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P51945 (CCNG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-G1

Short name=Cyclin-G
Gene names
Name:Ccng1
Synonyms:Ccng
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation. Ref.4 Ref.5

Subunit structure

Binds to B' regulatory B subunits of protein phosphatase A (PP2A) following induction by p53 (in vitro).

Subcellular location

Nucleus Ref.5.

Tissue specificity

Highest levels in kidney, heart and skeletal muscle.

Sequence similarities

Belongs to the cyclin family. Cyclin G subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Cyclin-G1
PRO_0000080466

Experimental info

Sequence conflict1751D → G in BAA24492. Ref.3
Sequence conflict192 – 1987IIFSKAK → SYFLRQ in BAA24492. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P51945 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 09640ADF4E739BAA

FASTA29433,903
        10         20         30         40         50         60 
MIEVLTTDSQ KLLHQLNTLL EQESRCQPKV CGLKLIESAH DNGLRMTARL RDFEVKDLLS 

        70         80         90        100        110        120 
LTQFFGFDTE TFSLAVNLLD RFLSKMKVQA KHLGCVGLSC FYLAVKATEE ERNVPLATDL 

       130        140        150        160        170        180 
IRISQYRFTV SDLMRMEKIV LEKVCWKVKA TTAFQFLQLY YSLVHDTLPF ERRNDLNFER 

       190        200        210        220        230        240 
LEAQLKACHC RIIFSKAKPS VLALSILALE IQALKYVELT EGVECIQKHS KISGRDLTFW 

       250        260        270        280        290 
QELVSKCLTE YSSNKCSKPN GQKLKWIVSG RTARQLKHSY YRITHLPTIP ETIC 

« Hide

References

[1]"Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression."
Horne M.C., Goolsby G.L., Donaldson K.L., Tran D., Neubauer M.G., Wahl A.F.
J. Biol. Chem. 271:6050-6061(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Blood.
[2]"Cyclin G is a transcriptional target of the p53 tumor suppressor protein."
Okamoto K., Beach D.
EMBO J. 13:4816-4822(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-294.
[3]"Genomic structure and chromosomal localization of mouse cyclin G1 gene."
Kimura S.H., Kataoka T.R., Endo Y., Nojima H.
Genomics 46:483-486(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
[4]"p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A."
Okamoto K., Kamibayashi C., Serrano M., Prives C., Mumby M.C., Beach D.
Mol. Cell. Biol. 16:6593-6602(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Regulation of cyclin G1 during murine hepatic regeneration following Dipin-induced DNA damage."
Jensen M.R., Factor V.M., Thorgeirsson S.S.
Hepatology 28:537-546(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L49507 mRNA. Translation: AAC42082.1.
Z37110 mRNA. Translation: CAA85474.1.
AB005559 Genomic DNA. Translation: BAA24492.1.
CCDSCCDS24550.1.
PIRS51621.
RefSeqNP_033961.1. NM_009831.2.
UniGeneMm.2103.

3D structure databases

ProteinModelPortalP51945.
SMRP51945. Positions 16-221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198555. 6 interactions.
DIPDIP-24179N.

PTM databases

PhosphoSiteP51945.

Proteomic databases

PRIDEP51945.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020576; ENSMUSP00000020576; ENSMUSG00000020326.
GeneID12450.
KEGGmmu:12450.
UCSCuc007ilz.1. mouse.

Organism-specific databases

CTD900.
MGIMGI:102890. Ccng1.

Phylogenomic databases

eggNOGNOG281302.
HOGENOMHOG000059559.
HOVERGENHBG050839.
InParanoidP51945.
KOK10145.
OMASDMMRME.
OrthoDBEOG7HB59M.
PhylomeDBP51945.
TreeFamTF101007.

Gene expression databases

ArrayExpressP51945.
BgeeP51945.
CleanExMM_CCNG1.
GenevestigatorP51945.

Family and domain databases

Gene3D1.10.472.10. 1 hit.
InterProIPR028860. CCNG1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERPTHR10177:SF59. PTHR10177:SF59. 1 hit.
PfamPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 1 hit.
ProtoNetSearch...

Other

NextBio281286.
PROP51945.
SOURCESearch...

Entry information

Entry nameCCNG1_MOUSE
AccessionPrimary (citable) accession number: P51945
Secondary accession number(s): O54779
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot