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Reviewed, UniProtKB/Swiss-Prot P51943 (CCNA2_MOUSE)

Last modified December 15, 2009. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cyclin-A2
      Short name=Cyclin-A
Gene names
Name: Ccna2
Synonyms: Ccna, Cyca
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. Ref.3

Subunit structure

Interacts with the CDK2 and CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. In the testis, interacts only with CDK2. When associated with CDK2 (but not with CDC2), interacts with SCAPER By similarity.

Subcellular location

Nucleus. Cytoplasm. Note: Cytoplasmic when associated with SCAPER By similarity.

Tissue specificity

Ubiquitous. In the testis, expressed in germ cells and in the ovary, in both germline and somatic cells.

Developmental stage

Accumulates steadily during G2 and is abruptly destroyed at mitosis. Expressed in spermatogonia and is most abundant in preleptotene spermatocytes, cells which will enter the meiotic pathway.

Sequence similarities

Belongs to the cyclin family. Cyclin AB subfamily.

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Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Cellular componentCytoplasm
Nucleus
   Molecular functionCyclin
Gene Ontology (GO)
   Biological processcell division

Inferred from electronic annotation. Source: UniProtKB-KW

mitosis

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of transcription

Inferred from genetic interaction. Source: MGI

   Cellular componentcytoplasm

Inferred from direct assay. Source: MGI

female pronucleus

Inferred from direct assay. Source: MGI

male pronucleus

Inferred from direct assay. Source: MGI

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

Cdc2P114402EBI-846980,EBI-846949
Cdk2P973773EBI-846980,EBI-847048

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Cyclin-A2
PRO_0000080340

Experimental info

Sequence conflict3911A → P in CAA53212. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P51943-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4986C12023A1C7F0

FASTA42247,283
        10         20         30         40         50         60 
MPGTSRHSGR DAGSALLSLH QEDQENVNPE KLAPAQQPRA QAVLKAGNVR GPAPQQKLKT 

        70         80         90        100        110        120 
RRVAPLKDLP INDEHVTAGP SWKAVSKQPA FTIHVDEAEE TQKRPAELKE TECEDALAFN 

       130        140        150        160        170        180 
AAVSLPAARK PLTPLDYPMD GSFESPHAMD MSIVLEDKPV NVNEVPDYQE DIHTYLREME 

       190        200        210        220        230        240 
VKCKPKVGYM KRQPDITNSM RAILVDWLVE VGEEYKLQNE TLHLAVNYID RFLSSMSVLR 

       250        260        270        280        290        300 
GKLQLVGTAA MLLASKFEEI YPPEVAEFVY ITDDTYSKKQ VLRMEHLVLK VLAFDLAAPT 

       310        320        330        340        350        360 
VNQFLTQYFL HLQPANCKVE SLAMFLGELS LIDADPYLKY LPSLIAGAAF HLALYTVTGQ 

       370        380        390        400        410        420 
SWPESLAQQT GYTLESLKPC LVDLHQTYLK APQHAQQSIR EKYKHSKYHS VSLLNPPETL 


SV

« Hide

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References

[1]"The developmentally restricted pattern of expression in the male germ line of a murine cyclin A, cyclin A2, suggests roles in both mitotic and meiotic cell cycles."
Ravnik S.E., Wolgemuth D.J.
Dev. Biol. 173:69-78(1996) [PubMed: 8575639] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A distinct cyclin A is expressed in germ cells in the mouse."
Sweeney C., Murphy M., Kubelka M., Ravnik S.E., Hawkins C.F., Wolgemuth D.J., Carrington M.
Development 122:53-64(1996) [PubMed: 8565853] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Thymus.
[3]"Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage."
Ravnik S.E., Wolgemuth D.J.
Dev. Biol. 207:408-418(1999) [PubMed: 10068472] [Abstract]
Cited for: FUNCTION.
Strain: Swiss Webster.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z26580 mRNA. Translation: CAA81331.1.
X75483 mRNA. Translation: CAA53212.1.
IPIIPI00128671.
PIRS37280.
S38501.
RefSeqNP_033958.2.
UniGeneMm.4189

3D structure databases

SMRP51943. Positions 163-422.
ModBaseSearch...

Protein-protein interaction databases

IntActP51943. 2 interactions.
STRINGP51943.

PTM databases

PhosphoSiteP51943.

Proteomic databases

PRIDEP51943.

Genome annotation databases

EnsemblENSMUST00000029270; ENSMUSP00000029270; ENSMUSG00000027715; Mus musculus. [Genome view]
GeneID12428.
KEGGmmu:12428.
UCSCuc008ozo.1. mouse.

Organism-specific databases

CTD12428.
MGIMGI:108069. Ccna2.

Phylogenomic databases

HOGENOMHBG750484.
HOVERGENP51943.
InParanoidP51943.

Gene expression databases

ArrayExpressP51943.
BgeeP51943.
CleanExMM_CCNA2.
GenevestigatorP51943.
GermOnlineENSMUSG00000027715. Mus musculus.

Family and domain databases

InterProIPR015453. CycA.
IPR006670. Cyclin.
IPR011028. Cyclin-like.
IPR014400. Cyclin_A_B_D_E.
IPR004367. Cyclin_C.
IPR006671. Cyclin_N.
IPR013763. Cyclin_related.
[Graphical view]
Gene3DG3DSA:1.10.472.10. Cyclin_related. 1 hit.
PANTHERPTHR10177:SF23. CycA. 1 hit.
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameCCNA2_MOUSE
AccessionPrimary (citable) accession number: P51943
Secondary accession number(s): Q61459
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 15, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents