riboflavin synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Riboflavin synthesis genes are linked with the lux operon of Photobacterium phosphoreum." Lee C.Y., O'Kane D.J., Meighen E.A. J. Bacteriol. 176:2100-2104(1994) [PubMed: 8144477] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 2167 / LMG 4231 / NCIMB 844. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L11391 Genomic DNA. Translation: AAA25628.1. |
3D structure databases | |
| ProteinModelPortal | P51961. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR023366. ATPase_F1/A1-cplx_a_su_N. IPR001783. Lumazine-bd. IPR017938. Riboflavin_synthase-like_b-brl. [Graphical view] |
| Gene3D | G3DSA:2.40.30.20. G3DSA:2.40.30.20. 2 hits. |
| PANTHER | PTHR21098. Lumazine_bd. 1 hit. |
| Pfam | PF00677. Lum_binding. 2 hits. [Graphical view] |
| PIRSF | PIRSF000498. Riboflavin_syn_A. 1 hit. |
| SUPFAM | SSF63380. Riboflavin_synthase_like_b-brl. 2 hits. |
| TIGRFAMs | TIGR00187. RibE. 1 hit. |
| PROSITE | PS51177. LUMAZINE_BIND. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RISA_PHOPO | ||||||||
| Accession | Primary (citable) accession number: P51961 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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