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P51959

- CCNG1_HUMAN

UniProt

P51959 - CCNG1_HUMAN

Protein

Cyclin-G1

Gene

CCNG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cell growth Source: Ensembl
    3. mitotic G2 DNA damage checkpoint Source: Ensembl
    4. mitotic nuclear division Source: UniProtKB-KW
    5. negative regulation of apoptotic process Source: Ensembl
    6. regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
    7. response to organonitrogen compound Source: Ensembl
    8. syncytium formation Source: Ensembl

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    SignaLinkiP51959.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-G1
    Short name:
    Cyclin-G
    Gene namesi
    Name:CCNG1
    Synonyms:CCNG, CYCG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:1592. CCNG1.

    Subcellular locationi

    Nucleus 1 Publication
    Note: DNA replication foci after DNA damage.

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. neuronal cell body Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell
    4. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26157.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Cyclin-G1PRO_0000080465Add
    BLAST

    Proteomic databases

    PaxDbiP51959.
    PRIDEiP51959.

    PTM databases

    PhosphoSiteiP51959.

    Expressioni

    Tissue specificityi

    High levels in skeletal muscle, ovary, kidney and colon.

    Developmental stagei

    Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle.

    Inductioni

    Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage.

    Gene expression databases

    ArrayExpressiP51959.
    BgeeiP51959.
    CleanExiHS_CCNG1.
    GenevestigatoriP51959.

    Organism-specific databases

    HPAiCAB000350.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TNIP1Q150254EBI-3905829,EBI-357849

    Protein-protein interaction databases

    BioGridi107340. 16 interactions.
    IntActiP51959. 9 interactions.
    MINTiMINT-4299131.
    STRINGi9606.ENSP00000344635.

    Structurei

    3D structure databases

    ProteinModelPortaliP51959.
    SMRiP51959. Positions 17-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin G subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG281302.
    HOGENOMiHOG000059559.
    HOVERGENiHBG050839.
    InParanoidiP51959.
    KOiK10145.
    OMAiSDMMRME.
    OrthoDBiEOG7HB59M.
    PhylomeDBiP51959.
    TreeFamiTF101007.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR028860. CCNG1.
    IPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    [Graphical view]
    PANTHERiPTHR10177:SF59. PTHR10177:SF59. 1 hit.
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P51959-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIEVLTTTDS QKLLHQLNAL LEQESRCQPK VCGLRLIESA HDNGLRMTAR    50
    LRDFEVKDLL SLTQFFGFDT ETFSLAVNLL DRFLSKMKVQ PKHLGCVGLS 100
    CFYLAVKSIE EERNVPLATD LIRISQYRFT VSDLMRMEKI VLEKVCWKVK 150
    ATTAFQFLQL YYSLLQENLP LERRNSINFE RLEAQLKACH CRIIFSKAKP 200
    SVLALSIIAL EIQAQKCVEL TEGIECLQKH SKINGRDLTF WQELVSKCLT 250
    EYSSNKCSKP NVQKLKWIVS GRTARQLKHS YYRITHLPTI PEMVP 295
    Length:295
    Mass (Da):34,074
    Last modified:November 1, 1997 - v2
    Checksum:iEA0B02C83F3B6BF3
    GO

    Sequence cautioni

    The sequence AAB03903.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA54821.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti128 – 1281R → M in AAB03903. (PubMed:10196184)Curated
    Sequence conflicti256 – 2561K → E in AAH07093. (PubMed:15489334)Curated
    Sequence conflicti275 – 29521RQLKH…PEMVP → LKWSLNWIITAPKNFSEAFL HNLVLWIP in AAB03903. (PubMed:10196184)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti178 – 1781N → H.1 Publication
    Corresponds to variant rs2069352 [ dbSNP | Ensembl ].
    VAR_021079
    Natural varianti179 – 1791F → L.1 Publication
    Corresponds to variant rs11541970 [ dbSNP | Ensembl ].
    VAR_021080

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L49504 mRNA. Translation: AAC41977.1.
    U47413 mRNA. Translation: AAC50688.1.
    D86077 Genomic DNA. Translation: BAA13007.1.
    D78341 mRNA. Translation: BAA11353.1.
    U53328 mRNA. Translation: AAB03903.1. Different initiation.
    AK312913 mRNA. Translation: BAG35759.1.
    BT007134 mRNA. Translation: AAP35798.1.
    AY791292 Genomic DNA. Translation: AAV40836.1.
    CH471062 Genomic DNA. Translation: EAW61528.1.
    CH471062 Genomic DNA. Translation: EAW61529.1.
    CH471062 Genomic DNA. Translation: EAW61530.1.
    BC000196 mRNA. Translation: AAH00196.1.
    BC007093 mRNA. Translation: AAH07093.1.
    X77794 mRNA. Translation: CAA54821.1. Different initiation.
    CCDSiCCDS4360.1.
    PIRiG02401.
    RefSeqiNP_004051.1. NM_004060.3.
    NP_954854.1. NM_199246.1.
    UniGeneiHs.79101.

    Genome annotation databases

    EnsembliENST00000340828; ENSP00000344635; ENSG00000113328.
    ENST00000393929; ENSP00000377506; ENSG00000113328.
    GeneIDi900.
    KEGGihsa:900.
    UCSCiuc003lzb.3. human.

    Polymorphism databases

    DMDMi2506334.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L49504 mRNA. Translation: AAC41977.1 .
    U47413 mRNA. Translation: AAC50688.1 .
    D86077 Genomic DNA. Translation: BAA13007.1 .
    D78341 mRNA. Translation: BAA11353.1 .
    U53328 mRNA. Translation: AAB03903.1 . Different initiation.
    AK312913 mRNA. Translation: BAG35759.1 .
    BT007134 mRNA. Translation: AAP35798.1 .
    AY791292 Genomic DNA. Translation: AAV40836.1 .
    CH471062 Genomic DNA. Translation: EAW61528.1 .
    CH471062 Genomic DNA. Translation: EAW61529.1 .
    CH471062 Genomic DNA. Translation: EAW61530.1 .
    BC000196 mRNA. Translation: AAH00196.1 .
    BC007093 mRNA. Translation: AAH07093.1 .
    X77794 mRNA. Translation: CAA54821.1 . Different initiation.
    CCDSi CCDS4360.1.
    PIRi G02401.
    RefSeqi NP_004051.1. NM_004060.3.
    NP_954854.1. NM_199246.1.
    UniGenei Hs.79101.

    3D structure databases

    ProteinModelPortali P51959.
    SMRi P51959. Positions 17-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107340. 16 interactions.
    IntActi P51959. 9 interactions.
    MINTi MINT-4299131.
    STRINGi 9606.ENSP00000344635.

    PTM databases

    PhosphoSitei P51959.

    Polymorphism databases

    DMDMi 2506334.

    Proteomic databases

    PaxDbi P51959.
    PRIDEi P51959.

    Protocols and materials databases

    DNASUi 900.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340828 ; ENSP00000344635 ; ENSG00000113328 .
    ENST00000393929 ; ENSP00000377506 ; ENSG00000113328 .
    GeneIDi 900.
    KEGGi hsa:900.
    UCSCi uc003lzb.3. human.

    Organism-specific databases

    CTDi 900.
    GeneCardsi GC05P162864.
    HGNCi HGNC:1592. CCNG1.
    HPAi CAB000350.
    MIMi 601578. gene.
    neXtProti NX_P51959.
    PharmGKBi PA26157.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281302.
    HOGENOMi HOG000059559.
    HOVERGENi HBG050839.
    InParanoidi P51959.
    KOi K10145.
    OMAi SDMMRME.
    OrthoDBi EOG7HB59M.
    PhylomeDBi P51959.
    TreeFami TF101007.

    Enzyme and pathway databases

    SignaLinki P51959.

    Miscellaneous databases

    GeneWikii CCNG1.
    GenomeRNAii 900.
    NextBioi 3718.
    PROi P51959.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51959.
    Bgeei P51959.
    CleanExi HS_CCNG1.
    Genevestigatori P51959.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR028860. CCNG1.
    IPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    [Graphical view ]
    PANTHERi PTHR10177:SF59. PTHR10177:SF59. 1 hit.
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression."
      Horne M.C., Goolsby G.L., Donaldson K.L., Tran D., Neubauer M.G., Wahl A.F.
      J. Biol. Chem. 271:6050-6061(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterisation of human cyclin G1 and G2: DNA damage inducible genes."
      Bates S.A., Rowan S., Vousden K.H.
      Oncogene 13:1103-1109(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal spleen.
    3. "Structure and chromosomal assignment of the human cyclin G gene."
      Endo Y., Fujita T., Tamura K., Tsuruga H., Nojima H.
      Genomics 38:92-95(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    4. "Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells."
      Reimer C.L., Borras A.M., Kurdistani S.K., Garreau J.R., Chung M., Aaronson S.A., Lee S.W.
      J. Biol. Chem. 274:11022-11029(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
      Tissue: Mammary gland.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. NIEHS SNPs program
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-178 AND LEU-179.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye and Prostate.
    10. Wu L., Hall F.L.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-295.
      Tissue: Fibroblast.

    Entry informationi

    Entry nameiCCNG1_HUMAN
    AccessioniPrimary (citable) accession number: P51959
    Secondary accession number(s): B2R7B2
    , D3DQK7, Q15757, Q96L32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3