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P51959 (CCNG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-G1

Short name=Cyclin-G
Gene names
Name:CCNG1
Synonyms:CCNG, CYCG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation By similarity.

Subcellular location

Nucleus. Note: DNA replication foci after DNA damage. Ref.4

Tissue specificity

High levels in skeletal muscle, ovary, kidney and colon.

Developmental stage

Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle.

Induction

Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage.

Sequence similarities

Belongs to the cyclin family. Cyclin G subfamily.

Sequence caution

The sequence AAB03903.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA54821.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TNIP1Q150254EBI-3905829,EBI-357849

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Cyclin-G1
PRO_0000080465

Natural variations

Natural variant1781N → H. Ref.7
Corresponds to variant rs2069352 [ dbSNP | Ensembl ].
VAR_021079
Natural variant1791F → L. Ref.7
Corresponds to variant rs11541970 [ dbSNP | Ensembl ].
VAR_021080

Experimental info

Sequence conflict1281R → M in AAB03903. Ref.4
Sequence conflict2561K → E in AAH07093. Ref.9
Sequence conflict275 – 29521RQLKH…PEMVP → LKWSLNWIITAPKNFSEAFL HNLVLWIP in AAB03903. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P51959 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: EA0B02C83F3B6BF3

FASTA29534,074
        10         20         30         40         50         60 
MIEVLTTTDS QKLLHQLNAL LEQESRCQPK VCGLRLIESA HDNGLRMTAR LRDFEVKDLL 

        70         80         90        100        110        120 
SLTQFFGFDT ETFSLAVNLL DRFLSKMKVQ PKHLGCVGLS CFYLAVKSIE EERNVPLATD 

       130        140        150        160        170        180 
LIRISQYRFT VSDLMRMEKI VLEKVCWKVK ATTAFQFLQL YYSLLQENLP LERRNSINFE 

       190        200        210        220        230        240 
RLEAQLKACH CRIIFSKAKP SVLALSIIAL EIQAQKCVEL TEGIECLQKH SKINGRDLTF 

       250        260        270        280        290 
WQELVSKCLT EYSSNKCSKP NVQKLKWIVS GRTARQLKHS YYRITHLPTI PEMVP 

« Hide

References

« Hide 'large scale' references
[1]"Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression."
Horne M.C., Goolsby G.L., Donaldson K.L., Tran D., Neubauer M.G., Wahl A.F.
J. Biol. Chem. 271:6050-6061(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterisation of human cyclin G1 and G2: DNA damage inducible genes."
Bates S.A., Rowan S., Vousden K.H.
Oncogene 13:1103-1109(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal spleen.
[3]"Structure and chromosomal assignment of the human cyclin G gene."
Endo Y., Fujita T., Tamura K., Tsuruga H., Nojima H.
Genomics 38:92-95(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[4]"Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells."
Reimer C.L., Borras A.M., Kurdistani S.K., Garreau J.R., Chung M., Aaronson S.A., Lee S.W.
J. Biol. Chem. 274:11022-11029(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
Tissue: Mammary gland.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]NIEHS SNPs program
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-178 AND LEU-179.
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Prostate.
[10]Wu L., Hall F.L.
Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-295.
Tissue: Fibroblast.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L49504 mRNA. Translation: AAC41977.1.
U47413 mRNA. Translation: AAC50688.1.
D86077 Genomic DNA. Translation: BAA13007.1.
D78341 mRNA. Translation: BAA11353.1.
U53328 mRNA. Translation: AAB03903.1. Different initiation.
AK312913 mRNA. Translation: BAG35759.1.
BT007134 mRNA. Translation: AAP35798.1.
AY791292 Genomic DNA. Translation: AAV40836.1.
CH471062 Genomic DNA. Translation: EAW61528.1.
CH471062 Genomic DNA. Translation: EAW61529.1.
CH471062 Genomic DNA. Translation: EAW61530.1.
BC000196 mRNA. Translation: AAH00196.1.
BC007093 mRNA. Translation: AAH07093.1.
X77794 mRNA. Translation: CAA54821.1. Different initiation.
PIRG02401.
RefSeqNP_004051.1. NM_004060.3.
NP_954854.1. NM_199246.1.
UniGeneHs.79101.

3D structure databases

ProteinModelPortalP51959.
SMRP51959. Positions 15-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107340. 16 interactions.
IntActP51959. 9 interactions.
MINTMINT-4299131.
STRING9606.ENSP00000344635.

PTM databases

PhosphoSiteP51959.

Polymorphism databases

DMDM2506334.

Proteomic databases

PaxDbP51959.
PRIDEP51959.

Protocols and materials databases

DNASU900.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000340828; ENSP00000344635; ENSG00000113328.
ENST00000393929; ENSP00000377506; ENSG00000113328.
GeneID900.
KEGGhsa:900.
UCSCuc003lzb.3. human.

Organism-specific databases

CTD900.
GeneCardsGC05P162864.
HGNCHGNC:1592. CCNG1.
HPACAB000350.
MIM601578. gene.
neXtProtNX_P51959.
PharmGKBPA26157.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG281302.
HOGENOMHOG000059559.
HOVERGENHBG050839.
InParanoidP51959.
KOK10145.
OMASDMMRME.
OrthoDBEOG7HB59M.
PhylomeDBP51959.
TreeFamTF101007.

Enzyme and pathway databases

SignaLinkP51959.

Gene expression databases

ArrayExpressP51959.
BgeeP51959.
CleanExHS_CCNG1.
GenevestigatorP51959.

Family and domain databases

Gene3D1.10.472.10. 1 hit.
InterProIPR028860. CCNG1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERPTHR10177:SF5. PTHR10177:SF5. 1 hit.
PfamPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 1 hit.
ProtoNetSearch...

Other

GeneWikiCCNG1.
GenomeRNAi900.
NextBio3718.
PROP51959.
SOURCESearch...

Entry information

Entry nameCCNG1_HUMAN
AccessionPrimary (citable) accession number: P51959
Secondary accession number(s): B2R7B2 expand/collapse secondary AC list , D3DQK7, Q15757, Q96L32
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: March 19, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM