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P51959

- CCNG1_HUMAN

UniProt

P51959 - CCNG1_HUMAN

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Protein
Cyclin-G1
Gene
CCNG1, CCNG, CYCG1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. brain development Source: Ensembl
  2. cell growth Source: Ensembl
  3. mitotic G2 DNA damage checkpoint Source: Ensembl
  4. mitotic nuclear division Source: UniProtKB-KW
  5. negative regulation of apoptotic process Source: Ensembl
  6. regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
  7. response to organonitrogen compound Source: Ensembl
  8. syncytium formation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

SignaLinkiP51959.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-G1
Short name:
Cyclin-G
Gene namesi
Name:CCNG1
Synonyms:CCNG, CYCG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:1592. CCNG1.

Subcellular locationi

Nucleus
Note: DNA replication foci after DNA damage.1 Publication

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. neuronal cell body Source: Ensembl
  3. nucleus Source: UniProtKB-SubCell
  4. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Cyclin-G1
PRO_0000080465Add
BLAST

Proteomic databases

PaxDbiP51959.
PRIDEiP51959.

PTM databases

PhosphoSiteiP51959.

Expressioni

Tissue specificityi

High levels in skeletal muscle, ovary, kidney and colon.

Developmental stagei

Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle.

Inductioni

Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage.

Gene expression databases

ArrayExpressiP51959.
BgeeiP51959.
CleanExiHS_CCNG1.
GenevestigatoriP51959.

Organism-specific databases

HPAiCAB000350.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TNIP1Q150254EBI-3905829,EBI-357849

Protein-protein interaction databases

BioGridi107340. 16 interactions.
IntActiP51959. 9 interactions.
MINTiMINT-4299131.
STRINGi9606.ENSP00000344635.

Structurei

3D structure databases

ProteinModelPortaliP51959.
SMRiP51959. Positions 17-224.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG281302.
HOGENOMiHOG000059559.
HOVERGENiHBG050839.
InParanoidiP51959.
KOiK10145.
OMAiSDMMRME.
OrthoDBiEOG7HB59M.
PhylomeDBiP51959.
TreeFamiTF101007.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR028860. CCNG1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF59. PTHR10177:SF59. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Complete.

P51959-1 [UniParc]FASTAAdd to Basket

« Hide

MIEVLTTTDS QKLLHQLNAL LEQESRCQPK VCGLRLIESA HDNGLRMTAR    50
LRDFEVKDLL SLTQFFGFDT ETFSLAVNLL DRFLSKMKVQ PKHLGCVGLS 100
CFYLAVKSIE EERNVPLATD LIRISQYRFT VSDLMRMEKI VLEKVCWKVK 150
ATTAFQFLQL YYSLLQENLP LERRNSINFE RLEAQLKACH CRIIFSKAKP 200
SVLALSIIAL EIQAQKCVEL TEGIECLQKH SKINGRDLTF WQELVSKCLT 250
EYSSNKCSKP NVQKLKWIVS GRTARQLKHS YYRITHLPTI PEMVP 295
Length:295
Mass (Da):34,074
Last modified:November 1, 1997 - v2
Checksum:iEA0B02C83F3B6BF3
GO

Sequence cautioni

The sequence AAB03903.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA54821.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti178 – 1781N → H.1 Publication
Corresponds to variant rs2069352 [ dbSNP | Ensembl ].
VAR_021079
Natural varianti179 – 1791F → L.1 Publication
Corresponds to variant rs11541970 [ dbSNP | Ensembl ].
VAR_021080

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281R → M in AAB03903. 1 Publication
Sequence conflicti256 – 2561K → E in AAH07093. 1 Publication
Sequence conflicti275 – 29521RQLKH…PEMVP → LKWSLNWIITAPKNFSEAFL HNLVLWIP in AAB03903. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L49504 mRNA. Translation: AAC41977.1.
U47413 mRNA. Translation: AAC50688.1.
D86077 Genomic DNA. Translation: BAA13007.1.
D78341 mRNA. Translation: BAA11353.1.
U53328 mRNA. Translation: AAB03903.1. Different initiation.
AK312913 mRNA. Translation: BAG35759.1.
BT007134 mRNA. Translation: AAP35798.1.
AY791292 Genomic DNA. Translation: AAV40836.1.
CH471062 Genomic DNA. Translation: EAW61528.1.
CH471062 Genomic DNA. Translation: EAW61529.1.
CH471062 Genomic DNA. Translation: EAW61530.1.
BC000196 mRNA. Translation: AAH00196.1.
BC007093 mRNA. Translation: AAH07093.1.
X77794 mRNA. Translation: CAA54821.1. Different initiation.
CCDSiCCDS4360.1.
PIRiG02401.
RefSeqiNP_004051.1. NM_004060.3.
NP_954854.1. NM_199246.1.
UniGeneiHs.79101.

Genome annotation databases

EnsembliENST00000340828; ENSP00000344635; ENSG00000113328.
ENST00000393929; ENSP00000377506; ENSG00000113328.
GeneIDi900.
KEGGihsa:900.
UCSCiuc003lzb.3. human.

Polymorphism databases

DMDMi2506334.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L49504 mRNA. Translation: AAC41977.1 .
U47413 mRNA. Translation: AAC50688.1 .
D86077 Genomic DNA. Translation: BAA13007.1 .
D78341 mRNA. Translation: BAA11353.1 .
U53328 mRNA. Translation: AAB03903.1 . Different initiation.
AK312913 mRNA. Translation: BAG35759.1 .
BT007134 mRNA. Translation: AAP35798.1 .
AY791292 Genomic DNA. Translation: AAV40836.1 .
CH471062 Genomic DNA. Translation: EAW61528.1 .
CH471062 Genomic DNA. Translation: EAW61529.1 .
CH471062 Genomic DNA. Translation: EAW61530.1 .
BC000196 mRNA. Translation: AAH00196.1 .
BC007093 mRNA. Translation: AAH07093.1 .
X77794 mRNA. Translation: CAA54821.1 . Different initiation.
CCDSi CCDS4360.1.
PIRi G02401.
RefSeqi NP_004051.1. NM_004060.3.
NP_954854.1. NM_199246.1.
UniGenei Hs.79101.

3D structure databases

ProteinModelPortali P51959.
SMRi P51959. Positions 17-224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107340. 16 interactions.
IntActi P51959. 9 interactions.
MINTi MINT-4299131.
STRINGi 9606.ENSP00000344635.

PTM databases

PhosphoSitei P51959.

Polymorphism databases

DMDMi 2506334.

Proteomic databases

PaxDbi P51959.
PRIDEi P51959.

Protocols and materials databases

DNASUi 900.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340828 ; ENSP00000344635 ; ENSG00000113328 .
ENST00000393929 ; ENSP00000377506 ; ENSG00000113328 .
GeneIDi 900.
KEGGi hsa:900.
UCSCi uc003lzb.3. human.

Organism-specific databases

CTDi 900.
GeneCardsi GC05P162864.
HGNCi HGNC:1592. CCNG1.
HPAi CAB000350.
MIMi 601578. gene.
neXtProti NX_P51959.
PharmGKBi PA26157.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG281302.
HOGENOMi HOG000059559.
HOVERGENi HBG050839.
InParanoidi P51959.
KOi K10145.
OMAi SDMMRME.
OrthoDBi EOG7HB59M.
PhylomeDBi P51959.
TreeFami TF101007.

Enzyme and pathway databases

SignaLinki P51959.

Miscellaneous databases

GeneWikii CCNG1.
GenomeRNAii 900.
NextBioi 3718.
PROi P51959.
SOURCEi Search...

Gene expression databases

ArrayExpressi P51959.
Bgeei P51959.
CleanExi HS_CCNG1.
Genevestigatori P51959.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR028860. CCNG1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10177:SF59. PTHR10177:SF59. 1 hit.
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression."
    Horne M.C., Goolsby G.L., Donaldson K.L., Tran D., Neubauer M.G., Wahl A.F.
    J. Biol. Chem. 271:6050-6061(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterisation of human cyclin G1 and G2: DNA damage inducible genes."
    Bates S.A., Rowan S., Vousden K.H.
    Oncogene 13:1103-1109(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal spleen.
  3. "Structure and chromosomal assignment of the human cyclin G gene."
    Endo Y., Fujita T., Tamura K., Tsuruga H., Nojima H.
    Genomics 38:92-95(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  4. "Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells."
    Reimer C.L., Borras A.M., Kurdistani S.K., Garreau J.R., Chung M., Aaronson S.A., Lee S.W.
    J. Biol. Chem. 274:11022-11029(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Mammary gland.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. NIEHS SNPs program
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-178 AND LEU-179.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Prostate.
  10. Wu L., Hall F.L.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-295.
    Tissue: Fibroblast.

Entry informationi

Entry nameiCCNG1_HUMAN
AccessioniPrimary (citable) accession number: P51959
Secondary accession number(s): B2R7B2
, D3DQK7, Q15757, Q96L32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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