P51957 (NEK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase Nek4
EC=2.7.11.1

Alternative name(s):
Never in mitosis A-related kinase 4
Short name=NimA-related protein kinase 4
Serine/threonine-protein kinase 2
Serine/threonine-protein kinase NRK2

Gene names

Name:	NEK4
Synonyms:	STK2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	841 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to act exclusively upon threonine residues By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Subcellular location	Nucleus Probable.
Tissue specificity	Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, liver, kidney, lung and placenta. Present in most primary carcinomas.
Sequence similarities	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay. Source: HPA
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P51957-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P51957-2)

The sequence of this isoform differs from the canonical sequence as follows:
     457-502: Missing.
     813-841: RLREHMGEKYTTYSVKARQLKFFEENMNF → SVSLTVSRCLCYRIF

Note: No experimental confirmation available.

Isoform 3 (identifier: P51957-3)

The sequence of this isoform differs from the canonical sequence as follows:
     32-120: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 841	841	Serine/threonine-protein kinase Nek4		PRO_0000086425
Regions
	Domain	6 – 261	256	Protein kinase
	Nucleotide binding	12 – 20	9	ATP By similarity
Sites
	Active site	131	1	Proton acceptor By similarity
	Binding site	35	1	ATP By similarity
Amino acid modifications
	Modified residue	165	1	Phosphothreonine; by autocatalysis By similarity
	Modified residue	563	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	32 – 120	89	Missing in isoform 3.		VSP_043334
	Alternative sequence	457 – 502	46	Missing in isoform 2.		VSP_037123
	Alternative sequence	813 – 841	29	RLREH…ENMNF → SVSLTVSRCLCYRIF in isoform 2.		VSP_037124
	Natural variant	225	1	P → A. Ref.1 Ref.2 Ref.5 Ref.8 Corresponds to variant rs1029871 [ dbSNP | Ensembl ].		VAR_040915
	Natural variant	239	1	R → G. Ref.8 Corresponds to variant rs35778416 [ dbSNP | Ensembl ].		VAR_040916
	Natural variant	250	1	P → L. Ref.8 Corresponds to variant rs56408749 [ dbSNP | Ensembl ].		VAR_040917
	Natural variant	357	1	T → I. Ref.8 Corresponds to variant rs2230537 [ dbSNP | Ensembl ].		VAR_040918
	Natural variant	456	1	Q → E. Ref.8 Corresponds to variant rs56019351 [ dbSNP | Ensembl ].		VAR_040919
	Natural variant	567	1	F → L. Ref.8 Corresponds to variant rs34986855 [ dbSNP | Ensembl ].		VAR_040920
	Natural variant	777	1	R → K in a colorectal adenocarcinoma sample; somatic mutation. Ref.8		VAR_040921
Experimental info
	Sequence conflict	63	1	P → L in BAG35330. Ref.3
	Sequence conflict	64	1	N → D in ABQ59054. Ref.2
	Sequence conflict	333	1	R → K in BAG35330. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 43E8F11BA4007263	FASTA	841	94,597
	10 20 30 40 50 60 MPLAAYCYLR VVGKGSYGEV TLVKHRRDGK QYVIKKLNLR NASSRERRAA EQEAQLLSQL 70 80 90 100 110 120 KHPNIVTYKE SWEGGDGLLY IVMGFCEGGD LYRKLKEQKG QLLPENQVVE WFVQIAMALQ 130 140 150 160 170 180 YLHEKHILHR DLKTQNVFLT RTNIIKVGDL GIARVLENHC DMASTLIGTP YYMSPELFSN 190 200 210 220 230 240 KPYNYKSDVW ALGCCVYEMA TLKHAFNAKD MNSLVYRIIE GKLPPMPRDY SPELAELIRT 250 260 270 280 290 300 MLSKRPEERP SVRSILRQPY IKRQISFFLE ATKIKTSKNN IKNGDSQSKP FATVVSGEAE 310 320 330 340 350 360 SNHEVIHPQP LSSEGSQTYI MGEGKCLSQE KPRASGLLKS PASLKAHTCK QDLSNTTELA 370 380 390 400 410 420 TISSVNIDIL PAKGRDSVSD GFVQENQPRY LDASNELGGI CSISQVEEEM LQDNTKSSAQ 430 440 450 460 470 480 PENLIPMWSS DIVTGEKNEP VKPLQPLIKE QKPKDQSLAL SPKLECSGTI LAHSNLRLLG 490 500 510 520 530 540 SSDSPASASR VAGITGVCHH AQDQVAGECI IEKQGRIHPD LQPHNSGSEP SLSRQRRQKR 550 560 570 580 590 600 REQTEHRGEK RQVRRDLFAF QESPPRFLPS HPIVGKVDVT STQKEAENQR RVVTGSVSSS 610 620 630 640 650 660 RSSEMSSSKD RPLSARERRR LKQSQEEMSS SGPSVRKASL SVAGPGKPQE EDQPLPARRL 670 680 690 700 710 720 SSDCSVTQER KQIHCLSEDE LSSSTSSTDK SDGDYGEGKG QTNEINALVQ LMTQTLKLDS 730 740 750 760 770 780 KESCEDVPVA NPVSEFKLHR KYRDTLILHG KVAEEAEEIH FKELPSAIMP GSEKIRRLVE 790 800 810 820 830 840 VLRTDVIRGL GVQLLEQVYD LLEEEDEFDR EVRLREHMGE KYTTYSVKAR QLKFFEENMN F
	Isoform 2 [UniParc]. Checksum: B251D19895A2AD44	FASTA	781	88,094
	10 20 30 40 50 60 MPLAAYCYLR VVGKGSYGEV TLVKHRRDGK QYVIKKLNLR NASSRERRAA EQEAQLLSQL 70 80 90 100 110 120 KHPNIVTYKE SWEGGDGLLY IVMGFCEGGD LYRKLKEQKG QLLPENQVVE WFVQIAMALQ 130 140 150 160 170 180 YLHEKHILHR DLKTQNVFLT RTNIIKVGDL GIARVLENHC DMASTLIGTP YYMSPELFSN 190 200 210 220 230 240 KPYNYKSDVW ALGCCVYEMA TLKHAFNAKD MNSLVYRIIE GKLPPMPRDY SPELAELIRT 250 260 270 280 290 300 MLSKRPEERP SVRSILRQPY IKRQISFFLE ATKIKTSKNN IKNGDSQSKP FATVVSGEAE 310 320 330 340 350 360 SNHEVIHPQP LSSEGSQTYI MGEGKCLSQE KPRASGLLKS PASLKAHTCK QDLSNTTELA 370 380 390 400 410 420 TISSVNIDIL PAKGRDSVSD GFVQENQPRY LDASNELGGI CSISQVEEEM LQDNTKSSAQ 430 440 450 460 470 480 PENLIPMWSS DIVTGEKNEP VKPLQPLIKE QKPKDQDQVA GECIIEKQGR IHPDLQPHNS 490 500 510 520 530 540 GSEPSLSRQR RQKRREQTEH RGEKRQVRRD LFAFQESPPR FLPSHPIVGK VDVTSTQKEA 550 560 570 580 590 600 ENQRRVVTGS VSSSRSSEMS SSKDRPLSAR ERRRLKQSQE EMSSSGPSVR KASLSVAGPG 610 620 630 640 650 660 KPQEEDQPLP ARRLSSDCSV TQERKQIHCL SEDELSSSTS STDKSDGDYG EGKGQTNEIN 670 680 690 700 710 720 ALVQLMTQTL KLDSKESCED VPVANPVSEF KLHRKYRDTL ILHGKVAEEA EEIHFKELPS 730 740 750 760 770 780 AIMPGSEKIR RLVEVLRTDV IRGLGVQLLE QVYDLLEEED EFDREVSVSL TVSRCLCYRI F
	Isoform 3 [UniParc]. Checksum: 9518EF5A24A1795A	FASTA	752	84,348
	10 20 30 40 50 60 MPLAAYCYLR VVGKGSYGEV TLVKHRRDGK QYLHEKHILH RDLKTQNVFL TRTNIIKVGD 70 80 90 100 110 120 LGIARVLENH CDMASTLIGT PYYMSPELFS NKPYNYKSDV WALGCCVYEM ATLKHAFNAK 130 140 150 160 170 180 DMNSLVYRII EGKLPPMPRD YSPELAELIR TMLSKRPEER PSVRSILRQP YIKRQISFFL 190 200 210 220 230 240 EATKIKTSKN NIKNGDSQSK PFATVVSGEA ESNHEVIHPQ PLSSEGSQTY IMGEGKCLSQ 250 260 270 280 290 300 EKPRASGLLK SPASLKAHTC KQDLSNTTEL ATISSVNIDI LPAKGRDSVS DGFVQENQPR 310 320 330 340 350 360 YLDASNELGG ICSISQVEEE MLQDNTKSSA QPENLIPMWS SDIVTGEKNE PVKPLQPLIK 370 380 390 400 410 420 EQKPKDQSLA LSPKLECSGT ILAHSNLRLL GSSDSPASAS RVAGITGVCH HAQDQVAGEC 430 440 450 460 470 480 IIEKQGRIHP DLQPHNSGSE PSLSRQRRQK RREQTEHRGE KRQVRRDLFA FQESPPRFLP 490 500 510 520 530 540 SHPIVGKVDV TSTQKEAENQ RRVVTGSVSS SRSSEMSSSK DRPLSARERR RLKQSQEEMS 550 560 570 580 590 600 SSGPSVRKAS LSVAGPGKPQ EEDQPLPARR LSSDCSVTQE RKQIHCLSED ELSSSTSSTD 610 620 630 640 650 660 KSDGDYGEGK GQTNEINALV QLMTQTLKLD SKESCEDVPV ANPVSEFKLH RKYRDTLILH 670 680 690 700 710 720 GKVAEEAEEI HFKELPSAIM PGSEKIRRLV EVLRTDVIRG LGVQLLEQVY DLLEEEDEFD 730 740 750 REVRLREHMG EKYTTYSVKA RQLKFFEENM NF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern." Levedakou E.N., He M., Baptist E.W., Craven R.J., Cance W.G., Welcsh P.L., Simmons A., Naylor S.L., Leach R.J., Lewis T.B., Bowcock A., Liu E.T. Oncogene 9:1977-1988(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-225. Tissue: Mammary gland.
[2]	Schupp I. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-225.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Amygdala and Brain.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-225. Tissue: Brain.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-225; GLY-239; LEU-250; ILE-357; GLU-456; LEU-567 AND LYS-777.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L20321 mRNA. Translation: AAA36658.1. EF560744 mRNA. Translation: ABQ59054.1. AK294165 mRNA. Translation: BAH11686.1. AK312420 mRNA. Translation: BAG35330.1. AC006254 Genomic DNA. No translation available. AC104446 Genomic DNA. No translation available. BC063044 mRNA. Translation: AAH63044.1.
IPI	IPI00021333. IPI00440811. IPI00946811.
PIR	I78885.
RefSeq	NP_001180462.1. NM_001193533.1. NP_003148.2. NM_003157.4.
UniGene	Hs.631921.
3D structure databases
ProteinModelPortal	P51957.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000233027.
PTM databases
PhosphoSite	P51957.
Polymorphism databases
DMDM	229462924.
Proteomic databases
PaxDb	P51957.
PRIDE	P51957.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000233027; ENSP00000233027; ENSG00000114904. ENST00000383721; ENSP00000373227; ENSG00000114904. ENST00000535191; ENSP00000437703; ENSG00000114904.
GeneID	6787.
KEGG	hsa:6787.
UCSC	uc003dfq.4. human. uc003dfr.3. human. uc011bej.2. human.
Organism-specific databases
CTD	6787.
GeneCards	GC03M052719.
H-InvDB	HIX0030800.
HGNC	HGNC:11399. NEK4.
HPA	HPA015750.
MIM	601959. gene.
neXtProt	NX_P51957.
PharmGKB	PA31548.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000294177.
HOVERGEN	HBG031740.
InParanoid	P51957.
KO	K08857.
OMA	EVRLQEH.
OrthoDB	EOG4GXFM4.
PhylomeDB	P51957.
Enzyme and pathway databases
SignaLink	P51957.
Gene expression databases
ArrayExpress	P51957.
Bgee	P51957.
CleanEx	HS_NEK4.
Genevestigator	P51957.
GermOnline	ENSG00000114904. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P51957.
ChEMBL	CHEMBL5819.
ChiTaRS	NEK4. human.
GenomeRNAi	6787.
NextBio	26500.
PMAP-CutDB	P51957.
SOURCE	Search...

Entry information

Entry name

NEK4_HUMAN

Accession

Primary (citable) accession number: P51957
Secondary accession number(s): A5YM70 , B2R633, B7Z200, Q6P576

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	May 5, 2009
Last modified:	May 29, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.