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Protein

Cartilage matrix protein

Gene

Matn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.

GO - Molecular functioni

GO - Biological processi

  • chondrocyte differentiation Source: MGI
  • growth plate cartilage chondrocyte morphogenesis Source: MGI
  • regulation of bone mineralization Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Cartilage matrix protein
Alternative name(s):
Matrilin-1
Gene namesi
Name:Matn1
Synonyms:Cmp, Crtm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:106591. Matn1.

Subcellular locationi

GO - Cellular componenti

  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000749630 – 500Cartilage matrix proteinAdd BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 225Sequence analysis
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi231 ↔ 242By similarity
Disulfide bondi238 ↔ 251By similarity
Disulfide bondi253 ↔ 266By similarity
Disulfide bondi269 ↔ 456Sequence analysis
Glycosylationi348N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP51942.
PaxDbiP51942.
PRIDEiP51942.

PTM databases

PhosphoSitePlusiP51942.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040533.
CleanExiMM_MATN1.
GenevisibleiP51942. MM.

Interactioni

Subunit structurei

Homotrimer. Interacts with COMP (By similarity).By similarity

Protein-protein interaction databases

IntActiP51942. 1 interactor.
STRINGi10090.ENSMUSP00000099636.

Structurei

3D structure databases

ProteinModelPortaliP51942.
SMRiP51942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 226VWFA 1PROSITE-ProRule annotationAdd BLAST197
Domaini227 – 267EGF-likeAdd BLAST41
Domaini268 – 457VWFA 2PROSITE-ProRule annotationAdd BLAST190

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili471 – 499Sequence analysisAdd BLAST29

Sequence similaritiesi

Contains 1 EGF-like domain.Curated
Contains 2 VWFA domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KD9M. Eukaryota.
ENOG410XSCQ. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000263415.
HOVERGENiHBG056906.
InParanoidiP51942.
OMAiQIASEPQ.
OrthoDBiEOG091G04O4.
TreeFamiTF330078.

Family and domain databases

Gene3Di1.20.5.30. 1 hit.
3.40.50.410. 2 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR030751. Matrilin-1.
IPR019466. Matrilin_coiled-coil_trimer.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR11132:SF91. PTHR11132:SF91. 1 hit.
PfamiPF10393. Matrilin_ccoil. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM01279. Matrilin_ccoil. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTSGPAFA LCSLLLLLLL LLQVPDSLSL VPQPRGHLCR TRPTDLVFVV
60 70 80 90 100
DSSRSVRPVE FEKVKVFLSQ VIESLDVGPN ATRVGLVNYA STVKPEFPLR
110 120 130 140 150
AHGSKASLLQ AVRRIQPLST GTMTGLALQF AITKALSDAE GGRARSPDIS
160 170 180 190 200
KVVIVVTDGR PQDSVRDVSE RARASGIELF AIGVGRVDKA TLRQIASEPQ
210 220 230 240 250
DEHVDYVESY NVIEKLAKKF QEAFCVVSDL CATGDHDCEQ LCVSSPGSYT
260 270 280 290 300
CACHEGFTLN SDGKTCNVCR GGGSGSATDL VFLIDGSKSV RPENFELVKK
310 320 330 340 350
FINQIVDTLD VSDRLAQVGL VQYSSSIRQE FPLGRFHTKK DIKAAVRNMS
360 370 380 390 400
YMEKGTMTGA ALKYLIDNSF TVSSGARPGA QKVGIVFTDG RSQDYINDAA
410 420 430 440 450
RKAKDLGFKM FAVGVGNAVE EELREIASEP VADHYFYTAD FKTINQIGKK
460 470 480 490 500
LQKQICVEED PCACESILKF EAKVEGLLQA LTRKLEAVSG RLAVLENRII
Length:500
Mass (Da):54,421
Last modified:July 27, 2011 - v2
Checksum:iDD034F293479A882
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9F → S in AAB06521 (PubMed:8665920).Curated1
Sequence conflicti184V → L in AAB06521 (PubMed:8665920).Curated1
Sequence conflicti338T → S in AAB06521 (PubMed:8665920).Curated1
Sequence conflicti345A → R in AAB06521 (PubMed:8665920).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35035 mRNA. Translation: AAB06521.1.
Y13902 Genomic DNA. Translation: CAC79633.1.
AL669980 Genomic DNA. Translation: CAM17812.1.
CU210856 Genomic DNA. Translation: CAQ51562.1.
BC047140 mRNA. Translation: AAH47140.1.
CCDSiCCDS18713.1.
PIRiS66522.
RefSeqiNP_034899.2. NM_010769.2.
UniGeneiMm.271796.

Genome annotation databases

EnsembliENSMUST00000102576; ENSMUSP00000099636; ENSMUSG00000040533.
GeneIDi17180.
KEGGimmu:17180.
UCSCiuc008uzx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35035 mRNA. Translation: AAB06521.1.
Y13902 Genomic DNA. Translation: CAC79633.1.
AL669980 Genomic DNA. Translation: CAM17812.1.
CU210856 Genomic DNA. Translation: CAQ51562.1.
BC047140 mRNA. Translation: AAH47140.1.
CCDSiCCDS18713.1.
PIRiS66522.
RefSeqiNP_034899.2. NM_010769.2.
UniGeneiMm.271796.

3D structure databases

ProteinModelPortaliP51942.
SMRiP51942.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP51942. 1 interactor.
STRINGi10090.ENSMUSP00000099636.

PTM databases

PhosphoSitePlusiP51942.

Proteomic databases

MaxQBiP51942.
PaxDbiP51942.
PRIDEiP51942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102576; ENSMUSP00000099636; ENSMUSG00000040533.
GeneIDi17180.
KEGGimmu:17180.
UCSCiuc008uzx.2. mouse.

Organism-specific databases

CTDi4146.
MGIiMGI:106591. Matn1.

Phylogenomic databases

eggNOGiENOG410KD9M. Eukaryota.
ENOG410XSCQ. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000263415.
HOVERGENiHBG056906.
InParanoidiP51942.
OMAiQIASEPQ.
OrthoDBiEOG091G04O4.
TreeFamiTF330078.

Enzyme and pathway databases

ReactomeiR-MMU-3000178. ECM proteoglycans.

Miscellaneous databases

PROiP51942.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040533.
CleanExiMM_MATN1.
GenevisibleiP51942. MM.

Family and domain databases

Gene3Di1.20.5.30. 1 hit.
3.40.50.410. 2 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR030751. Matrilin-1.
IPR019466. Matrilin_coiled-coil_trimer.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR11132:SF91. PTHR11132:SF91. 1 hit.
PfamiPF10393. Matrilin_ccoil. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM01279. Matrilin_ccoil. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMATN1_MOUSE
AccessioniPrimary (citable) accession number: P51942
Secondary accession number(s): Q80VN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.