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P51945

- CCNG1_MOUSE

UniProt

P51945 - CCNG1_MOUSE

Protein

Cyclin-G1

Gene

Ccng1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.2 Publications

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cell growth Source: Ensembl
    3. mitotic G2 DNA damage checkpoint Source: Ensembl
    4. mitotic nuclear division Source: UniProtKB-KW
    5. negative regulation of apoptotic process Source: Ensembl
    6. response to organonitrogen compound Source: Ensembl
    7. syncytium formation Source: Ensembl

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-G1
    Short name:
    Cyclin-G
    Gene namesi
    Name:Ccng1
    Synonyms:Ccng
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:102890. Ccng1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. neuronal cell body Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell
    4. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Cyclin-G1PRO_0000080466Add
    BLAST

    Proteomic databases

    PRIDEiP51945.

    PTM databases

    PhosphoSiteiP51945.

    Expressioni

    Tissue specificityi

    Highest levels in kidney, heart and skeletal muscle.

    Gene expression databases

    ArrayExpressiP51945.
    BgeeiP51945.
    CleanExiMM_CCNG1.
    GenevestigatoriP51945.

    Interactioni

    Subunit structurei

    Binds to B' regulatory B subunits of protein phosphatase A (PP2A) following induction by p53 (in vitro).

    Protein-protein interaction databases

    BioGridi198555. 6 interactions.
    DIPiDIP-24179N.

    Structurei

    3D structure databases

    ProteinModelPortaliP51945.
    SMRiP51945. Positions 16-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin G subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG281302.
    HOGENOMiHOG000059559.
    HOVERGENiHBG050839.
    InParanoidiP51945.
    KOiK10145.
    OMAiSDMMRME.
    OrthoDBiEOG7HB59M.
    PhylomeDBiP51945.
    TreeFamiTF101007.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR028860. CCNG1.
    IPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    [Graphical view]
    PANTHERiPTHR10177:SF59. PTHR10177:SF59. 1 hit.
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P51945-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIEVLTTDSQ KLLHQLNTLL EQESRCQPKV CGLKLIESAH DNGLRMTARL    50
    RDFEVKDLLS LTQFFGFDTE TFSLAVNLLD RFLSKMKVQA KHLGCVGLSC 100
    FYLAVKATEE ERNVPLATDL IRISQYRFTV SDLMRMEKIV LEKVCWKVKA 150
    TTAFQFLQLY YSLVHDTLPF ERRNDLNFER LEAQLKACHC RIIFSKAKPS 200
    VLALSILALE IQALKYVELT EGVECIQKHS KISGRDLTFW QELVSKCLTE 250
    YSSNKCSKPN GQKLKWIVSG RTARQLKHSY YRITHLPTIP ETIC 294
    Length:294
    Mass (Da):33,903
    Last modified:November 1, 1997 - v2
    Checksum:i09640ADF4E739BAA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1751D → G in BAA24492. (PubMed:9441755)Curated
    Sequence conflicti192 – 1987IIFSKAK → SYFLRQ in BAA24492. (PubMed:9441755)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L49507 mRNA. Translation: AAC42082.1.
    Z37110 mRNA. Translation: CAA85474.1.
    AB005559 Genomic DNA. Translation: BAA24492.1.
    CCDSiCCDS24550.1.
    PIRiS51621.
    RefSeqiNP_033961.1. NM_009831.2.
    UniGeneiMm.2103.

    Genome annotation databases

    EnsembliENSMUST00000020576; ENSMUSP00000020576; ENSMUSG00000020326.
    GeneIDi12450.
    KEGGimmu:12450.
    UCSCiuc007ilz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L49507 mRNA. Translation: AAC42082.1 .
    Z37110 mRNA. Translation: CAA85474.1 .
    AB005559 Genomic DNA. Translation: BAA24492.1 .
    CCDSi CCDS24550.1.
    PIRi S51621.
    RefSeqi NP_033961.1. NM_009831.2.
    UniGenei Mm.2103.

    3D structure databases

    ProteinModelPortali P51945.
    SMRi P51945. Positions 16-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198555. 6 interactions.
    DIPi DIP-24179N.

    PTM databases

    PhosphoSitei P51945.

    Proteomic databases

    PRIDEi P51945.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020576 ; ENSMUSP00000020576 ; ENSMUSG00000020326 .
    GeneIDi 12450.
    KEGGi mmu:12450.
    UCSCi uc007ilz.1. mouse.

    Organism-specific databases

    CTDi 900.
    MGIi MGI:102890. Ccng1.

    Phylogenomic databases

    eggNOGi NOG281302.
    HOGENOMi HOG000059559.
    HOVERGENi HBG050839.
    InParanoidi P51945.
    KOi K10145.
    OMAi SDMMRME.
    OrthoDBi EOG7HB59M.
    PhylomeDBi P51945.
    TreeFami TF101007.

    Miscellaneous databases

    NextBioi 281286.
    PROi P51945.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51945.
    Bgeei P51945.
    CleanExi MM_CCNG1.
    Genevestigatori P51945.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR028860. CCNG1.
    IPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    [Graphical view ]
    PANTHERi PTHR10177:SF59. PTHR10177:SF59. 1 hit.
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression."
      Horne M.C., Goolsby G.L., Donaldson K.L., Tran D., Neubauer M.G., Wahl A.F.
      J. Biol. Chem. 271:6050-6061(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Blood.
    2. "Cyclin G is a transcriptional target of the p53 tumor suppressor protein."
      Okamoto K., Beach D.
      EMBO J. 13:4816-4822(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-294.
    3. "Genomic structure and chromosomal localization of mouse cyclin G1 gene."
      Kimura S.H., Kataoka T.R., Endo Y., Nojima H.
      Genomics 46:483-486(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    4. "p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A."
      Okamoto K., Kamibayashi C., Serrano M., Prives C., Mumby M.C., Beach D.
      Mol. Cell. Biol. 16:6593-6602(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Regulation of cyclin G1 during murine hepatic regeneration following Dipin-induced DNA damage."
      Jensen M.R., Factor V.M., Thorgeirsson S.S.
      Hepatology 28:537-546(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCCNG1_MOUSE
    AccessioniPrimary (citable) accession number: P51945
    Secondary accession number(s): O54779
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3