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Protein

Cyclin-H

Gene

ccnh

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-H
Alternative name(s):
MO15-associated protein
p36
Gene namesi
Name:ccnh
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-922574. ccnh.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804741 – 323Cyclin-HAdd BLAST323

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP51947.

Interactioni

Subunit structurei

Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.

Structurei

3D structure databases

ProteinModelPortaliP51947.
SMRiP51947.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

HOVERGENiHBG050840.
KOiK06634.

Family and domain databases

CDDicd00043. CYCLIN. 1 hit.
Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR036915. Cyclin-like_sf.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
IPR027081. CyclinH/Ccl1.
PfamiView protein in Pfam
PF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
TIGRFAMsiTIGR00569. ccl1. 1 hit.

Sequencei

Sequence statusi: Complete.

P51947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYHNSTQKKH WTFLSEDEPL RRRIQANVRY RARIRATEKP RLSEIFSLEP
60 70 80 90 100
HEELAICKYY EKRLLDFCNA FKPTMPKSVL GTACMYFKRF YLNNSVMEHH
110 120 130 140 150
PRIIMLTCVF LACKVDEFNV SSIQFVGNLG ENPLGQEKIL EQILEYELLL
160 170 180 190 200
IQQLNFHLIV HNPYRPFEGF LIDVKTRYPM LENPEVLRKS ADEFLNRVAL
210 220 230 240 250
TDACLLFAPS VIALTAILST ASRAGLNMES YLTECLSLKD NQETMSHLLD
260 270 280 290 300
GMRRLKILVS KYEPARPEEV AALKKRLDHC HSTEVTLSVH GRKRKGYEDD
310 320
GYISKKPKTE EDEWTDEDFG DSL
Length:323
Mass (Da):37,600
Last modified:October 1, 1996 - v1
Checksum:i14BCDCA000843DC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti266R → Y AA sequence (PubMed:7957080).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20505 mRNA. Translation: AAA62236.1.
RefSeqiNP_001081052.1. NM_001087583.1.
UniGeneiXl.910.

Genome annotation databases

GeneIDi394356.
KEGGixla:394356.

Similar proteinsi

Entry informationi

Entry nameiCCNH_XENLA
AccessioniPrimary (citable) accession number: P51947
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families