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P51945

- CCNG1_MOUSE

UniProt

P51945 - CCNG1_MOUSE

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Protein

Cyclin-G1

Gene

Ccng1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.2 Publications

GO - Biological processi

  1. brain development Source: Ensembl
  2. cell growth Source: Ensembl
  3. mitotic G2 DNA damage checkpoint Source: Ensembl
  4. mitotic nuclear division Source: UniProtKB-KW
  5. negative regulation of apoptotic process Source: Ensembl
  6. response to organonitrogen compound Source: Ensembl
  7. syncytium formation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-G1
Short name:
Cyclin-G
Gene namesi
Name:Ccng1
Synonyms:Ccng
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:102890. Ccng1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. neuronal cell body Source: Ensembl
  3. nucleus Source: UniProtKB-KW
  4. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Cyclin-G1PRO_0000080466Add
BLAST

Proteomic databases

PRIDEiP51945.

PTM databases

PhosphoSiteiP51945.

Expressioni

Tissue specificityi

Highest levels in kidney, heart and skeletal muscle.

Gene expression databases

BgeeiP51945.
CleanExiMM_CCNG1.
ExpressionAtlasiP51945. baseline and differential.
GenevestigatoriP51945.

Interactioni

Subunit structurei

Binds to B' regulatory B subunits of protein phosphatase A (PP2A) following induction by p53 (in vitro).

Protein-protein interaction databases

BioGridi198555. 6 interactions.
DIPiDIP-24179N.

Structurei

3D structure databases

ProteinModelPortaliP51945.
SMRiP51945. Positions 16-221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin G subfamily.Curated

Phylogenomic databases

eggNOGiNOG281302.
HOGENOMiHOG000059559.
HOVERGENiHBG050839.
InParanoidiP51945.
KOiK10145.
OMAiSDMMRME.
OrthoDBiEOG7HB59M.
PhylomeDBiP51945.
TreeFamiTF101007.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR028860. CCNG1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF59. PTHR10177:SF59. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Complete.

P51945-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIEVLTTDSQ KLLHQLNTLL EQESRCQPKV CGLKLIESAH DNGLRMTARL
60 70 80 90 100
RDFEVKDLLS LTQFFGFDTE TFSLAVNLLD RFLSKMKVQA KHLGCVGLSC
110 120 130 140 150
FYLAVKATEE ERNVPLATDL IRISQYRFTV SDLMRMEKIV LEKVCWKVKA
160 170 180 190 200
TTAFQFLQLY YSLVHDTLPF ERRNDLNFER LEAQLKACHC RIIFSKAKPS
210 220 230 240 250
VLALSILALE IQALKYVELT EGVECIQKHS KISGRDLTFW QELVSKCLTE
260 270 280 290
YSSNKCSKPN GQKLKWIVSG RTARQLKHSY YRITHLPTIP ETIC
Length:294
Mass (Da):33,903
Last modified:November 1, 1997 - v2
Checksum:i09640ADF4E739BAA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751D → G in BAA24492. (PubMed:9441755)Curated
Sequence conflicti192 – 1987IIFSKAK → SYFLRQ in BAA24492. (PubMed:9441755)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L49507 mRNA. Translation: AAC42082.1.
Z37110 mRNA. Translation: CAA85474.1.
AB005559 Genomic DNA. Translation: BAA24492.1.
CCDSiCCDS24550.1.
PIRiS51621.
RefSeqiNP_033961.1. NM_009831.2.
UniGeneiMm.2103.

Genome annotation databases

EnsembliENSMUST00000020576; ENSMUSP00000020576; ENSMUSG00000020326.
GeneIDi12450.
KEGGimmu:12450.
UCSCiuc007ilz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L49507 mRNA. Translation: AAC42082.1 .
Z37110 mRNA. Translation: CAA85474.1 .
AB005559 Genomic DNA. Translation: BAA24492.1 .
CCDSi CCDS24550.1.
PIRi S51621.
RefSeqi NP_033961.1. NM_009831.2.
UniGenei Mm.2103.

3D structure databases

ProteinModelPortali P51945.
SMRi P51945. Positions 16-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198555. 6 interactions.
DIPi DIP-24179N.

PTM databases

PhosphoSitei P51945.

Proteomic databases

PRIDEi P51945.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020576 ; ENSMUSP00000020576 ; ENSMUSG00000020326 .
GeneIDi 12450.
KEGGi mmu:12450.
UCSCi uc007ilz.1. mouse.

Organism-specific databases

CTDi 900.
MGIi MGI:102890. Ccng1.

Phylogenomic databases

eggNOGi NOG281302.
HOGENOMi HOG000059559.
HOVERGENi HBG050839.
InParanoidi P51945.
KOi K10145.
OMAi SDMMRME.
OrthoDBi EOG7HB59M.
PhylomeDBi P51945.
TreeFami TF101007.

Miscellaneous databases

NextBioi 281286.
PROi P51945.
SOURCEi Search...

Gene expression databases

Bgeei P51945.
CleanExi MM_CCNG1.
ExpressionAtlasi P51945. baseline and differential.
Genevestigatori P51945.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR028860. CCNG1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10177:SF59. PTHR10177:SF59. 1 hit.
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression."
    Horne M.C., Goolsby G.L., Donaldson K.L., Tran D., Neubauer M.G., Wahl A.F.
    J. Biol. Chem. 271:6050-6061(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  2. "Cyclin G is a transcriptional target of the p53 tumor suppressor protein."
    Okamoto K., Beach D.
    EMBO J. 13:4816-4822(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-294.
  3. "Genomic structure and chromosomal localization of mouse cyclin G1 gene."
    Kimura S.H., Kataoka T.R., Endo Y., Nojima H.
    Genomics 46:483-486(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  4. "p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A."
    Okamoto K., Kamibayashi C., Serrano M., Prives C., Mumby M.C., Beach D.
    Mol. Cell. Biol. 16:6593-6602(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Regulation of cyclin G1 during murine hepatic regeneration following Dipin-induced DNA damage."
    Jensen M.R., Factor V.M., Thorgeirsson S.S.
    Hepatology 28:537-546(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCCNG1_MOUSE
AccessioniPrimary (citable) accession number: P51945
Secondary accession number(s): O54779
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3