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P51957

- NEK4_HUMAN

UniProt

P51957 - NEK4_HUMAN

Protein

Serine/threonine-protein kinase Nek4

Gene

NEK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Seems to act exclusively upon threonine residues.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351ATPPROSITE-ProRule annotation
    Active sitei131 – 1311Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 209ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein serine/threonine kinase activity Source: ProtInc

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. protein phosphorylation Source: ProtInc

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiP51957.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase Nek4 (EC:2.7.11.1)
    Alternative name(s):
    Never in mitosis A-related kinase 4
    Short name:
    NimA-related protein kinase 4
    Serine/threonine-protein kinase 2
    Serine/threonine-protein kinase NRK2
    Gene namesi
    Name:NEK4
    Synonyms:STK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11399. NEK4.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31548.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 841841Serine/threonine-protein kinase Nek4PRO_0000086425Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei165 – 1651Phosphothreonine; by autocatalysisBy similarity
    Modified residuei563 – 5631Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP51957.
    PaxDbiP51957.
    PRIDEiP51957.

    PTM databases

    PhosphoSiteiP51957.

    Miscellaneous databases

    PMAP-CutDBP51957.

    Expressioni

    Tissue specificityi

    Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, liver, kidney, lung and placenta. Present in most primary carcinomas.

    Gene expression databases

    ArrayExpressiP51957.
    BgeeiP51957.
    CleanExiHS_NEK4.
    GenevestigatoriP51957.

    Organism-specific databases

    HPAiHPA015750.

    Interactioni

    Protein-protein interaction databases

    BioGridi112663. 2 interactions.
    IntActiP51957. 1 interaction.
    STRINGi9606.ENSP00000233027.

    Structurei

    3D structure databases

    ProteinModelPortaliP51957.
    SMRiP51957. Positions 1-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 261256Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000294177.
    HOVERGENiHBG031740.
    InParanoidiP51957.
    KOiK08857.
    OMAiELPSAIM.
    OrthoDBiEOG7D59P5.
    PhylomeDBiP51957.
    TreeFamiTF106472.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P51957-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPLAAYCYLR VVGKGSYGEV TLVKHRRDGK QYVIKKLNLR NASSRERRAA    50
    EQEAQLLSQL KHPNIVTYKE SWEGGDGLLY IVMGFCEGGD LYRKLKEQKG 100
    QLLPENQVVE WFVQIAMALQ YLHEKHILHR DLKTQNVFLT RTNIIKVGDL 150
    GIARVLENHC DMASTLIGTP YYMSPELFSN KPYNYKSDVW ALGCCVYEMA 200
    TLKHAFNAKD MNSLVYRIIE GKLPPMPRDY SPELAELIRT MLSKRPEERP 250
    SVRSILRQPY IKRQISFFLE ATKIKTSKNN IKNGDSQSKP FATVVSGEAE 300
    SNHEVIHPQP LSSEGSQTYI MGEGKCLSQE KPRASGLLKS PASLKAHTCK 350
    QDLSNTTELA TISSVNIDIL PAKGRDSVSD GFVQENQPRY LDASNELGGI 400
    CSISQVEEEM LQDNTKSSAQ PENLIPMWSS DIVTGEKNEP VKPLQPLIKE 450
    QKPKDQSLAL SPKLECSGTI LAHSNLRLLG SSDSPASASR VAGITGVCHH 500
    AQDQVAGECI IEKQGRIHPD LQPHNSGSEP SLSRQRRQKR REQTEHRGEK 550
    RQVRRDLFAF QESPPRFLPS HPIVGKVDVT STQKEAENQR RVVTGSVSSS 600
    RSSEMSSSKD RPLSARERRR LKQSQEEMSS SGPSVRKASL SVAGPGKPQE 650
    EDQPLPARRL SSDCSVTQER KQIHCLSEDE LSSSTSSTDK SDGDYGEGKG 700
    QTNEINALVQ LMTQTLKLDS KESCEDVPVA NPVSEFKLHR KYRDTLILHG 750
    KVAEEAEEIH FKELPSAIMP GSEKIRRLVE VLRTDVIRGL GVQLLEQVYD 800
    LLEEEDEFDR EVRLREHMGE KYTTYSVKAR QLKFFEENMN F 841
    Length:841
    Mass (Da):94,597
    Last modified:May 5, 2009 - v2
    Checksum:i43E8F11BA4007263
    GO
    Isoform 2 (identifier: P51957-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         457-502: Missing.
         813-841: RLREHMGEKYTTYSVKARQLKFFEENMNF → SVSLTVSRCLCYRIF

    Note: No experimental confirmation available.

    Show »
    Length:781
    Mass (Da):88,094
    Checksum:iB251D19895A2AD44
    GO
    Isoform 3 (identifier: P51957-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-120: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:752
    Mass (Da):84,348
    Checksum:i9518EF5A24A1795A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti63 – 631P → L in BAG35330. (PubMed:14702039)Curated
    Sequence conflicti64 – 641N → D in ABQ59054. 1 PublicationCurated
    Sequence conflicti333 – 3331R → K in BAG35330. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti225 – 2251P → A.4 Publications
    Corresponds to variant rs1029871 [ dbSNP | Ensembl ].
    VAR_040915
    Natural varianti239 – 2391R → G.1 Publication
    Corresponds to variant rs35778416 [ dbSNP | Ensembl ].
    VAR_040916
    Natural varianti250 – 2501P → L.1 Publication
    Corresponds to variant rs56408749 [ dbSNP | Ensembl ].
    VAR_040917
    Natural varianti357 – 3571T → I.1 Publication
    Corresponds to variant rs2230537 [ dbSNP | Ensembl ].
    VAR_040918
    Natural varianti456 – 4561Q → E.1 Publication
    Corresponds to variant rs56019351 [ dbSNP | Ensembl ].
    VAR_040919
    Natural varianti567 – 5671F → L.1 Publication
    Corresponds to variant rs34986855 [ dbSNP | Ensembl ].
    VAR_040920
    Natural varianti777 – 7771R → K in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040921

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei32 – 12089Missing in isoform 3. 1 PublicationVSP_043334Add
    BLAST
    Alternative sequencei457 – 50246Missing in isoform 2. 1 PublicationVSP_037123Add
    BLAST
    Alternative sequencei813 – 84129RLREH…ENMNF → SVSLTVSRCLCYRIF in isoform 2. 1 PublicationVSP_037124Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20321 mRNA. Translation: AAA36658.1.
    EF560744 mRNA. Translation: ABQ59054.1.
    AK294165 mRNA. Translation: BAH11686.1.
    AK312420 mRNA. Translation: BAG35330.1.
    AC006254 Genomic DNA. No translation available.
    AC104446 Genomic DNA. No translation available.
    BC063044 mRNA. Translation: AAH63044.1.
    CCDSiCCDS2863.1. [P51957-1]
    CCDS54593.1. [P51957-3]
    PIRiI78885.
    RefSeqiNP_001180462.1. NM_001193533.1. [P51957-3]
    NP_003148.2. NM_003157.4. [P51957-1]
    UniGeneiHs.631921.

    Genome annotation databases

    EnsembliENST00000233027; ENSP00000233027; ENSG00000114904. [P51957-1]
    ENST00000383721; ENSP00000373227; ENSG00000114904. [P51957-2]
    ENST00000535191; ENSP00000437703; ENSG00000114904. [P51957-3]
    GeneIDi6787.
    KEGGihsa:6787.
    UCSCiuc003dfq.4. human. [P51957-1]
    uc003dfr.3. human. [P51957-2]
    uc011bej.2. human. [P51957-3]

    Polymorphism databases

    DMDMi229462924.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20321 mRNA. Translation: AAA36658.1 .
    EF560744 mRNA. Translation: ABQ59054.1 .
    AK294165 mRNA. Translation: BAH11686.1 .
    AK312420 mRNA. Translation: BAG35330.1 .
    AC006254 Genomic DNA. No translation available.
    AC104446 Genomic DNA. No translation available.
    BC063044 mRNA. Translation: AAH63044.1 .
    CCDSi CCDS2863.1. [P51957-1 ]
    CCDS54593.1. [P51957-3 ]
    PIRi I78885.
    RefSeqi NP_001180462.1. NM_001193533.1. [P51957-3 ]
    NP_003148.2. NM_003157.4. [P51957-1 ]
    UniGenei Hs.631921.

    3D structure databases

    ProteinModelPortali P51957.
    SMRi P51957. Positions 1-322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112663. 2 interactions.
    IntActi P51957. 1 interaction.
    STRINGi 9606.ENSP00000233027.

    Chemistry

    BindingDBi P51957.
    ChEMBLi CHEMBL5819.
    GuidetoPHARMACOLOGYi 2119.

    PTM databases

    PhosphoSitei P51957.

    Polymorphism databases

    DMDMi 229462924.

    Proteomic databases

    MaxQBi P51957.
    PaxDbi P51957.
    PRIDEi P51957.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000233027 ; ENSP00000233027 ; ENSG00000114904 . [P51957-1 ]
    ENST00000383721 ; ENSP00000373227 ; ENSG00000114904 . [P51957-2 ]
    ENST00000535191 ; ENSP00000437703 ; ENSG00000114904 . [P51957-3 ]
    GeneIDi 6787.
    KEGGi hsa:6787.
    UCSCi uc003dfq.4. human. [P51957-1 ]
    uc003dfr.3. human. [P51957-2 ]
    uc011bej.2. human. [P51957-3 ]

    Organism-specific databases

    CTDi 6787.
    GeneCardsi GC03M052719.
    H-InvDB HIX0030800.
    HGNCi HGNC:11399. NEK4.
    HPAi HPA015750.
    MIMi 601959. gene.
    neXtProti NX_P51957.
    PharmGKBi PA31548.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000294177.
    HOVERGENi HBG031740.
    InParanoidi P51957.
    KOi K08857.
    OMAi ELPSAIM.
    OrthoDBi EOG7D59P5.
    PhylomeDBi P51957.
    TreeFami TF106472.

    Enzyme and pathway databases

    SignaLinki P51957.

    Miscellaneous databases

    ChiTaRSi NEK4. human.
    GenomeRNAii 6787.
    NextBioi 26500.
    PMAP-CutDB P51957.
    PROi P51957.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51957.
    Bgeei P51957.
    CleanExi HS_NEK4.
    Genevestigatori P51957.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern."
      Levedakou E.N., He M., Baptist E.W., Craven R.J., Cance W.G., Welcsh P.L., Simmons A., Naylor S.L., Leach R.J., Lewis T.B., Bowcock A., Liu E.T.
      Oncogene 9:1977-1988(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-225.
      Tissue: Mammary gland.
    2. Schupp I.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-225.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Amygdala and Brain.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-225.
      Tissue: Brain.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-225; GLY-239; LEU-250; ILE-357; GLU-456; LEU-567 AND LYS-777.

    Entry informationi

    Entry nameiNEK4_HUMAN
    AccessioniPrimary (citable) accession number: P51957
    Secondary accession number(s): A5YM70
    , B2R633, B7Z200, Q6P576
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3