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P51956

- NEK3_HUMAN

UniProt

P51956 - NEK3_HUMAN

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Protein

Serine/threonine-protein kinase Nek3

Gene

NEK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Enzyme regulationi

Prolactin stimulates its activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei127 – 1271Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB
  2. protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 2681.
SignaLinkiP51956.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek3 (EC:2.7.11.1)
Alternative name(s):
HSPK 36
Never in mitosis A-related kinase 3
Short name:
NimA-related protein kinase 3
Gene namesi
Name:NEK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:7746. NEK3.

Subcellular locationi

Cytoplasm By similarity. Cell projectionaxon By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Serine/threonine-protein kinase Nek3PRO_0000086423Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei161 – 1611Phosphothreonine; by autocatalysisBy similarity
Modified residuei479 – 4791Phosphothreonine1 Publication

Post-translational modificationi

Phosphorylation at Thr-479 regulates its catalytic activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP51956.
PaxDbiP51956.
PRIDEiP51956.

PTM databases

PhosphoSiteiP51956.

Expressioni

Tissue specificityi

Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain.2 Publications

Gene expression databases

BgeeiP51956.
CleanExiHS_NEK3.
ExpressionAtlasiP51956. baseline and differential.
GenevestigatoriP51956.

Organism-specific databases

HPAiHPA019062.
HPA043230.

Interactioni

Subunit structurei

Interacts with PXN, PRLR, VAV1 and VAV2 and this interaction is prolactin-dependent.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VAV2P527353EBI-476041,EBI-297549

Protein-protein interaction databases

BioGridi110827. 6 interactions.
IntActiP51956. 5 interactions.
STRINGi9606.ENSP00000383210.

Structurei

3D structure databases

ProteinModelPortaliP51956.
SMRiP51956. Positions 1-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 257254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 285285Interaction with VAV2Add
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118997.
HOGENOMiHOG000261617.
HOVERGENiHBG003063.
InParanoidiP51956.
KOiK08857.
OrthoDBiEOG7D59P5.
PhylomeDBiP51956.
TreeFamiTF106472.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P51956-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDYMVLRMI GEGSFGRALL VQHESSNQMF AMKEIRLPKS FSNTQNSRKE
60 70 80 90 100
AVLLAKMKHP NIVAFKESFE AEGHLYIVME YCDGGDLMQK IKQQKGKLFP
110 120 130 140 150
EDMILNWFTQ MCLGVNHIHK KRVLHRDIKS KNIFLTQNGK VKLGDFGSAR
160 170 180 190 200
LLSNPMAFAC TYVGTPYYVP PEIWENLPYN NKSDIWSLGC ILYELCTLKH
210 220 230 240 250
PFQANSWKNL ILKVCQGCIS PLPSHYSYEL QFLVKQMFKR NPSHRPSATT
260 270 280 290 300
LLSRGIVARL VQKCLPPEII MEYGEEVLEE IKNSKHNTPR KKTNPSRIRI
310 320 330 340 350
ALGNEASTVQ EEEQDRKGSH TDLESINENL VESALRRVNR EEKGNKSVHL
360 370 380 390 400
RKASSPNLHR RQWEKNVPNT ALTALENASI LTSSLTAEDD RGGSVIKYSK
410 420 430 440 450
NTTRKQWLKE TPDTLLNILK NADLSLAFQT YTIYRPGSEG FLKGPLSEET
460 470 480 490 500
EASDSVDGGH DSVILDPERL EPGLDEEDTD FEEEDDNPDW VSELKKRAGW

QGLCDR
Length:506
Mass (Da):57,705
Last modified:April 16, 2002 - v2
Checksum:i4437EB4A41A44777
GO
Isoform 2 (identifier: P51956-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-309: Missing.

Note: No experimental confirmation available.

Show »
Length:489
Mass (Da):55,924
Checksum:iBAF871DA589E7BD3
GO

Sequence cautioni

The sequence CAI12895.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAX08907.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141S → F in BAC15599. (PubMed:12063396)Curated
Sequence conflicti54 – 541L → S in CAA82310. (PubMed:7522034)Curated
Sequence conflicti77 – 782IV → LY in CAA80921. (PubMed:8274451)Curated
Sequence conflicti187 – 1893SLG → PSV in CAA80921. (PubMed:8274451)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231H → L.1 Publication
Corresponds to variant rs17482764 [ dbSNP | Ensembl ].
VAR_033906
Natural varianti60 – 601P → R.1 Publication
Corresponds to variant rs55946204 [ dbSNP | Ensembl ].
VAR_040908
Natural varianti122 – 1221R → H.1 Publication
Corresponds to variant rs56190615 [ dbSNP | Ensembl ].
VAR_040909
Natural varianti170 – 1701P → L.1 Publication
Corresponds to variant rs56021040 [ dbSNP | Ensembl ].
VAR_040910
Natural varianti259 – 2591R → G.1 Publication
Corresponds to variant rs34077016 [ dbSNP | Ensembl ].
VAR_040911
Natural varianti305 – 3051E → D.1 Publication
Corresponds to variant rs55969405 [ dbSNP | Ensembl ].
VAR_040912
Natural varianti461 – 4611D → N.1 Publication
Corresponds to variant rs34076988 [ dbSNP | Ensembl ].
VAR_040913
Natural varianti477 – 4771E → K.1 Publication
Corresponds to variant rs34488913 [ dbSNP | Ensembl ].
VAR_040914

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei293 – 30917Missing in isoform 2. 1 PublicationVSP_035427Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072828 mRNA. Translation: BAC15599.1.
AK290259 mRNA. Translation: BAF82948.1.
AL139082 Genomic DNA. Translation: CAI12895.1. Sequence problems.
CH471075 Genomic DNA. Translation: EAX08907.1. Sequence problems.
BC019916 mRNA. Translation: AAH19916.2.
Z29067 mRNA. Translation: CAA82310.1.
Z25434 mRNA. Translation: CAA80921.1.
CCDSiCCDS73576.1. [P51956-1]
PIRiI38224.
RefSeqiNP_001139571.1. NM_001146099.1. [P51956-2]
NP_002489.1. NM_002498.2. [P51956-1]
NP_689933.1. NM_152720.2. [P51956-1]
UniGeneiHs.409989.

Genome annotation databases

EnsembliENST00000610828; ENSP00000480328; ENSG00000136098. [P51956-1]
ENST00000611833; ENSP00000484086; ENSG00000136098. [P51956-2]
ENST00000618534; ENSP00000484443; ENSG00000136098. [P51956-1]
GeneIDi4752.
KEGGihsa:4752.
UCSCiuc001vgi.3. human. [P51956-1]
uc010tgy.2. human. [P51956-2]

Polymorphism databases

DMDMi20178297.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072828 mRNA. Translation: BAC15599.1 .
AK290259 mRNA. Translation: BAF82948.1 .
AL139082 Genomic DNA. Translation: CAI12895.1 . Sequence problems.
CH471075 Genomic DNA. Translation: EAX08907.1 . Sequence problems.
BC019916 mRNA. Translation: AAH19916.2 .
Z29067 mRNA. Translation: CAA82310.1 .
Z25434 mRNA. Translation: CAA80921.1 .
CCDSi CCDS73576.1. [P51956-1 ]
PIRi I38224.
RefSeqi NP_001139571.1. NM_001146099.1. [P51956-2 ]
NP_002489.1. NM_002498.2. [P51956-1 ]
NP_689933.1. NM_152720.2. [P51956-1 ]
UniGenei Hs.409989.

3D structure databases

ProteinModelPortali P51956.
SMRi P51956. Positions 1-317.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110827. 6 interactions.
IntActi P51956. 5 interactions.
STRINGi 9606.ENSP00000383210.

Chemistry

BindingDBi P51956.
ChEMBLi CHEMBL5679.
GuidetoPHARMACOLOGYi 2118.

PTM databases

PhosphoSitei P51956.

Polymorphism databases

DMDMi 20178297.

Proteomic databases

MaxQBi P51956.
PaxDbi P51956.
PRIDEi P51956.

Protocols and materials databases

DNASUi 4752.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000610828 ; ENSP00000480328 ; ENSG00000136098 . [P51956-1 ]
ENST00000611833 ; ENSP00000484086 ; ENSG00000136098 . [P51956-2 ]
ENST00000618534 ; ENSP00000484443 ; ENSG00000136098 . [P51956-1 ]
GeneIDi 4752.
KEGGi hsa:4752.
UCSCi uc001vgi.3. human. [P51956-1 ]
uc010tgy.2. human. [P51956-2 ]

Organism-specific databases

CTDi 4752.
GeneCardsi GC13M052706.
HGNCi HGNC:7746. NEK3.
HPAi HPA019062.
HPA043230.
MIMi 604044. gene.
neXtProti NX_P51956.
PharmGKBi PA31547.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118997.
HOGENOMi HOG000261617.
HOVERGENi HBG003063.
InParanoidi P51956.
KOi K08857.
OrthoDBi EOG7D59P5.
PhylomeDBi P51956.
TreeFami TF106472.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 2681.
SignaLinki P51956.

Miscellaneous databases

GeneWikii NEK3.
GenomeRNAii 4752.
NextBioi 18314.
PROi P51956.
SOURCEi Search...

Gene expression databases

Bgeei P51956.
CleanExi HS_NEK3.
ExpressionAtlasi P51956. baseline and differential.
Genevestigatori P51956.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3)."
    Kimura M., Okano Y.
    Cytogenet. Cell Genet. 95:177-182(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. "Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans."
    Schultz S.J., Fry A.M., Suetterlin C., Ried T., Nigg E.A.
    Cell Growth Differ. 5:625-635(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-506 (ISOFORM 1).
    Tissue: Placenta.
  7. "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans."
    Schultz S.J., Nigg E.A.
    Cell Growth Differ. 4:821-830(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 76-189.
  8. "Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor."
    Miller S.L., DeMaria J.E., Freier D.O., Riegel A.M., Clevenger C.V.
    Mol. Endocrinol. 19:939-949(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PRLR; VAV1 AND VAV2, ENZYME REGULATION.
  9. "Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells."
    Miller S.L., Antico G., Raghunath P.N., Tomaszewski J.E., Clevenger C.V.
    Oncogene 26:4668-4678(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH PXN.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-479, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-23; ARG-60; HIS-122; LEU-170; GLY-259; ASP-305; ASN-461 AND LYS-477.

Entry informationi

Entry nameiNEK3_HUMAN
AccessioniPrimary (citable) accession number: P51956
Secondary accession number(s): A8K2J4
, Q5TAP2, Q8J023, Q8WUN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 16, 2002
Last modified: November 26, 2014
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3