P51961 (RISA_PHOPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Riboflavin synthase
Short name=RS
EC=2.5.1.9

Gene names

Name:

ribE

Organism

Photobacterium phosphoreum

Taxonomic identifier

659 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil By similarity.
Catalytic activity	2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.
Subunit structure	Homotrimer By similarity.
Sequence similarities	Contains 2 lumazine-binding repeats.

Ontologies

Keywords
Biological process	Riboflavin biosynthesis
Domain	Repeat
Molecular function	Transferase
Gene Ontology (GO)
Biological_process	riboflavin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	oxidoreductase activity Inferred from electronic annotation. Source: InterPro riboflavin synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Riboflavin synthase		PRO_0000068171
Regions
	Repeat	1 – 97	97	Lumazine-binding 1
	Repeat	98 – 194	97	Lumazine-binding 2
	Region	4 – 6	3	Substrate binding By similarity
	Region	48 – 50	3	Substrate binding By similarity
	Region	62 – 67	6	Substrate binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51961 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 309B197A71430975	FASTA	218	23,639
	10 20 30 40 50 60 MFTGIIEAVG NISAITSKGS DFEVSVNCDT LDLADVKIGD SIATNGICLT VVKLTANSYV 70 80 90 100 110 120 ADLSIETLSR TAFNYYKVGQ AVNLEKAMLP TTRFGGHIVS GHVDAVAEVI ECRTSGRAID 130 140 150 160 170 180 IWIRVPSQIE KYLSEKGSVT VDGVSLTVNA VTGNEFKLTI VPHTVVETTI ADFKVGNKVN 190 200 210 IEVDVLARYI ERLLLVDKPE DKQSKISMDL LERNGFLL

References

[1]	"Riboflavin synthesis genes are linked with the lux operon of Photobacterium phosphoreum." Lee C.Y., O'Kane D.J., Meighen E.A. J. Bacteriol. 176:2100-2104(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 2167 / LMG 4231 / NCIMB 844.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L11391 Genomic DNA. Translation: AAA25628.1.
3D structure databases
ProteinModelPortal	P51961.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00275; UER00405.
Family and domain databases
Gene3D	2.40.30.20. 2 hits.
InterPro	IPR023366. ATPase_F1/A1-cplx_a_su_N. IPR001783. Lumazine-bd. IPR026017. Lumazine-bd_dom. IPR017938. Riboflavin_synthase-like_b-brl. [Graphical view]
PANTHER	PTHR21098. PTHR21098. 1 hit.
Pfam	PF00677. Lum_binding. 2 hits. [Graphical view]
PIRSF	PIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAM	SSF63380. Riboflavin_synthase_like_b-brl. 2 hits.
TIGRFAMs	TIGR00187. ribE. 1 hit.
PROSITE	PS51177. LUMAZINE_BIND. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RISA_PHOPO

Accession

Primary (citable) accession number: P51961

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program