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P51943

- CCNA2_MOUSE

UniProt

P51943 - CCNA2_MOUSE

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Protein

Cyclin-A2

Gene
Ccna2, Ccna, Cyca
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein kinase binding Source: MGI

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. organ regeneration Source: Ensembl
  3. positive regulation of fibroblast proliferation Source: Ensembl
  4. positive regulation of transcription, DNA-templated Source: MGI
  5. Ras protein signal transduction Source: Ensembl
  6. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
  7. regulation of G2/M transition of mitotic cell cycle Source: InterPro
  8. response to estradiol Source: Ensembl
  9. response to glucagon Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_188819. DNA Damage/Telomere Stress Induced Senescence.
REACT_199110. G0 and Early G1.
REACT_206033. Senescence-Associated Secretory Phenotype (SASP).
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
REACT_223647. Cyclin A:Cdk2-associated events at S phase entry.
REACT_227891. G2 Phase.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-A2
Short name:
Cyclin-A
Gene namesi
Name:Ccna2
Synonyms:Ccna, Cyca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:108069. Ccna2.

Subcellular locationi

Nucleus. Cytoplasm
Note: Cytoplasmic when associated with SCAPER By similarity.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. female pronucleus Source: MGI
  3. male pronucleus Source: MGI
  4. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Cyclin-A2PRO_0000080340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei5 – 51Phosphoserine By similarity

Post-translational modificationi

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP51943.
PRIDEiP51943.

PTM databases

PhosphoSiteiP51943.

Expressioni

Tissue specificityi

Ubiquitous. In the testis, expressed in germ cells and in the ovary, in both germline and somatic cells.

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis. Expressed in spermatogonia and is most abundant in preleptotene spermatocytes, cells which will enter the meiotic pathway.

Gene expression databases

ArrayExpressiP51943.
BgeeiP51943.
CleanExiMM_CCNA2.
GenevestigatoriP51943.

Interactioni

Subunit structurei

Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. In the testis, interacts only with CDK2. When associated with CDK2 (but not with CDK1), interacts with SCAPER By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Cdk1P114402EBI-846980,EBI-846949
Cdk2P973773EBI-846980,EBI-847048

Protein-protein interaction databases

BioGridi198545. 10 interactions.
DIPiDIP-45864N.
IntActiP51943. 3 interactions.
STRINGi10090.ENSMUSP00000029270.

Structurei

Secondary structure

1
422
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi166 – 18217
Helixi189 – 1924
Helixi198 – 21417
Helixi219 – 23517
Helixi240 – 2423
Helixi243 – 25816
Helixi265 – 2717
Beta strandi274 – 2763
Helixi278 – 29114
Turni292 – 2943
Helixi301 – 3088
Helixi309 – 3113
Beta strandi312 – 3143
Helixi317 – 33216
Helixi334 – 3374
Helixi342 – 35817
Helixi364 – 3707
Helixi374 – 39017
Helixi391 – 3933
Helixi398 – 4025
Helixi406 – 4083
Helixi411 – 4133

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QHRX-ray2.17B/D163-422[»]
3QHWX-ray1.91B/D163-422[»]
4I3ZX-ray2.05B/D165-421[»]
4II5X-ray2.15B/D165-422[»]
ProteinModelPortaliP51943.
SMRiP51943. Positions 163-422.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00740000115500.
HOGENOMiHOG000167672.
HOVERGENiHBG106244.
InParanoidiQ8BRG1.
KOiK06627.
OMAiNPEKAAP.
OrthoDBiEOG7G7KQ0.
TreeFamiTF101002.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR015453. Cyclin_A_chordates.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF69. PTHR10177:SF69. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51943-1 [UniParc]FASTAAdd to Basket

« Hide

MPGTSRHSGR DAGSALLSLH QEDQENVNPE KLAPAQQPRA QAVLKAGNVR    50
GPAPQQKLKT RRVAPLKDLP INDEHVTAGP SWKAVSKQPA FTIHVDEAEE 100
TQKRPAELKE TECEDALAFN AAVSLPGARK PLTPLDYPMD GSFESPHAMD 150
MSIVLEDKPV NVNEVPDYQE DIHTYLREME VKCKPKVGYM KRQPDITNSM 200
RAILVDWLVE VGEEYKLQNE TLHLAVNYID RFLSSMSVLR GKLQLVGTAA 250
MLLASKFEEI YPPEVAEFVY ITDDTYSKKQ VLRMEHLVLK VLAFDLAAPT 300
VNQFLTQYFL HLQPANCKVE SLAMFLGELS LIDADPYLKY LPSLIAGAAF 350
HLALYTVTGQ SWPESLAQQT GYTLESLKPC LVDLHQTYLK APQHAQQSIR 400
EKYKHSKYHS VSLLNPPETL SV 422
Length:422
Mass (Da):47,269
Last modified:July 27, 2011 - v2
Checksum:i1818B92552E4D0D1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271G → A in CAA81331. 1 Publication
Sequence conflicti127 – 1271G → A in CAA53212. 1 Publication
Sequence conflicti391 – 3911A → P in CAA53212. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26580 mRNA. Translation: CAA81331.1.
X75483 mRNA. Translation: CAA53212.1.
AK044924 mRNA. Translation: BAC32144.1.
CH466530 Genomic DNA. Translation: EDL35081.1.
BC052730 mRNA. Translation: AAH52730.1.
CCDSiCCDS17313.1.
PIRiS37280.
S38501.
RefSeqiNP_033958.2. NM_009828.2.
UniGeneiMm.4189.

Genome annotation databases

EnsembliENSMUST00000029270; ENSMUSP00000029270; ENSMUSG00000027715.
GeneIDi12428.
KEGGimmu:12428.
UCSCiuc012cov.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26580 mRNA. Translation: CAA81331.1 .
X75483 mRNA. Translation: CAA53212.1 .
AK044924 mRNA. Translation: BAC32144.1 .
CH466530 Genomic DNA. Translation: EDL35081.1 .
BC052730 mRNA. Translation: AAH52730.1 .
CCDSi CCDS17313.1.
PIRi S37280.
S38501.
RefSeqi NP_033958.2. NM_009828.2.
UniGenei Mm.4189.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3QHR X-ray 2.17 B/D 163-422 [» ]
3QHW X-ray 1.91 B/D 163-422 [» ]
4I3Z X-ray 2.05 B/D 165-421 [» ]
4II5 X-ray 2.15 B/D 165-422 [» ]
ProteinModelPortali P51943.
SMRi P51943. Positions 163-422.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198545. 10 interactions.
DIPi DIP-45864N.
IntActi P51943. 3 interactions.
STRINGi 10090.ENSMUSP00000029270.

PTM databases

PhosphoSitei P51943.

Proteomic databases

PaxDbi P51943.
PRIDEi P51943.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029270 ; ENSMUSP00000029270 ; ENSMUSG00000027715 .
GeneIDi 12428.
KEGGi mmu:12428.
UCSCi uc012cov.1. mouse.

Organism-specific databases

CTDi 890.
MGIi MGI:108069. Ccna2.

Phylogenomic databases

eggNOGi COG5024.
GeneTreei ENSGT00740000115500.
HOGENOMi HOG000167672.
HOVERGENi HBG106244.
InParanoidi Q8BRG1.
KOi K06627.
OMAi NPEKAAP.
OrthoDBi EOG7G7KQ0.
TreeFami TF101002.

Enzyme and pathway databases

Reactomei REACT_188819. DNA Damage/Telomere Stress Induced Senescence.
REACT_199110. G0 and Early G1.
REACT_206033. Senescence-Associated Secretory Phenotype (SASP).
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
REACT_223647. Cyclin A:Cdk2-associated events at S phase entry.
REACT_227891. G2 Phase.

Miscellaneous databases

ChiTaRSi CCNA2. mouse.
NextBioi 281244.
PROi P51943.
SOURCEi Search...

Gene expression databases

ArrayExpressi P51943.
Bgeei P51943.
CleanExi MM_CCNA2.
Genevestigatori P51943.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR015453. Cyclin_A_chordates.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10177:SF69. PTHR10177:SF69. 1 hit.
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The developmentally restricted pattern of expression in the male germ line of a murine cyclin A, cyclin A2, suggests roles in both mitotic and meiotic cell cycles."
    Ravnik S.E., Wolgemuth D.J.
    Dev. Biol. 173:69-78(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A distinct cyclin A is expressed in germ cells in the mouse."
    Sweeney C., Murphy M., Kubelka M., Ravnik S.E., Hawkins C.F., Wolgemuth D.J., Carrington M.
    Development 122:53-64(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage."
    Ravnik S.E., Wolgemuth D.J.
    Dev. Biol. 207:408-418(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: Swiss Webster.

Entry informationi

Entry nameiCCNA2_MOUSE
AccessioniPrimary (citable) accession number: P51943
Secondary accession number(s): Q61459, Q8BRG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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