P51953 (CDK7_CARAU) Reviewed, UniProtKB/Swiss-Prot
Last modified May 1, 2013. Version 71. History...
Names and origin
|Protein names||Recommended name:|
Cyclin-dependent kinase 7
40 kDa protein kinase
Cell division protein kinase 7
|Organism||Carassius auratus (Goldfish)|
|Taxonomic identifier||7957 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Carassius|
|Sequence length||344 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of cdk1/cyclin-B during G2-M transition, and for activation of cdk2/cyclins during G1-S transition (but not complex formation). cdk7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. CAK activates the cyclin-associated kinases cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts By similarity.
ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Phosphorylation at Thr-169 is required for enzymatic activity.
Probably associates with cyclin-H (ccnh) and mat1 to form a multimeric active enzyme By similarity.
Nucleus By similarity.
Phosphorylation of Ser-163 during mitosis inactivates the enzyme. Phosphorylation of Thr-169 is required for activity. Phosphorylated at Ser-163 and Thr-169 by CDK2 By similarity.
Contains 1 protein kinase domain.
|Biological process||Cell cycle|
|Gene Ontology (GO)|
Inferred from electronic annotation. Source: UniProtKB-KWmeiosis
Inferred from electronic annotation. Source: UniProtKB-KW
Inferred from electronic annotation. Source: UniProtKB-SubCell
Inferred from electronic annotation. Source: UniProtKB-KWRNA polymerase II carboxy-terminal domain kinase activity
Inferred from electronic annotation. Source: ECcyclin-dependent protein serine/threonine kinase activity
Inferred from electronic annotation. Source: EC
|Complete GO annotation...|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 344||344||Cyclin-dependent kinase 7||PRO_0000085794|
|Domain||12 – 294||283||Protein kinase|
|Nucleotide binding||18 – 26||9||ATP By similarity|
|Active site||136||1||Proton acceptor By similarity|
|Binding site||41||1||ATP By similarity|
Amino acid modifications
|Modified residue||163||1||Phosphoserine; by CDK1 and CDK2 By similarity|
|Modified residue||169||1||Phosphothreonine; by CDK2 By similarity|
|D38631 mRNA. Translation: BAA07611.1.|
3D structure databases
|SMR||P51953. Positions 13-310. |
Protocols and materials databases
Family and domain databases
|InterPro||IPR011009. Kinase-like_dom. |
|Pfam||PF00069. Pkinase. 1 hit. |
|SMART||SM00220. S_TKc. 1 hit. |
|SUPFAM||SSF56112. Kinase_like. 1 hit. |
|PROSITE||PS00107. PROTEIN_KINASE_ATP. 1 hit. |
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
|Accession||Primary (citable) accession number: P51953|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|
Index of protein domains and families