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P51957

- NEK4_HUMAN

UniProt

P51957 - NEK4_HUMAN

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Protein

Serine/threonine-protein kinase Nek4

Gene

NEK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Seems to act exclusively upon threonine residues.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351ATPPROSITE-ProRule annotation
Active sitei131 – 1311Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 209ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: ProtInc

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. protein phosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP51957.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek4 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 4
Short name:
NimA-related protein kinase 4
Serine/threonine-protein kinase 2
Serine/threonine-protein kinase NRK2
Gene namesi
Name:NEK4
Synonyms:STK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11399. NEK4.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31548.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 841841Serine/threonine-protein kinase Nek4PRO_0000086425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651Phosphothreonine; by autocatalysisBy similarity
Modified residuei563 – 5631Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP51957.
PaxDbiP51957.
PRIDEiP51957.

PTM databases

PhosphoSiteiP51957.

Miscellaneous databases

PMAP-CutDBP51957.

Expressioni

Tissue specificityi

Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, liver, kidney, lung and placenta. Present in most primary carcinomas.

Gene expression databases

BgeeiP51957.
CleanExiHS_NEK4.
ExpressionAtlasiP51957. baseline and differential.
GenevestigatoriP51957.

Organism-specific databases

HPAiHPA015750.

Interactioni

Protein-protein interaction databases

BioGridi112663. 17 interactions.
IntActiP51957. 1 interaction.
STRINGi9606.ENSP00000233027.

Structurei

3D structure databases

ProteinModelPortaliP51957.
SMRiP51957. Positions 1-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 261256Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118997.
HOGENOMiHOG000294177.
HOVERGENiHBG031740.
InParanoidiP51957.
KOiK08857.
OMAiELPSAIM.
OrthoDBiEOG7D59P5.
PhylomeDBiP51957.
TreeFamiTF106472.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P51957-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLAAYCYLR VVGKGSYGEV TLVKHRRDGK QYVIKKLNLR NASSRERRAA
60 70 80 90 100
EQEAQLLSQL KHPNIVTYKE SWEGGDGLLY IVMGFCEGGD LYRKLKEQKG
110 120 130 140 150
QLLPENQVVE WFVQIAMALQ YLHEKHILHR DLKTQNVFLT RTNIIKVGDL
160 170 180 190 200
GIARVLENHC DMASTLIGTP YYMSPELFSN KPYNYKSDVW ALGCCVYEMA
210 220 230 240 250
TLKHAFNAKD MNSLVYRIIE GKLPPMPRDY SPELAELIRT MLSKRPEERP
260 270 280 290 300
SVRSILRQPY IKRQISFFLE ATKIKTSKNN IKNGDSQSKP FATVVSGEAE
310 320 330 340 350
SNHEVIHPQP LSSEGSQTYI MGEGKCLSQE KPRASGLLKS PASLKAHTCK
360 370 380 390 400
QDLSNTTELA TISSVNIDIL PAKGRDSVSD GFVQENQPRY LDASNELGGI
410 420 430 440 450
CSISQVEEEM LQDNTKSSAQ PENLIPMWSS DIVTGEKNEP VKPLQPLIKE
460 470 480 490 500
QKPKDQSLAL SPKLECSGTI LAHSNLRLLG SSDSPASASR VAGITGVCHH
510 520 530 540 550
AQDQVAGECI IEKQGRIHPD LQPHNSGSEP SLSRQRRQKR REQTEHRGEK
560 570 580 590 600
RQVRRDLFAF QESPPRFLPS HPIVGKVDVT STQKEAENQR RVVTGSVSSS
610 620 630 640 650
RSSEMSSSKD RPLSARERRR LKQSQEEMSS SGPSVRKASL SVAGPGKPQE
660 670 680 690 700
EDQPLPARRL SSDCSVTQER KQIHCLSEDE LSSSTSSTDK SDGDYGEGKG
710 720 730 740 750
QTNEINALVQ LMTQTLKLDS KESCEDVPVA NPVSEFKLHR KYRDTLILHG
760 770 780 790 800
KVAEEAEEIH FKELPSAIMP GSEKIRRLVE VLRTDVIRGL GVQLLEQVYD
810 820 830 840
LLEEEDEFDR EVRLREHMGE KYTTYSVKAR QLKFFEENMN F
Length:841
Mass (Da):94,597
Last modified:May 5, 2009 - v2
Checksum:i43E8F11BA4007263
GO
Isoform 2 (identifier: P51957-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     457-502: Missing.
     813-841: RLREHMGEKYTTYSVKARQLKFFEENMNF → SVSLTVSRCLCYRIF

Note: No experimental confirmation available.

Show »
Length:781
Mass (Da):88,094
Checksum:iB251D19895A2AD44
GO
Isoform 3 (identifier: P51957-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-120: Missing.

Note: No experimental confirmation available.

Show »
Length:752
Mass (Da):84,348
Checksum:i9518EF5A24A1795A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631P → L in BAG35330. (PubMed:14702039)Curated
Sequence conflicti64 – 641N → D in ABQ59054. 1 PublicationCurated
Sequence conflicti333 – 3331R → K in BAG35330. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti225 – 2251P → A.4 Publications
Corresponds to variant rs1029871 [ dbSNP | Ensembl ].
VAR_040915
Natural varianti239 – 2391R → G.1 Publication
Corresponds to variant rs35778416 [ dbSNP | Ensembl ].
VAR_040916
Natural varianti250 – 2501P → L.1 Publication
Corresponds to variant rs56408749 [ dbSNP | Ensembl ].
VAR_040917
Natural varianti357 – 3571T → I.1 Publication
Corresponds to variant rs2230537 [ dbSNP | Ensembl ].
VAR_040918
Natural varianti456 – 4561Q → E.1 Publication
Corresponds to variant rs56019351 [ dbSNP | Ensembl ].
VAR_040919
Natural varianti567 – 5671F → L.1 Publication
Corresponds to variant rs34986855 [ dbSNP | Ensembl ].
VAR_040920
Natural varianti777 – 7771R → K in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040921

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei32 – 12089Missing in isoform 3. 1 PublicationVSP_043334Add
BLAST
Alternative sequencei457 – 50246Missing in isoform 2. 1 PublicationVSP_037123Add
BLAST
Alternative sequencei813 – 84129RLREH…ENMNF → SVSLTVSRCLCYRIF in isoform 2. 1 PublicationVSP_037124Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20321 mRNA. Translation: AAA36658.1.
EF560744 mRNA. Translation: ABQ59054.1.
AK294165 mRNA. Translation: BAH11686.1.
AK312420 mRNA. Translation: BAG35330.1.
AC006254 Genomic DNA. No translation available.
AC104446 Genomic DNA. No translation available.
BC063044 mRNA. Translation: AAH63044.1.
CCDSiCCDS2863.1. [P51957-1]
CCDS54593.1. [P51957-3]
PIRiI78885.
RefSeqiNP_001180462.1. NM_001193533.1. [P51957-3]
NP_003148.2. NM_003157.4. [P51957-1]
UniGeneiHs.631921.

Genome annotation databases

EnsembliENST00000233027; ENSP00000233027; ENSG00000114904. [P51957-1]
ENST00000383721; ENSP00000373227; ENSG00000114904. [P51957-2]
ENST00000535191; ENSP00000437703; ENSG00000114904. [P51957-3]
GeneIDi6787.
KEGGihsa:6787.
UCSCiuc003dfq.4. human. [P51957-1]
uc003dfr.3. human. [P51957-2]
uc011bej.2. human. [P51957-3]

Polymorphism databases

DMDMi229462924.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20321 mRNA. Translation: AAA36658.1 .
EF560744 mRNA. Translation: ABQ59054.1 .
AK294165 mRNA. Translation: BAH11686.1 .
AK312420 mRNA. Translation: BAG35330.1 .
AC006254 Genomic DNA. No translation available.
AC104446 Genomic DNA. No translation available.
BC063044 mRNA. Translation: AAH63044.1 .
CCDSi CCDS2863.1. [P51957-1 ]
CCDS54593.1. [P51957-3 ]
PIRi I78885.
RefSeqi NP_001180462.1. NM_001193533.1. [P51957-3 ]
NP_003148.2. NM_003157.4. [P51957-1 ]
UniGenei Hs.631921.

3D structure databases

ProteinModelPortali P51957.
SMRi P51957. Positions 1-322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112663. 17 interactions.
IntActi P51957. 1 interaction.
STRINGi 9606.ENSP00000233027.

Chemistry

BindingDBi P51957.
ChEMBLi CHEMBL5819.
GuidetoPHARMACOLOGYi 2119.

PTM databases

PhosphoSitei P51957.

Polymorphism databases

DMDMi 229462924.

Proteomic databases

MaxQBi P51957.
PaxDbi P51957.
PRIDEi P51957.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000233027 ; ENSP00000233027 ; ENSG00000114904 . [P51957-1 ]
ENST00000383721 ; ENSP00000373227 ; ENSG00000114904 . [P51957-2 ]
ENST00000535191 ; ENSP00000437703 ; ENSG00000114904 . [P51957-3 ]
GeneIDi 6787.
KEGGi hsa:6787.
UCSCi uc003dfq.4. human. [P51957-1 ]
uc003dfr.3. human. [P51957-2 ]
uc011bej.2. human. [P51957-3 ]

Organism-specific databases

CTDi 6787.
GeneCardsi GC03M052744.
H-InvDB HIX0030800.
HGNCi HGNC:11399. NEK4.
HPAi HPA015750.
MIMi 601959. gene.
neXtProti NX_P51957.
PharmGKBi PA31548.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118997.
HOGENOMi HOG000294177.
HOVERGENi HBG031740.
InParanoidi P51957.
KOi K08857.
OMAi ELPSAIM.
OrthoDBi EOG7D59P5.
PhylomeDBi P51957.
TreeFami TF106472.

Enzyme and pathway databases

SignaLinki P51957.

Miscellaneous databases

ChiTaRSi NEK4. human.
GenomeRNAii 6787.
NextBioi 26500.
PMAP-CutDB P51957.
PROi P51957.
SOURCEi Search...

Gene expression databases

Bgeei P51957.
CleanExi HS_NEK4.
ExpressionAtlasi P51957. baseline and differential.
Genevestigatori P51957.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern."
    Levedakou E.N., He M., Baptist E.W., Craven R.J., Cance W.G., Welcsh P.L., Simmons A., Naylor S.L., Leach R.J., Lewis T.B., Bowcock A., Liu E.T.
    Oncogene 9:1977-1988(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-225.
    Tissue: Mammary gland.
  2. Schupp I.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-225.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Amygdala and Brain.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-225.
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-225; GLY-239; LEU-250; ILE-357; GLU-456; LEU-567 AND LYS-777.

Entry informationi

Entry nameiNEK4_HUMAN
AccessioniPrimary (citable) accession number: P51957
Secondary accession number(s): A5YM70
, B2R633, B7Z200, Q6P576
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3