ID   CCNG1_MOUSE             Reviewed;         294 AA.
AC   P51945; O54779;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   24-JAN-2024, entry version 162.
DE   RecName: Full=Cyclin-G1;
DE            Short=Cyclin-G;
GN   Name=Ccng1; Synonyms=Ccng;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RX   PubMed=8626390; DOI=10.1074/jbc.271.11.6050;
RA   Horne M.C., Goolsby G.L., Donaldson K.L., Tran D., Neubauer M.G.,
RA   Wahl A.F.;
RT   "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting
RT   tissue-specific and cell cycle-regulated expression.";
RL   J. Biol. Chem. 271:6050-6061(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 46-294.
RX   PubMed=7957050; DOI=10.1002/j.1460-2075.1994.tb06807.x;
RA   Okamoto K., Beach D.;
RT   "Cyclin G is a transcriptional target of the p53 tumor suppressor
RT   protein.";
RL   EMBO J. 13:4816-4822(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129;
RX   PubMed=9441755; DOI=10.1006/geno.1997.5034;
RA   Kimura S.H., Kataoka T.R., Endo Y., Nojima H.;
RT   "Genomic structure and chromosomal localization of mouse cyclin G1 gene.";
RL   Genomics 46:483-486(1997).
RN   [4]
RP   FUNCTION.
RX   PubMed=8887688; DOI=10.1128/mcb.16.11.6593;
RA   Okamoto K., Kamibayashi C., Serrano M., Prives C., Mumby M.C., Beach D.;
RT   "p53-dependent association between cyclin G and the B' subunit of protein
RT   phosphatase 2A.";
RL   Mol. Cell. Biol. 16:6593-6602(1996).
RN   [5]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=9696022; DOI=10.1002/hep.510280235;
RA   Jensen M.R., Factor V.M., Thorgeirsson S.S.;
RT   "Regulation of cyclin G1 during murine hepatic regeneration following
RT   Dipin-induced DNA damage.";
RL   Hepatology 28:537-546(1998).
CC   -!- FUNCTION: May play a role in growth regulation. Is associated with G2/M
CC       phase arrest in response to DNA damage. May be an intermediate by which
CC       p53 mediates its role as an inhibitor of cellular proliferation.
CC       {ECO:0000269|PubMed:8887688, ECO:0000269|PubMed:9696022}.
CC   -!- SUBUNIT: Binds to B' regulatory B subunits of protein phosphatase A
CC       (PP2A) following induction by p53 (in vitro).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9696022}.
CC   -!- TISSUE SPECIFICITY: Highest levels in kidney, heart and skeletal
CC       muscle.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin G subfamily.
CC       {ECO:0000305}.
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DR   EMBL; L49507; AAC42082.1; -; mRNA.
DR   EMBL; Z37110; CAA85474.1; -; mRNA.
DR   EMBL; AB005559; BAA24492.1; -; Genomic_DNA.
DR   CCDS; CCDS24550.1; -.
DR   PIR; S51621; S51621.
DR   RefSeq; NP_033961.1; NM_009831.2.
DR   AlphaFoldDB; P51945; -.
DR   SMR; P51945; -.
DR   BioGRID; 198555; 5.
DR   DIP; DIP-24179N; -.
DR   STRING; 10090.ENSMUSP00000020576; -.
DR   iPTMnet; P51945; -.
DR   PhosphoSitePlus; P51945; -.
DR   PaxDb; 10090-ENSMUSP00000020576; -.
DR   PeptideAtlas; P51945; -.
DR   ProteomicsDB; 280016; -.
DR   Antibodypedia; 28603; 368 antibodies from 30 providers.
DR   DNASU; 12450; -.
DR   Ensembl; ENSMUST00000020576.8; ENSMUSP00000020576.8; ENSMUSG00000020326.8.
DR   GeneID; 12450; -.
DR   KEGG; mmu:12450; -.
DR   UCSC; uc007ilz.1; mouse.
DR   AGR; MGI:102890; -.
DR   CTD; 900; -.
DR   MGI; MGI:102890; Ccng1.
DR   VEuPathDB; HostDB:ENSMUSG00000020326; -.
DR   eggNOG; KOG0653; Eukaryota.
DR   GeneTree; ENSGT00940000154726; -.
DR   HOGENOM; CLU_062642_0_0_1; -.
DR   InParanoid; P51945; -.
DR   OMA; CFEAQEE; -.
DR   OrthoDB; 3032827at2759; -.
DR   PhylomeDB; P51945; -.
DR   TreeFam; TF101007; -.
DR   Reactome; R-MMU-6804757; Regulation of TP53 Degradation.
DR   BioGRID-ORCS; 12450; 3 hits in 78 CRISPR screens.
DR   ChiTaRS; Ccng1; mouse.
DR   PRO; PR:P51945; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; P51945; Protein.
DR   Bgee; ENSMUSG00000020326; Expressed in intercostal muscle and 256 other cell types or tissues.
DR   ExpressionAtlas; P51945; baseline and differential.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; ISO:MGI.
DR   GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; ISO:MGI.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR   GO; GO:0009629; P:response to gravity; IEA:Ensembl.
DR   GO; GO:0010243; P:response to organonitrogen compound; IEA:Ensembl.
DR   GO; GO:0006949; P:syncytium formation; ISO:MGI.
DR   CDD; cd20583; CYCLIN_CCNG1; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 2.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like_dom.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177:SF59; CYCLIN-G1; 1.
DR   PANTHER; PTHR10177; CYCLINS; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; Cyclin-like; 1.
DR   Genevisible; P51945; MM.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cyclin; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..294
FT                   /note="Cyclin-G1"
FT                   /id="PRO_0000080466"
FT   CONFLICT        175
FT                   /note="D -> G (in Ref. 3; BAA24492)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        192..198
FT                   /note="IIFSKAK -> SYFLRQ (in Ref. 3; BAA24492)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   294 AA;  33903 MW;  09640ADF4E739BAA CRC64;
     MIEVLTTDSQ KLLHQLNTLL EQESRCQPKV CGLKLIESAH DNGLRMTARL RDFEVKDLLS
     LTQFFGFDTE TFSLAVNLLD RFLSKMKVQA KHLGCVGLSC FYLAVKATEE ERNVPLATDL
     IRISQYRFTV SDLMRMEKIV LEKVCWKVKA TTAFQFLQLY YSLVHDTLPF ERRNDLNFER
     LEAQLKACHC RIIFSKAKPS VLALSILALE IQALKYVELT EGVECIQKHS KISGRDLTFW
     QELVSKCLTE YSSNKCSKPN GQKLKWIVSG RTARQLKHSY YRITHLPTIP ETIC
//