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Protein

Cyclin-H

Gene

ccnh

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-H
Alternative name(s):
MO15-associated protein
p36
Gene namesi
Name:ccnh
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-922574. ccnh.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Cyclin-HPRO_0000080474Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.

Structurei

3D structure databases

ProteinModelPortaliP51947.
SMRiP51947. Positions 11-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

HOVERGENiHBG050840.
KOiK06634.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
IPR027081. CyclinH/Ccl1.
[Graphical view]
PfamiPF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
TIGRFAMsiTIGR00569. ccl1. 1 hit.

Sequencei

Sequence statusi: Complete.

P51947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYHNSTQKKH WTFLSEDEPL RRRIQANVRY RARIRATEKP RLSEIFSLEP
60 70 80 90 100
HEELAICKYY EKRLLDFCNA FKPTMPKSVL GTACMYFKRF YLNNSVMEHH
110 120 130 140 150
PRIIMLTCVF LACKVDEFNV SSIQFVGNLG ENPLGQEKIL EQILEYELLL
160 170 180 190 200
IQQLNFHLIV HNPYRPFEGF LIDVKTRYPM LENPEVLRKS ADEFLNRVAL
210 220 230 240 250
TDACLLFAPS VIALTAILST ASRAGLNMES YLTECLSLKD NQETMSHLLD
260 270 280 290 300
GMRRLKILVS KYEPARPEEV AALKKRLDHC HSTEVTLSVH GRKRKGYEDD
310 320
GYISKKPKTE EDEWTDEDFG DSL
Length:323
Mass (Da):37,600
Last modified:October 1, 1996 - v1
Checksum:i14BCDCA000843DC8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti266 – 2661R → Y AA sequence (PubMed:7957080).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20505 mRNA. Translation: AAA62236.1.
RefSeqiNP_001081052.1. NM_001087583.1.
UniGeneiXl.910.

Genome annotation databases

GeneIDi394356.
KEGGixla:394356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20505 mRNA. Translation: AAA62236.1.
RefSeqiNP_001081052.1. NM_001087583.1.
UniGeneiXl.910.

3D structure databases

ProteinModelPortaliP51947.
SMRiP51947. Positions 11-287.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi394356.
KEGGixla:394356.

Organism-specific databases

CTDi902.
XenbaseiXB-GENE-922574. ccnh.

Phylogenomic databases

HOVERGENiHBG050840.
KOiK06634.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
IPR027081. CyclinH/Ccl1.
[Graphical view]
PfamiPF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
TIGRFAMsiTIGR00569. ccl1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCNH_XENLA
AccessioniPrimary (citable) accession number: P51947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 20, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.