Reviewed, UniProtKB/Swiss-Prot P51925 (GON2_SPAAU)

Names and origin

Protein names

Recommended name:
    Progonadoliberin-2
Alternative name(s):
    Progonadoliberin II
Cleaved into the following 2 chains:
    1- Recommended name:
            Gonadoliberin-2
        Alternative name(s):
            Gonadoliberin II
            Luteinizing hormone-releasing hormone II
              Short name=LH-RH II
            Gonadotropin-releasing hormone II
              Short name=GnRH II
            Luliberin II
    2- Recommended name:
            GnRH-associated peptide 2
        Alternative name(s):
            GnRH-associated peptide II

Gene names

Name:

gnrh2

Organism

Sparus aurata (Gilthead sea bream)

Taxonomic identifier

8175 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Percoidei › Sparidae › Sparus

Protein attributes

Sequence length	85 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Stimulates the secretion of gonadotropins.
Subcellular location	Secreted.
Sequence similarities	Belongs to the GnRH family.
Mass spectrometry	Molecular mass is 1236.6 Da from positions 24 - 33. Determined by MALDI. Ref.2

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Pyrrolidone carboxylic acid
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Ref.2
	Chain	24 – 85	62	Progonadoliberin-2		PRO_0000012496
	Peptide	24 – 33	10	Gonadoliberin-2		PRO_0000012497
	Peptide	37 – 85	49	GnRH-associated peptide 2		PRO_0000012498
Amino acid modifications
	Modified residue	24	1	Pyrrolidone carboxylic acid
	Modified residue	33	1	Glycine amide

Sequences

	Sequence		Length	Mass (Da)
	P51925-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: B53165C1227722CC	FASTA	85	9,543
	10 20 30 40 50 60 MCVSRLVLLL GLLLCVGAQL SNGQHWSHGW YPGGKRELDS FGTSEISEEI KLCEAGECSY 70 80 LTPQRRSVLR NILLDALARE LQKRK

References

[1]	"Levels of the native forms of GnRH in the pituitary of the gilthead seabream, Sparus aurata, at several characteristic stages of the gonadal cycle." Holland M.C.H., Gothilf Y., Meiri I., King J.A., Okuzawa K., Elizur A., Zohar Y. Gen. Comp. Endocrinol. 112:394-405(1998) [PubMed: 9843645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Three forms of gonadotropin-releasing hormone characterized from brains of one species." Powell J.F.F., Zohar Y., Elizur A., Park M., Fischer W.H., Craig A.G., Rivier J.E., Lovejoy D.A., Sherwood N.M. Proc. Natl. Acad. Sci. U.S.A. 91:12081-12085(1994) [PubMed: 7991588] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-33, MASS SPECTROMETRY. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U30325 mRNA. Translation: AAA75447.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P51925.
Family and domain databases
InterPro	IPR002012. GnRH. IPR019792. Gonadoliberin_I. [Graphical view]
PANTHER	PTHR10522. GnRH. 1 hit.
Pfam	PF00446. GnRH. 1 hit. [Graphical view]
PROSITE	PS00473. GNRH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GON2_SPAAU

Accession

Primary (citable) accession number: P51925

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)