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Protein

Cyclin-G1

Gene

CCNG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

SignaLinkiP51959.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-G1
Short name:
Cyclin-G
Gene namesi
Name:CCNG1
Synonyms:CCNG, CYCG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1592. CCNG1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26157.

Polymorphism and mutation databases

BioMutaiCCNG1.
DMDMi2506334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Cyclin-G1PRO_0000080465Add
BLAST

Proteomic databases

PaxDbiP51959.
PRIDEiP51959.

PTM databases

PhosphoSiteiP51959.

Expressioni

Tissue specificityi

High levels in skeletal muscle, ovary, kidney and colon.

Developmental stagei

Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle.

Inductioni

Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage.

Gene expression databases

BgeeiP51959.
CleanExiHS_CCNG1.
ExpressionAtlasiP51959. baseline and differential.
GenevisibleiP51959. HS.

Organism-specific databases

HPAiCAB000350.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HMBOX1Q6NT763EBI-3905829,EBI-2549423
KRT40Q6A1623EBI-3905829,EBI-10171697
KRTAP10-7P604093EBI-3905829,EBI-10172290
LZTS2Q9BRK43EBI-3905829,EBI-741037
PAK7Q8TB933EBI-3905829,EBI-741896
PNMA1Q8ND903EBI-3905829,EBI-302345
RBPMSQ930623EBI-3905829,EBI-740322
SPERTQ8NA613EBI-3905829,EBI-741724
TFIP11Q9UBB93EBI-3905829,EBI-1105213
TNIP1Q150257EBI-3905829,EBI-357849

Protein-protein interaction databases

BioGridi107340. 37 interactions.
IntActiP51959. 18 interactions.
MINTiMINT-4299131.
STRINGi9606.ENSP00000344635.

Structurei

3D structure databases

ProteinModelPortaliP51959.
SMRiP51959. Positions 17-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin G subfamily.Curated

Phylogenomic databases

eggNOGiNOG281302.
GeneTreeiENSGT00530000062971.
HOGENOMiHOG000059559.
HOVERGENiHBG050839.
InParanoidiP51959.
KOiK10145.
OMAiSDMMRME.
OrthoDBiEOG7HB59M.
PhylomeDBiP51959.
TreeFamiTF101007.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR028860. CCNG1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF59. PTHR10177:SF59. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51959-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIEVLTTTDS QKLLHQLNAL LEQESRCQPK VCGLRLIESA HDNGLRMTAR
60 70 80 90 100
LRDFEVKDLL SLTQFFGFDT ETFSLAVNLL DRFLSKMKVQ PKHLGCVGLS
110 120 130 140 150
CFYLAVKSIE EERNVPLATD LIRISQYRFT VSDLMRMEKI VLEKVCWKVK
160 170 180 190 200
ATTAFQFLQL YYSLLQENLP LERRNSINFE RLEAQLKACH CRIIFSKAKP
210 220 230 240 250
SVLALSIIAL EIQAQKCVEL TEGIECLQKH SKINGRDLTF WQELVSKCLT
260 270 280 290
EYSSNKCSKP NVQKLKWIVS GRTARQLKHS YYRITHLPTI PEMVP
Length:295
Mass (Da):34,074
Last modified:November 1, 1997 - v2
Checksum:iEA0B02C83F3B6BF3
GO
Isoform 2 (identifier: P51959-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Note: No experimental confirmation available.
Show »
Length:161
Mass (Da):18,769
Checksum:i9FE30F82BC8EF510
GO

Sequence cautioni

The sequence AAB03903.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA54821.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281R → M in AAB03903 (PubMed:10196184).Curated
Sequence conflicti256 – 2561K → E in AAH07093 (PubMed:15489334).Curated
Sequence conflicti275 – 29521RQLKH…PEMVP → LKWSLNWIITAPKNFSEAFL HNLVLWIP in AAB03903 (PubMed:10196184).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti178 – 1781N → H.1 Publication
Corresponds to variant rs2069352 [ dbSNP | Ensembl ].
VAR_021079
Natural varianti179 – 1791F → L.1 Publication
Corresponds to variant rs11541970 [ dbSNP | Ensembl ].
VAR_021080

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 134134Missing in isoform 2. 1 PublicationVSP_056943Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49504 mRNA. Translation: AAC41977.1.
U47413 mRNA. Translation: AAC50688.1.
D86077 Genomic DNA. Translation: BAA13007.1.
D78341 mRNA. Translation: BAA11353.1.
U53328 mRNA. Translation: AAB03903.1. Different initiation.
AK297190 mRNA. Translation: BAG59679.1.
AK312913 mRNA. Translation: BAG35759.1.
AK316234 mRNA. Translation: BAH14605.1.
BT007134 mRNA. Translation: AAP35798.1.
AY791292 Genomic DNA. Translation: AAV40836.1.
AC112205 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61528.1.
CH471062 Genomic DNA. Translation: EAW61529.1.
CH471062 Genomic DNA. Translation: EAW61530.1.
BC000196 mRNA. Translation: AAH00196.1.
BC007093 mRNA. Translation: AAH07093.1.
X77794 mRNA. Translation: CAA54821.1. Different initiation.
CCDSiCCDS4360.1. [P51959-1]
PIRiG02401.
RefSeqiNP_004051.1. NM_004060.3. [P51959-1]
NP_954854.1. NM_199246.1. [P51959-1]
UniGeneiHs.79101.

Genome annotation databases

EnsembliENST00000340828; ENSP00000344635; ENSG00000113328. [P51959-1]
ENST00000393929; ENSP00000377506; ENSG00000113328. [P51959-1]
ENST00000512163; ENSP00000424315; ENSG00000113328. [P51959-2]
GeneIDi900.
KEGGihsa:900.
UCSCiuc003lzb.3. human. [P51959-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49504 mRNA. Translation: AAC41977.1.
U47413 mRNA. Translation: AAC50688.1.
D86077 Genomic DNA. Translation: BAA13007.1.
D78341 mRNA. Translation: BAA11353.1.
U53328 mRNA. Translation: AAB03903.1. Different initiation.
AK297190 mRNA. Translation: BAG59679.1.
AK312913 mRNA. Translation: BAG35759.1.
AK316234 mRNA. Translation: BAH14605.1.
BT007134 mRNA. Translation: AAP35798.1.
AY791292 Genomic DNA. Translation: AAV40836.1.
AC112205 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61528.1.
CH471062 Genomic DNA. Translation: EAW61529.1.
CH471062 Genomic DNA. Translation: EAW61530.1.
BC000196 mRNA. Translation: AAH00196.1.
BC007093 mRNA. Translation: AAH07093.1.
X77794 mRNA. Translation: CAA54821.1. Different initiation.
CCDSiCCDS4360.1. [P51959-1]
PIRiG02401.
RefSeqiNP_004051.1. NM_004060.3. [P51959-1]
NP_954854.1. NM_199246.1. [P51959-1]
UniGeneiHs.79101.

3D structure databases

ProteinModelPortaliP51959.
SMRiP51959. Positions 17-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107340. 37 interactions.
IntActiP51959. 18 interactions.
MINTiMINT-4299131.
STRINGi9606.ENSP00000344635.

PTM databases

PhosphoSiteiP51959.

Polymorphism and mutation databases

BioMutaiCCNG1.
DMDMi2506334.

Proteomic databases

PaxDbiP51959.
PRIDEiP51959.

Protocols and materials databases

DNASUi900.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340828; ENSP00000344635; ENSG00000113328. [P51959-1]
ENST00000393929; ENSP00000377506; ENSG00000113328. [P51959-1]
ENST00000512163; ENSP00000424315; ENSG00000113328. [P51959-2]
GeneIDi900.
KEGGihsa:900.
UCSCiuc003lzb.3. human. [P51959-1]

Organism-specific databases

CTDi900.
GeneCardsiGC05P162864.
HGNCiHGNC:1592. CCNG1.
HPAiCAB000350.
MIMi601578. gene.
neXtProtiNX_P51959.
PharmGKBiPA26157.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG281302.
GeneTreeiENSGT00530000062971.
HOGENOMiHOG000059559.
HOVERGENiHBG050839.
InParanoidiP51959.
KOiK10145.
OMAiSDMMRME.
OrthoDBiEOG7HB59M.
PhylomeDBiP51959.
TreeFamiTF101007.

Enzyme and pathway databases

SignaLinkiP51959.

Miscellaneous databases

ChiTaRSiCCNG1. human.
GeneWikiiCCNG1.
GenomeRNAii900.
NextBioi35473160.
PROiP51959.
SOURCEiSearch...

Gene expression databases

BgeeiP51959.
CleanExiHS_CCNG1.
ExpressionAtlasiP51959. baseline and differential.
GenevisibleiP51959. HS.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR028860. CCNG1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF59. PTHR10177:SF59. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression."
    Horne M.C., Goolsby G.L., Donaldson K.L., Tran D., Neubauer M.G., Wahl A.F.
    J. Biol. Chem. 271:6050-6061(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Characterisation of human cyclin G1 and G2: DNA damage inducible genes."
    Bates S.A., Rowan S., Vousden K.H.
    Oncogene 13:1103-1109(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal spleen.
  3. "Structure and chromosomal assignment of the human cyclin G gene."
    Endo Y., Fujita T., Tamura K., Tsuruga H., Nojima H.
    Genomics 38:92-95(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  4. "Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells."
    Reimer C.L., Borras A.M., Kurdistani S.K., Garreau J.R., Chung M., Aaronson S.A., Lee S.W.
    J. Biol. Chem. 274:11022-11029(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    Tissue: Mammary gland.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. NIEHS SNPs program
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-178 AND LEU-179.
  8. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye and Prostate.
  11. Wu L., Hall F.L.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-295 (ISOFORM 1).
    Tissue: Fibroblast.

Entry informationi

Entry nameiCCNG1_HUMAN
AccessioniPrimary (citable) accession number: P51959
Secondary accession number(s): B2R7B2
, B4DLW7, D3DQK7, Q15757, Q96L32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: June 24, 2015
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.